2-methoxy-6-methyl pyrazine
2-methoxy-6-methylpyrazine

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CODE146414 CODE146414
Product(s):
2882-21-5 Pyrazine,2-methoxy-6-methyl-

Name:	2-methoxy-6-methylpyrazine
CAS Number:	2882-21-5	3D/inchi
ECHA EINECS - REACH Pre-Reg:	220-737-3
FDA UNII:	18565KT6V3
Nikkaji Web:	J143.096C
CoE Number:	2266
XlogP3:	1.30 (est)
Molecular Weight:	124.14296000
Formula:	C6 H8 N2 O
BioActivity Summary:	listing
NMR Predictor:	Predict (works with chrome, Edge or firefox)
EFSA/JECFA Comments:
JECFA evaluated (2,5 or 6)-methoxy-3-methylpyrazine (CASrn 2847-30-5, 2882-22-6, 2882-21-5). Register CASrn refers to methoxymethylpyrazine.

Category:flavoring agents

US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:

Google Scholar:	Search
Google Books:	Search
Google Scholar: with word "volatile"	Search
Google Scholar: with word "flavor"	Search
Google Scholar: with word "odor"	Search
Perfumer and Flavorist:	Search
Google Patents:	Search
US Patents:	Search
EU Patents:	Search
Pubchem Patents:	Search
PubMed:	Search
NCBI:	Search
DG SANTE Food Flavourings:	14.025 2-methoxy-6-methylpyrazine
FEMA Number:	3183 2-methoxy-6-methylpyrazine
FDA:	No longer provide for the use of these seven synthetic flavoring substances

Physical Properties:

Appearance:	colorless clear liquid (est)
Food Chemicals Codex Listed:	No
Boiling Point:	170.00 to 171.00 °C. @ 760.00 mm Hg
Vapor Pressure:	1.931000 mmHg @ 25.00 °C. (est)
Flash Point:	144.00 °F. TCC ( 62.22 °C. )
logP (o/w):	1.290
Soluble in:
	alcohol
	water, 7665 mg/L @ 25 °C (est)

Organoleptic Properties:

Odor Type: nutty

hazelnut roasted hazelnut almond roasted almond peanut roasted peanut

Odor Description:at 0.10 % in propylene glycol. roasted hazelnut almond peanut

Odor and/or flavor descriptions from others (if found).

Cosmetic Information:

None found

Suppliers:

BOC Sciences

For experimental / research use only.

Pyrazine,2-methoxy-6-methyl-

Parchem

2-methoxy-6-methyl pyrazine

Safety Information:


Hazards identification

Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements

Pictogram

Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined

Safety in Use Information:

Category:
flavoring agents
Recommendation for 2-methoxy-6-methyl pyrazine usage levels up to:
	not for fragrance use.

Maximised Survey-derived Daily Intakes (MSDI-EU):		2.20 (μg/capita/day)
Maximised Survey-derived Daily Intakes (MSDI-USA):		15.00 (μg/capita/day)
Structure Class:		II
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 4
Click here to view publication 4
		average usual ppm	average maximum ppm
baked goods:		-	4.00000
beverages(nonalcoholic):		-	-
beverages(alcoholic):		-	-
breakfast cereal:		-	-
cheese:		-	-
chewing gum:		-	-
condiments / relishes:		-	-
confectionery froastings:		-	-
egg products:		-	-
fats / oils:		-	-
fish products:		-	-
frozen dairy:		-	2.00000
fruit ices:		-	2.00000
gelatins / puddings:		-	2.00000
granulated sugar:		-	-
gravies:		-	-
hard candy:		-	4.00000
imitation dairy:		-	-
instant coffee / tea:		-	-
jams / jellies:		-	-
meat products:		-	-
milk products:		-	-
nut products:		-	-
other grains:		-	-
poultry:		-	-
processed fruits:		-	-
processed vegetables:		-	-
reconstituted vegetables:		-	-
seasonings / flavors:		-	-
snack foods:		-	-
soft candy:		-	-
soups:		-	-
sugar substitutes:		-	-
sweet sauces:		-	-

Safety References:

European Food Safety Athority(EFSA):Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies...

European Food Safety Authority (EFSA) reference(s):

Safety and efficacy of pyrazine derivatives including saturated ones belonging to chemical group 24 when used as flavourings for all animal species
View page or View pdf

EPI System: View

AIDS Citations:Search

Cancer Citations:Search

Toxicology Citations:Search

EPA Substance Registry Services (TSCA):2882-21-5

EPA ACToR:Toxicology Data

EPA Substance Registry Services (SRS):Registry

Laboratory Chemical Safety Summary :520395

National Institute of Allergy and Infectious Diseases:Data

2-methoxy-6-methylpyrazine

Chemidplus:0002882215

References:

	2-methoxy-6-methylpyrazine
NIST Chemistry WebBook:	Search Inchi
Pubchem (cid):	520395
Pubchem (sid):	134982610
Pherobase:	View

Other Information:

(IUPAC):	Atomic Weights of the Elements 2011 (pdf)
Videos:	The Periodic Table of Videos
tgsc:	Atomic Weights use for this web site
(IUPAC):	Periodic Table of the Elements
FDA Substances Added to Food (formerly EAFUS):	View
CHEMBL:	View
HMDB (The Human Metabolome Database):	HMDB40143
FooDB:	FDB019840
VCF-Online:	VCF Volatile Compounds in Food
ChemSpider:	View