Category:flavor and fragrance agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
Appearance: | colorless to pale yellow liquid to solid (est) |
Assay: | 97.00 to 100.00
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Food Chemicals Codex Listed: | No |
Specific Gravity: | 0.96700 to 0.97500 @ 20.00 °C.
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Pounds per Gallon - (est).: | 8.056 to 8.122
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Refractive Index: | 1.49000 to 1.49800 @ 20.00 °C.
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Melting Point: | 112.00 °C. @ 760.00 mm Hg
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Boiling Point: | 267.00 °C. @ 760.00 mm Hg
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Vapor Pressure: | 0.076000 mmHg @ 25.00 °C. (est) |
Flash Point: | 75.00 °F. TCC ( 23.89 °C. )
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logP (o/w): | 2.224 (est) |
Soluble in: |
| alcohol | | water, 22.21 mg/L @ 25 °C (est) |
Insoluble in: |
| water |
Stability: |
| stable in most media |
Organoleptic Properties:
Odor Type: green |
Odor Strength:high , recommend smelling in a 0.10 % solution or less |
Substantivity:89 hour(s) at 100.00 % |
geranium green rose red rose nutty vegetable nut skin earthy beany |
Odor Description:at 0.10 % in dipropylene glycol. geranium green red rose nutty vegetable nut skin earthy beany Luebke, William tgsc, (2017) |
Odor sample from: R C Treatt and Co Ltd |
Flavor Type: green |
green vegetable nut flesh earthy nut skin licorice rose red rose fennel |
Taste Description: green vegetable nut flesh earthy nut skin licorice red rose fennel Luebke, William tgsc, (2017) |
Odor and/or flavor descriptions from others (if found). |
Cosmetic Information:
Suppliers:
Safety Information:
Preferred SDS: View |
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Hazards identification |
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Classification of the substance or mixture |
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
None found. |
GHS Label elements, including precautionary statements |
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Pictogram | |
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Hazard statement(s) |
None found. |
Precautionary statement(s) |
None found. |
Oral/Parenteral Toxicity: |
Not determined
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Dermal Toxicity: |
Not determined
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Inhalation Toxicity: |
Not determined
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Safety in Use Information:
Category: | flavor and fragrance agents |
RIFM Fragrance Material Safety Assessment: Search |
IFRA Code of Practice Notification of the 49th Amendment to the IFRA Code of Practice |
Recommendation for geranium thiazole usage levels up to: | | 0.0500 % in the fragrance concentrate.
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Maximised Survey-derived Daily Intakes (MSDI-EU): | 0.12 (μg/capita/day) |
Modified Theoretical Added Maximum Daily Intake (mTAMDI): | 160 (μg/person/day) |
Threshold of Concern: | 540 (μg/person/day) |
Structure Class: | II |
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS). |
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library |
publication number: 24 |
Click here to view publication 24 |
| average usual ppm | average maximum ppm |
baked goods: | - | - |
beverages(nonalcoholic): | 0.00100 | 0.00100 |
beverages(alcoholic): | - | - |
breakfast cereal: | - | - |
cheese: | - | - |
chewing gum: | - | - |
condiments / relishes: | - | - |
confectionery froastings: | - | - |
egg products: | - | - |
fats / oils: | - | - |
fish products: | - | - |
frozen dairy: | - | - |
fruit ices: | - | - |
gelatins / puddings: | - | - |
granulated sugar: | - | - |
gravies: | - | - |
hard candy: | 0.00500 | 0.05000 |
imitation dairy: | - | - |
instant coffee / tea: | - | - |
jams / jellies: | - | - |
meat products: | - | - |
milk products: | - | - |
nut products: | - | - |
other grains: | - | - |
poultry: | - | - |
processed fruits: | - | - |
processed vegetables: | - | - |
reconstituted vegetables: | - | - |
seasonings / flavors: | 0.00200 | 0.01000 |
snack foods: | - | - |
soft candy: | - | - |
soups: | - | - |
sugar substitutes: | - | - |
sweet sauces: | - | - |
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Food categories according to Commission Regulation EC No. 1565/2000 (EC, 2000) in FGE.06 (EFSA, 2002a). According to the Industry the "normal" use is defined as the average of reported usages and "maximum use" is defined as the 95th percentile of reported usages (EFSA, 2002i). |
Note: mg/kg = 0.001/1000 = 0.000001 = 1/1000000 = ppm. |
| average usage mg/kg | maximum usage mg/kg |
Dairy products, excluding products of category 02.0 (01.0): | 0.40000 | 2.00000 |
Fats and oils, and fat emulsions (type water-in-oil) (02.0): | 0.20000 | 1.00000 |
Edible ices, including sherbet and sorbet (03.0): | 0.40000 | 2.00000 |
Processed fruit (04.1): | 0.30000 | 1.50000 |
Processed vegetables (incl. mushrooms & fungi, roots & tubers, pulses and legumes), and nuts & seeds (04.2): | - | - |
Confectionery (05.0): | 0.40000 | 2.00000 |
Chewing gum (05.3): | - | - |
Cereals and cereal products, incl. flours & starches from roots & tubers, pulses & legumes, excluding bakery (06.0): | 0.20000 | 1.00000 |
Bakery wares (07.0): | 0.40000 | 2.00000 |
Meat and meat products, including poultry and game (08.0): | 0.10000 | 0.40000 |
Fish and fish products, including molluscs, crustaceans and echinoderms (MCE) (09.0): | 0.10000 | 0.40000 |
Eggs and egg products (10.0): | - | - |
Sweeteners, including honey (11.0): | - | - |
Salts, spices, soups, sauces, salads, protein products, etc. (12.0): | 0.20000 | 1.00000 |
Foodstuffs intended for particular nutritional uses (13.0): | 0.40000 | 2.00000 |
Non-alcoholic ("soft") beverages, excl. dairy products (14.1): | 0.20000 | 1.00000 |
Alcoholic beverages, incl. alcohol-free and low-alcoholic counterparts (14.2): | 0.40000 | 2.00000 |
Ready-to-eat savouries (15.0): | 1.00000 | 5.00000 |
Composite foods (e.g. casseroles, meat pies, mincemeat) - foods that could not be placed in categories 01.0 - 15.0 (16.0): | 0.20000 | 1.00000 |
Safety References:
European Food Safety Athority(EFSA):Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies...
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European Food Safety Authority (EFSA) reference(s):
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Flavouring Group Evaluation 21: Thiazoles, thiophene, thiazoline and thienyl derivatives from chemical group 29. Miscellaneous substances from chemical group 30. (Commission Regulation (EC) No 1565/2000 of 18 July 2000) - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC) View page or View pdf
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Flavouring Group Evaluation 76, (FGE.76)[1] - Consideration of sulphur-containing heterocyclic compounds evaluated by JECFA (59th meeting) structurally related to thiazoles, thiophene, thiazoline and thienyl derivatives from chemical group 29, miscellaneous substances from chemical group 30 evaluated by EFSA in FGE.21 - Scientific Opinion of the Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food View page or View pdf
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Flavouring Group Evaluation 21, Revision 1 (FGE.21Rev1): Thiazoles, thiophene, thiazoline and thienyl derivatives from chemical group 29 Miscellaneous substances from chemical group 30 View page or View pdf
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Flavouring Group Evaluation 93 (FGE.93): Consideration of sulphur heterocyclic evaluated by JECFA (68th meeting) structurally related to thiazoles, thiophene, thiazoline and thienyl evaluated by EFSA in FGE.21Rev1 (2009) View page or View pdf
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Scientific Opinion on Flavouring Group Evaluation 21, Revision 2 (FGE.21Rev2): Thiazoles, thiophene, thiazoline and thienyl derivatives from chemical group 29. Miscellaneous substances from chemical group 30. View page or View pdf
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Scientific Opinion on Flavouring Group Evaluation 21, Revision 3 (FGE.21Rev3): Thiazoles, thiophenes, thiazoline and thienyl derivatives from chemical groups 29 and 30 View page or View pdf
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Scientific Opinion on Flavouring Group Evaluation 21, Revision 4 (FGE.21Rev4): Thiazoles, thiophenes, thiazoline and thienyl derivatives from chemical groups 29 and 30 View page or View pdf
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Scientific Opinion on Flavouring Group Evaluation 21, Revision 5 (FGE.21Rev5): Thiazoles, thiophenes, thiazoline and thienyl derivatives from chemical groups 29 and 30 View page or View pdf
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EPI System: View |
AIDS Citations:Search |
Cancer Citations:Search |
Toxicology Citations:Search |
EPA Substance Registry Services (TSCA):53498-32-1 |
EPA ACToR:Toxicology Data |
EPA Substance Registry Services (SRS):Registry |
Laboratory Chemical Safety Summary :104513 |
National Institute of Allergy and Infectious Diseases:Data |
WGK Germany:3 |
4,5-dimethyl-2-(2-methylpropyl)-1,3-thiazole |
Chemidplus:0053498321 |
References:
Other Information:
Potential Blenders and core components note
For Odor |
aldehydic |
undecenal mixture (aldehyde C-11 mixed) FL/FR |
alliaceous |
dibutyl sulfide FL/FR |
dipropyl disulfide FL/FR |
balsamic |
benzophenone FR |
caramellic |
2-iso butyl-3-methyl pyrazine FL/FR |
chocolate |
cocoa pentenal FL/FR |
2,4,5- trimethyl thiazole FL/FR |
citrus |
methyl heptenone FL/FR |
coumarinic |
phthalide FL/FR |
ethereal |
2- methyl valeraldehyde FL/FR |
floral |
acetaldehyde dibutyl acetal FL/FR |
aeolanthus graveolens oil FR |
laevo- citronellol FL/FR |
citronellyl acetate FL/FR |
citronellyl butyrate FL/FR |
(E)- citronellyl tiglate FL/FR |
iso cyclodimethyl octanol FR |
cyclohexyl propanol FR |
cymbopogon validus leaf oil FR |
gamma- damascone FR |
dihydrorose oxide FR |
dimethyl benzyl carbinol FL/FR |
floral pyran FR |
geranium dihydropyran FR |
geranium essence FL/FR |
geranium leaf oil india FL/FR |
geranium nitrile FR |
geranium oil FL/FR |
geranium oil africa FL/FR |
geranium oil bourbon FL/FR |
geranium oil bourbon replacer FR |
geranium oil china FL/FR |
geranium oil egypt FL/FR |
geranium oil egypt fractions FR |
geranium oil morocco FL/FR |
geranium oil replacer FR |
geranium oil rwanda FL/FR |
geranium oil terpeneless FL/FR |
geranium petiole oil india FL/FR |
geranium pyran FR |
geranium rose oil FL/FR |
geranium rose-scented oil cuba FR |
geranium specialty FR |
geranyl anthranilate FR |
geranyl hexanoate FL/FR |
geranyl nonanoate CS |
geranyl phenyl acetate FL/FR |
geranyl tiglate FL/FR |
glycoacetal FR |
hexyl nonanoate FL/FR |
hydroxycitronellal dimethyl acetal FL/FR |
magnolia indene FR |
southern magnolia leaf oil fractions FR |
(3- methoxy-2-methyl propyl) benzene FR |
methyl citronellate FL/FR |
muguet butanol FR |
muguet carbinol FL/FR |
musk acetate FR |
narcissus acetate FL/FR |
neryl formate FL/FR |
palmarosa oil FL/FR |
pelargonium graveolens extract FL/FR |
pelargonium graveolens flower water FR |
pelargonium graveolens flower/leaf/stem water FR |
peony acetonitrile FR |
phenethyl formate FL/FR |
phenethyl phenyl acetate FL/FR |
phenethyl pivalate FL/FR |
phenyl acetaldehyde dicitronellyl acetal FR |
phenyl acetaldehyde digeranyl acetal FR |
phenyl propyl phenyl acetate FR |
rhodinol FL/FR |
rhodinyl butyrate FL/FR |
rhodinyl formate FL/FR |
rhodinyl isobutyrate FL/FR |
rhodinyl phenyl acetate FL/FR |
rhodinyl propionate FL/FR |
rose absolute pentanol FR |
rose geranium fragrance FR |
(Z)- rose oxide FL/FR |
laevo- rose oxide FL/FR |
styralyl propionate FL/FR |
fruity |
citronellyl isobutyrate FL/FR |
geranyl acetoacetate FL/FR |
2- heptyl butyrate FL/FR |
neryl propionate FL/FR |
tropical thiazole FL/FR |
green |
acetaldehyde butyl phenethyl acetal FL/FR |
benzhydrol FR |
iso butyl methyl ketone FL/FR |
2-iso butyl pyrazine FL/FR |
2-iso butyl thiazole FL/FR |
cortex pyridine FL/FR |
cucumber essence FL/FR |
diphenyl methane FL/FR |
diphenyl oxide FL/FR |
galbanum decatriene FL/FR |
geranium absolute FL/FR |
geranium fragrance FR |
geranium stem oil india FL/FR |
1- hepten-3-ol FL/FR |
(Z)-4- heptenal FL/FR |
(Z)-2- hexen-1-ol FL/FR |
(Z)-4- hexen-1-ol FL/FR |
(Z)-3- hexen-1-yl (E)-crotonate FL/FR |
(Z)-3- hexen-1-yl phenyl acetate FL/FR |
(Z)-3- hexen-1-yl tiglate FL/FR |
3- hexenal FL/FR |
4- hexenol FL/FR |
(Z)- leaf acetal FL/FR |
magnolia leaf oil FL/FR |
methyl heptine carbonate FL/FR |
nerol oxide FL/FR |
(Z,Z)-3,6- nonadien-1-ol FL/FR |
2- octen-1-ol FL/FR |
pelargonium graveolens stem leaf extract FR |
1- penten-3-ol FL/FR |
(E)-2- pentenal FL/FR |
phenethyl isopropyl ether FR |
phenethyl oxyacetaldehyde FR |
phenethyl tiglate FL/FR |
iso propyl decanoate FL/FR |
rose leaf absolute (rosa centifolia) FL/FR |
terpinyl propionate FL/FR |
herbal |
3- butylidene phthalide FL/FR |
geranium concrete FL/FR |
geranium cyclohexane FR |
2- pentyl acetate FL/FR |
4,4,6- trimethyl-2-phenyl-1,3-dioxane FR |
leathery |
leather cyclohexanol FR |
melon |
(Z)-6- nonen-1-ol FL/FR |
minty |
iso propyl tiglate FL/FR |
musty |
3- acetyl-2,5-dimethyl furan FL/FR |
cocoa butenal FL/FR |
hazelnut pyrazine FL/FR |
menthofuran FL/FR |
nutty |
2- acetyl-3-ethyl pyrazine FL/FR |
sulfurous |
dimethyl sulfide FL/FR |
ethyl methyl mercaptopropionate FL/FR |
grapefruit menthane FL/FR |
methyl 3-(methyl thio) propionate FL/FR |
3-( methyl thio) hexanol FL/FR |
vegetable |
mesityl oxide FL/FR |
methional FL/FR |
endo-1,2,3,3- tetramethyl bicyclo(2.2.1)heptan-2-ol FR |
waxy |
propyl decanoate FL/FR |
2- tridecanone FL/FR |
woody |
convolvulus scoparius wood oil FR |
(E)- ethyl geranate FR |
alpha- farnesene FL/FR |
alpha- farnesene isomer FL/FR |
santalyl butyrate FL/FR |
vetiver oil haiti FL/FR |
yeasty |
2- octen-4-one FL/FR |
For Flavor |
No flavor group found for these |
acetaldehyde dibutyl acetal FL/FR |
1- acetyl cyclohexyl acetate FL |
2-iso butyl pyrazine FL/FR |
6,7- dimethyl dihydrocyclopentapyrazine FL |
dimethyl dihydrocyclopentapyrazine FL |
2- ethyl-4,5-dimethyl oxazole FL |
geranyl phenyl acetate FL/FR |
2- heptyl butyrate FL/FR |
(Z)-3- hexen-1-yl (E)-crotonate FL/FR |
(E)-4- hexenal FL |
hexyl nonanoate FL/FR |
magnolia leaf oil FL/FR |
2- methyl thiazole FL |
4-( methyl thio) butanol FL |
2- methyl-6-propoxypyrazine FL |
1,5- octadien-3-ol FL |
iso propyl decanoate FL/FR |
propyl decanoate FL/FR |
2-iso propyl pyridine FL |
2-iso propyl-3-(methyl thio) pyrazine FL |
santalyl butyrate FL/FR |
undecenal mixture (aldehyde C-11 mixed) FL/FR |
alliaceous |
alliaceous |
allyl thiopropionate FL |
dipropyl disulfide FL/FR |
3- tetrahydrothiophenone FL |
tropical thiazole FL/FR |
balsamic |
phenethyl pivalate FL/FR |
celery |
3- butylidene phthalide FL/FR |
citrus |
styralyl propionate FL/FR |
coffee |
difurfuryl ether FL |
coumarinic |
phthalide FL/FR |
dairy |
2- pentyl acetate FL/FR |
fatty |
2- octen-1-ol FL/FR |
2- tridecanone FL/FR |
fermented |
methyl thio isovalerate FL |
floral |
laevo- citronellol FL/FR |
citronellyl acetate FL/FR |
cocoa pentenal FL/FR |
geranium essence FL/FR |
geranium leaf oil india FL/FR |
geranium oil FL/FR |
geranium oil africa FL/FR |
geranium oil bourbon FL/FR |
geranium oil china FL/FR |
geranium oil egypt FL/FR |
geranium oil morocco FL/FR |
geranium oil rwanda FL/FR |
geranium oil terpeneless FL/FR |
geranium petiole oil india FL/FR |
geranium rose oil FL/FR |
geranyl tiglate FL/FR |
methyl citronellate FL/FR |
muguet carbinol FL/FR |
pelargonium graveolens extract FL/FR |
rhodinol FL/FR |
rhodinyl butyrate FL/FR |
rhodinyl isobutyrate FL/FR |
laevo- rose oxide FL/FR |
fruity |
citronellyl butyrate FL/FR |
citronellyl isobutyrate FL/FR |
geranyl hexanoate FL/FR |
2,4- hexadien-1-ol FL |
neryl formate FL/FR |
rhodinyl formate FL/FR |
rhodinyl propionate FL/FR |
grassy |
palmarosa oil FL/FR |
green |
acetaldehyde butyl phenethyl acetal FL/FR |
iso butyl methyl ketone FL/FR |
2-iso butyl thiazole FL/FR |
2-iso butyl-3-methyl pyrazine FL/FR |
(E)- citronellyl tiglate FL/FR |
cocoa butenal FL/FR |
cortex pyridine FL/FR |
cucumber essence FL/FR |
dibutyl sulfide FL/FR |
dihydroxyacetophenone (mixed isomers) FL |
diphenyl methane FL/FR |
diphenyl oxide FL/FR |
2- ethyl-5-methyl thiophene FL |
alpha- farnesene FL/FR |
alpha- farnesene isomer FL/FR |
galbanum decatriene FL/FR |
geranium absolute FL/FR |
geranium stem oil india FL/FR |
1- hepten-3-ol FL/FR |
(Z)-4- heptenal FL/FR |
(E)-2- heptenal FL |
(Z)-2- hexen-1-ol FL/FR |
(Z)-4- hexen-1-ol FL/FR |
(Z)-3- hexen-1-yl phenyl acetate FL/FR |
(Z)-3- hexen-1-yl tiglate FL/FR |
3- hexenal FL/FR |
2- hexyl pyridine FL |
horseradish oil FL |
(Z)- leaf acetal FL/FR |
methyl heptenone FL/FR |
methyl heptine carbonate FL/FR |
4- methyl thiazole FL |
3-(5- methyl-2-furyl) butanal FL |
2- methyl-5-isopropyl pyrazine FL |
narcissus acetate FL/FR |
nerol oxide FL/FR |
neryl propionate FL/FR |
2,4- octadienal FL |
4- penten-1-yl acetate FL |
1- penten-3-ol FL/FR |
(E)-2- pentenal FL/FR |
phenethyl formate FL/FR |
phenethyl tiglate FL/FR |
2- propyl pyrazine FL |
iso propyl tiglate FL/FR |
propylene glycol acetone ketal FL |
rose leaf absolute (rosa centifolia) FL/FR |
(Z)- rose oxide FL/FR |
terpinyl propionate FL/FR |
herbal |
geranium concrete FL/FR |
honey |
phenethyl phenyl acetate FL/FR |
medicinal |
dimethyl benzyl carbinol FL/FR |
metallic |
2,5- dihydroxy-1,4-dithiane FL |
4- hexenol FL/FR |
3-( methyl thio) hexanol FL/FR |
musty |
geranyl acetoacetate FL/FR |
hazelnut pyrazine FL/FR |
menthofuran FL/FR |
nutty |
3- acetyl-2,5-dimethyl furan FL/FR |
2- acetyl-3-ethyl pyrazine FL/FR |
aconitic acid FL |
nutty thiazole FL |
peanut oxazole FL |
2,4,5- trimethyl thiazole FL/FR |
onion |
methyl propyl disulfide FL |
propyl thioacetate FL |
potato |
mesityl oxide FL/FR |
spicy |
geranium flavor FL |
sulfurous |
dimethyl sulfide FL/FR |
ethyl methyl mercaptopropionate FL/FR |
ethyl methyl sulfide FL |
grapefruit menthane FL/FR |
methyl benzyl disulfide FL |
potato butanone FL |
tomato |
methional FL/FR |
vegetable |
methyl 3-(methyl thio) propionate FL/FR |
2- methyl valeraldehyde FL/FR |
2- octen-4-one FL/FR |
radish isothiocyanate FL |
waxy |
hydroxycitronellal dimethyl acetal FL/FR |
(Z,Z)-3,6- nonadien-1-ol FL/FR |
(Z)-6- nonen-1-ol FL/FR |
rhodinyl phenyl acetate FL/FR |
woody |
vetiver oil haiti FL/FR |
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
2-iso | butyl-4,5-dimethyl thiazole | 2-iso | butyl-4,5-dimethyl-1,3-thiazole | iso | butyl-4,5-dimethyl-3-thiazole | 2-iso | butyl-4,5-dimethylthiazole | 4,5- | dimethyl-2-(2-methyl propyl) thiazole | 4,5- | dimethyl-2-(2-methylpropyl)-1,3-thiazole | 4,5- | dimethyl-2-(2-methylpropyl)thiazole | 4,5- | dimethyl-2-isobutyl thiazole | 4,5- | dimethyl-2-isobutylthiazole | | thiazole, 4,5-dimethyl-2-(2-methylpropyl)- |
Articles:
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