EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

dihydrocoumarin
3,4-dihydrocoumarin

Supplier Sponsors

Fragrance Demo Formulas
Flavor Demo Formulas
Name:chroman-2-one
CAS Number: 119-84-6Picture of molecule3D/inchi
Other(deleted CASRN):1341-36-2
ECHA EINECS - REACH Pre-Reg:204-354-9
FDA UNII: NM5K1Y1BT2
Nikkaji Web:J36.832F
Beilstein Number:0004584
MDL:MFCD00006881
CoE Number:535
XlogP3-AA:1.60 (est)
Molecular Weight:148.16116000
Formula:C9 H8 O2
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category: flavor and fragrance agents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Perfumer and Flavorist:Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
JECFA Food Flavoring:1171 dihydrocoumarin
DG SANTE Food Flavourings:13.009 3,4-dihydrocoumarin
FEMA Number:2381 dihydrocoumarin
FDA:No longer provide for the use of these seven synthetic flavoring substances
FDA Mainterm (SATF):119-84-6 ; DIHYDROCOUMARIN
 
Physical Properties:
Appearance:colorless to pale yellow clear liquid to solid (est)
Assay: 99.00 to 100.00
Food Chemicals Codex Listed: Yes
Specific Gravity:1.18600 to 1.19200 @ 25.00 °C.
Pounds per Gallon - (est).: 9.869 to 9.919
Refractive Index:1.54000 to 1.58000 @ 20.00 °C.
Melting Point: 24.00 to 25.00 °C. @ 760.00 mm Hg
Boiling Point: 271.00 to 272.00 °C. @ 760.00 mm Hg
Congealing Point:23.00 °C.
Acid Value: 5.00 max. KOH/g
Vapor Pressure:4.000000 mmHg @ 25.00 °C.
Flash Point:> 230.00 °F. TCC ( > 110.00 °C. )
logP (o/w): 2.428 (est)
Shelf Life: 24.00 month(s) or longer if stored properly.
Storage:store in cool, dry place in tightly sealed containers, protected from heat and light.
Soluble in:
 alcohol
 water, 3000 mg/L @ 37 °C (exp)
Insoluble in:
 water
 
Organoleptic Properties:
Odor Type: tonka
Odor Strength:medium ,
recommend smelling in a 10.00 % solution or less
Substantivity:228 hour(s) at 100.00 %
sweet tonka coumarinic coconut herbal cinnamon balsamic
Odor Description:at 10.00 % in dipropylene glycol. sweet tonka coumarinic coconut herbal cinnamon balsamic
Luebke, William tgsc, (1987)
Odor sample from: Elan Inc.
sweet creamy coconut coumarinic vanilla spicy
Odor Description:Sweet, creamy, coconut, coumarin, vanilla with a slight spice nuance
Mosciano, Gerard P&F 17, No. 3, 57, (1992)
Flavor Type: creamy
creamy coconut coumarinic vanilla cinnamyl balsamic spicy cardamom
Taste Description: creamy coconut coumarinic vanilla cinnamyl balsamic spicy cardamom
Luebke, William tgsc, (1987)
sweet creamy vanilla coconut milky
Taste Description: at 10.00 ppm. Sweet, creamy, vanilla, coconut and milky
Mosciano, Gerard P&F 17, No. 3, 57, (1992)
Odor and/or flavor descriptions from others (if found).
Sigma-Aldrich
Dihydrocoumarin, ≥99%, FCC, FG
Odor Description:almond; coconut; creamy; herbaceous; sweet; vanilla; nutty; tobacco.
Taste Description:sweet creamy vanilla coconut milky
Moellhausen
DIHYDROCOUMARIN
Odor Description:sweet, cocoa
Taste Description:sweet, vanilla, milk
PerfumersWorld
Dihydro coumarin
Odor Description:sweet rose coumarin tonka herbal sweet aromatic coumarin coconut
Perfumery Laboratory
TONCAINOL
Odor Description:Sweet, vanilla with bright notes of beans
Indukern F&F
DIHYDROCOUMARIN NATURAL
Odor Description:SWEET, AROMATIC, COUMARIN, CINNAMON
 
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: not used anymore
 
Suppliers:
ACS International
Dihydrocumarine
Odor: sweet tonka coumarin coconut herbal cinnamon
Operational Capabilities
Advanced Biotech
BENZO DIHYDROPYRONE NATURAL
98% min.
Odor: Herbaceous, Woody
Advanced Biotech
BENZO DIHYDROPYRONE SYNTHETIC
98% min.
Odor: Herbaceous, Woody
Alfa Biotechnology
For experimental / research use only.
Hydrocoumarin 98%
Anhui Haibei
Dihydro coumarin
Odor: Sweetish, fruity or herbal
Augustus Oils
Dihydro Coumarin
Services
Aurochemicals
BENZODIHYDROPYRONE, Natural
Beijing Lys Chemicals
Dihydrocoumarin (natural)
Beijing Lys Chemicals
Dihydrocoumarin
Bell Flavors & Fragrances
Natural Benzodihydropyrone (BDHP)
Berjé
Benzo Dihydropyrone
Media
BOC Sciences
For experimental / research use only.
Hydrocoumarin >98%
Citrus and Allied Essences
Benzo Dihydropyrone
Market Report
Diffusions Aromatiques
DIHYDROCOUMARINE
Elan Inc.
BENZO DIHYDRO PYRONE
FCC, Kosher
EMD Millipore
For experimental / research use only.
Dihydrocoumarin
Ernesto Ventós
DIHYDROCOUMARIN, NATURAL
Ernesto Ventós
DIHYDROCOUMARIN
Odor: SWEET,COUMARIN BUT SLIGHTLY BITTER
Excellentia International
Benzodihydropyrone FCC (Dihydrocoumarin)
ExtraSynthese
For experimental / research use only.
3,4-Dihydrocoumarin (GC) ≥95%
Fleurchem
benzodihydropyrone
Indukern F&F
DIHYDROCOUMARIN NATURAL
Odor: SWEET, AROMATIC, COUMARIN, CINNAMON
Indukern F&F
DIHYDROCOUMARIN
Jiangyin Healthway
Dihydrocoumarin Natural99%
New functional food ingredients
K.L. Koh Enterprise
DIHYDROCOUMARIN
Lluch Essence
DIHYDROCOUMARIN NATURAL 99%
Lluch Essence
DIHYDROCOUMARIN
M&U International
Dihydrocoumarin, Kosher
M&U International
NAT.DIHYDROCOUMARIN
Moellhausen
DIHYDROCOUMARIN
Odor: sweet, cocoa
Flavor: sweet, vanilla, milk
Pearlchem Corporation
Dihydro Coumarin
Penta International
BENZODIHYDROPYRONE NATURAL
Penta International
BENZODIHYDROPYRONE
PerfumersWorld
Dihydro coumarin
Odor: sweet rose coumarin tonka herbal sweet aromatic coumarin coconut
Perfumery Laboratory
TONCAINOL
Odor: Sweet, vanilla with bright notes of beans
Phoenix Aromas & Essential Oils
Dihydrocoumarin (Benzodihydropyrone)
Prinova
Di Hydro Coumarin
R C Treatt & Co Ltd
Dihydrocoumarin
Reincke & Fichtner
Dihydrocoumarin
Santa Cruz Biotechnology
For experimental / research use only.
Dihydrocoumarin ≥98%
Sigma-Aldrich
Dihydrocoumarin, ≥99%, FCC, FG
Odor: almond; coconut; creamy; herbaceous; sweet; vanilla; nutty; tobacco.
Certified Food Grade Products
SRS Aromatics
DIHYDRO COUMARIN EU NATURAL
SRS Aromatics
DIHYDRO COUMARIN
Sunaux International
Dihydrocoumarin
TCI AMERICA
For experimental / research use only.
3,4-Dihydrocoumarin >98.0%(GC)
Tengzhou Xiang Yuan Aroma Chemicals
Dihydrocoumarin
The Lermond Company
DIHYDRO COUMARIN
The Perfumers Apprentice
Dihydrocoumarin 10% (PG)
Odor: Sweet, creamy, vanilla, coconut and milky
United International
3,4-Dihydrocoumarin
Universal Preserv-A-Chem Inc.
BENZODIHYDROPYRONE
Vigon International
Dihydrocoumarin FCC
Odor: Sweet-aromatic like coumarin, with pronounced cinnamon and caramel note
Vigon International
Dihydrocoumarin Natural
Vistachem
Dihydrocoumarin
WEN International
BENZODIHYDROPYRONE, natural
WholeChem
Dihydrocoumarin
 
Safety Information:
Preferred SDS: View
European information :
Most important hazard(s):
Xn - Harmful.
R 22 - Harmful if swallowed.
R 36/38 - Irritating to skin and eyes.
S 02 - Keep out of the reach of children.
S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S 36/37/39 - Wear suitable clothing, gloves and eye/face protection.
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Human Experience:
20 % solution: no irritation or sensitization.
Oral/Parenteral Toxicity:
oral-rat LD50 1460 mg/kg
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Food and Cosmetics Toxicology. Vol. 2, Pg. 327, 1964.

intraperitoneal-mouse LD50 200 mg/kg
National Technical Information Service. Vol. AD277-689

oral-guinea pig LD50 1760 mg/kg
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Food and Cosmetics Toxicology. Vol. 2, Pg. 327, 1964.

Dermal Toxicity:
skin-rabbit LD50 > 5000 mg/kg
Food and Cosmetics Toxicology. Vol. 12, Pg. 521, 1974.

Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
flavor and fragrance agents
RIFM Fragrance Material Safety Assessment: Search
IFRA Code of Practice Notification of the 49th Amendment to the IFRA Code of Practice
IFRA Critical Effect:
Dermal sensitization and systemic toxicity
 View the IFRA Standard
View IFRA Standards Library for complete information.
Please review Amendment 49 IFRA documentation for complete information.
IFRA RESTRICTION LIMITS IN THE FINISHED PRODUCT (%):
Category 1: Products applied to the lips
0.077 %
Category 2: Products applied to the axillae
0.023 %
Category 3: Products applied to the face/body using fingertips
0.46 %
Category 4: Products related to fine fragrance
0.43 %
 Category 5: Products applied to the face and body using the hands (palms), primarily leave-on
Category 5A: Body lotion products applied to the body using the hands (palms), primarily leave-on
0.11 %
Category 5B: Face moisturizer products applied to the face using the hands (palms), primarily leave-on
0.11 %
Category 5C: Hand cream products applied to the hands using the hands (palms), primarily leave-on
0.11 %
Category 5D: Baby Creams, baby Oils and baby talc
0.03 %
Category 6: Products with oral and lip exposure
0.25 %
 Category 7: Products applied to the hair with some hand contact
Category 7A: Rinse-off products applied to the hair with some hand contact
0.88 %
Category 7B: Leave-on products applied to the hair with some hand contact
0.88 %
Category 8: Products with significant anogenital exposure
0.03 %
Category 9: Products with body and hand exposure, primarily rinse off
0.84 %
 Category 10: Household care products with mostly hand contact
Category 10A: Household care excluding aerosol products (excluding aerosol/spray products)
0.84 %
Category 10B: Household aerosol/spray products
3.00 %
 Category 11: Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate
Category 11A: Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
0.03 %
Category 11B: Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
0.03 %
Category 12: Products not intended for direct skin contact, minimal or insignificant transfer to skin
No Restriction
 Notes:
IFRA FLAVOR REQUIREMENTS:

Due to the possible ingestion of small amounts of fragrance ingredients from their use in products in Categories 1 and 6, materials must not only comply with IFRA Standards but must also be recognized as safe as a flavoring ingredient as defined by the IOFI Code of Practice (www.iofi.org). For more details see chapter 1 of the Guidance for the use of IFRA Standards.

 
Maximised Survey-derived Daily Intakes (MSDI-EU): 1200.00 (μg/capita/day)
Maximised Survey-derived Daily Intakes (MSDI-USA): 1111.00 (μg/capita/day)
Structure Class: III
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 3. Update in publication number(s): 29
Click here to view publication 3
 average usual ppmaverage maximum ppm
baked goods: 141.00000165.00000
beverages(nonalcoholic): 25.0000028.00000
beverages(alcoholic): 0.300002.00000
breakfast cereal: --
cheese: --
chewing gum: 20.00000250.00000
condiments / relishes: 10.0000015.00000
confectionery froastings: --
egg products: --
fats / oils: --
fish products: --
frozen dairy: 95.00000104.00000
fruit ices: --
gelatins / puddings: 116.00000132.00000
granulated sugar: --
gravies: --
hard candy: 8.0000044.00000
imitation dairy: --
instant coffee / tea: --
jams / jellies: --
meat products: --
milk products: --
nut products: --
other grains: --
poultry: --
processed fruits: --
processed vegetables: --
reconstituted vegetables: --
seasonings / flavors: --
snack foods: --
soft candy: 111.00000131.00000
soups: --
sugar substitutes: --
sweet sauces: --
 
Safety References:
European Food Safety Athority(EFSA):Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies...

European Food Safety Authority (EFSA) reference(s):

Flavouring Group Evaluation 80 (FGE.80) - Consideration of alicyclic, alicyclic-fused and aromatic-fused ring lactones evaluated by JECFA (61st meeting) structurally related to a aromatic lactone evaluated by EFSA in FGE.27 (2008)
View page or View pdf

Flavouring Group Evaluation 80, Revision 1 (FGE.80Rev1): Consideration of alicyclic, alicyclic-fused and aromatic-fused ring lactones evaluated by JECFA (61st meeting) structurally related to a aromatic lactone evaluated by EFSA in FGE.27 (2008)
View page or View pdf

Scientific Opinion on the safety and efficacy of alicyclic and aromatic lactones (chemical group 11) when used as flavourings for all animal species
View page or View pdf

EPI System: View
Chemical Carcinogenesis Research Information System:Search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
Carcinogenic Potency Database:Search
EPA Substance Registry Services (TSCA):119-84-6
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :660
National Institute of Allergy and Infectious Diseases:Data
SCCNFP:opinion
WGK Germany:3
chroman-2-one
Chemidplus:0000119846
EPA/NOAA CAMEO:hazardous materials
RTECS:MW5775000 for cas# 119-84-6
 
References:
 chroman-2-one
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:119-84-6
Pubchem (cid):660
Pubchem (sid):134974732
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Substances Added to Food (formerly EAFUS):View
CHEBI:View
CHEMBL:View
Metabolomics Database:Search
UM BBD:Search
KEGG (GenomeNet):C02274
HMDB (The Human Metabolome Database):HMDB36626
FooDB:FDB015543
Export Tariff Code:2932.20.4500
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
Wikipedia:View
 
Potential Blenders and core components note
For Odor
aldehydic
acetyl nonyryl
FL/FR
amber
angelica root oil
FL/FR
cistus ladaniferus resinoid
FL/FR
animal
animal carbolactone
FR
civet absolute
FL/FR
costus valerolactone
FR
indole
FL/FR
6-
methyl quinoline
FL/FR
anisic
para-
anisaldehyde
FL/FR
balsamic
amyris wood oil
FL/FR
siam
benzoin resinoid
FL/FR
sumatra
benzoin resinoid
FL/FR
benzyl cinnamate
FL/FR
benzyl salicylate
FL/FR
iso
butyl cinnamate
FL/FR
copaiba balsam oil
FL/FR
ethyl cinnamate
FL/FR
fir balsam absolute
FR
methyl cinnamate
FL/FR
peru balsam oil
FL/FR
pine needle absolute
FL/FR
berry
raspberry ketone
FL/FR
buttery
acetoin
FL/FR
acetyl butyryl
FL/FR
acetyl isobutyryl
FL/FR
acetyl propionyl
FL/FR
butyl butyryl lactate
FL/FR
caramellic
2-oxo
butyric acid
FL/FR
ethyl maltol
FL/FR
fenugreek absolute
FL/FR
immortelle absolute
FL/FR
strawberry furanone acetate
FL/FR
cheesy
butyric acid
FL/FR
2-
heptanone
FL/FR
citrus
lime oil expressed florida
FL/FR
coconut
alpha-
angelica lactone
FL/FR
coconut decanone methyl
FR
coconut naphthalenone
FL/FR
delta-
decalactone
FL/FR
delta-2-
dodecenolactone
FL/FR
delta-
heptalactone
FL/FR
gamma-
heptalactone
FL/FR
delta-
nonalactone
FL/FR
gamma-
nonalactone (aldehyde C-18 (so-called))
FL/FR
delta-
octalactone
FL/FR
gamma-
octalactone
FL/FR
propyl octanoate
FL/FR
tetrahydrojasmone
FR
delta-
undecalactone
FL/FR
wine lactone
FL/FR
coumarinic
coumane
FL/FR
phthalide
FL/FR
tonka bean oleoresin
FR
tonka bean resinoid
FR
tonka furanone
FL/FR
tonka ketone
FR
tonkavert
FR
creamy
gamma-
butyrolactone
FL/FR
creamy lactone
FL/FR
3-
heptyl dihydro-5-methyl-2(3H)-furanone
FL/FR
para-
vanillic acid
FL/FR
para-
vanillyl alcohol
FL/FR
earthy
1-
nonen-3-ol
FL/FR
fatty
(Z)-
dairy lactone
FL/FR
ethyl undecylenate
FL/FR
4-
methyl octanoic acid
FL/FR
fermented
butyl laevo-lactate
FL/FR
floral
acetophenone
FL/FR
iso
amyl salicylate
FL/FR
para-
anisyl nitrile
FR
iso
butyl salicylate
FL/FR
cananga oil
FL/FR
dihydrojasmone
FL/FR
dihydrojasmone lactone
FL/FR
floral pyranol
FR
heliotropin
FL/FR
heliotropyl acetone
FL/FR
heliotropyl diethyl acetal
FR
hexenyl cyclopentanone
FR
alpha-
hexyl cinnamaldehyde
FL/FR
hydroxycitronellal
FL/FR
jasmin lactone (IFF)
FL/FR
lavender oil
FL/FR
para-
methyl acetophenone
FL/FR
nerolidol
FL/FR
ocean propanal
FL/FR
orris rhizome absolute (iris pallida)
FL/FR
palmarosa oil
FL/FR
2-
pentyl cyclopentanone
FR
phenethyl phenyl acetate
FL/FR
fruity
acetoin acetate
FL/FR
amyl heptanoate
FL/FR
iso
amyl octanoate
FL/FR
benzaldehyde
FL/FR
cherry propanol
FL/FR
gamma-
decalactone
FL/FR
farnesyl acetone
FL/FR
4-
hydroxybenzyl alcohol
FL/FR
methyl (Z)-5-octenoate
FL/FR
octyl butyrate
FL/FR
iso
propyl octanoate
FL/FR
tolualdehydes (mixed o,m,p)
FL/FR
gamma-
undecalactone (aldehyde C-14 (so-called))
FL/FR
green
iso
butyl benzyl carbinol
FL/FR
butyl lactate
FL/FR
alpha-
decalactone
FL/FR
diphenyl methane
FL/FR
galbanum oil
FL/FR
(Z)-4-
hepten-1-ol
FL/FR
(Z)-4-
heptenal
FL/FR
(Z)-4-
heptenal diethyl acetal
FL/FR
heptyl heptanoate
FL/FR
3-
phenyl propionaldehyde
FL/FR
syringaldehyde
FL/FR
hay
hay absolute
FR
herbal
apium graveolens seed oil india
FL/FR
immortelle flower oil
FL/FR
abrialis
lavandin oil
FL/FR
linalyl acetate
FL/FR
origanum oil greece
FL/FR
melon
watermelon ketone
FR
mossy
oakmoss absolute
FL/FR
treemoss absolute
FR
veramoss (IFF)
FR
mushroom
3-
octen-2-ol
FL/FR
musty
2-
acetyl pyrrole
FL/FR
naphthyl
2,4-
dimethyl benzaldehyde
FL/FR
beta-
naphthyl ethyl ether
FL/FR
beta-
naphthyl methyl ether
FL/FR
nutty
2-
acetyl-5-methyl furan
FL/FR
phenolic
ortho-
guaiacol
FL/FR
powdery
para-
anisyl acetate
FL/FR
para-
anisyl alcohol
FL/FR
soapy
ethyl undecanoate
FL/FR
spicy
benzyl isoeugenol
FL/FR
croton eluteria bark oil
FL/FR
cubeb oil
FL/FR
iso
eugenyl acetate
FL/FR
ginger root oil china
FL/FR
levisticum officinale root oil
FL/FR
para-
methoxy-alpha-methyl cinnamaldehyde
FL/FR
para-
methoxycinnamaldehyde
FL/FR
alpha-
methyl cinnamaldehyde
FL/FR
methyl heptadienone
FL/FR
alpha-
methyl-(E)-cinnamaldehyde
FL/FR
myrtenal
FL/FR
nutmeg oil
FL/FR
sweet
vanilla oleoresin bali
FL/FR
thujonic
armoise oil
FR
tonka
6-
amyl-alpha-pyrone
FL/FR
coumarin
FR
deertongue absolute
FR
deertongue oleoresin
FR
flouve absolute
FR
gamma-
hexalactone
FL/FR
melilot absolute
FR
7-
methyl coumarin
CS
mint lactone
FL/FR
octahydrocoumarin
FL/FR
tonka bean absolute
FR
tonka undecanone
FR
whiskey lactone
FL/FR
tropical
delta-
dodecalactone
FL/FR
glyceryl 5-hydroxydecanoate
FL/FR
glyceryl 5-hydroxydodecanoate
FL/FR
vanilla
ortho-
dimethyl hydroquinone
FL/FR
ethyl vanillin
FL/FR
ethyl vanillin isobutyrate
FL/FR
ethyl vanillin propylene glycol acetal
FL/FR
methyl vanillate
FL/FR
propenyl guaethol
FL/FR
vanilla bean absolute (vanilla planifolia)
FL/FR
vanillin
FL/FR
vanillyl acetate
FL/FR
vanillyl isobutyrate
FL/FR
vanillylidene acetone
FL/FR
vegetable
methional
FL/FR
waxy
allyl nonanoate
FL/FR
1-
dodecanol
FL/FR
ethyl palmitate
FL/FR
methyl laurate
FL/FR
myristyl alcohol
FL/FR
2-
nonanol
FL/FR
octyl isobutyrate
FL/FR
delta-
tetradecalactone
FL/FR
2-
tridecanone
FL/FR
undecanoic acid
FL/FR
woody
guaiacwood oil
FL/FR
methyl cedryl ketone
FL/FR
patchouli ethanone
FR
patchouli oil
FL/FR
sandalwood oil
FL/FR
santall
FR
spruce needle oil canada
FL/FR
tobacarol (IFF)
FR
vetiver oil haiti
FL/FR
vetiverol
FL/FR
woody acetate
FR
(Z)-
woody amylene
FR
woody propanol
FR
For Flavor
No flavor group found for these
allyl methyl trisulfide
FL
cistus ladaniferus resinoid
FL/FR
coconut naphthalenone
FL/FR
coumane
FL/FR
alpha-
decalactone
FL/FR
6-
decenoic acid
FL
(S)-
dihydroactinidiolide
FL
dimethyl benzofuranone
FL
ortho-
dimethyl hydroquinone
FL/FR
delta-2-
dodecenolactone
FL/FR
farnesyl acetone
FL/FR
fig leaf absolute
FL
2-
furfurylidene butyraldehyde
FL
jasmin lactone (IFF)
FL/FR
melilot oleoresin
FL
para-
methoxy-alpha-methyl cinnamaldehyde
FL/FR
7-
methoxycoumarin
FL
methyl vanillate
FL/FR
myristyl alcohol
FL/FR
4-
octen-3-one
FL
pine needle absolute
FL/FR
propyl octanoate
FL/FR
tonka furanone
FL/FR
(R)-
tonka furanone
FL
wine lactone
FL/FR
aldehydic
aldehydic
acetyl nonyryl
FL/FR
amber
iso
butyl benzyl carbinol
FL/FR
animal
civet absolute
FL/FR
indole
FL/FR
6-
methyl quinoline
FL/FR
balsamic
siam
benzoin resinoid
FL/FR
sumatra
benzoin resinoid
FL/FR
benzyl salicylate
FL/FR
iso
butyl cinnamate
FL/FR
copaiba balsam oil
FL/FR
ethyl cinnamate
FL/FR
peru balsam oil
FL/FR
vanillylidene acetone
FL/FR
berry
heliotropyl acetone
FL/FR
raspberry ketone
FL/FR
bitter
glyceryl tributyrate
FL
brown
2-oxo
butyric acid
FL/FR
buttery
butter cream frosting flavor
FL
butyl laevo-lactate
FL/FR
diacetyl
FL
cabbage
methyl 2-thiofuroate
FL
caramellic
caramel furanone
FL
ethyl maltol
FL/FR
fenugreek absolute
FL/FR
strawberry furanone acetate
FL/FR
cheesy
2-
heptanone
FL/FR
cherry
heliotropin
FL/FR
para-
methoxycinnamaldehyde
FL/FR
citrus
lime oil expressed florida
FL/FR
cocoa
syringaldehyde
FL/FR
coconut
delta-
decalactone
FL/FR
(R)-
massoia lactone
FL
6-
methyl coumarin
FL
gamma-
nonalactone (aldehyde C-18 (so-called))
FL/FR
octahydrocoumarin
FL/FR
delta-
octalactone
FL/FR
cooling
iso
butyl salicylate
FL/FR
coumarinic
phthalide
FL/FR
creamy
acetoin
FL/FR
acetyl butyryl
FL/FR
acetyl isobutyryl
FL/FR
6-
amyl-alpha-pyrone
FL/FR
alpha-
angelica lactone
FL/FR
para-
anisaldehyde
FL/FR
butyl butyryl lactate
FL/FR
creamy lactone
FL/FR
5,5-
dibutyl dihydrofuran-2(3H)-one
FL
delta-
dodecalactone
FL/FR
glyceryl 5-hydroxydecanoate
FL/FR
glyceryl 5-hydroxydodecanoate
FL/FR
gamma-
hexalactone
FL/FR
massoia lactone
FL
para-
methyl acetophenone
FL/FR
mint lactone
FL/FR
delta-
nonalactone
FL/FR
octyl isobutyrate
FL/FR
delta-
undecalactone
FL/FR
gamma-
undecalactone (aldehyde C-14 (so-called))
FL/FR
para-
vanillic acid
FL/FR
para-
vanillyl alcohol
FL/FR
dairy
methyl (Z)-5-octenoate
FL/FR
earthy
1-
nonen-3-ol
FL/FR
fatty
(Z)-
dairy lactone
FL/FR
ethyl undecylenate
FL/FR
4-
methyl octanoic acid
FL/FR
2,4-
octadien-1-ol
FL
2-
tridecanone
FL/FR
floral
cananga oil
FL/FR
dihydrojasmone
FL/FR
linalyl acetate
FL/FR
ocean propanal
FL/FR
fruity
acetoin acetate
FL/FR
acetyl isovaleryl
FL
amyl heptanoate
FL/FR
iso
amyl octanoate
FL/FR
para-
anisyl acetate
FL/FR
para-
anisyl alcohol
FL/FR
benzaldehyde
FL/FR
cherry propanol
FL/FR
gamma-
decalactone
FL/FR
3-
heptyl dihydro-5-methyl-2(3H)-furanone
FL/FR
4-
hydroxybenzyl alcohol
FL/FR
iso
propyl octanoate
FL/FR
tolualdehydes (mixed o,m,p)
FL/FR
grassy
palmarosa oil
FL/FR
green
iso
amyl salicylate
FL/FR
angelica root oil
FL/FR
butyl lactate
FL/FR
diphenyl methane
FL/FR
galbanum oil
FL/FR
heptanal 2,3-butane diol acetal
FL
(Z)-4-
hepten-1-ol
FL/FR
(Z)-4-
heptenal
FL/FR
(Z)-4-
heptenal diethyl acetal
FL/FR
heptyl heptanoate
FL/FR
immortelle absolute
FL/FR
methyl heptadienone
FL/FR
nerolidol
FL/FR
oakmoss absolute
FL/FR
3-
phenyl propionaldehyde
FL/FR
herbal
apium graveolens seed oil india
FL/FR
immortelle flower oil
FL/FR
abrialis
lavandin oil
FL/FR
lavender oil
FL/FR
massoia bark oil
FL
origanum oil greece
FL/FR
honey
phenethyl phenyl acetate
FL/FR
lactonic
gamma-
heptalactone
FL/FR
delta-
heptalactone
FL/FR
gamma-
octalactone
FL/FR
meaty
4-
allyl-2,6-dimethoxyphenol
FL
milky
gamma-
butyrolactone
FL/FR
minty
(1R)-(-)-
myrtenal
FL
myrtenal
FL/FR
mushroom
3-
octen-2-ol
FL/FR
naphthyl
2,4-
dimethyl benzaldehyde
FL/FR
beta-
naphthyl methyl ether
FL/FR
nutty
2-
acetyl pyrrole
FL/FR
2-
acetyl-5-methyl furan
FL/FR
powdery
acetophenone
FL/FR
beta-
naphthyl ethyl ether
FL/FR
powdery ketone
FL
soapy
1-
dodecanol
FL/FR
sour
butyric acid
FL/FR
spicy
benzyl cinnamate
FL/FR
benzyl isoeugenol
FL/FR
benzylidene acetone
FL
croton eluteria bark oil
FL/FR
cubeb oil
FL/FR
iso
eugenyl acetate
FL/FR
ginger root oil china
FL/FR
levisticum officinale oleoresin
FL
levisticum officinale root oil
FL/FR
alpha-
methyl cinnamaldehyde
FL/FR
methyl cinnamate
FL/FR
alpha-
methyl-(E)-cinnamaldehyde
FL/FR
nutmeg oil
FL/FR
root beer float flavor
FL
sweet
ethyl 3-(2-hydroxyphenyl) propionate
FL
orange vanilla cream flavor
FL
orris rhizome absolute (iris pallida)
FL/FR
vanilla oleoresin bali
FL/FR
toasted
acetyl propionyl
FL/FR
tomato
methional
FL/FR
vanilla
ethyl vanillin
FL/FR
ethyl vanillin isobutyrate
FL/FR
ethyl vanillin propylene glycol acetal
FL/FR
vanilla
ice cream flavor
FL
propenyl guaethol
FL/FR
vanilla bean absolute (vanilla planifolia)
FL/FR
vanillin
FL/FR
vanillyl acetate
FL/FR
vanillyl isobutyrate
FL/FR
waxy
allyl nonanoate
FL/FR
dihydrojasmone lactone
FL/FR
ethyl palmitate
FL/FR
ethyl undecanoate
FL/FR
alpha-
hexyl cinnamaldehyde
FL/FR
hydroxycitronellal
FL/FR
methyl laurate
FL/FR
2-
nonanol
FL/FR
octyl 2-furoate
FL
octyl butyrate
FL/FR
delta-
tetradecalactone
FL/FR
undecanoic acid
FL/FR
woody
amyris wood oil
FL/FR
ortho-
guaiacol
FL/FR
guaiacwood oil
FL/FR
methyl cedryl ketone
FL/FR
patchouli oil
FL/FR
sandalwood oil
FL/FR
spruce needle oil canada
FL/FR
vetiver oil haiti
FL/FR
vetiverol
FL/FR
whiskey lactone
FL/FR
 
Potential Uses:
FRaldehydic
FLalmond
FRamber
FRbalsam
FRbriar wood
FLcaramel
FLchocolate cocoa
FRchypre
FLcinnamon
FRclover
FLcoconut
FRfern
FRhawthorn
FRhay new mown hay
FRheather
FRlavandin
FLmalt
FRoriental
FLrose
FLspice
FRtobacco
FRtonka bean
FLvanilla
FRwoodruff
 
Occurrence (nature, food, other):note
 cherry sour cherry plant
Search Trop Picture
 clover sweet clover
Search PMC Picture
 clover yellow sweet clover
Search Trop Picture
 deertongue
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 tarragon plant
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Synonyms:
 benzo dihydro pyrone
 benzo dihydropyrone
 benzo dihydropyrone natural
 benzo dihydropyrone synthetic
 benzodihydropyrone
1,2-benzodihydropyrone
 benzodihydropyrone FCC
 benzodihydropyrone, natural
2H-1-benzopyran-2-one, 3,4-dihydro-
 benzopyranone, dihydro-
2-oxo-chroman
oxochroman
 chroman-2-one
 chroman, 2-oxo-
2-chromanone
 coumarin, 3,4-dihydro-
 coumarin, dihydro-
 di hydro coumarin
 dihydro coumarin
3,4-dihydro-1-benzopyran-2-one
3,4-dihydro-2H-1-benzopyran-2-one
3,4-dihydro-2H-chromen-2-on
3,4-dihydro-2H,1-benzopyran-2-one
 dihydrobenzopyrone
3,4-dihydrocoumarin
 dihydrocoumarin (benzodihydropyrone)
 dihydrocoumarin FCC
 hydrocinnamic acid, o-hydroxy-, d-lactone
 hydrocoumarin
o-hydroxydihydrocinnamic acid delta-lactone
ortho-hydroxydihydrocinnamic acid delta-lactone
2-hydroxydihydrocinnamic acid lactone
 hydroxydihydrocinnamic acid lactone, o-
 melilotic acid lactone
 melilotic lactone
 melilotin
 melilotine
 melilotol
 meliotine
 

Articles:

Info:EVALUATION OF CERTAIN FOOD ADDITIVES AND CONTAMINANTS
PubMed:Tandem ruthenium-catalyzed transfer-hydrogenative cyclization/intramolecular Diels-Alder reaction of enediynes affording dihydrocoumarin-fused polycycles.
PubMed:Study of possible mechanisms involved in the inhibitory effects of coumarin derivatives on neutrophil activity.
PubMed:Effect of the nutritional supplement ALAnerv® on the serum PON1 activity in post-acute stroke patients.
PubMed:Serum lactonase and arylesterase activities in alcoholic hepatitis and hepatitis B.
PubMed:N-heterocyclic carbene-catalyzed [4 + 2] cycloaddition of ketenes and 3-aroylcoumarins: highly enantioselective synthesis of dihydrocoumarin-fused dihydropyranones.
PubMed:Cancer chemoprevention and nutriepigenetics: state of the art and future challenges.
PubMed:Synthesis and biological evaluation of α-methylidene-δ-lactones with 3,4-dihydrocoumarin skeleton.
PubMed:[Determination of five coumarins in toys by high performance liquid chromatography-tandem mass spectrometry].
PubMed:Novel associations of nonstructural Loci with paraoxonase activity.
PubMed:Oxidative potential of some endophytic fungi using 1-indanone as a substrate.
PubMed:Catalytic versatility and backups in enzyme active sites: the case of serum paraoxonase 1.
PubMed:Facile synthesis of 4-substituted 3,4-dihydrocoumarins via an organocatalytic double decarboxylation process.
PubMed:An enantioselective approach toward 3,4-dihydroisocoumarin through the bromocyclization of styrene-type carboxylic acids.
PubMed:High-Density Real-Time PCR-Based in Vivo Toxicogenomic Screen to Predict Organ-Specific Toxicity.
PubMed:Asymmetric synthesis of 3,4-dihydrocoumarin motif with an all-carbon quaternary stereocenter via a Michael-acetalization sequence with bifunctional amine-thiourea organocatalysts.
PubMed:Atom arrangement strategy for designing a turn-on 1H magnetic resonance probe: a dual activatable probe for multimodal detection of hypochlorite.
PubMed:Chemical composition, anti-inflammatory, molluscicidal and free-radical scavenging activities of the leaves of Ficus radicans 'Variegata' (Moraceae).
PubMed:Development and validation of two methods based on high-performance liquid chromatography-tandem mass spectrometry for determining 1,2-benzopyrone, dihydrocoumarin, o-coumaric acid, syringaldehyde and kaurenoic acid in guaco extracts and pharmaceutical preparations.
PubMed:Coumarin metabolic routes in Aspergillus spp.
PubMed:Paraoxonase 2 (PON2) in the mouse central nervous system: a neuroprotective role?
PubMed:Synthesis and biological activity of splitomicin analogs targeted at human NAD(+)-dependent histone deacetylases (sirtuins).
PubMed:Different effect of two synthetic coumarin-stilbene hybrid compounds on phagocyte activity.
PubMed:Cancer chemoprevention by targeting the epigenome.
PubMed:Organocatalytic asymmetric tandem Michael addition-hemiacetalization: a route to chiral dihydrocoumarins, chromanes, and 4H-chromenes.
PubMed:A reinvestigation of the reaction of coumarins with superoxide in the liposomal bilayer: correlation between depth and reactivity.
PubMed:Lactonases with organophosphatase activity: structural and evolutionary perspectives.
PubMed:The thioesterase Bhp is involved in the formation of beta-hydroxytyrosine during balhimycin biosynthesis in Amycolatopsis balhimycina.
PubMed:Interaction between human serum esterases and environmental metal compounds.
PubMed:Determinants of variation in human serum paraoxonase activity.
PubMed:Asymmetric cycloadditions of o-quinone methides employing chiral ammonium fluoride precatalysts.
PubMed:A novel method for the synthesis of substituted 3,4-dihydrocoumarin derivatives via isocyanide-based three-component reaction.
PubMed:Synthesis, spectroscopy and alkylating properties of Pd(II) complexes of phosphorohydrazones of coumarin and chromone with potential antibacterial activity.
PubMed:Novel isocyanide-based four-component reaction: a facile synthesis of fully substituted 3,4-dihydrocoumarin derivatives.
PubMed:AlCl3-mediated direct carbon-carbon bond-forming reaction of alpha-hydroxyketene-S,S-acetals with arenes and synthesis of 3,4-disubstituted dihydrocoumarin derivatives.
PubMed:Aging and anti-aging: unexpected side effects of everyday medication through sirtuin1 modulation.
PubMed:Lack of evidence for allergenic properties of coumarin in a fragrance allergy mouse model.
PubMed:Biocatalytic production of dihydrocoumarin from coumarin by Saccharomyces cerevisiae.
PubMed:Xenobiotic reductase A in the degradation of quinoline by Pseudomonas putida 86: physiological function, structure and mechanism of 8-hydroxycoumarin reduction.
PubMed:The flavoring agent dihydrocoumarin reverses epigenetic silencing and inhibits sirtuin deacetylases.
PubMed:Isolation, structure elucidation, antioxidative and immunomodulatory properties of two novel dihydrocoumarins from Aloe vera.
PubMed:Cloning, purification, and refolding of human paraoxonase-3 expressed in Escherichia coli and its characterization.
PubMed:Cloning, high level expression of human paraoxonase-3 in Sf9 cells and pharmacological characterization of its product.
PubMed:Regioselective synthesis and estrogenicity of (+/-)-8-alkyl-5,7-dihydroxy-4-(4-hydroxyphenyl)-3,4-dihydrocoumarins.
PubMed:Senescence marker protein-30 is a unique enzyme that hydrolyzes diisopropyl phosphorofluoridate in the liver.
PubMed:Chromanones and dihydrocoumarins from Calophyllum blancoi.
PubMed:Mouse macrophage paraoxonase 2 activity is increased whereas cellular paraoxonase 3 activity is decreased under oxidative stress.
PubMed:Role of Acinetobacter calcoaceticus 3,4-dihydrocoumarin hydrolase in oxidative stress defence against peroxoacids.
PubMed:Enzymatic preparation of D-beta-acetylthioisobutyric acid and cetraxate hydrochloride using a stereo- and/or regioselective hydrolase, 3,4-dihydrocoumarin hydrolase from Acinetobacter calcoaceticus.
PubMed:Coupling of the lactone-ring conformation with crystal symmetry in 6-hydroxy-4,4,5,7,8-pentamethyl-3,4-dihydrocoumarin.
PubMed:Lactone-ring-cleaving enzymes of microorganisms: their diversity and applications.
PubMed:Purification and characterization of a novel lactonohydrolase from Agrobacterium tumefaciens.
PubMed:3,4-Dihydrocoumarin hydrolase with haloperoxidase activity from Acinetobacter calcoaceticus F46.
PubMed:A "cephalosporin-like" cyclic depsipeptide: synthesis and reaction with beta-lactam-recognizing enzymes.
PubMed:Selective Clara cell injury in mouse lung following acute administration of coumarin.
PubMed:Intraperitoneal administration of coumarin causes tissue-selective depletion of cytochromes P450 and cytotoxicity in the olfactory mucosa.
PubMed:Inhibition of the mutagenicity of 2-nitrofluorene, 3-nitrofluoranthene and 1-nitropyrene by flavonoids, coumarins, quinones and other phenolic compounds.
PubMed:New metabolites in the degradation of fluorene by Arthrobacter sp. strain F101.
PubMed:Natural ingredients based cosmetics. Content of selected fragrance sensitizers.
PubMed:Structure-activity relationship of coumarins in xanthine oxidase inhibition.
PubMed:HPLC analysis of tonka bean extracts.
PubMed:Comparison of the hepatic effects of coumarin, 3,4-dimethylcoumarin, dihydrocoumarin and 6-methylcoumarin in the rat.
PubMed:NTP Toxicology and Carcinogenesis Studies of Coumarin (CAS No. 91-64-5) in F344/N Rats and B6C3F1 Mice (Gavage Studies).
PubMed:NTP Toxicology and Carcinogenesis Studies of 3,4-Dihydrocoumarin (CAS No. 119-84-6) in F344/N Rats and B6C3F1 Mice (Gavage Studies).
PubMed:Structural requirements for the direct and cytochrome P450-dependent reaction of cyclic alpha,beta-unsaturated carbonyl compounds with glutathione: a study with coumarin and related compounds.
PubMed:Purification and characterization of a novel lactonohydrolase, catalyzing the hydrolysis of aldonate lactones and aromatic lactones, from Fusarium oxysporum.
PubMed:Isolation and characterization of a fluorene-degrading bacterium: identification of ring oxidation and ring fission products.
PubMed:Toxicity of coumarin and various methyl derivatives in cultures of rat hepatocytes and V79 cells.
PubMed:Anamnestic responses to contact allergens: application in the murine local lymph node assay.
PubMed:Amine prodrugs which utilize hydroxy amide lactonization. II. A potential esterase-sensitive amide prodrug.
PubMed:Acyloxybenzyl halides, inhibitors of elastases.
PubMed:A prospective toxicity evaluation (COMPACT) on 40 chemicals currently being tested by the National Toxicology Program.
PubMed:Reaction of thrombin and proteinases of the fibrinolytic system with a mechanism-based inhibitor, 3,4-dihydro-3-benzyl-6-chloromethylcoumarin.
PubMed:Studies on the mechanism of coumarin-induced toxicity in rat hepatocytes: comparison with dihydrocoumarin and other coumarin metabolites.
PubMed:Constituents of Justicia pectoralis Jacq. 2. Gas chromatography/mass spectrometry of simple coumarins, 3-phenylpropionic acids and their hydroxy and methoxy derivatives.
PubMed:The sensitizing capacity of coumarins (II).
PubMed:The epicutaneous maximization test.
PubMed:Inactivation of human high- and low-molecular-weight urokinases. Analysis of their active site.
PubMed:Reactions in selected patients to 22 fragrance materials.
PubMed:Comparative study of methods chosen by the Association Française de Normalisation (AFNOR) for evaluating sensitizing potential in the albino guinea-pig.
PubMed:Degradation of 3-phenylbutyric acid by Pseudomonas sp.
PubMed:Further studies of effects of vehicles and elicitation concentration in experimental contact sensitization testing in humans.
PubMed:Physiologically active substances from marine sponges V: Isolation of physiologically active compounds from the sponge Verongia archeri.
PubMed:The metabolism of aromatic compounds in higher plants. V. Purification and properties of dihydrocoumarin hydrolase of Melilotus alba.
PubMed:[Application of Baeyer-Villiger reaction in synthesis of dihydrocoumarin].
 
Notes:
Isol. from flowers of Melilotus alba (white melilot) Isol. from Melilotus officinalis (sweet clover). Flavouring ingredient
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