Category: flavor and fragrance agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
Appearance: | yellow clear oily liquid (est) |
Assay: | 99.00 to 100.00 sum of isomers
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Food Chemicals Codex Listed: | No |
Specific Gravity: | 1.10300 @ 25.00 °C.
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Specific Gravity: | 1.09800 to 1.10300 @ 25.00 °C.
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Pounds per Gallon - est.: | 9.136 to 9.178
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Boiling Point: | 319.00 to 321.00 °C. @ 760.00 mm Hg
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Boiling Point: | 139.00 to 142.00 °C. @ 5.00 mm Hg
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Vapor Pressure: | 0.001000 mmHg @ 25.00 °C. (est) |
Flash Point: | > 212.00 °F. TCC ( > 100.00 °C. )
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logP (o/w): | 3.388 (est) |
Soluble in: |
| alcohol | | water, slightly | | water, 353.5 mg/L @ 25 °C (est) |
Insoluble in: |
| water |
Organoleptic Properties:
Odor Type: herbal |
Odor Strength:medium , recommend smelling in a 10.00 % solution or less |
Substantivity:376 hour(s) at 100.00 % |
herbal lovage celery |
Odor Description:at 10.00 % in dipropylene glycol. herbal lovage celery Luebke, William tgsc, (1991) |
Odor sample from: FRUTAROM USA INC, |
celery green vegetable lovage herbal |
Odor Description:Celery, green, vegetable, lovage-like with a herbal note Mosciano, Gerard P&F 17, No. 4, 33, (1992) |
Flavor Type: celery |
celery green vegetable herbal |
Taste Description: at 15.00 ppm. Celery, green, vegetable-like with a herbal nuance Mosciano, Gerard P&F 17, No. 4, 33, (1992) |
Odor and/or flavor descriptions from others (if found). |
Cosmetic Information:
Suppliers:
Alfa Biotechnology |
For experimental / research use only. |
3-Butylidenephthalide 98%
|
Berjé |
Butylidene Phthalate
|
Media |
BOC Sciences |
For experimental / research use only. |
n-Butylidenephthalide
|
Frutarom |
BUTYLIDENE PHTHALIDE
KOSHER Flavor: Herbal, Lovage, Celery, Vegetable |
CBD Offering |
IFF |
BUTYLIDENE PHTHALIDE
KOSHER Flavor: Herbal, Lovage, Celery, Vegetable |
Lluch Essence |
BUTYLIDENE PHTHALIDE
|
O'Laughlin Industries |
BUTYLIDENE PHTALIDE
|
Penta International |
3-BUTYLIDENE PHTHALIDE
|
R C Treatt & Co Ltd |
3-Butylidene Phthalide
|
Santa Cruz Biotechnology |
For experimental / research use only. |
n-Butylidenephthalide, (E)+(Z) ≥95%
|
Sigma-Aldrich |
3-Butylidenephthalide, mixture of cis and trans isomers, ≥96%, FG
|
Certified Food Grade Products |
Synerzine |
3-BUTYLIDENEPHTHALIDE; HIGH PURITY
|
Synerzine |
3-Butylidenephthalide
|
Synerzine |
3-BUTYLIDENEPHTHALIDE
|
Tianjin Danjun International |
:3-Butylidenephthalide
|
Safety Information:
Preferred SDS: View |
European information : |
Most important hazard(s): | Xn - Harmful. |
R 22 - Harmful if swallowed. S 02 - Keep out of the reach of children. S 20/21 - When using do not eat, drink or smoke. S 24/25 - Avoid contact with skin and eyes. S 36/37/39 - Wear suitable clothing, gloves and eye/face protection.
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Hazards identification |
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Classification of the substance or mixture |
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
None found. |
GHS Label elements, including precautionary statements |
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Pictogram | |
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Hazard statement(s) |
None found. |
Precautionary statement(s) |
None found. |
Human Experience: |
2 % solution: no irritation or sensitization. |
Oral/Parenteral Toxicity: |
oral-rat LD50 1850 mg/kg (Moreno, 1980n)
oral-rat LD50 2200 mg/kg (Posternak, 1965)
oral-rat LD50 1850 mg/kg Food and Chemical Toxicology. Vol. 21, Pg. 659, 1983.
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Dermal Toxicity: |
skin-rabbit LD50 > 5000 mg/kg Food and Chemical Toxicology. Vol. 21, Pg. 659, 1983.
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Inhalation Toxicity: |
Not determined
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Safety in Use Information:
Category: | flavor and fragrance agents |
RIFM Fragrance Material Safety Assessment: Search |
IFRA Code of Practice Notification of the 49th Amendment to the IFRA Code of Practice |
Recommendation for 3-butylidene phthalide usage levels up to: | | 2.0000 % in the fragrance concentrate.
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Maximised Survey-derived Daily Intakes (MSDI-EU): | 8.60 (μg/capita/day) |
Maximised Survey-derived Daily Intakes (MSDI-USA): | 7.00 (μg/capita/day) |
Structure Class: | III |
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS). |
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library |
publication number: 6 |
Click here to view publication 6 |
| average usual ppm | average maximum ppm |
baked goods: | - | 8.00000 |
beverages(nonalcoholic): | - | - |
beverages(alcoholic): | - | - |
breakfast cereal: | - | - |
cheese: | - | - |
chewing gum: | - | - |
condiments / relishes: | - | 5.00000 |
confectionery froastings: | - | - |
egg products: | - | - |
fats / oils: | - | - |
fish products: | - | - |
frozen dairy: | - | - |
fruit ices: | - | - |
gelatins / puddings: | - | - |
granulated sugar: | - | - |
gravies: | - | 5.00000 |
hard candy: | - | - |
imitation dairy: | - | - |
instant coffee / tea: | - | - |
jams / jellies: | - | - |
meat products: | - | 5.00000 |
milk products: | - | - |
nut products: | - | - |
other grains: | - | - |
poultry: | - | - |
processed fruits: | - | - |
processed vegetables: | - | - |
reconstituted vegetables: | - | - |
seasonings / flavors: | - | - |
snack foods: | - | - |
soft candy: | - | - |
soups: | - | 5.00000 |
sugar substitutes: | - | - |
sweet sauces: | - | - |
Safety References:
References:
Other Information:
Potential Blenders and core components note
For Odor |
alliaceous |
dibutyl sulfide FL/FR |
dipropyl disulfide FL/FR |
amber |
angelica root oil FL/FR |
camphoreous |
dextro- camphor FL/FR |
verbenone FL/FR |
caramellic |
2-iso butyl-3-methyl pyrazine FL/FR |
fenugreek absolute FL/FR |
fenugreek oleoresin FL/FR |
mesitene lactone FR |
chocolate |
2,4,5- trimethyl thiazole FL/FR |
citrus |
methyl heptenone FL/FR |
ocimene quintoxide FL/FR |
coumarinic |
phthalide FL/FR |
ethereal |
2- methyl valeraldehyde FL/FR |
floral |
hexahydrofarnesyl acetone FL/FR |
hexyl nonanoate FL/FR |
(Z)- jasmone FL/FR |
iso jasmone FL/FR |
2- pentadecanone FL/FR |
(Z)- rose oxide FL/FR |
fruity |
2- heptyl butyrate FL/FR |
methyl nonanoate FL/FR |
tropical thiazole FL/FR |
green |
acetaldehyde butyl phenethyl acetal FL/FR |
artichoke absolute FR |
artichoke concrete FR |
iso butyl benzyl carbinol FL/FR |
iso butyl methyl ketone FL/FR |
2-iso butyl pyrazine FL/FR |
2-iso butyl thiazole FL/FR |
cortex pyridine FL/FR |
cucumber essence FL/FR |
galbanum decatriene FL/FR |
geranium thiazole FL/FR |
(Z)-4- heptenal FL/FR |
(Z)-4- hexen-1-ol FL/FR |
(Z)-2- hexen-1-ol FL/FR |
(Z)-3- hexen-1-yl (E)-crotonate FL/FR |
(Z)-3- hexen-1-yl tiglate FL/FR |
4- hexenol FL/FR |
(Z)- leaf acetal FL/FR |
methyl heptine carbonate FL/FR |
nerol oxide FL/FR |
(Z,Z)-3,6- nonadien-1-ol FL/FR |
2- octen-1-ol FL/FR |
1- penten-3-ol FL/FR |
iso propyl decanoate FL/FR |
herbal |
apium graveolens seed oil india FL/FR |
3- butyl phthalide FL/FR |
celery ketone FL/FR |
celery leaf oil FL/FR |
celery seed oil CO2 extract FL/FR |
celery undecene FR |
levisticum officinale herb oil FL/FR |
levisticum officinale root absolute FL/FR |
levisticum officinale root extract FL/FR |
lovage tincture FL/FR |
curled parsley seed oil FL/FR |
2- pentyl acetate FL/FR |
3- propylidene phthalide FL/FR |
melon |
(Z)-6- nonen-1-ol FL/FR |
minty |
carvyl acetate FL/FR |
iso propyl tiglate FL/FR |
musty |
cocoa butenal FL/FR |
roasted |
fenugreek resinoid FL/FR |
spicy |
iso butyl angelate FL/FR |
cumin oil replacer FR |
cumin seed oil FL/FR |
cuminaldehyde FL/FR |
levisticum officinale root oil FL/FR |
sulfurous |
grapefruit menthane FL/FR |
3-( methyl thio) hexanol FL/FR |
tonka |
whiskey lactone FL/FR |
vegetable |
endo-1,2,3,3- tetramethyl bicyclo(2.2.1)heptan-2-ol FR |
waxy |
methyl octanoate FL/FR |
propyl decanoate FL/FR |
woody |
amber dodecane FR |
alpha- farnesene FL/FR |
alpha- farnesene isomer FL/FR |
yeasty |
2- octen-4-one FL/FR |
For Flavor |
No flavor group found for these |
3- butyl phthalide FL/FR |
2-iso butyl pyrazine FL/FR |
2- ethyl-4,5-dimethyl oxazole FL |
2- heptyl butyrate FL/FR |
(Z)-3- hexen-1-yl (E)-crotonate FL/FR |
(E)-4- hexenal FL |
hexyl nonanoate FL/FR |
2- methyl thiazole FL |
4-( methyl thio) butanol FL |
2- methyl-6-propoxypyrazine FL |
iso propyl decanoate FL/FR |
propyl decanoate FL/FR |
2-iso propyl pyridine FL |
2-iso propyl-3-(methyl thio) pyrazine FL |
verbenone FL/FR |
alliaceous |
alliaceous |
allyl thiopropionate FL |
cyclopentyl mercaptan FL |
dipropyl disulfide FL/FR |
3- tetrahydrothiophenone FL |
tropical thiazole FL/FR |
amber |
iso butyl benzyl carbinol FL/FR |
brown |
fenugreek oleoresin FL/FR |
caramellic |
fenugreek absolute FL/FR |
fenugreek resinoid FL/FR |
coumarinic |
phthalide FL/FR |
dairy |
2- pentyl acetate FL/FR |
fatty |
2- octen-1-ol FL/FR |
2- pentadecanone FL/FR |
fruity |
2,4- hexadien-1-ol FL |
green |
acetaldehyde butyl phenethyl acetal FL/FR |
angelica root oil FL/FR |
iso butyl angelate FL/FR |
iso butyl methyl ketone FL/FR |
2-iso butyl thiazole FL/FR |
2-iso butyl-3-methyl pyrazine FL/FR |
celery ketone FL/FR |
cocoa butenal FL/FR |
cortex pyridine FL/FR |
cucumber essence FL/FR |
dibutyl sulfide FL/FR |
dihydroxyacetophenone (mixed isomers) FL |
alpha- farnesene FL/FR |
alpha- farnesene isomer FL/FR |
galbanum decatriene FL/FR |
geranium thiazole FL/FR |
(E)-2- heptenal FL |
(Z)-4- heptenal FL/FR |
hexahydrofarnesyl acetone FL/FR |
(Z)-4- hexen-1-ol FL/FR |
(Z)-2- hexen-1-ol FL/FR |
(Z)-3- hexen-1-yl tiglate FL/FR |
2- hexyl pyridine FL |
horseradish oil FL |
iso jasmone FL/FR |
(Z)- leaf acetal FL/FR |
methyl heptenone FL/FR |
methyl heptine carbonate FL/FR |
methyl octanoate FL/FR |
4- methyl thiazole FL |
3-(5- methyl-2-furyl) butanal FL |
nerol oxide FL/FR |
ocimene quintoxide FL/FR |
2,4- octadienal FL |
4- penten-1-yl acetate FL |
1- penten-3-ol FL/FR |
2- propyl pyrazine FL |
iso propyl tiglate FL/FR |
propylene glycol acetone ketal FL |
3- propylidene phthalide FL/FR |
(Z)- rose oxide FL/FR |
herbal |
apium graveolens seed oil india FL/FR |
celery leaf oil FL/FR |
celery seed oil CO2 extract FL/FR |
celery seed oleoresin FL |
lovage tincture FL/FR |
curled parsley seed oil FL/FR |
medicinal |
dextro- camphor FL/FR |
metallic |
4- hexenol FL/FR |
3-( methyl thio) hexanol FL/FR |
minty |
carvyl acetate FL/FR |
nutty |
2,4,5- trimethyl thiazole FL/FR |
radish |
horseradish flavor FL |
spicy |
cumin seed oil FL/FR |
cuminaldehyde FL/FR |
levisticum officinale herb oil FL/FR |
levisticum officinale oleoresin FL |
levisticum officinale root absolute FL/FR |
levisticum officinale root extract FL/FR |
levisticum officinale root oil FL/FR |
sulfurous |
broccoli flavor FL |
grapefruit menthane FL/FR |
methyl benzyl disulfide FL |
vegetable |
2- methyl valeraldehyde FL/FR |
2- octen-4-one FL/FR |
waxy |
(Z,Z)-3,6- nonadien-1-ol FL/FR |
(Z)-6- nonen-1-ol FL/FR |
winey |
methyl nonanoate FL/FR |
woody |
(Z)- jasmone FL/FR |
whiskey lactone FL/FR |
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
1(3H)-iso | benzofuranone, 3-butylidene- | 3- | butylidene-1(3H)-isobenzofuranone | 3- | butylidene-2-benzofuran-1-one | 3- | butylidene-2-benzofuran-1(3H)-one | 3-N- | butylidene-phthalide | 3- | butylidenephthalide | N- | butylidenephthalide | | ligusticum lactone |
Articles:
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