Name: | (2R,3R,4R,5R,6R)-2-[(2R,3S,4S,5S)-2,5-bis(chloromethyl)-3,4-dihydroxyoxolan-2-yl]oxy-5-chloro-6-(hydroxymethyl)oxane-3,4-diol |
CAS Number: | 56038-13-2 | 3D/inchi
|
ECHA EINECS - REACH Pre-Reg: | 259-952-2 |
FDA UNII: | 96K6UQ3ZD4 |
Nikkaji Web: | J247.962A |
Beilstein Number: | 3654410 |
MDL: | MFCD03648615 |
XlogP3: | -1.50 (est) |
Molecular Weight: | 397.63303000 |
Formula: | C12 H19 Cl3 O8 |
BioActivity Summary: | listing |
NMR Predictor: | Predict (works with chrome, Edge or firefox) |
Category:sweeteners, flavor enhancers
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
Appearance: | white crystalline powder (est) |
Assay: | 98.00 to 100.00
|
Food Chemicals Codex Listed: | No |
Melting Point: | 130.00 °C. @ 760.00 mm Hg
|
Boiling Point: | 669.43 °C. @ 760.00 mm Hg (est)
|
Flash Point: | 678.00 °F. TCC ( 358.70 °C. ) (est)
|
logP (o/w): | 0.229 (est) |
Soluble in: |
| water, 2.275e+004 mg/L @ 25 °C (est) | | alcohol |
Organoleptic Properties:
Flavor Type: sweet |
sweet |
Odor and/or flavor descriptions from others (if found). |
Cosmetic Information:
Suppliers:
Allan Chemical |
Sucralose
|
Anhui Haibei |
Sucralose
|
Atlantic Chemicals |
Sucralose
|
BOC Sciences |
For experimental / research use only. |
Sucralose >98%
Odor: characteristic Use: Sucralose is an artificial and noncaloric sweetener, not broken down by the body. |
Carbosynth |
For experimental / research use only. |
Sucralose
|
ECSA Chemicals |
SUCRALOSE 100 MESH
|
ECSA TRADE THE MOST UPDATED FINANCIAL PUBLICATION ON THE WORLD OF CHEMISTRY |
ECSA Chemicals |
SUCRALOSE
|
Flavorchem |
Sucralose
|
Foodchem International |
Compound Sweetener
|
Foodchem International |
Sucralose
|
Glentham Life Sciences |
Sucralose, USP grade
|
Glentham Life Sciences |
Sucralose
|
Graham Chemical |
Sucralose
|
Jiangyin Healthway |
Sucralose
|
New functional food ingredients |
Kraft Chemical |
Sucralose
|
OQEMA |
Sucralose
|
Prinova |
Sucralose FCC
|
Qingdao Dacon Trading |
Sucralose
|
Sigma-Aldrich |
For experimental / research use only. |
Sucralose analytical standard
|
Sinofi Food Ingredients |
Sucralose
Flavor: characteristic Sugar Substitutes, Chewing Gum, Dairy Products, Confections, Baking Food, Yogurt, Desserts, Alcoholic Beverages, Beverage Powder, Instant Coffee, Chai Tea, Gelatins, Puddings, Ice Cream, Cosmetics, Feed, Pharmaceutical. |
SRS Aromatics |
SUCRALOSE (FG)
|
Tate & Lyle |
SPLENDA® Sucralose
|
Tianjin Talent Chemical |
Sucralose
|
United International |
TGS Sucralose
|
Viachem |
Sucralose – Powder and Liquid
Flavor: sweet Sucralose, C12H19Cl3O8, is a zero-calorie high-intensity, non-nutritive sweetener. Sucralose is approximately 600 times as sweet as sucrose (table sugar), twice as sweet as saccharin, and 3.3 times as sweet as aspartame. It is stable under heat and over a broad range of pH conditions. Therefore, it can be used in baking or in products that require a longer shelf life. The commercial success of sucralose-based products stems from its favorable comparison to other low-calorie sweeteners in terms of taste, stability, and safety.
Sucralose is typically added to foods in very small quantities. It can be found in more than 4,500 food and beverage products and is used because it is a no-calorie sweetener, does not promote dental cavities, and is safe for consumption by diabetics. Sucralose is used as a replacement for, or in combination with, other artificial or natural sweeteners such as aspartame, acesulfame potassium (Ace-K) or high-fructose corn syrup. Sucralose is used in products such as candy, breakfast bars and soft drinks. It is also used in canned fruits wherein water and sucralose take the place of much higher calorie corn syrup based additives. |
Safety Information:
|
Hazards identification |
|
Classification of the substance or mixture |
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
None found. |
GHS Label elements, including precautionary statements |
|
Pictogram | |
|
Hazard statement(s) |
None found. |
Precautionary statement(s) |
None found. |
Oral/Parenteral Toxicity: |
unreported-mouse LD50 > 16000 mg/kg Trends in Biochemical Sciences. Vol. 3, Pg. 61, 1978.
|
Dermal Toxicity: |
Not determined
|
Inhalation Toxicity: |
Not determined
|
Safety in Use Information:
Category: | sweeteners, flavor enhancers |
Recommendation for sucralose usage levels up to: | | not for fragrance use.
|
|
Safety References:
European Food Safety Authority (EFSA) reference(s):
|
Safety of the proposed extension of use of sucralose (E 955) in foods for special medical purposes in young children View page or View pdf
|
Statement on the validity of the conclusions of a mouse carcinogenicity study on sucralose (E 955) performed by the Ramazzini Institute View page or View pdf
|
Outcome of the public consultation on a draft protocol for assessing exposure to sweeteners as part of their safety assessment under the food additives re-evaluation programme View page or View pdf
|
EPI System: View |
Chemical Carcinogenesis Research Information System:Search |
AIDS Citations:Search |
Cancer Citations:Search |
Toxicology Citations:Search |
Carcinogenic Potency Database:Search |
EPA ACToR:Toxicology Data |
EPA Substance Registry Services (SRS):Registry |
Laboratory Chemical Safety Summary :71485 |
National Institute of Allergy and Infectious Diseases:Data |
WGK Germany:3 |
(2R,3R,4R,5R,6R)-2-[(2R,3S,4S,5S)-2,5-bis(chloromethyl)-3,4-dihydroxyoxolan-2-yl]oxy-5-chloro-6-(hydroxymethyl)oxane-3,4-diol |
Chemidplus:0056038132 |
References:
| (2R,3R,4R,5R,6R)-2-[(2R,3S,4S,5S)-2,5-bis(chloromethyl)-3,4-dihydroxyoxolan-2-yl]oxy-5-chloro-6-(hydroxymethyl)oxane-3,4-diol |
NIST Chemistry WebBook: | Search Inchi |
Canada Domestic Sub. List: | 56038-13-2 |
Pubchem (cid): | 71485 |
Pubchem (sid): | 135029485 |
Other Information:
Potential Blenders and core components note
For Odor |
alcoholic |
fusel oil FL/FR |
animal |
methyl (E)-2-octenoate FL/FR |
anise |
star anise seed oil terpeneless FL/FR |
anisic |
para- acetanisole FL/FR |
ethyl para-anisate FL/FR |
balsamic |
benzyl salicylate FL/FR |
ethyl cinnamate FL/FR |
dextro- fenchone FL/FR |
guaiacyl phenyl acetate FL/FR |
hexyl benzoate FL/FR |
bready |
furfural FL/FR |
buttery |
acetoin FL/FR |
caramellic |
caramel furanone solution FL/FR |
caramel pentadione FL/FR |
coffee dione FL/FR |
cyclotene FL/FR |
cyclotene hydrate FL/FR |
ethyl cyclopentenolone FL/FR |
ethyl furaneol FL/FR |
ethyl maltol FL/FR |
levulinic acid FL/FR |
maltol FL/FR |
maltyl isobutyrate FL/FR |
maltyl propionate FL/FR |
maple furanone FL/FR |
5- methyl furfural FL/FR |
shoyu furanone FL/FR |
strawberry furanone FL/FR |
strawberry furanone acetate FL/FR |
strawberry furanone solution FL/FR |
cheesy |
iso valeric acid FL/FR |
chemical |
iso butyl formate FL/FR |
propyl propionate FL/FR |
chocolate |
iso amyl phenyl acetate FL/FR |
cocoa pentenal FL/FR |
citrus |
2- ethyl-1-hexanol FL/FR |
lime essence oil FL/FR |
dextro- limonene FL/FR |
alpha- terpinyl methyl ether FL/FR |
coconut |
delta- octalactone FL/FR |
creamy |
3- heptyl dihydro-5-methyl-2(3H)-furanone FL/FR |
para- vanillic acid FL/FR |
para- vanillyl alcohol FL/FR |
veratraldehyde FL/FR |
dry |
3,4- xylenol FL/FR |
earthy |
methyl 3-hexenoate FL/FR |
ethereal |
ethyl acetate FL/FR |
ethyl formate FL/FR |
ethyl pyruvate FL/FR |
iso propyl formate FL/FR |
fatty |
(E)-2- octenal FL/FR |
(E,Z,Z)-2,4,7- tridecatrienal FL/FR |
floral |
acetophenone FL/FR |
benzyl acetate FL/FR |
benzyl isobutyrate FL/FR |
citronellyl anthranilate FL/FR |
citronellyl phenyl acetate FL/FR |
ethyl phenyl acetate FL/FR |
geranyl isobutyrate FL/FR |
heliotropyl acetone FL/FR |
(Z)-3- hexen-1-yl salicylate FL/FR |
alpha- hexyl cinnamaldehyde FL/FR |
hexyl lactate FL/FR |
hydroxycitronellal FL/FR |
hydroxycitronellol FL/FR |
alpha- ionol FL/FR |
para- methyl acetophenone FL/FR |
beta- naphthyl methyl ketone FL/FR |
nonanol FL/FR |
phenethyl alcohol FL/FR |
phenethyl propionate FL/FR |
4- phenyl-3-buten-2-ol FL/FR |
iso propyl phenyl acetate FL/FR |
rhodinyl phenyl acetate FL/FR |
rose butanoate FL/FR |
rose oil (rosa damascena) russia FL/FR |
rose oil (rosa damascena) turkey FL/FR |
terpinyl valerate FL/FR |
tuberose absolute (from pommade) FL/FR |
fruity |
allyl hexanoate FL/FR |
iso butyl 2-butenoate FL/FR |
iso butyl acetoacetate FL/FR |
iso butyl anthranilate FL/FR |
iso butyl butyrate FL/FR |
butyl butyrate FL/FR |
butyl isovalerate FL/FR |
iso butyl isovalerate FL/FR |
ethyl 3-(2-furyl) propanoate FL/FR |
ethyl 3-hexenoate FL/FR |
ethyl 3-hydroxyhexanoate FL/FR |
ethyl benzoyl acetate FL/FR |
ethyl butyrate FL/FR |
ethyl isovalerate FL/FR |
ethyl lactate FL/FR |
ethyl methyl-para-tolyl glycidate FL/FR |
ethyl propionate FL/FR |
(E,E)- ethyl sorbate FL/FR |
ethyl valerate FL/FR |
2- hexen-1-ol FL/FR |
hexyl acetate FL/FR |
linalyl isobutyrate FL/FR |
menthyl isovalerate FL/FR |
methyl 3-nonenoate FL/FR |
methyl anthranilate FL/FR |
2- methyl butyl acetate FL/FR |
methyl heptanoate FL/FR |
methyl isobutyrate FL/FR |
methyl valerate FL/FR |
neryl isobutyrate FL/FR |
octyl butyrate FL/FR |
octyl propionate FL/FR |
2- pentanone FL/FR |
pineapple hydroxyhexanoate FL/FR |
prenyl acetate FL/FR |
iso propyl 2-methyl butyrate FL/FR |
iso propyl butyrate FL/FR |
propyl butyrate FL/FR |
propyl heptanoate FL/FR |
propyl hexanoate FL/FR |
propyl isobutyrate FL/FR |
iso propyl octanoate FL/FR |
strawberry glycidate 1 (aldehyde C-16 (so-called)) FL/FR |
strawberry glycidate 2 FL/FR |
tetrahydrofurfuryl acetate FL/FR |
para- tolualdehyde FL/FR |
tolualdehydes (mixed o,m,p) FL/FR |
tropical ionone FL/FR |
vanilla carboxylate FL/FR |
green |
cucumber essence FL/FR |
(Z)-4- hepten-1-ol FL/FR |
hexyl isobutyrate FL/FR |
hexyl phenyl acetate FL/FR |
(E,Z)-3,6- nonadien-1-yl acetate FL/FR |
(E)-2- octen-1-ol FL/FR |
2- octen-1-ol FL/FR |
phenethyl tiglate FL/FR |
terpinyl propionate FL/FR |
herbal |
anethum graveolens herb tincture FL/FR |
clary sage absolute FL/FR |
linalyl isovalerate FL/FR |
linalyl octanoate FL/FR |
lovage tincture FL/FR |
perillaldehyde FL/FR |
3- propylidene phthalide FL/FR |
honey |
methyl phenyl acetate FL/FR |
propyl phenyl acetate FL/FR |
licorice |
(E)- anethol FL/FR |
medicinal |
2,6- xylenol FL/FR |
minty |
ethyl benzoate FL/FR |
ethyl salicylate FL/FR |
methyl salicylate FL/FR |
peppermint oil america FL/FR |
peppermint oil idaho FL/FR |
musk |
ethylene brassylate FL/FR |
musty |
ketoiso phorone FL/FR |
spicy |
iso butyl angelate FL/FR |
4- ethyl guaiacol FL/FR |
eugenol FL/FR |
iso eugenol FL/FR |
iso eugenyl acetate FL/FR |
iso eugenyl phenyl acetate FL/FR |
para- methoxycinnamaldehyde FL/FR |
alpha- methyl cinnamaldehyde FL/FR |
methyl heptadienone FL/FR |
alpha- methyl-(E)-cinnamaldehyde FL/FR |
(E)- propyl 2-furan acrylate FL/FR |
(E)- tiglic acid FL/FR |
sweet |
vanilla bean absolute (vanilla spp.) FL/FR |
vanilla oleoresin bali FL/FR |
vanilla resinoid FL/FR |
vanilla tahitensis fruit extract FL/FR |
tonka |
mint lactone FL/FR |
octahydrocoumarin FL/FR |
tropical |
genet absolute FL/FR |
vanilla |
ethyl vanillin FL/FR |
ethyl vanillin propylene glycol acetal FL/FR |
propenyl guaethol FL/FR |
vanilla aromatica fruit extract FL/FR |
vanilla bean absolute (vanilla planifolia) FL/FR |
vanilla oleoresin bourbon FL/FR |
vanillin FL/FR |
vanillin propylene glycol acetal FL/FR |
vanillyl acetate FL/FR |
vanillyl isobutyrate FL/FR |
vanillylidene acetone FL/FR |
waxy |
ethyl decanoate FL/FR |
ethyl myristate FL/FR |
ethyl octanoate FL/FR |
nonanoic acid FL/FR |
1- undecanol FL/FR |
woody |
2- methoxy-4-vinyl phenol FL/FR |
For Flavor |
acidic |
(E)-2- hexenoic acid FL |
levulinic acid FL/FR |
aldehydic |
1- undecanol FL/FR |
anise |
(E)- anethol FL/FR |
star anise seed oil terpeneless FL/FR |
ethyl para-anisate FL/FR |
anisic |
para- acetanisole FL/FR |
balsamic |
benzyl salicylate FL/FR |
ethyl cinnamate FL/FR |
vanillylidene acetone FL/FR |
berry |
heliotropyl acetone FL/FR |
bitter |
(E,Z,Z)-2,4,7- tridecatrienal FL/FR |
brown |
furfural FL/FR |
5- methyl furfural FL/FR |
tetrahydrofurfuryl acetate FL/FR |
(E)- tiglic acid FL/FR |
burnt |
furfuryl alcohol FL |
2,6- xylenol FL/FR |
caramellic |
caramel dione FL |
caramel furanone FL |
caramel furanone solution FL/FR |
caramel pentadione FL/FR |
cyclotene FL/FR |
cyclotene hydrate FL/FR |
ethyl furaneol FL/FR |
ethyl maltol FL/FR |
lucuma flavor FL |
maltol FL/FR |
maltyl propionate FL/FR |
maple distillates FL |
maple furanone FL/FR |
3- methyl butyl 2-furyl butyrate FL |
pyruvaldehyde FL |
shoyu furanone FL/FR |
strawberry furanone FL/FR |
strawberry furanone acetate FL/FR |
strawberry furanone solution FL/FR |
cheesy |
ammonium isovalerate 30% in pg FL |
iso valeric acid FL/FR |
cherry |
para- methoxycinnamaldehyde FL/FR |
chocolate |
bittersweet chocolate flavor FL |
citrus |
lime essence oil FL/FR |
dextro- limonene FL/FR |
ketoiso phorone FL/FR |
coconut |
massoia bark oil CO2 extract FL |
octahydrocoumarin FL/FR |
delta- octalactone FL/FR |
coffee |
coffee dione FL/FR |
cooling |
dextro- fenchone FL/FR |
peppermint oil america FL/FR |
creamy |
acetoin FL/FR |
divanillin FL |
para- methyl acetophenone FL/FR |
mint lactone FL/FR |
para- vanillic acid FL/FR |
para- vanillyl alcohol FL/FR |
veratraldehyde FL/FR |
estery |
octyl propionate FL/FR |
ethereal |
ethyl acetate FL/FR |
ethyl formate FL/FR |
methyl isobutyrate FL/FR |
fatty |
2- ethyl-1-hexanol FL/FR |
nonanoic acid FL/FR |
2- octen-1-ol FL/FR |
(E)-2- octen-1-ol FL/FR |
(E)-2- octenal FL/FR |
floral |
2- acetyl-5-methyl thiophene FL |
iso amyl phenyl acetate FL/FR |
citronellyl phenyl acetate FL/FR |
cocoa pentenal FL/FR |
geranyl isobutyrate FL/FR |
linalyl isobutyrate FL/FR |
methyl phenyl acetate FL/FR |
beta- naphthyl methyl ketone FL/FR |
phenethyl alcohol FL/FR |
phenethyl propionate FL/FR |
rose oil (rosa damascena) russia FL/FR |
rose oil (rosa damascena) turkey FL/FR |
tropical ionone FL/FR |
tuberose absolute (from pommade) FL/FR |
fruity |
allyl hexanoate FL/FR |
benzyl acetate FL/FR |
benzyl isobutyrate FL/FR |
iso butyl acetoacetate FL/FR |
iso butyl anthranilate FL/FR |
butyl butyrate FL/FR |
iso butyl butyrate FL/FR |
butyl isovalerate FL/FR |
citronellyl anthranilate FL/FR |
(E)-2- decenoic acid FL |
ethyl 3-(2-furyl) propanoate FL/FR |
ethyl 3-hexenoate FL/FR |
ethyl 3-hydroxyhexanoate FL/FR |
ethyl 3-oxohexanoate FL |
ethyl benzoyl acetate FL/FR |
ethyl butyrate FL/FR |
ethyl isovalerate FL/FR |
ethyl lactate FL/FR |
ethyl methyl-para-tolyl glycidate FL/FR |
ethyl propionate FL/FR |
(E,E)- ethyl sorbate FL/FR |
ethyl valerate FL/FR |
furfuryl valerate FL |
2- furyl pentyl ketone FL |
fusel oil FL/FR |
3- heptyl dihydro-5-methyl-2(3H)-furanone FL/FR |
2- hexen-1-ol FL/FR |
hexyl acetate FL/FR |
hexyl lactate FL/FR |
hexyl phenyl acetate FL/FR |
linalyl isovalerate FL/FR |
linalyl octanoate FL/FR |
menthyl isovalerate FL/FR |
methyl (E)-2-octenoate FL/FR |
methyl (E)-3-nonenoate FL |
methyl 3-hexenoate FL/FR |
methyl 3-nonenoate FL/FR |
methyl anthranilate FL/FR |
2- methyl butyl acetate FL/FR |
methyl heptanoate FL/FR |
(E,E)- methyl sorbate FL |
methyl valerate FL/FR |
neryl isobutyrate FL/FR |
2- pentanone FL/FR |
pineapple hydroxyhexanoate FL/FR |
prenyl acetate FL/FR |
(E)- propyl 2-furan acrylate FL/FR |
iso propyl 2-methyl butyrate FL/FR |
iso propyl butyrate FL/FR |
propyl butyrate FL/FR |
iso propyl formate FL/FR |
propyl hexanoate FL/FR |
propyl isobutyrate FL/FR |
iso propyl octanoate FL/FR |
rose butanoate FL/FR |
strawberry glycidate 1 (aldehyde C-16 (so-called)) FL/FR |
strawberry glycidate 2 FL/FR |
terpinyl valerate FL/FR |
tolualdehydes (mixed o,m,p) FL/FR |
vanilla carboxylate FL/FR |
green |
anethum graveolens herb tincture FL/FR |
iso butyl 2-butenoate FL/FR |
iso butyl angelate FL/FR |
iso butyl isovalerate FL/FR |
cucumber essence FL/FR |
2- ethyl butyraldehyde FL |
(Z)-4- hepten-1-ol FL/FR |
(E)-2- heptenal FL |
(Z)-3- hexen-1-yl salicylate FL/FR |
hexyl benzoate FL/FR |
hexyl isobutyrate FL/FR |
methyl heptadienone FL/FR |
(E,Z)-3,6- nonadien-1-yl acetate FL/FR |
phenethyl tiglate FL/FR |
3- propylidene phthalide FL/FR |
terpinyl propionate FL/FR |
hay |
genet absolute FL/FR |
herbal |
clary sage absolute FL/FR |
lovage tincture FL/FR |
honey |
ethyl phenyl acetate FL/FR |
dehydrated and ground honey FL |
honey flavor FL |
iso propyl phenyl acetate FL/FR |
propyl phenyl acetate FL/FR |
jammy |
ethyl cyclopentenolone FL/FR |
maltyl isobutyrate FL/FR |
medicinal |
ethyl benzoate FL/FR |
minty |
ethyl salicylate FL/FR |
methyl salicylate FL/FR |
peppermint oil idaho FL/FR |
molasses |
molasses blackstrap FL |
mushroom |
methional diethyl acetal FL |
musk |
ethylene brassylate FL/FR |
phenolic |
guaiacyl phenyl acetate FL/FR |
potato |
sweet potato flavor FL |
powdery |
acetophenone FL/FR |
hydroxycitronellol FL/FR |
praline |
praline flavor FL |
rummy |
iso butyl formate FL/FR |
ethyl pyruvate FL/FR |
salty |
1-(2- hydroxy-4-methoxyphenyl)-3-(pyridin-2-yl)propan-1-one FL |
smoky |
2- methoxy-4-vinyl phenol FL/FR |
3,4- xylenol FL/FR |
spicy |
iso eugenol FL/FR |
eugenol FL/FR |
iso eugenyl acetate FL/FR |
iso eugenyl phenyl acetate FL/FR |
alpha- methyl cinnamaldehyde FL/FR |
alpha- methyl-(E)-cinnamaldehyde FL/FR |
perillaldehyde FL/FR |
para- tolualdehyde FL/FR |
sulfurous |
S- ethyl thioacetate FL |
sweet |
acesulfame potassium FL |
acetone alcohol FL |
advantame FL |
agave flavor FL |
alitame anhydrous FL |
aspartame FL |
aspartame-acesulfame salt FL |
corn syrup high fructose FL |
corn syrups FL |
dextrose monohydrate FL |
3',7- dihydroxy-4'-methoxyflavan FL |
ethyl 3-(2-hydroxyphenyl) propionate FL |
glucosyl steviol glycosides FL |
glycyrrhizic acid FL |
honey enhancer FL |
levulose FL |
luo han fruit concentrate FL |
maltitol FL |
maltose FL |
iso maltulose FL |
molasses FL |
molasses concentrate FL |
molasses distillates FL |
molasses flavor FL |
laevo- ornithine hydrochloride FL |
rebaudioside C FL |
rebaudioside C 30% FL |
glucosylated rubus suavissimus extract, 60% glucosylated rubusoside glycosides FL |
sodium 2-(4-methoxyphenoxy) propionate FL |
dextro- sorbitol FL |
stevia rebaudiana extract, rebaudioside A 22% FL |
stevia rebaudiana extract, rebaudioside A 60% FL |
stevia rebaudiana extract, rebaudioside A 80% FL |
steviol FL |
steviol glycoside extract, rebaudioside C 22% FL |
enzyme modified steviol glycosides FL |
stevioside FL |
sugar FL |
maple sugar FL |
sugar cane distillate FL |
sugar extenders FL |
sugar flavor FL |
brown sugar flavor FL |
burnt sugar flavor FL |
sugar replacers FL |
sweet & sour candy flavor FL |
sweet flavor FL |
thaumatin b-recombinant FL |
vanilla bean absolute (vanilla spp.) FL/FR |
vanilla concentrate FL |
vanilla oleoresin bali FL/FR |
vanilla resinoid FL/FR |
vanilla tahitensis fruit extract FL/FR |
dextro,laevo- xylose FL |
tropical |
propyl propionate FL/FR |
vanilla |
ethyl vanillin FL/FR |
ethyl vanillin propylene glycol acetal FL/FR |
propenyl guaethol FL/FR |
vanilla aromatica fruit extract FL/FR |
vanilla bean absolute (vanilla planifolia) FL/FR |
vanilla oleoresin bourbon FL/FR |
vanillin FL/FR |
vanillin propylene glycol acetal FL/FR |
vanillyl acetate FL/FR |
vanillyl isobutyrate FL/FR |
vegetable |
tyramine FL |
waxy |
ethyl decanoate FL/FR |
ethyl myristate FL/FR |
ethyl octanoate FL/FR |
alpha- hexyl cinnamaldehyde FL/FR |
hydroxycitronellal FL/FR |
nonanol FL/FR |
octyl butyrate FL/FR |
4- phenyl-3-buten-2-ol FL/FR |
propyl heptanoate FL/FR |
rhodinyl phenyl acetate FL/FR |
woody |
4- ethyl guaiacol FL/FR |
alpha- ionol FL/FR |
alpha- terpinyl methyl ether FL/FR |
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
(2R,3R,4R,5R,6R)-2-[(2R,3S,4S,5S)-2,5-bis( | chloromethyl)-3,4-dihydroxyoxolan-2-yl]oxy-5-chloro-6-(hydroxymethyl)oxane-3,4-diol | 1,6- | dichlor-1,6-dideoxy-β-D-fructofuranosyl-4-chlor-4-deoxy-a-D-galactopyranoside | 1,6- | dichloro-1,6-dideoxy-b-D-fructofuranosyl 4-chloro-4-deoxy-a-D-galactose | 1,6- | dichloro-1,6-dideoxy-b-D-fructofuranosyl-4-chloro-4-deoxy-a-D-galacotopyranoside | 1,6- | dichloro-1,6-dideoxy-b-D-fructofuranosyl-4-chloro-4-deoxy-a-D-galactopyranoside | a-D- | galactopyranoside, 1,6-dichloro-1,6-dideoxy-b-D-fructofuranosyl 4-chloro-4-deoxy- | | splenda | 4,1',6'- | trichloro-4,1',6'-trideoxy-galacto-sucrose | | trichlorogalactosucrose | 1',4,6'- | trichlorogalactosucrose | | trichlorosucrose |
Articles:
PubMed:Fortification with iron chelate and substitution of sucrose by sucralose in light uvaia sherbet (Eugenia pyriformis Cambess): physical, chemical and sensory characteristics. |
PubMed:Influence of high intensity sweeteners and sugar alcohols on a beverage microemulsion. |
PubMed:Metabolic effects of non-nutritive sweeteners. |
PubMed:[Association between non-nutritive sweeteners and obesity risk among university students in Latin America]. |
PubMed:Ghrelin signaling is not essential for sugar or fat conditioned flavor preferences in mice. |
PubMed:Determination of high-intensity sweeteners in river water and wastewater by solid-phase extraction and liquid chromatography-tandem mass spectrometry. |
PubMed:Passion fruit juice with different sweeteners: sensory profile by descriptive analysis and acceptance. |
PubMed:Quality characteristics of no added sugar ready to drink milk supplemented with mango pulp. |
PubMed:Simultaneous determination of sweeteners in beverages by LC-MS/MS. |
PubMed:Postoral glucose sensing, not caloric content, determines sugar reward in C57BL/6J mice. |
PubMed:Process optimization for a nutritious low-calorie high-fiber whey-based ready-to-serve watermelon beverage. |
PubMed:Time-intensity profile of pitanga nectar (Eugenia uniflora L.) with different sweeteners: Sweetness and bitterness. |
PubMed:[Consumption of carbonated beverages with nonnutritive sweeteners in Latin American university students]. |
PubMed:Mealtime exposure to food advertisements while watching television increases food intake in overweight and obese girls but has a paradoxical effect in boys. |
PubMed:Influence of temperature and fat content on ideal sucrose concentration, sweetening power, and sweetness equivalence of different sweeteners in chocolate milk beverage. |
PubMed:Dietary glucose regulates yeast consumption in adult Drosophila males. |
PubMed:Development of low calorie snack food based on intense sweeteners. |
PubMed:Hydrophilic interaction liquid chromatography coupled to high-resolution mass spectrometry to determine artificial sweeteners in environmental waters. |
PubMed:Single Lgr5- or Lgr6-expressing taste stem/progenitor cells generate taste bud cells ex vivo. |
PubMed:[Determination of sucralose in foods and beverages by ultraviolet derivatization-high performance liquid chromatography]. |
PubMed:Fructose- and glucose-conditioned preferences in FVB mice: strain differences in post-oral sugar appetition. |
PubMed:The effect of five artificial sweeteners on Caco-2, HT-29 and HEK-293 cells. |
PubMed:Elimination of polar micropollutants and anthropogenic markers by wastewater treatment in Beijing, China. |
PubMed:Assessment of the capability of a gelling complex made of tara gum and the exopolysaccharides produced by the microorganism Streptococcus thermophilus ST10 to prospectively restore the gut physiological barrier: a pilot study. |
PubMed:Determination of artificial sweeteners in beverages with green mobile phases and high temperature liquid chromatography-tandem mass spectrometry. |
PubMed:Artificial sweeteners induce glucose intolerance by altering the gut microbiota. |
PubMed:Effect of heat treatment on the storage stability of low calorie milk drinks. |
PubMed:Pre-meal video game playing and a glucose preload suppress food intake in normal weight boys. |
PubMed:BMI modulates calorie-dependent dopamine changes in accumbens from glucose intake. |
PubMed:Nonnutritive sweeteners are not supernormal stimuli. |
PubMed:Consumption of non-nutritive sweeteners and nutritional status in 10-16 year old students. |
PubMed:Electrosprayed core-shell solid dispersions of acyclovir fabricated using an epoxy-coated concentric spray head. |
PubMed:Effect of sugars in solutions on subjective appetite and short-term food intake in 9- to 14-year-old normal weight boys. |
PubMed:Development of chocolate dairy dessert with addition of prebiotics and replacement of sucrose with different high-intensity sweeteners. |
PubMed:The reward value of sucrose in leptin-deficient obese mice. |
PubMed:Efficient hydrolysis of cellulose over a novel sucralose-derived solid acid with cellulose-binding and catalytic sites. |
PubMed:Hypothalamic melanin concentrating hormone neurons communicate the nutrient value of sugar. |
PubMed:Artificial sweeteners in a large Canadian river reflect human consumption in the watershed. |
PubMed:Effect of fat and sugar substitution on the quality characteristics of low calorie milk drinks. |
PubMed:Evaluating the environmental impact of artificial sweeteners: a study of their distributions, photodegradation and toxicities. |
PubMed:A preference test for sweet taste that uses edible strips. |
PubMed:Sucralose, a synthetic organochlorine sweetener: overview of biological issues. |
PubMed:Determination of artificial sweeteners in sewage sludge samples using pressurised liquid extraction and liquid chromatography-tandem mass spectrometry. |
PubMed:Dessert formulation using sucralose and dextrin affects favorably postprandial response to glucose, insulin, and C-peptide in type 2 diabetic patients. |
PubMed:Quantification of four artificial sweeteners in Finnish surface waters with isotope-dilution mass spectrometry. |
PubMed:Biosynthesis of sucrose-6-acetate catalyzed by surfactant-coated Candida rugosa lipase immobilized on sol-gel supports. |
PubMed:Ecotoxicity of artificial sweeteners and stevioside. |
PubMed:[Simultaneous determination of twelve sweeteners and nine preservatives in foods by solid-phase extraction and LC-MS/MS]. |
PubMed:Artificial sweeteners produce the counterintuitive effect of inducing metabolic derangements. |
PubMed:The influence of sweeteners in probiotic Petit Suisse cheese in concentrations equivalent to that of sucrose. |
PubMed:Beneficial effect of tagatose consumption on postprandial hyperglycemia in Koreans: a double-blind crossover designed study. |
PubMed:Altered insula response to sweet taste processing after recovery from anorexia and bulimia nervosa. |
PubMed:Assessment of exposure of Korean consumers to acesulfame K and sucralose using a stepwise approach. |
PubMed:Effect of sweeteners and hydrocolloids on quality attributes of reduced-calorie carrot juice. |
PubMed:Decreased consumption of sweet fluids in μ opioid receptor knockout mice: a microstructural analysis of licking behavior. |
PubMed:Five amino acid residues in cysteine-rich domain of human T1R3 were involved in the response for sweet-tasting protein, thaumatin. |
PubMed:Sensory characteristics and relative sweetness of tagatose and other sweeteners. |
PubMed:Novel multi-sugar assay for site-specific gastrointestinal permeability analysis: a randomized controlled crossover trial. |
PubMed:Determination of artificial sweeteners in water samples by solid-phase extraction and liquid chromatography-tandem mass spectrometry. |
PubMed:Organic micropollutants in rivers downstream of the megacity Beijing: sources and mass fluxes in a large-scale wastewater irrigation system. |
PubMed:The content of high-intensity sweeteners in different categories of foods available on the Polish market. |
PubMed:Determinants of taste preference and acceptability: quality versus hedonics. |
PubMed:Bitter taste inhibiting agents for whey protein hydrolysate and whey protein hydrolysate beverages. |
PubMed:MSG intake and preference in mice are influenced by prior testing experience. |
PubMed:[Simultaneous determination of five synthetic sweeteners in food by solid phase extraction-high performance liquid chromatography-evaporative light scattering detection]. |
PubMed:Position of the Academy of Nutrition and Dietetics: use of nutritive and nonnutritive sweeteners. |
PubMed:Overweight and obese boys reduce food intake in response to a glucose drink but fail to increase intake in response to exercise of short duration. |
PubMed:[What is has the artificial sweeteners in indication the food of our diabetics?]. |
PubMed:Addition of sucralose enhances the release of satiety hormones in combination with pea protein. |
PubMed:Preference for sucralose predicts behavioral responses to sweet and bittersweet tastants. |
PubMed:Dietary intake of artificial sweeteners by the Belgian population. |
PubMed:Leptin regulates the reward value of nutrient. |
PubMed:Identification and structure elucidation of a p-phenoxybenzaldehyde in bamboo shoots by HPLC-ESI/MS/MS and NMR. |
PubMed:Rapid post-oral stimulation of intake and flavor conditioning by glucose and fat in the mouse. |
PubMed:Sucralose - an ecotoxicological challenger? |
PubMed:Novel analytical approach to a multi-sugar whole gut permeability assay. |
PubMed:Television viewing at mealtime reduces caloric compensation in peripubertal, but not postpubertal, girls. |
PubMed:Effects of the artificial sweetener sucralose on Daphnia magna and Americamysis bahia survival, growth and reproduction. |
PubMed:Taste-independent detection of the caloric content of sugar in Drosophila. |
PubMed:Rats display a robust bimodal preference profile for sucralose. |
PubMed:Implicit media frames: automated analysis of public debate on artificial sweeteners. |
PubMed:Determination of nine high-intensity sweeteners in various foods by high-performance liquid chromatography with mass spectrometric detection. |
PubMed:Development of a quantitative high-performance thin-layer chromatographic method for sucralose in sewage effluent, surface water, and drinking water. |
PubMed:Bioconcentration of the intense sweetener sucralose in a multitrophic battery of aquatic organisms. |
PubMed:Cob(I)alamin reacts with sucralose to afford an alkylcobalamin: relevance to in vivo cobalamin and sucralose interaction. |
PubMed:Pilot study: alterations of intestinal microbiota in obese humans are not associated with colonic inflammation or disturbances of barrier function. |
PubMed:Gut T1R3 sweet taste receptors do not mediate sucrose-conditioned flavor preferences in mice. |
PubMed:The absence of genotoxicity of sucralose. |
PubMed:Analysis of multiple sweeteners and their degradation products in lassi by HPLC and HPTLC plates. |
PubMed:Study on the synthesis of sucrose-6-acetate catalyzed by fructosyltransferase from Aspergillus oryzae. |
PubMed:Gain weight by "going diet?" Artificial sweeteners and the neurobiology of sugar cravings: Neuroscience 2010. |
PubMed:Application of agonist-receptor modeling to the sweetness synergy between high fructose corn syrup and sucralose, and between high-potency sweeteners. |
PubMed:Understanding consumption-related sucralose emissions - A conceptual approach combining substance-flow analysis with sampling analysis. |
PubMed:Role of protein concentration and protein-saliva interactions in the astringency of whey proteins at low pH. |
PubMed:Positive allosteric modulators of the human sweet taste receptor enhance sweet taste. |
PubMed:Inadequate toxicity tests of food additive acesulfame. |
PubMed:Neonatal exposure to sucralose does not alter biochemical markers of neuronal development or adult behavior. |
PubMed:Determination of sucralose in soft drinks by high-performance thin-layer chromatography: interlaboratory study. |
PubMed:Sweet taste signaling functions as a hypothalamic glucose sensor. |
PubMed:An overview of the safety of sucralose. |
PubMed:Determination of nine intense sweeteners in foodstuffs by high-performance liquid chromatography and evaporative light-scattering detection: interlaboratory study. |
PubMed:Simultaneous determination of nonnutritive sweeteners in foods by HPLC/ESI-MS. |
PubMed:Consumption of SC45647 and sucralose by rats selectively bred for high and low saccharin intake. |
PubMed:Allelic variation of the Tas1r3 taste receptor gene selectively affects taste responses to sweeteners: evidence from 129.B6-Tas1r3 congenic mice. |
PubMed:Analysis and stability of sucralose in a milk-based confection by a simple planar chromatographic method. |
PubMed:Simultaneous determination of nine intense sweeteners in foodstuffs by high performance liquid chromatography and evaporative light scattering detection--development and single-laboratory validation. |
PubMed:Effect of short-duration physical activity and ventilation threshold on subjective appetite and short-term energy intake in boys. |
PubMed:Effect of television viewing at mealtime on food intake after a glucose preload in boys. |
PubMed:Consumer acceptability of low-sugar watermelon sweetened with non-calorie sweetener by a Native American community. |
PubMed:Food labeling: health claims; dietary noncariogenic carbohydrate sweeteners and dental caries. Final rule. |
PubMed:The intake of intense sweeteners - an update review. |
PubMed:[Analysis of nine kinds of sweeteners in foods by LC/MS]. |
PubMed:Experimental design-based development and single laboratory validation of a capillary zone electrophoresis method for the determination of the artificial sweetener sucralose in food matrices. |
PubMed:Artificial sweeteners--do they bear a carcinogenic risk? |
PubMed:Female rats show a bimodal preference response to the artificial sweetener sucralose. |
PubMed:Determination of sucralose in Splenda and a sugar-free beverage using high-performance anion-exchange chromatography with pulsed amperometric detection. |
PubMed:Position of the American Dietetic Association: use of nutritive and nonnutritive sweeteners. |
PubMed:Long-term food consumption and body weight changes in neotame safety studies are consistent with the allometric relationship observed for other sweeteners and during dietary restrictions. |
PubMed:Determination of the artificial sweetener Sucralose by capillary electrophoresis. |
PubMed:[Determination of sucralose in foods by HPLC using pre-column derivatization]. |
PubMed:[Determination of sucralose in foods by liquid chromatography/tandem mass spectrometry]. |
PubMed:The comet assay with 8 mouse organs: results with 39 currently used food additives. |
PubMed:Sweetener preference of C57BL/6ByJ and 129P3/J mice. |
PubMed:[Determination of sucralose in foods by HPLC]. |
PubMed:[Determination of sucralose in foods by anion-exchange chromatography and reverse-phase chromatography]. |
PubMed:Repeated dose study of sucralose tolerance in human subjects. |
PubMed:The metabolic fate of sucralose in rats. |
PubMed:The pharmacokinetics and metabolism of sucralose in the rabbit. |
PubMed:The pharmacokinetics and metabolism of sucralose in the mouse. |
PubMed:The pharmacokinetics and metabolism of sucralose in the dog. |
PubMed:A carcinogenicity study of sucralose in the CD-1 mouse. |
PubMed:A combined chronic toxicity/carcinogenicity study of sucralose in Sprague-Dawley rats. |
PubMed:Acute and subchronic toxicity of sucralose. |
PubMed:Sucralose: assessment of teratogenic potential in the rat and the rabbit. |
PubMed:Sucralose metabolism and pharmacokinetics in man. |
PubMed:Sucralose: lack of effects on sperm glycolysis and reproduction in the rat. |
PubMed:Neurotoxicity studies on sucralose and its hydrolysis products with special reference to histopathologic and ultrastructural changes. |
PubMed:Sucralose--an overview of the toxicity data. |
PubMed:Lack of DNA-damaging activity of five non-nutritive sweeteners in the rat hepatocyte/DNA repair assay. |
PubMed:Effect of storage on the flavours of cola drinks sweetened with different sweetener systems. |
PubMed:The development and applications of sucralose, a new high-intensity sweetener. |
PubMed:Review of present and future use of nonnutritive sweeteners. |
PubMed:Renal mineralization--a ubiquitous lesion in chronic rat studies. |
PubMed:Determination of seven artificial sweeteners in diet food preparations by reverse-phase liquid chromatography with absorbance detection. |
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sweetness intensity roughly 600 times that of sucrose and is nonnutritive and noncaloric; largely unabsorbed in the gastrointestinal tract. Noncalorific sweetener with good taste props.
One report suggests sucralose is a possible trigger for some migraine patients. Another study published in the Journal of Mutation Research linked doses of sucralose equivalent to 11,450 packets per day in a person to DNA damage in mice.; Results from over 100 animal and clinical studies in the FDA approval process unanimously indicated a lack of risk associated with sucralose intake. However, some adverse effects were seen at doses that significantly exceeded the estimated daily intake (EDI), which is 1.1 mg/kg/day. When the EDI is compared to the intake at which adverse effects are seen, known as the highest no adverse effects limit (HNEL), at 1500 mg/kg/day, there is a large margin of safety. The bulk of sucralose ingested is not absorbed by the gastrointestinal (GI) tract and is directly excreted in the feces, while 11-27% of it is absorbed. The amount that is absorbed from the GI tract is largely removed from the blood stream by the kidneys and eliminated in the urine with 20-30% of the absorbed sucralose being metabolized.; Sucralose belongs to a class of compounds known as organochlorides (or chlorocarbons). Some organochlorides, particularly those that accumulate in fatty tissues, are toxic to plants or animals, including humans. Sucralose, however, is not known to be toxic in small quantities and is extremely insoluble in fat; it cannot accumulate in fat like chlorinated hydrocarbons. In addition, sucralose does not break down or dechlorinate.; Sucralose can be found in more than 4,500 food and beverage products. It is used because it is a no-calorie sweetener, does not promote dental caries, and is safe for consumption by diabetics. Sucralose is used as a replacement for, or in combination with, other artificial or natural sweeteners such as aspartame, acesulfame potassium or high-fructose corn syrup. Sucralose is used in products such as candy, breakfast bars and soft drinks. It is also used in canned fruits wherein water and sucralose take the place of much higher calorie corn syrup based additives. Sucralose mixed with maltodextrin or dextrose (both made from corn) as bulking agents is sold internationally by McNeil Nutritionals under the Splenda brand name. In the United States and Canada, this blend is increasingly found in restaurants, including McDonald's, Tim Hortons and Starbucks, in yellow packets, in contrast to the blue packets commonly used by aspartame and the pink packets used by those containing saccharin sweeteners; though in Canada yellow packets are also associated with the SugarTwin brand of cyclamate sweetener.; Sucralose is a highly heat-stable artificial sweetener, allowing it to be used in many recipes with little or no sugar. Sucralose is available in a granulated form that allows for same-volume substitution with sugar. This mix of granulated sucralose includes fillers, all of which rapidly dissolve in liquids.[citation needed] Unlike sucrose which dissolves to a clear state, sucralose suspension in clear liquids such as water results in a cloudy state. For example, gelatin and fruit preserves made with sucrose have a satiny, near jewel-like appearance, whereas the same products made with sucralose (whether cooked or not) appear translucent and marginally glistening.[citation needed] While the granulated sucralose provides apparent volume-for-volume sweetness, the texture in baked products may be noticeably different. Sucralose is non-hygroscopic, meaning it does not attract moisture, which can lead to baked goods that are noticeably drier and manifesting a less dense texture than baked products made with sucrose. Unlike sucrose which melts when baked at high temperatures, sucralose maintains its granular structure when subjected to dry, high heat (e.g., in a 350 °F (177 °C) oven). Thus, in some baking recipes, such as crème brûlée, which require sugar sprinkled on top to partially or fully melt and crystallize, substituting sucralose will not result in the same surface texture, crispness, or crystalline structure.; Sucralose is a zero-calorie sugar substitute artificial sweetener. In the European Union, it is also known under the E number (additive code) E955. Sucralose is approximately 600 times as sweet as sucrose (table sugar), twice as sweet as saccharin, and 3.3 times as sweet as aspartame. Unlike aspartame, it is stable under heat and over a broad range of pH conditions. Therefore, it can be used in baking or in products that require a longer shelf life. The commercial success of sucralose-based products stems from its favorable comparison to other low-calorie sweeteners in terms of taste, stability, and safety.
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