| Name: | 6,7-dihydro-2,5-dimethyl-5H-cyclopentapyrazine |
| CAS Number: | 38917-61-2 |  3D/inchi
|
| % from: | 60.00% to 100.00% |
| FDA UNII: | Search |
| Nikkaji Web: | J532.775J |
| CoE Number: | 11310 |
| XlogP3-AA: | 1.20 (est) |
| Molecular Weight: | 148.20864000 |
| Formula: | C9 H12 N2 |
| NMR Predictor: | Predict (works with chrome, Edge or firefox) |
| Also(can) Contains: | 6,7-dihydro-2,3-dimethyl-5H-cyclopentapyrazine 30.00% to 60.00% |
| EFSA/JECFA Comments: |
| Change name to: 2,5-dimethyl-6,7-dihydro-5Hcyclopentapyrazine. Covers mix of 2,5-dimethyl-6,7-dihydro-5Hcyclopentapyrazine (60-100%) & 3,5-dimethyl-6,7-dihydro-5Hcyclopentapyrazine (up to 40 %). Composition of mixture and stereoisomeric composition to be more specified. |
Category: flavoring agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Appearance: | colorless to pale yellow clear liquid (est) |
| Assay: | 95.00 to 100.00
|
| Food Chemicals Codex Listed: | No |
| Specific Gravity: | 1.02000 to 1.03000 @ 20.00 °C.
|
| Pounds per Gallon - (est).: | 8.497 to 8.581
|
| Refractive Index: | 1.52400 to 1.53200 @ 20.00 °C.
|
| Melting Point: | 130.00 °C. @ 760.00 mm Hg
|
| Boiling Point: | 230.00 to 231.00 °C. @ 760.00 mm Hg
|
| Vapor Pressure: | 0.154000 mmHg @ 25.00 °C. (est) |
| Vapor Density: | 5.1 ( Air = 1 ) |
| Flash Point: | 149.00 °F. TCC ( 65.00 °C. )
|
| logP (o/w): | 1.770 |
| Soluble in: |
| | alcohol | | | water, 719 mg/L @ 25 °C (est) |
Organoleptic Properties:
| Odor Type: burnt |
| burnt earthy nutty coffee roasted coffee |
| Odor Description:at 0.10 % in propylene glycol. burnt earthy nutty roasted coffee |
| Odor and/or flavor descriptions from others (if found). |
| Taytonn ASCC |
| Dimethyl Dihydrocyclopentapyrazine |
| Odor Description:Burnt, Earthy, Nutty, Roast |
Cosmetic Information:
Suppliers:
| BOC Sciences |
| For experimental / research use only. |
| 5H-Cyclopentapyrazine, 6,7-dihydro-2,5-dimethyl-
|
| Carbosynth |
| For experimental / research use only. |
| 2(3)-5-Dimethyl-6,7-dihydro-5h-cyclopentapyrazine
|
| Endeavour Specialty Chemicals |
| 2(3)-5-Dimethyl-6,7-dihydro-5h-cyclopentapyrazine
|
| Speciality Chemical Product Groups |
| Frutarom |
| DIMETHYL DIHYDROCYCLOPENTAPYRAZINE
KOSHER Flavor: Burnt, Earthy, Roasted, Nutty |
| CBD Offering |
| IFF |
| DIMETHYL DIHYDROCYCLOPENTAPYRAZINE
KOSHER Flavor: Burnt, Earthy, Roasted, Nutty |
| R C Treatt & Co Ltd |
| 2,5-Dimethyl-6,7-dihydro-5H-cyclopentapyrazine
Kosher |
| Robinson Brothers |
| 2(3)-5-Dimethyl-6,7-dihydro-5h-cyclopentapyrazine F&F
|
| https://www.robinsonbrothers.uk/chemistry-competences |
| Taytonn ASCC |
| Dimethyl Dihydrocyclopentapyrazine
Odor: Burnt, Earthy, Nutty, Roast |
Safety Information:
| European information : |
| Most important hazard(s): | | Xi - Irritant |
R 36/37/38 - Irritating to eyes, respiratory system, and skin.
S 02 - Keep out of the reach of children.
S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S 36/37/39 - Wear suitable clothing, gloves and eye/face protection.
|
| |
| Hazards identification |
| |
| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
| |
| Pictogram | |
| |
| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
|
Not determined
|
| Dermal Toxicity: |
|
Not determined
|
| Inhalation Toxicity: |
|
Not determined
|
Safety in Use Information:
| Category: | | flavoring agents |
| Recommendation for dimethyl dihydrocyclopentapyrazine usage levels up to: | | | not for fragrance use.
|
| |
| Maximised Survey-derived Daily Intakes (MSDI-EU): | 0.10 (μg/capita/day) |
| Modified Theoretical Added Maximum Daily Intake (mTAMDI): | 270 (μg/person/day) |
| Threshold of Concern: | 540 (μg/person/day) |
| Structure Class: | II |
| Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS). |
| The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library |
| publication number: 25 |
| Click here to view publication 25 |
| | average usual ppm | average maximum ppm |
| baked goods: | 10.00000 | 15.00000 |
| beverages(nonalcoholic): | 10.00000 | 15.00000 |
| beverages(alcoholic): | 10.00000 | 15.00000 |
| breakfast cereal: | 10.00000 | 15.00000 |
| cheese: | 10.00000 | 15.00000 |
| chewing gum: | 10.00000 | 15.00000 |
| condiments / relishes: | 10.00000 | 15.00000 |
| confectionery froastings: | 10.00000 | 15.00000 |
| egg products: | - | - |
| fats / oils: | 20.00000 | 25.00000 |
| fish products: | - | - |
| frozen dairy: | 10.00000 | 15.00000 |
| fruit ices: | 10.00000 | 15.00000 |
| gelatins / puddings: | 12.00000 | 18.00000 |
| granulated sugar: | 10.00000 | 15.00000 |
| gravies: | 15.00000 | 20.00000 |
| hard candy: | 20.00000 | 25.00000 |
| imitation dairy: | 10.00000 | 15.00000 |
| instant coffee / tea: | 10.00000 | 15.00000 |
| jams / jellies: | 10.00000 | 15.00000 |
| meat products: | - | - |
| milk products: | 10.00000 | 15.00000 |
| nut products: | 10.00000 | 15.00000 |
| other grains: | 10.00000 | 15.00000 |
| poultry: | - | - |
| processed fruits: | - | - |
| processed vegetables: | - | - |
| reconstituted vegetables: | 10.00000 | 15.00000 |
| seasonings / flavors: | 10.00000 | 15.00000 |
| snack foods: | 10.00000 | 15.00000 |
| soft candy: | 10.00000 | 15.00000 |
| soups: | 10.00000 | 15.00000 |
| sugar substitutes: | 10.00000 | 15.00000 |
| sweet sauces: | 10.00000 | 15.00000 |
| |
| Food categories according to Commission Regulation EC No. 1565/2000 (EC, 2000) in FGE.06 (EFSA, 2002a). According to the Industry the "normal" use is defined as the average of reported usages and "maximum use" is defined as the 95th percentile of reported usages (EFSA, 2002i). |
| Note: mg/kg = 0.001/1000 = 0.000001 = 1/1000000 = ppm. |
| | average usage mg/kg | maximum usage mg/kg |
| Dairy products, excluding products of category 02.0 (01.0): | 0.40000 | 2.00000 |
| Fats and oils, and fat emulsions (type water-in-oil) (02.0): | 0.10000 | 0.50000 |
| Edible ices, including sherbet and sorbet (03.0): | 0.40000 | 2.00000 |
| Processed fruit (04.1): | 0.40000 | 2.00000 |
| Processed vegetables (incl. mushrooms & fungi, roots & tubers, pulses and legumes), and nuts & seeds (04.2): | - | - |
| Confectionery (05.0): | 1.00000 | 5.00000 |
| Chewing gum (05.3): | - | - |
| Cereals and cereal products, incl. flours & starches from roots & tubers, pulses & legumes, excluding bakery (06.0): | 0.20000 | 1.00000 |
| Bakery wares (07.0): | 1.00000 | 5.00000 |
| Meat and meat products, including poultry and game (08.0): | 0.10000 | 0.40000 |
| Fish and fish products, including molluscs, crustaceans and echinoderms (MCE) (09.0): | 0.10000 | 0.40000 |
| Eggs and egg products (10.0): | - | - |
| Sweeteners, including honey (11.0): | - | - |
| Salts, spices, soups, sauces, salads, protein products, etc. (12.0): | 0.10000 | 0.50000 |
| Foodstuffs intended for particular nutritional uses (13.0): | 0.20000 | 1.00000 |
| Non-alcoholic ("soft") beverages, excl. dairy products (14.1): | 0.20000 | 1.00000 |
| Alcoholic beverages, incl. alcohol-free and low-alcoholic counterparts (14.2): | 1.00000 | 5.00000 |
| Ready-to-eat savouries (15.0): | 1.00000 | 5.00000 |
| Composite foods (e.g. casseroles, meat pies, mincemeat) - foods that could not be placed in categories 01.0 - 15.0 (16.0): | 0.20000 | 1.00000 |
Safety References:
European Food Safety Athority(EFSA):Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies...
|
European Food Safety Authority (EFSA) reference(s):
|
Opinion of the Scientific Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) on a request from the Commission related to Flavouring Group Evaluation 17 (FGE.17): Pyrazine derivatives from chemical group 24 (Commission Regulation (EC) No 1565/2000 of 18 July 2000)
View page or View pdf
|
Flavouring Group Evaluation 50 (FGE.50): Consideration of pyrazine derivatives evaluated by JECFA (57th meeting) structurally related to pyrazine derivatives evaluated by EFSA in FGE.17 (2005) (Commission Regulation (EC) No 1565/2000 of 18 July 2000) - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC)
View page or View pdf
|
Flavouring Group Evaluation 17, Revision 1 (FGE.17Rev1): Pyrazine derivatives from chemical group 24 - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC) [1]
View page or View pdf
|
Scientific Opinion on Flavouring Group Evaluation 17, Revision 2 (FGE.17Rev2): Pyrazine derivatives from chemical group 24
View page or View pdf
|
Scientific Opinion on Flavouring Group Evaluation 50, Revision 1 (FGE.50Rev1): Consideration of pyrazine derivatives evaluated by JECFA (57th meeting) structurally related to pyrazine derivatives evaluated by EFSA in FGE.17Rev2 (2010)
View page or View pdf
|
Scientific Opinion on Flavouring Group Evaluation 17, Revision 3 (FGE.17Rev3): Pyrazine derivatives from chemical group 24
View page or View pdf
|
| EPI System: View |
| AIDS Citations:Search |
| Cancer Citations:Search |
| Toxicology Citations:Search |
| EPA ACToR:Toxicology Data |
| EPA Substance Registry Services (SRS):Registry |
| Laboratory Chemical Safety Summary :530404 |
| National Institute of Allergy and Infectious Diseases:Data |
| 6,7-dihydro-2,5-dimethyl-5H-cyclopentapyrazine |
| Chemidplus:0038917612 |
References:
Other Information:
Potential Blenders and core components note
| For Odor |
| No odor group found for these |
sulfuryl octanoate
FL/FR |
|
sulfuryl butyrate
FL/FR |
sulfuryl decanoate
FL/FR |
sulfuryl hexanoate
FL/FR |
sulfuryl isobutyrate
FL/FR |
sulfuryl propionate
FL/FR |
| alliaceous |
| alliaceous |
dipropyl disulfide
FL/FR |
| fruity |
tropical trithiane
FL/FR |
| green |
geranium thiazole
FL/FR |
2- heptyl furan
FL/FR |
| musty |
3- acetyl-2,5-dimethyl furan
FL/FR |
hazelnut pyrazine
FL/FR |
menthofuran
FL/FR |
| nutty |
2- acetyl-3-ethyl pyrazine
FL/FR |
2- acetyl-3-methyl pyrazine
FL/FR |
3,6- cocoa pyrazine
FL/FR |
2,3- dimethyl pyrazine
FL/FR |
filbert heptenone
FL/FR |
2- methyl thio-3,5 or 6-methyl pyrazine
FL/FR |
nutty quinoxaline
FL/FR |
| sulfurous |
furfuryl thioacetate
FL/FR |
S- furfuryl thioformate
FL/FR |
| vegetable |
mesityl oxide
FL/FR |
| waxy |
2- tridecanone
FL/FR |
| For Flavor |
| No flavor group found for these |
benzyl disulfide
FL |
6,7- dihydro-2,3-dimethyl-5H-cyclopentapyrazine
FL |
6,7- dimethyl dihydrocyclopentapyrazine
FL |
2,5- dimethyl thiazole
FL |
sulfuryl butyrate
FL/FR |
sulfuryl decanoate
FL/FR |
sulfuryl hexanoate
FL/FR |
sulfuryl isobutyrate
FL/FR |
|
sulfuryl formate
FL |
sulfuryl octanoate
FL/FR |
sulfuryl propionate
FL/FR |
| alliaceous |
| alliaceous |
dipropyl disulfide
FL/FR |
| coffee |
difurfuryl ether
FL |
| fatty |
2- heptyl furan
FL/FR |
2- tridecanone
FL/FR |
| fishy |
4,5- dimethyl thiazole
FL |
| fruity |
tropical trithiane
FL/FR |
| green |
dihydroxyacetophenone (mixed isomers)
FL |
geranium thiazole
FL/FR |
2- methyl-5-isopropyl pyrazine
FL |
| musty |
hazelnut pyrazine
FL/FR |
menthofuran
FL/FR |
| nutty |
3- acetyl-2,5-dimethyl furan
FL/FR |
2- acetyl-3-ethyl pyrazine
FL/FR |
2- acetyl-3-methyl pyrazine
FL/FR |
3,6- cocoa pyrazine
FL/FR |
2,3- dimethyl pyrazine
FL/FR |
filbert heptenone
FL/FR |
2- methyl thio-3,5 or 6-methyl pyrazine
FL/FR |
nutty quinoxaline
FL/FR |
nutty thiazole
FL |
| popcorn |
2- propionyl-2-thiazoline
FL |
| potato |
mesityl oxide
FL/FR |
| roasted |
furfuryl thioacetate
FL/FR |
| solvent |
2- ethyl furan
FL |
| sulfurous |
diphenyl disulfide
FL |
S- furfuryl thioformate
FL/FR |
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| 5H- | cyclopentapyrazine, 6,7-dihydro-2,5-dimethyl- | | 6,7- | dihydro-2,5-dimethyl-5H-cyclopentapyrazine | | 6,7- | dihydro-2,5(2,3)-dimethyl-5H-cyclopentapyrazine | | 2,5- | dimethyl-6,7-dihydro-(5H)-cyclopentapyrazine | | 2,5- | dimethyl-6,7-dihydro-5H-cyclopenta[b]pyrazine | | 2,5- | dimethyl-6,7-dihydro-5H-cyclopentapyrazine | | 2,5- and 2,3- | dimethyl-6,7-dihydro-5H-cyclopentapyrazine | | 2(3),5- | dimethyl-6,7-dihydro-5H-cyclopentapyrazine |
Articles:
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