Category:flavor and fragrance agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
Appearance: | white powder (est) |
Assay: | 95.00 to 100.00
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Food Chemicals Codex Listed: | No |
Melting Point: | 63.00 °C. @ 760.00 mm Hg
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Boiling Point: | 286.00 °C. @ 760.00 mm Hg
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Vapor Pressure: | 0.002000 mmHg @ 25.00 °C. (est) |
Flash Point: | 248.00 °F. TCC ( 120.20 °C. ) (est)
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logP (o/w): | 2.231 (est) |
Soluble in: |
| alcohol | | water, very slightly | | water, 1495 mg/L @ 25 °C (est) |
Insoluble in: |
| water |
Organoleptic Properties:
Odor Type: vanilla |
Odor Strength:medium |
Substantivity:232 hour(s) at 100.00 % |
warm spicy vanilla guaiacol phenolic carnation |
Odor Description:at 100.00 %. warm spicy vanilla guaiacol phenolic carnation |
Odor and/or flavor descriptions from others (if found). |
Cosmetic Information:
Suppliers:
Safety Information:
Preferred SDS: View |
European information : |
Most important hazard(s): | Xi - Irritant |
R 36/38 - Irritating to skin and eyes. S 02 - Keep out of the reach of children. S 22 - Do not breath dust. S 24/25 - Avoid contact with skin and eyes. S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S 36 - Wear suitable protective clothing.
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Hazards identification |
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Classification of the substance or mixture |
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
None found. |
GHS Label elements, including precautionary statements |
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Pictogram | |
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Hazard statement(s) |
None found. |
Precautionary statement(s) |
None found. |
Oral/Parenteral Toxicity: |
intravenous-mouse LD50 180 mg/kg U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#06782
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Dermal Toxicity: |
Not determined
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Inhalation Toxicity: |
Not determined
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Safety in Use Information:
Category: | flavor and fragrance agents |
RIFM Fragrance Material Safety Assessment: Search |
IFRA Code of Practice Notification of the 49th Amendment to the IFRA Code of Practice |
Recommendation for methyl vanillate usage levels up to: | | 2.0000 % in the fragrance concentrate.
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Maximised Survey-derived Daily Intakes (MSDI-EU): | 0.011 (μg/capita/day) |
Modified Theoretical Added Maximum Daily Intake (mTAMDI): | 3900 (μg/person/day) |
Threshold of Concern: | 1800 (μg/person/day) |
Structure Class: | I |
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Food categories according to Commission Regulation EC No. 1565/2000 (EC, 2000) in FGE.06 (EFSA, 2002a). According to the Industry the "normal" use is defined as the average of reported usages and "maximum use" is defined as the 95th percentile of reported usages (EFSA, 2002i). |
Note: mg/kg = 0.001/1000 = 0.000001 = 1/1000000 = ppm. |
| average usage mg/kg | maximum usage mg/kg |
Dairy products, excluding products of category 02.0 (01.0): | 7.00000 | 35.00000 |
Fats and oils, and fat emulsions (type water-in-oil) (02.0): | 5.00000 | 25.00000 |
Edible ices, including sherbet and sorbet (03.0): | 10.00000 | 50.00000 |
Processed fruit (04.1): | 7.00000 | 35.00000 |
Processed vegetables (incl. mushrooms & fungi, roots & tubers, pulses and legumes), and nuts & seeds (04.2): | - | - |
Confectionery (05.0): | 10.00000 | 50.00000 |
Chewing gum (05.3): | - | - |
Cereals and cereal products, incl. flours & starches from roots & tubers, pulses & legumes, excluding bakery (06.0): | 5.00000 | 25.00000 |
Bakery wares (07.0): | 10.00000 | 50.00000 |
Meat and meat products, including poultry and game (08.0): | 2.00000 | 10.00000 |
Fish and fish products, including molluscs, crustaceans and echinoderms (MCE) (09.0): | 2.00000 | 10.00000 |
Eggs and egg products (10.0): | - | - |
Sweeteners, including honey (11.0): | - | - |
Salts, spices, soups, sauces, salads, protein products, etc. (12.0): | 5.00000 | 25.00000 |
Foodstuffs intended for particular nutritional uses (13.0): | 10.00000 | 50.00000 |
Non-alcoholic ("soft") beverages, excl. dairy products (14.1): | 5.00000 | 25.00000 |
Alcoholic beverages, incl. alcohol-free and low-alcoholic counterparts (14.2): | 10.00000 | 50.00000 |
Ready-to-eat savouries (15.0): | 20.00000 | 100.00000 |
Composite foods (e.g. casseroles, meat pies, mincemeat) - foods that could not be placed in categories 01.0 - 15.0 (16.0): | 5.00000 | 25.00000 |
Safety References:
European Food Safety Athority(EFSA):Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies...
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European Food Safety Authority (EFSA) reference(s):
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Opinion of the Scientific Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) on a request from the Commission related to Flavouring Group Evaluation 20 (FGE.20): Benzyl alcohols, benzaldehydes, a related acetal, benzoic acids, and related esters from chemical group 23 View page or View pdf
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Flavouring Group Evaluation 52 (FGE.52): Consideration of hydroxy- and alkoxy-substituted benzyl derivatives evaluated by JECFA (57th meeting) structurally related to benzyl alcohols, benzaldehydes, a related acetal, benzoic acids, and related esters evaluated by EFSA in FGE.20 (2005) (Commission Regulation (EC) No 1565/2000 of 18 July 2000) - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC) View page or View pdf
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Flavouring Group Evaluation 54 (FGE.54)[1] - Consideration of benzyl derivatives evaluated by JECFA (57th meeting) structurally related to benzyl alcohols, benzaldehydes, a related acetal, benzoic acids and related esters evaluated by EFSA in FGE.20 (2005) - Scientific Opinion of the Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food View page or View pdf
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Flavouring Group Evaluation 20, Revision 1 (FGE.20Rev1): Benzyl alcohols, benzaldehydes, a related acetal, benzoic acids and related esters from chemical group 23 View page or View pdf
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Flavouring Group Evaluation 54, Revision 1 (FGE.54Rev1): Consideration of benzyl derivatives evaluated by JECFA (57th meeting) structurally related to benzyl alcohols, benzaldehydes, a related acetal, benzoic acids and related esters evaluated by EFSA in FGE.20Rev1 (2009) View page or View pdf
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Scientific Opinion on Flavouring Group Evaluation 20, Revision 2 (FGE.20Rev2): Benzyl alcohols, benzaldehydes, a related acetal, benzoic acids, and related esters from chemical groups 23 and 30 View page or View pdf
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Scientific Opinion on Flavouring Group Evaluation 20, Revision 3(FGE.20Rev3): Benzyl alcohols, benzaldehydes, a related acetal, benzoic acids, and related esters from chemical groups 23 and 30 View page or View pdf
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Scientific Opinion on Flavouring Group Evaluation 20, Revision 4 (FGE.20Rev4): Benzyl alcohols, benzaldehydes, a related acetal, benzoic acids, and related esters from chemical groups 23 and 30 View page or View pdf
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EPI System: View |
AIDS Citations:Search |
Cancer Citations:Search |
Toxicology Citations:Search |
EPA Substance Registry Services (TSCA):3943-74-6 |
EPA ACToR:Toxicology Data |
EPA Substance Registry Services (SRS):Registry |
Laboratory Chemical Safety Summary :19844 |
National Institute of Allergy and Infectious Diseases:Data |
WGK Germany:3 |
methyl 4-hydroxy-3-methoxybenzoate |
Chemidplus:0003943746 |
RTECS:DH2430000 for cas# 3943-74-6 |
References:
Other Information:
Potential Blenders and core components note
For Odor |
No odor group found for these |
bird of paradise fragrance FR |
anisic |
anisic |
para- acetanisole FL/FR |
ortho- anisaldehyde FL/FR |
para- anisaldehyde FL/FR |
methyl para-anisate FL/FR |
balsamic |
benzoin FL/FR |
sumatra benzoin absolute FL/FR |
siam benzoin absolute FL/FR |
benzoin absolute replacer FL/FR |
sumatra benzoin gum FL/FR |
siam benzoin resin FL/FR |
sumatra benzoin resin FL/FR |
benzoin resin replacer FR |
sumatra benzoin resinoid FL/FR |
siam benzoin resinoid FL/FR |
1- benzoyl acetone FL/FR |
ethyl cinnamate FL/FR |
peru balsam absolute FL/FR |
peru balsam oil FL/FR |
peru balsam resinoid FL/FR |
berry |
raspberry ketone methyl ether FL/FR |
caramellic |
levulinic acid FL/FR |
chocolate |
chocolate specialty FR |
vanillyl ethyl ether FL/FR |
coconut |
alpha- angelica lactone FL/FR |
coumarinic |
coumane FL/FR |
creamy |
geranyl ethyl acetal FR |
para- vanillic acid FL/FR |
para- vanillyl alcohol FL/FR |
veratraldehyde FL/FR |
floral |
acetophenone FL/FR |
anisyl propanal / methyl anthranilate schiff's base FR |
coffee flower absolute FR |
para- cresyl laurate FL/FR |
heliotropin FL/FR |
para- methyl acetophenone FL/FR |
fruity |
para- anisyl propionate FL/FR |
ethyl methyl-para-tolyl glycidate FL/FR |
guaiacyl propionate FL/FR |
tolualdehydes (mixed o,m,p) FL/FR |
vanilla carboxylate FL/FR |
green |
butyl lactate FL/FR |
minty |
menthoxypropane diol FL/FR |
vanillin menthoxypropane diol acetal FL/FR |
musk |
omega- pentadecalactone FL/FR |
naphthyl |
2,4- dimethyl benzaldehyde FL/FR |
nutty |
nutty cyclohexenone FL/FR |
resorcinol FR |
2,3,5,6- tetramethyl pyrazine FL/FR |
phenolic |
ethyl vanillate FL/FR |
ortho- guaiacol FL/FR |
powdery |
para- anisyl acetate FL/FR |
smoky |
alpha- ethoxy-ortho-cresol FL/FR |
spicy |
para- anisyl formate FL/FR |
clove leaf absolute FR |
clove leaf resinoid FR |
dianthus ethone FR |
4- ethyl guaiacol FL/FR |
ethyl isoeugenol FL/FR |
(E)-iso eugenol FR |
3-(2- furyl) acrolein FL/FR |
(E)-para- methoxycinnamaldehyde FL/FR |
para- methoxycinnamaldehyde FL/FR |
4- methyl guaiacol FL/FR |
spicy acetoacetate FL/FR |
zingerone FL/FR |
sweet |
tonka bean absolute replacer FR |
vanilla bean absolute (vanilla spp.) FL/FR |
vanilla oleoresin bali FL/FR |
vanilla resinoid FL/FR |
vanilla tahitensis fruit extract FL/FR |
tonka |
coumarin FR |
mint lactone FL/FR |
octahydrocoumarin FL/FR |
tropical |
curcuma amada roxb. rhizome oil CO2 extract FL/FR |
vanilla |
acetovanillone FL/FR |
crème brulee fragrance FR |
ortho- dimethyl hydroquinone FL/FR |
ethyl vanillin FL/FR |
ethyl vanillin acetate FR |
ethyl vanillin diethyl acetal FR |
ethyl vanillin hexylene glycol acetal FR |
ethyl vanillin isobutyrate FL/FR |
ethyl vanillin propylene glycol acetal FL/FR |
heliotropyl alcohol FL/FR |
propenyl guaethol FL/FR |
vanilla FR |
vanilla aromatica fruit extract FL/FR |
vanilla bean absolute (vanilla planifolia) FL/FR |
vanilla bean absolute CO2 extract (vanilla planifolia) FL/FR |
vanilla bean fragrance FR |
vanilla bean oil (vanilla planifolia) FR |
vanilla bean oil (vanilla tahitensis) FL/FR |
vanilla bean oil CO2 extract FL/FR |
vanilla bean tincture FR |
vanilla cresol FR |
vanilla extract FL/FR |
country vanilla fragrance FR |
french vanilla fragrance FR |
vanilla fragrance FR |
vanilla oleoresin bourbon FL/FR |
vanilla planifolia fruit extract FL/FR |
vanilla planifolia fruit infusion FR |
vanilla planifolia fruit water FL/FR |
vanilla specialty FR |
vanilla tahitensis fruit absolute FR |
vanilla tahitensis fruit absolute CO2 extract FL/FR |
vanilla tahitensis fruit oil CO2 extract FR |
vanillin FL/FR |
vanillin 2,3-butylene glycol acetal FL/FR |
vanillin hexylene glycol acetal FR |
vanillin propylene glycol acetal FL/FR |
vanillyl acetate FL/FR |
vanillyl butyl ether FL/FR |
vanillyl isobutyrate FL/FR |
vanillylidene acetone FL/FR |
woody |
guaiacwood oil FL/FR |
guaiacyl acetate FL/FR |
4- hydroxybenzaldehyde FL/FR |
For Flavor |
No flavor group found for these |
para- anisyl propionate FL/FR |
benzoin FL/FR |
1- benzoyl acetone FL/FR |
coumane FL/FR |
ortho- dimethyl hydroquinone FL/FR |
alpha- ethoxy-ortho-cresol FL/FR |
3-(2- furyl) acrolein FL/FR |
glucoethyl vanillin FL |
glucovanillin FL |
guaiacyl propionate FL/FR |
heliotropyl alcohol FL/FR |
(E)-para- methoxycinnamaldehyde FL/FR |
4- methoxysalicylaldehyde FL |
methyl para-anisate FL/FR |
vanillin menthoxypropane diol acetal FL/FR |
vanillyl butyl ether FL/FR |
vanilmandelic acid FL |
acidic |
acidic |
levulinic acid FL/FR |
anisic |
para- acetanisole FL/FR |
ortho- anisaldehyde FL/FR |
balsamic |
benzoin absolute replacer FL/FR |
sumatra benzoin gum FL/FR |
sumatra benzoin resin FL/FR |
siam benzoin resin FL/FR |
sumatra benzoin resinoid FL/FR |
siam benzoin resinoid FL/FR |
ethyl cinnamate FL/FR |
peru balsam FL |
peru balsam absolute FL/FR |
peru balsam oil FL/FR |
peru balsam resinoid FL/FR |
vanillylidene acetone FL/FR |
berry |
raspberry ketone methyl ether FL/FR |
bready |
2- propionyl thiazole FL |
cherry |
heliotropin FL/FR |
para- methoxycinnamaldehyde FL/FR |
coconut |
6- methyl coumarin FL |
octahydrocoumarin FL/FR |
cooling |
menthoxypropane diol FL/FR |
creamy |
alpha- angelica lactone FL/FR |
para- anisaldehyde FL/FR |
divanillin FL |
ethyl vanillate FL/FR |
4- hydroxybenzaldehyde FL/FR |
para- methyl acetophenone FL/FR |
mint lactone FL/FR |
para- vanillic acid FL/FR |
para- vanillyl alcohol FL/FR |
veratraldehyde FL/FR |
floral |
pseudo ionone FL |
fruity |
para- anisyl acetate FL/FR |
ethyl methyl-para-tolyl glycidate FL/FR |
tolualdehydes (mixed o,m,p) FL/FR |
vanilla carboxylate FL/FR |
green |
butyl lactate FL/FR |
meaty |
4- allyl-2,6-dimethoxyphenol FL |
ortho- thioguaiacol FL |
naphthyl |
2,4- dimethyl benzaldehyde FL/FR |
nutty |
furfural acetone FL |
nutty cyclohexenone FL/FR |
2,3,5,6- tetramethyl pyrazine FL/FR |
powdery |
acetophenone FL/FR |
powdery ketone FL |
rummy |
vanillyl ethyl ether FL/FR |
spicy |
para- anisyl formate FL/FR |
siam benzoin absolute FL/FR |
sumatra benzoin absolute FL/FR |
ethyl isoeugenol FL/FR |
4- methyl guaiacol FL/FR |
spicy acetoacetate FL/FR |
zingerone FL/FR |
sweet |
vanilla bean absolute (vanilla spp.) FL/FR |
vanilla bean aromatica FL |
vanilla bean planifolia FL |
vanilla oleoresin bali FL/FR |
vanilla resinoid FL/FR |
vanilla tahitensis fruit extract FL/FR |
tropical |
curcuma amada roxb. rhizome oil CO2 extract FL/FR |
vanilla |
acetovanillone FL/FR |
ethyl vanillin FL/FR |
ethyl vanillin isobutyrate FL/FR |
ethyl vanillin propylene glycol acetal FL/FR |
omega- pentadecalactone FL/FR |
propenyl guaethol FL/FR |
vanilla aromatica fruit extract FL/FR |
vanilla bean absolute (vanilla planifolia) FL/FR |
vanilla bean absolute CO2 extract (vanilla planifolia) FL/FR |
vanilla bean oil (vanilla tahitensis) FL/FR |
vanilla bean oil CO2 extract FL/FR |
vanilla bean tahitensis FL |
vanilla extract FL/FR |
vanilla oleoresin bourbon FL/FR |
vanilla planifolia fruit extract FL/FR |
vanilla planifolia fruit water FL/FR |
vanilla tahitensis fruit absolute CO2 extract FL/FR |
vanillin FL/FR |
vanillin 2,3-butylene glycol acetal FL/FR |
vanillin propylene glycol acetal FL/FR |
vanillyl acetate FL/FR |
vanillyl isobutyrate FL/FR |
waxy |
para- cresyl laurate FL/FR |
woody |
4- ethyl guaiacol FL/FR |
ortho- guaiacol FL/FR |
guaiacwood oil FL/FR |
guaiacyl acetate FL/FR |
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| benzoic acid, 4-hydroxy-3-methoxy-, methyl ester | 4- | hydroxy-3-methoxybenzoic acid methyl ester | | methyl 3-methoxy-4-hydroxybenzoate | | methyl 4-hydroxy-3-methoxybenzoate | | vanillic acid methyl ester | | vanillic acid, methyl ester |
Articles:
PubMed:[Chemical constituents of Illicium burmanicum]. |
J-Stage:Antioxidative Properties of Vanillic Acid Esters in Multiple Antioxidant Assays |
PubMed:Laccase catalyzed synthesis of iodinated phenolic compounds with antifungal activity. |
PubMed:Hovenia dulcis Thunb extract and its ingredient methyl vanillate activate Wnt/β-catenin pathway and increase bone mass in growing or ovariectomized mice. |
PubMed:Polyphenolic profile as a useful tool to identify the wood used in wine aging. |
PubMed:Antioxidative properties of vanillic acid esters in multiple antioxidant assays. |
PubMed:Constituents with tyrosinase inhibitory activities from branches of Ficus erecta var. sieboldii King. |
PubMed:Phenolic compounds in cherry ( Prunus avium ) heartwood with a view to their use in cooperage. |
PubMed:Prediction of solubility of drugs and other compounds in organic solvents. |
PubMed:Volatile compounds of red wines macerated with Spanish, American, and French oak chips. |
PubMed:Novel caffeic acid ester derivative induces apoptosis by expressing FasL and downregulating NF-KappaB: Potentiation of cell death mediated by chemotherapeutic agents. |
PubMed:Downregulation of inflammatory responses by novel caffeic acid ester derivative by inhibiting NF-kappa B. |
PubMed:Oxidation of lignin using aqueous polyoxometalates in the presence of alcohols. |
PubMed:Preparation of lipophilic alkyl (hydroxy)benzoates by solvent-free lipase-catalyzed esterification and transesterification. |
PubMed:Linear sesquiterpene lactones from Anthemis auriculata and their antibacterial activity. |
PubMed:Neuroprotective and free radical scavenging activities of phenolic compounds from Hovenia dulcis. |
PubMed:Lignin-derived compounds as efficient laccase mediators for decolorization of different types of recalcitrant dyes. |
PubMed:Molecular determinants of substrate specificity in the feruloyl esterase module of xylanase 10B from Clostridium thermocellum. |
PubMed:Purification and characterization of PrbA, a new esterase from Enterobacter cloacae hydrolyzing the esters of 4-hydroxybenzoic acid (parabens). |
PubMed:Isolation and characterization of a veratrol:corrinoid protein methyl transferase from Acetobacterium dehalogenans. |
PubMed:Field Efficacy of Verticillium lecanii, Sex Pheromone, and Pheromone Analogs as Potential Management Agents for Soybean Cyst Nematode. |
PubMed:Isoprenyl phenyl ethers from liverworts of the genus Trichocolea: cytotoxic activity, structural corrections, and synthesis. |
PubMed:Application of a Sex Pheromone, Pheromone Analogs, and Verticillium lecanii for Management of Heterodera glycines. |
PubMed:Aristolochic acids, aristolactam alkaloids and amides from Aristolochia kankauensis. |
PubMed:Corrinoid-Dependent Methyl Transfer Reactions Are Involved in Methanol and 3,4-Dimethoxybenzoate Metabolism by Sporomusa ovata. |
PubMed:Multichannel coulometric detection coupled with liquid chromatography for determination of phenolic esters in honey. |
PubMed:The influence of heat on the aroma of cloudberries (rubus Chamaemorus l.). |
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