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Category:flavoring agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Appearance: | white orthorhombic needles (est) |
| Assay: | 98.00 to 100.00
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| Food Chemicals Codex Listed: | No |
| Melting Point: | 59.00 to 62.00 °C. @ 760.00 mm Hg
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| Boiling Point: | 310.00 °C. @ 760.00 mm Hg
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| Boiling Point: | 192.00 °C. @ 15.00 mm Hg
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| Vapor Pressure: | 0.001000 mmHg @ 25.00 °C. (est) |
| Vapor Density: | 7.53 ( Air = 1 ) |
| Flash Point: | 352.00 °F. TCC ( 177.78 °C. )
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| logP (o/w): | 4.410 |
| Soluble in: |
| | alcohol | | | ether | | | water, 6.019 mg/L @ 25 °C (est) |
| Insoluble in: |
| | water |
Organoleptic Properties:
| Odor Type: sulfurous |
| sulfurous earthy burnt |
| Odor Description:at 0.10 % in propylene glycol. sulfurous earthy burnt |
| Flavor Type: sulfurous |
| sulfurous earthy |
| Taste Description: sulfurous earthy |
| Odor and/or flavor descriptions from others (if found). |
Cosmetic Information:
Suppliers:
Safety Information:
| Preferred SDS: View |
| European information : |
| Most important hazard(s): | | Xi - Irritant |
R 36/37/38 - Irritating to eyes, respiratory system, and skin.
S 02 - Keep out of the reach of children.
S 24/25 - Avoid contact with skin and eyes.
S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S 36/37/39 - Wear suitable clothing, gloves and eye/face protection.
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
| |
| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
intraperitoneal-mouse LD50 100 mg/kg
National Technical Information Service. Vol. AD277-689
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | | flavoring agents |
| Recommendation for diphenyl disulfide usage levels up to: | | | not for fragrance use.
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| |
| Maximised Survey-derived Daily Intakes (MSDI-EU): | ND (μg/capita/day) |
| Structure Class: | III |
| Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS). |
| The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library |
| publication number: 4 |
| Click here to view publication 4 |
| | average usual ppm | average maximum ppm |
| baked goods: | - | - |
| beverages(nonalcoholic): | - | 1.00000 |
| beverages(alcoholic): | - | - |
| breakfast cereal: | - | - |
| cheese: | - | - |
| chewing gum: | - | - |
| condiments / relishes: | - | - |
| confectionery froastings: | - | - |
| egg products: | - | - |
| fats / oils: | - | - |
| fish products: | - | - |
| frozen dairy: | - | 1.00000 |
| fruit ices: | - | 1.00000 |
| gelatins / puddings: | - | 1.00000 |
| granulated sugar: | - | - |
| gravies: | - | - |
| hard candy: | - | 1.00000 |
| imitation dairy: | - | - |
| instant coffee / tea: | - | - |
| jams / jellies: | - | - |
| meat products: | - | - |
| milk products: | - | - |
| nut products: | - | - |
| other grains: | - | - |
| poultry: | - | - |
| processed fruits: | - | - |
| processed vegetables: | - | - |
| reconstituted vegetables: | - | - |
| seasonings / flavors: | - | - |
| snack foods: | - | - |
| soft candy: | - | - |
| soups: | - | - |
| sugar substitutes: | - | - |
| sweet sauces: | - | - |
Safety References:
European Food Safety Athority(EFSA):Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies...
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European Food Safety Authority (EFSA) reference(s):
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Flavouring Group Evaluation 8 (FGE.08)[1]: Aliphatic and alicyclic mono-, di-, tri-, and polysulphides with or without additional oxygenated functional groups from chemical group 20
View page or View pdf
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Flavouring Group Evaluation 74 (FGE.74)[1]: Consideration of Simple Aliphatic Sulphides and Thiols evaluated by JECFA (61st meeting) Structurally related to Aliphatic and Alicyclic Mono-, Di-, Tri-, and Polysulphides with or without Additional Oxygenated Functional Groups from Chemical Group 20 evaluated by EFSA in FGE.08 (2008)
View page or View pdf
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Flavouring Group Evaluation 8, Revision 1 (FGE.08Rev1): Aliphatic and alicyclic mono-, di-, tri-, and polysulphides with or without additional oxygenated functional groups from chemical groups 20 and 30
View page or View pdf
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Flavouring Group Evaluation 91 (FGE.91): Consideration of simple aliphatic and aromatic sulphides and thiols evaluated by JECFA (53rd and 68th meetings) structurally related to aliphatic and alicyclic mono-, di-, tri-, and polysulphides with or without additional oxygenated functional groups evaluated by EFSA in FGE.08Rev1 (2009)
View page or View pdf
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Scientific Opinion on Flavouring Group Evaluation 8, Revision 3 (FGE.08Rev3): Aliphatic and alicyclic mono-, di-, tri-, and polysulphides with or without additional oxygenated functional groups from chemical groups 20 and 30
View page or View pdf
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Scientific Opinion on Flavouring Group Evaluation 08, Revision 4 (FGE.08Rev4): Aliphatic and alicyclic mono-, di-, tri-, and polysulphides with or without additional oxygenated functional groups from chemical groups 20 and 30
View page or View pdf
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| EPI System: View |
| AIDS Citations:Search |
| Cancer Citations:Search |
| Toxicology Citations:Search |
| EPA Substance Registry Services (TSCA):882-33-7 |
| EPA ACToR:Toxicology Data |
| EPA Substance Registry Services (SRS):Registry |
| Laboratory Chemical Safety Summary :13436 |
| National Institute of Allergy and Infectious Diseases:Data |
| WGK Germany:3 |
| phenyldisulfanylbenzene |
| Chemidplus:0000882337 |
| RTECS:SS6825000 for cas# 882-33-7 |
References:
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| | biphenyl disulfide | | 1,2- | diphenyldisulfane | | 1,1'- | disulfanediyldibenzene | | | disulfide diphenyl | | | disulfide, diphenyl | | 1,1'- | dithiodibenzene | | | phenyl disulfide | | | phenyl disulphide | | | phenyl dithiobenzene | | | phenyldisulfanylbenzene | | | phenyldisulfide | | | phenyldithiobenzene |
Articles:
| US Patents:3,952,024 - Furfurylthioacetone |
| PubMed:Formation pathway of Roussin's red ester (RRE) via the reaction of a {Fe(NO)2}(10) dinitrosyliron complex (DNIC) and thiol: facile synthetic route for synthesizing cysteine-containing DNIC. |
| US Patents:3,931,166 - Certain 2,5-dimethyl-3-thiopyrazines |
| PubMed:Synthesis, guest-binding, and reduction-responsive degradation properties of water-soluble cyclophanes having disulfide moieties. |
| US Patents:3,968,264 - Flavoring agent |
| PubMed:Inhibition of biofilm formation, quorum sensing and infection in Pseudomonas aeruginosa by natural products-inspired organosulfur compounds. |
| PubMed:Deprotonative metalation of aromatic compounds by using an amino-based lithium cuprate. |
| PubMed:Sulfur-substituted tetrahedranes. |
| PubMed:Synthesis of stable silicon heterocycles by reaction of organic substrates with a chlorosilylene [PhC(NtBu)2SiCl]. |
| PubMed:Functional groups and sulfur K-edge XANES spectra: divalent sulfur and disulfides. |
| PubMed:Cesium carbonate-catalyzed alpha-phenylchalcogenation of carbonyl compounds with diphenyl dichalcogenide. |
| PubMed:Heterolytic cleavage of disulfides by frustrated Lewis pairs. |
| PubMed:Reductive addition of the benzenethiyl radical to alkynes by amine-mediated single electron transfer reaction to diphenyl disulfide. |
| PubMed:Photosensitized oxidation of alkyl phenyl sulfoxides. C-S bond cleavage in alkyl phenyl sulfoxide radical cations. |
| PubMed:Antioxidant activity of the new thiosulfinate derivative, S-benzyl phenylmethanethiosulfinate, from Petiveria alliacea L. |
| PubMed:Raman spectroscopy of benzenethiolates on nanometer-scale gold clusters. |
| PubMed:Mononitrosyl tris(thiolate) iron complex [Fe(NO)(SPh)3]- and dinitrosyl iron complex [(EtS)2Fe(NO)2]-: formation pathway of dinitrosyl iron complexes (DNICs) from nitrosylation of biomimetic rubredoxin [Fe(SR)4]2-/1- (R = Ph, Et). |
| PubMed:Temporary anion states and dissociative electron attachment in diphenyl disulfide. |
| PubMed:Disulfidation of alkynes and alkenes with gallium trichloride. |
| PubMed:The reaction of allyl and benzylarsonic acids with thiols: mechanistic aspects and implications for dioxygen activation by trivalent arsenic compounds. |
| PubMed:Capillary electrophoresis with laser induced-fluorescence detection of profens derivatized with the water-soluble fluorogenic reagent 4-N-(4-N'-aminoethyl)piperazino-7-nitro-2,1,3-benzoxadiazole. |
| PubMed:Organochalcogens effects on delta-aminolevulinate dehydratase activity from human erythrocytic cells in vitro. |
| PubMed:Rhodium-catalyzed disulfide exchange reaction. |
| PubMed:Preparation of tri- and difluoromethylsilanes via an unusual magnesium metal-mediated reductive tri- and difluoromethylation of chlorosilanes using tri- and difluoromethyl sulfides, sulfoxides, and sulfones. |
| PubMed:Diazenecarboxamide UP-91, a potential anticancer agent, acts by reducing cellular glutathione content. |
| PubMed:Antioxidant properties of new chalcogenides against lipid peroxidation in rat brain. |
| PubMed:Oxygen transfer reactions. 4. Reaction of high valent oxoruthenium compounds with sulfides. |
| PubMed:Diphenyl disulfide and sodium in NMP as an efficient protocol for in situ generation of thiophenolate anion: selective deprotection of aryl alkyl ethers and alkyl/aryl esters under nonhydrolytic conditions. |
| PubMed:Solid state optical activity of dichalcogenides: isolation by chiral crystallization and determination of absolute configuration. |
| PubMed:Synthesis, structure, and reactions of (acylimino)triaryl-lambda(5)-bismuthanes: first comparative study of the (acylimino)pnictorane series. |
| PubMed:Highly Selective Thioselenation of Vinylcyclopropanes with a (PhS)(2)-(PhSe)(2) Binary System and Its Application to Thiotelluration. |
| PubMed:Co-oxidation of 2,2,5,7,8-pentamethyl-6-chromanol and diphenyl disulfide with 3-chloroperoxybenzoic acid. |
| PubMed:Glutathione peroxidase-like antioxidant activity of diaryl diselenides: a mechanistic study. |
| PubMed:Screening of organosulfur compounds as inhibitors of human CYP2A6. |
| PubMed:Comparative Behavior of Aromatic Disulfide and Diselenide Monolayers on Polycrystalline Gold Films Using Cyclic Voltammetry, STM, and Quartz Crystal Microbalance. |
| PubMed:The fate of diphenyl sulphide, diphenyl sulphoxide and diphenyl sulphone in the rat. |
| PubMed:Effect of Co-Adsorbed Surfactant on the Structure of Self-Assembled Monolayer of Thiol on Polycrystalline Gold. |
| PubMed:Suppressing effects of S-methyl methanethiosulfonate and diphenyl disulfide on mitomycin C-induced somatic mutation and recombination in Drosophila melanogaster and micronuclei in mice. |
| PubMed:Suppression of aflatoxin B1- or methyl methanesulfonate-induced chromosome aberrations in rat bone marrow cells after treatment with S-methyl methanethiosulfonate. |
| PubMed:Thiol oxidation by 1,2,3-oxadiazolinium ions, presumed carcinogens. |
| PubMed:Catalytic effects of glutathione peroxidase mimetics on the thiol reduction of cytochrome c. |
| PubMed:Phenylselenenyl- and phenylthio-substituted pyrimidines as inhibitors of dihydrouracil dehydrogenase and uridine phosphorylase. |
| PubMed:Degradation of organic sulfur compounds by a coal-solubilizing fungus. |
| PubMed:Synthesis of L-gulose, L-galactose, and their acetylated aldehydo forms from 6-S-phenyl-6-thio-D-hexoses. |
| PubMed:Diphenyldisulfide inhibits indomethacin-induced ulcerogenesis in rats. |
| PubMed:Molecular modeling and enzyme kinetics indicate a novel mechanism for mammalian 5-lipoxygenase. |
| PubMed:Inhibition of mammalian 5-lipoxygenase by aromatic disulfides. |
| PubMed:Pyrrolopyrimidine nucleosides. 18. Synthesis and chemotherapeutic activity of 4-amino-7-(3-deoxy-beta-D-ribofuranosyl)pyrrolo[2,3-d] pyrimidine-5-carboxamide (3'-deoxysangivamycin) and 4-amino-7-(2-deoxy-beta-D-ribofuranosyl)pyrrolo[2,3-d] pyrimidine-5-carboxamide (2'-deoxysangivamycin). |
| PubMed:Movement and metabolism of S-benzyl O,O-diisopropyl phosphorothiolate (Kitazin P) and O-ethyl S,S-diphenyl phosphorodithiolate (edifenphos) in various types of soils. |
| PubMed:Letter: Silyl phosphites. I. The reaction of silyl phosphites with diphenyl disulfide. Synthesis of S-phenyl nucleoside phosphorothioates. |
| PubMed:[The diamides of phenyl-dithiobenzene-2,2', -3,3'- and 4,4'-disulfonic acids]. |
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3D/inchi