menthoxypropane diol, 87061-04-9

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Quality supplier of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
BOC Sciences provides a wide range of services to support the pharmaceutical industry through all stages of drug discovery including Custom Synthesis of those chemicals that are not in stock, Isotope Labeling Service, Chiral Synthesis and Resolution, Bioconjugation, PEGylation services, analytical services.
BOC Sciences is a brand of BOCSCI Inc. We leverage our wide spectrum of business in the fields of development, manufacturing, marketing, and distribution to help you make best-informed decisions tailored to your evolving needs for premium chemicals. Our complete suite of CRO services spans the entire molecule development pipeline including contract research for target identification, building blocks, compound synthesis, biochemical and cellular analysis, preclinical animal tests, and clinical studies.
Email:	Marketing
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CODE103834 CODE103834
Product(s):
87061-04-9 3-[[5-Methyl-2-(1-methylethyl)cyclohexyl]oxy]propane-1,2-diol

O'Laughlin Industries Inc.

Manufacturer of chemicals and ingredients used in flavors, fragrances, food, beverages and cosmetics
Leading the Flavor and Fragrance Industry since 1980.
O'Laughlin was established in 1980 by its owner and chief executive Michael O'Laughlin, when he moved to Beijing, China and established a small office. Since then it has grown to be a world class producer of chemicals, with significant production facilities in China, and distribution and sales in all major world markets.
Email:	Sales
US Email:	John Gick
Voice: (852) 2527-1031
Fax: (852) 2529-0231
US Voice: (973) 376-4600
US Fax: (973) 376-4630
CODE103834 CODE103834
Product(s):
773-1009 ARCTIC SW-10, TK-10 ?

OQEMA

With a focus on providing the highest level of service
OQEMA has established itself at the forefront of the global chemical industry.
The guiding principles of OQEMA have always been to establish long term relationships with customers and suppliers alike to build sustainable and profitable business for all parties. Through OQEMA’s business divisions the company tailors products and services to better support and service our customers requirements. This structure also allows the company to focus its marketing campaigns more effectively to certain industries. Over the last decade OQEMA has achieved strong growth as a result of the expansion of our business model. Going forward, the company will be expanding this business model into existing and new strategic territories.
Email:	Contact Us:
US Email:	Dean Matienzo
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Voice: +44 1993 843081
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CODE103834 CODE103834
Product(s):
Lansense 10

Penta International Corporation

Chemistry innovation
At Penta, our products and services help businesses do business better.
For over 30 years, Penta Manufacturing Company has played a growing role in worldwide chemistry innovations and applications. As an industry leader, Penta continues to pioneer chemistry-based solutions for practically every area of commerce. Our products and expertise have helped fuel technical advances in dozens of commercial applications including flavoring, coloring, fragrances and chemical processes.
US Email:	Technical Services
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CODE103834 CODE103834
Product(s):
13-13800 3-1-MENTHOXYPROPANE-1,2-DIOL

Name:	3-(5-methyl-2-propan-2-ylcyclohexyl)oxypropane-1,2-diol
CAS Number:	87061-04-9	3D/inchi
Other(deleted CASRN):	163271-16-7
ECHA EINECS - REACH Pre-Reg:	289-296-2
FDA UNII:	Search
Nikkaji Web:	J60.959E
XlogP3:	2.30 (est)
Molecular Weight:	230.34782000
Formula:	C13 H26 O3
NMR Predictor:	Predict (works with chrome, Edge or firefox)
EFSA/JECFA Comments:
JECFA name: 3-L-Menthoxypropane-1,2-diol. Racemate.

Category: flavor and fragrance agents

US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:

Google Scholar:	Search
Google Books:	Search
Google Scholar: with word "volatile"	Search
Google Scholar: with word "flavor"	Search
Google Scholar: with word "odor"	Search
Perfumer and Flavorist:	Search
Google Patents:	Search
US Patents:	Search
EU Patents:	Search
Pubchem Patents:	Search
PubMed:	Search
NCBI:	Search
JECFA Food Flavoring:	1408 3-L-menthoxypropane-1,2-diol
DG SANTE Food Flavourings:	02.224 3-(L-menthoxy)propane-1,2-diol
FEMA Number:	3784 3-L-menthoxypropane-1,2-diol
FDA:	No longer provide for the use of these seven synthetic flavoring substances
FDA Mainterm (SATF):	87061-04-9 ; 3-L-MENTHOXYPROPANE-1,2-DIOL

Physical Properties:

Appearance:	colorless clear viscous liquid (est)
Assay:	99.00 to 100.00
Food Chemicals Codex Listed:	No
Specific Gravity:	0.99000 to 1.00200 @ 25.00 °C.
Pounds per Gallon - (est).:	8.238 to 8.338
Refractive Index:	1.47200 to 1.47600 @ 20.00 °C.
Optical Rotation:	-86.0 to -80.0
Boiling Point:	121.00 to 125.00 °C. @ 0.25 mm Hg
Boiling Point:	361.00 to 362.00 °C. @ 760.00 mm Hg
Acid Value:	1.00 max. KOH/g
Flash Point:	343.00 °F. TCC ( 172.78 °C. )
logP (o/w):	2.625 (est)
Soluble in:
	alcohol
	water, very slightly
	water, 108.1 mg/L @ 25 °C (est)
Insoluble in:
	water

Organoleptic Properties:

Odor Type: minty

Odor Strength:low

Substantivity:81 hour(s) at 100.00 %

minty phenolic fruity jammy fruit dried fruit berry

Odor Description:at 100.00 %. very mild minty phenolic fruity jammy dried fruit berry
Luebke, William tgsc, (2021)

Odor sample from: Takasago International Corp

Flavor Type: cooling

cooling fresh aromatic mentholic eucalyptus

Taste Description: clean cooling fresh icy aromatic mentholic
Luebke, William tgsc, (2021)

Odor and/or flavor descriptions from others (if found).

Cosmetic Information:

CosIng:	cosmetic data
Cosmetic Uses:	fragrance refreshing agents

Suppliers:

Apple Flavor & Fragrance

Cooling agent MOPD

BeYonde

Coolact Agent 10 (MOPD)

BOC Sciences

For experimental / research use only.

3-[[5-Methyl-2-(1-methylethyl)cyclohexyl]oxy]propane-1,2-diol

Jinan Enlighten Chemical Technology(Wutong Aroma )

3-L-Menthoxypropane-1,2-diol, Kosherk

Lipo Chemicals

Coolact^® 10

Odor: characteristic

Use: Coolact^® 10 is a sensory agent that provides a cooling effect to the skin. The product functions by directly stimulating the receptors at the nerve endings of the skin to produce a cooling sensation. Coolact^® 10 provides a long lasting cooling effect.

O'Laughlin Industries

ARCTIC SW-10, TK-10 ?

3-1-MENTHOXYPROPANE-1,2-DIOL

Shanghai Vigen Fine Chemical

3-l-(p-menthan-3-yloxy)-1,2-propanediol

(Cooling Agent 10 )

Takasago

Coolact 10

The Fragrance Museum

Safety Information:


Hazards identification

Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements

Pictogram

Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined

Safety in Use Information:

Category:
flavor and fragrance agents
RIFM Fragrance Material Safety Assessment: Search
IFRA Code of Practice Notification of the 49th Amendment to the IFRA Code of Practice
Recommendation for menthoxypropane diol usage levels up to:
	3.0000 % in the fragrance concentrate.

Maximised Survey-derived Daily Intakes (MSDI-EU):		4.10 (μg/capita/day)
Maximised Survey-derived Daily Intakes (MSDI-USA):		789.00 (μg/capita/day)
Structure Class:		I
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 16
Click here to view publication 16
		average usual ppm	average maximum ppm
baked goods:		-	-
beverages(nonalcoholic):		300.00000	500.00000
beverages(alcoholic):		300.00000	500.00000
breakfast cereal:		-	-
cheese:		-	-
chewing gum:		3000.00000	4000.00000
condiments / relishes:		-	-
confectionery froastings:		100.00000	500.00000
egg products:		-	-
fats / oils:		-	-
fish products:		-	-
frozen dairy:		-	-
fruit ices:		-	-
gelatins / puddings:		500.00000	1000.00000
granulated sugar:		-	-
gravies:		-	-
hard candy:		500.00000	500.00000
imitation dairy:		100.00000	500.00000
instant coffee / tea:		-	-
jams / jellies:		-	-
meat products:		-	-
milk products:		-	-
nut products:		-	-
other grains:		-	-
poultry:		-	-
processed fruits:		-	-
processed vegetables:		-	-
reconstituted vegetables:		-	-
seasonings / flavors:		-	-
snack foods:		-	-
soft candy:		100.00000	500.00000
soups:		-	-
sugar substitutes:		-	-
sweet sauces:		-	-

Safety References:

European Food Safety Athority(EFSA):Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies...

European Food Safety Authority (EFSA) reference(s):

Flavouring Group Evaluation 23, Revision 1 (FGE.23Rev1): Aliphatic, alicyclic and aromatic ethers including anisole derivatives from chemical groups 15, 16, 26 and 30[1] - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food
View page or View pdf

Flavouring Group Evaluation 9, Revision 1: (FGE.09 Rev1)[1] - Secondary alicyclic saturated and unsaturated alcohols, ketones and esters containing secondary alicyclic alcohols from chemical groups 8 and 30, and an ester of a phenol carboxylic acid from chemical group 25 - Scientific Opinion of the Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food
View page or View pdf

Flavouring Group Evaluation 9, Revision 2 (FGE.09Rev2): Secondary alicyclic saturated and unsaturated alcohols, ketones and esters containing secondary alicyclic alcohols from chemical group 8 and 30, and an ester of a phenol derivative from chemical group 25
View page or View pdf

Scientific Opinion on Flavouring Group Evaluation 96 (FGE.96): Consideration of 88 flavouring substances considered by EFSA for which EU production volumes / anticipated production volumes have been submitted on request by DG SANCO. Addendum to FGE. 51, 52, 53, 54, 56, 58, 61, 62, 63, 64, 68, 69, 70, 71, 73, 76, 77, 79, 80, 83, 84, 85 and 87.
View page or View pdf

EPI System: View

AIDS Citations:Search

Cancer Citations:Search

Toxicology Citations:Search

EPA Substance Registry Services (TSCA):87061-04-9

EPA ACToR:Toxicology Data

EPA Substance Registry Services (SRS):Registry

Laboratory Chemical Safety Summary :5362595

National Institute of Allergy and Infectious Diseases:Data

3-(5-methyl-2-propan-2-ylcyclohexyl)oxypropane-1,2-diol

Chemidplus:0087061049

References:

Leffingwell:	Chirality or Article
	3-(5-methyl-2-propan-2-ylcyclohexyl)oxypropane-1,2-diol
NIST Chemistry WebBook:	Search Inchi
Canada Domestic Sub. List:	87061-04-9
Pubchem (cid):	5362595
Pubchem (sid):	135279774

Other Information:

(IUPAC):	Atomic Weights of the Elements 2011 (pdf)
Videos:	The Periodic Table of Videos
tgsc:	Atomic Weights use for this web site
(IUPAC):	Periodic Table of the Elements
FDA Substances Added to Food (formerly EAFUS):	View
HMDB (The Human Metabolome Database):	HMDB36133
FooDB:	FDB014982
ChemSpider:	View
Wikipedia:	View

Potential Blenders and core components note

For Odor

No odor group found for these

camel grass oil
FR

cyclopentanone
FL/FR

laevo-mono

menthyl glutarate
FL/FR

laevo-

menthyl methyl ether
FL/FR

pinocarvone
FL/FR

aldehydic

iso

butyraldehyde
FL/FR

camphoreous

dextro-

camphor
FL/FR

camphor tree bark oil
FL/FR

herbal ethanone
FR

thujyl alcohol
FL/FR

citrus

ocimene quintoxide
FL/FR

earthy

octanol
FL/FR

patchouli cyclohexanol
FR

floral

citronellal diisotridecyl acetal
FR

cyclohexyl ethyl acetate
FL/FR

cyclohexyl propanol
FR

decalinol
FR

dihydrocarvyl acetate
FL/FR

2',4'-

dimethyl acetophenone
FL/FR

earthy indane
FR

floral methanol
FR

geranium oil china
FL/FR

menthadienyl formate
FR

muguet butanol
FR

ylang ylang flower oil
FL/FR

ylang ylang flower oil CO2 extract
FL/FR

ylang ylang flower oil I
FL/FR

ylang ylang flower oil II
FL/FR

ylang ylang flower oil III
FL/FR

fruity

cyclopentyl cyclopentanone
FL/FR

lilac lactone
FL/FR

green

geranium absolute
FL/FR

thiogeraniol
FL/FR

herbal

barosma betulina leaf oil
FL/FR

1,4-

cineole
FL/FR

dehydroxylinalool oxide
FL/FR

iso

dihydrolavandulol
FR

(Z)-iso

dihydrolavandulyl acetate
FR

herbal undecanol
FR

hyssop oil
FL/FR

para-

menthane-3,8-diol
FL/FR

myrtenol
FL/FR

perillaldehyde
FL/FR

pine hexanol
FR

D-(+)-alpha-

pinene
FL/FR

piperitone
FL/FR

rosemary absolute
FL/FR

rosemary oil morocco
FL/FR

sabinene hydrate
FL/FR

viridiflorol
FL/FR

licorice

sweet

basil oleoresin
FL/FR

mentholic

cornmint oil
FL/FR

cornmint oil india
FL/FR

cornmint oil terpeneless
FL/FR

dextro,laevo-

menthol
FL/FR

dextro-neo

menthol
FL/FR

laevo-

menthol
FL/FR

(±)-

menthol
FL/FR

(±)-iso

menthone
FL/FR

laevo-

menthyl acetate
FL/FR

menthyl acetate racemic
FL/FR

peppermint cyclohexanone
FL/FR

dextro-

piperitone
FL/FR

minty

agathosma crenulata leaf oil
FL/FR

laevo-

carveol
FL/FR

laevo-

carvone
FL/FR

carvyl propionate
FL/FR

cyclohexanone
FR

dihydrocarveol
FL/FR

diosphenol
FL/FR

bitter

fennel seed oil
FR

mentha longifolia oil
FR

dextro-2,8-para-

menthadien-1-ol
FL/FR

trans-para-2,8-1-

menthadienol
FL/FR

trans-para-

menthan-2-one
FL/FR

homo

menthol
FL/FR

(-)-

menthone
FL/FR

homo

menthyl acetate
FL/FR

methyl cyclohexanone
FL/FR

pennyroyal oil
FL/FR

pennyroyal oil cuba
FL/FR

pennyroyal oil spain
FL/FR

pennyroyal oil uruguay
FL/FR

peppermint oil CO2 extract
FL/FR

peppermint oil idaho
FL/FR

peppermint oil terpeneless
FL/FR

beta-

phellandrene
FL/FR

piperitenone
FL/FR

laevo-

piperitone
FL/FR

iso

propyl tiglate
FL/FR

(-)-iso

pulegol
FL/FR

(R)-(+)-

pulegone
FR

iso

pulegone
FL/FR

iso

pulegyl formate
FL/FR

spearmint absolute
FL/FR

spearmint oil america
FL/FR

spearmint oil terpeneless
FL/FR

tetrahydrocarvone
FL/FR

wintergreen oil
FL/FR

WS-23
FL/FR

pine

plectranthus glandulosus hook f. leaf oil cameroon
FR

spicy

N,N-

diethyl octanamide
FR

laevo-

verbenone
FL/FR

sulfurous

buchu mercaptan
FL/FR

tropical

beta-

cyclocitral
FL/FR

woody

para-tert-

butyl cyclohexanone
FR

For Flavor

No flavor group found for these

carvone
FL/FR

cyclopentanone
FL/FR

cyclopentyl cyclopentanone
FL/FR

2',4'-

dimethyl acetophenone
FL/FR

(±)-N,N-

dimethyl menthyl succinamide
FL

lilac lactone
FL/FR

limonen-10-yl acetate
FL

dextro-2,8-para-

menthadien-1-ol
FL/FR

cis+trans-para-1(7)8-

menthadien-2-yl acetate
FL

trans-para-2,8-1-

menthadienol
FL/FR

para-

menthane-3,8-diol
FL/FR

3-laevo-

menthoxy-2-methyl propane-1,2-diol
FL

menthyl acetate racemic
FL/FR

laevo-mono

menthyl glutarate
FL/FR

laevo-

menthyl methyl ether
FL/FR

menthyl propylene glycol carbonate
FL

methyl cyclohexanone
FL/FR

beta-

phellandrene
FL/FR

(Z,Z)-

photocitral A
FL

D-(+)-alpha-

pinene
FL/FR

pinocarvone
FL/FR

piperitenone
FL/FR

piperitenone oxide
FL

iso

pulegone
FL/FR

iso

pulegyl formate
FL/FR

laevo-

verbenone
FL/FR

viridiflorol
FL/FR

thujyl alcohol
FL/FR

aldehydic

iso

butyraldehyde
FL/FR

camphoreous

camphor tree bark oil
FL/FR

coffee

2-iso

propyl pyrazine
FL

cooling

1,4-

cineole
FL/FR

dextro,laevo-

menthol
FL/FR

laevo-

menthol
FL/FR

menthyl acetate
FL/FR

homo

menthyl acetate
FL/FR

sabinene hydrate
FL/FR

WS-5
FL

floral

dihydrocarvyl acetate
FL/FR

geranium oil china
FL/FR

ylang ylang flower oil
FL/FR

ylang ylang flower oil CO2 extract
FL/FR

ylang ylang flower oil I
FL/FR

ylang ylang flower oil II
FL/FR

ylang ylang flower oil III
FL/FR

green

cyclohexyl ethyl acetate
FL/FR

dihydrocarveol
FL/FR

geranium absolute
FL/FR

ocimene quintoxide
FL/FR

iso

propyl tiglate
FL/FR

thiogeraniol
FL/FR

herbal

acetoxy-1,8-cineole
FL

barosma betulina leaf oil
FL/FR

hyssop oil
FL/FR

rosemary absolute
FL/FR

rosemary oil morocco
FL/FR

licorice

sweet

basil oleoresin
FL/FR

meaty

methyl 3-(methyl thio) furan
FL

medicinal

dextro-

camphor
FL/FR

mentholic

cornmint oil
FL/FR

cornmint oil terpeneless
FL/FR

dextro-neo

menthol
FL/FR

(±)-

menthol
FL/FR

peppermint cyclohexanone
FL/FR

minty

agathosma crenulata leaf oil
FL/FR

laevo-

carveol
FL/FR

laevo-

carvone
FL/FR

carvyl propionate
FL/FR

cornmint oil india
FL/FR

diosphenol
FL/FR

trans-para-

menthan-2-one
FL/FR

homo

menthol
FL/FR

(±)-iso

menthone
FL/FR

(-)-

menthone
FL/FR

laevo-

menthyl acetate
FL/FR

myrtenol
FL/FR

pennyroyal oil
FL/FR

pennyroyal oil cuba
FL/FR

pennyroyal oil spain
FL/FR

pennyroyal oil uruguay
FL/FR

peppermint oil CO2 extract
FL/FR

peppermint oil idaho
FL/FR

peppermint oil terpeneless
FL/FR

laevo-

piperitone
FL/FR

dextro-

piperitone
FL/FR

(-)-iso

pulegol
FL/FR

spearmint absolute
FL/FR

spearmint oil america
FL/FR

spearmint oil terpeneless
FL/FR

tetrahydrocarvone
FL/FR

wintergreen oil
FL/FR

WS-23
FL/FR

musty

octanol
FL/FR

spicy

perillaldehyde
FL/FR

sulfurous

buchu mercaptan
FL/FR

tropical

beta-

cyclocitral
FL/FR

woody

dehydroxylinalool oxide
FL/FR

Potential Uses:

FR	mint
	refreshing agents

Occurrence (nature, food, other):note

not found in nature

Synonyms:

	coolact 10 (Takasago)
	cooling agent moMOPDpd
	cooling agent no. 10
3-L-(p-	menthan-3-yl oxy)-1,2-propane diol
3-L-(para-	menthan-3-yl oxy)-1,2-propane diol
3-L-(p-	menthan-3-yloxy)-1,2-propanediol
3-L-(para-	menthan-3-yloxy)-1,2-propanediol
3-L-(p-	menthane-3-yl oxy)-1,2-propane diol
3-L-(para-	menthane-3-yl oxy)-1,2-propane diol
3-L-(p-	menthane-3-yloxy)-1,2-propanediol
3-L-(para-	menthane-3-yloxy)-1,2-propanediol
3-(L-	menthoxy) propane-1,2-diol
3-(L-	menthoxy)propane-1,2-diol
3-1-	menthoxypropane-1,2-diol
3-L-	menthoxypropane-1,2-diol
	menthoxypropanediol
3-((L-	menthyl)oxy)propane-1,2-diol
3-((5-	methyl-2-(1-methyl ethyl)cyclohexyl)oxy)-1,2-propane diol
3-((5-	methyl-2-(1-methylethyl)cyclohexyl)oxy)-1,2-propandiol
3-((5-	methyl-2-(1-methylethyl)cyclohexyl)oxy)-1,2-propanediol
3-((5-	methyl-2-(1-methylethyl)cyclohexyl)oxy)propane-1,2-diol
3-(5-	methyl-2-propan-2-ylcyclohexyl)oxypropane-1,2-diol
1,2-	propanediol, 3-((5-methyl-2-(1-methylethyl)cyclohexyl)oxy)-
1,2-	propanediol, 3-[[5-methyl-2-(1-methylethyl)cyclohexyl]oxy]-
3-[(2-iso	propyl-5-methylcyclohexyl)oxy]propane-1,2-diol
	rightcool cooler 10

Articles:

PubMed:A randomized, investigator-blinded efficacy assessment study of stand-alone emollient use in mild to moderately severe atopic dermatitis flares.

PubMed:Allergic contact dermatitis caused by menthoxypropanediol in a lip cosmetic.

PubMed:Comparison of skin permeation enhancement by 3-l-menthoxypropane-1,2-diol and l-menthol: the permeation of indomethacin and antipyrine through Yucatan micropig skin and changes in infrared spectra and X-ray diffraction patterns of stratum corneum.

Notes:

Physiol. cooling agent used in food and beverages

menthoxypropane diol 3-L-menthoxypropane-1,2-diol

Supplier Sponsors

Articles:

menthoxypropane diol
3-L-menthoxypropane-1,2-diol