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Category:flavor and fragrance agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Appearance: | white crystals (est) |
| Assay: | 99.00 to 100.00
|
| Food Chemicals Codex Listed: | No |
| Specific Gravity: | 0.97600 to 0.98200 @ 25.00 °C.
|
| Pounds per Gallon - (est).: | 8.121 to 8.171
|
| Melting Point: | 34.00 to 35.00 °C. @ 760.00 mm Hg
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| Boiling Point: | 266.00 to 268.00 °C. @ 760.00 mm Hg
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| Vapor Pressure: | 0.001000 mmHg @ 25.00 °C. (est) |
| Flash Point: | 248.00 °F. TCC ( 120.00 °C. )
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| logP (o/w): | 1.374 (est) |
| Soluble in: |
| | alcohol | | | water, slightly | | | water, 670.7 mg/L @ 25 °C (est) |
| Insoluble in: |
| | water |
Organoleptic Properties:
| Odor Type: herbal |
| minty herbal eucalyptus |
| Odor Description:at 10.00 % in dipropylene glycol. minty herbal eucalyptus |
| Odor and/or flavor descriptions from others (if found). |
Cosmetic Information:
Suppliers:
| BOC Sciences |
| For experimental / research use only. |
| p-Menthane-3,8-diol 99%
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| Foreverest Resources |
| Menthoglycol 80%
Odor: Minty, herbaceous, like Eucalyptus aroma Use: p-Menthane-3,8-diol, also known as para-menthane-3,8-diol, PMD, or menthoglycol. It is an organic compound classified as a diol and a terpinoid. |
| Lipo Chemicals |
| Coolact® 38D
Odor: characteristic Use: Coolact® 38D is a sensory agent that provides a cooling effect to the skin. The product functions by directly stimulating the receptors at the nerve endings of the skin to produce a cooling sensation. |
| Parchem |
| para-menthane-3,8-diol
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| Sigma-Aldrich: Aldrich |
| For experimental / research use only. |
| (+)-CIS-P-MENTHANE-3,8-DIOL
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| Takasago |
| Coolact® 38D
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| The Fragrance Museum |
| Chemical Sources Association |
| Need This Item for Flavor/Food?: You can contact the Chemical Sources Association |
Safety Information:
| Preferred SDS: View |
| |
| Hazards identification |
| |
| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
| |
| Pictogram | |
| |
| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
|
Not determined
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| Dermal Toxicity: |
|
Not determined
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| Inhalation Toxicity: |
|
Not determined
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Safety in Use Information:
| Category: | | flavor and fragrance agents |
| RIFM Fragrance Material Safety Assessment: Search |
| IFRA Code of Practice Notification of the 49th Amendment to the IFRA Code of Practice |
| Recommendation for para-menthane-3,8-diol usage levels up to: | | | 5.0000 % in the fragrance concentrate.
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| |
| Maximised Survey-derived Daily Intakes (MSDI-EU): | 39.00 (μg/capita/day) |
| Maximised Survey-derived Daily Intakes (MSDI-USA): | 18.00 (μg/capita/day) |
| Structure Class: | I |
| Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS). |
| The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library |
| publication number: 21. Update in publication number(s): 25 |
| Click here to view publication 21 |
| | average usual ppm | average maximum ppm |
| baked goods: | 100.00000 | 120.00000 |
| beverages(nonalcoholic): | 48.00000 | 50.00000 |
| beverages(alcoholic): | 40.00000 | 50.00000 |
| breakfast cereal: | 20.00000 | 50.00000 |
| cheese: | 50.00000 | 75.00000 |
| chewing gum: | 1500.00000 | 2000.00000 |
| condiments / relishes: | 50.00000 | 100.00000 |
| confectionery froastings: | 200.00000 | 350.00000 |
| egg products: | - | - |
| fats / oils: | 100.00000 | 500.00000 |
| fish products: | - | - |
| frozen dairy: | 5.00000 | 25.00000 |
| fruit ices: | 5.00000 | 25.00000 |
| gelatins / puddings: | 150.00000 | 200.00000 |
| granulated sugar: | 5.00000 | 25.00000 |
| gravies: | 35.00000 | 40.00000 |
| hard candy: | 500.00000 | 800.00000 |
| imitation dairy: | 75.00000 | 100.00000 |
| instant coffee / tea: | 25.00000 | 50.00000 |
| jams / jellies: | 150.00000 | 175.00000 |
| meat products: | - | - |
| milk products: | 75.00000 | 100.00000 |
| nut products: | 15.00000 | 50.00000 |
| other grains: | - | - |
| poultry: | - | - |
| processed fruits: | 20.00000 | 150.00000 |
| processed vegetables: | 20.00000 | 75.00000 |
| reconstituted vegetables: | 20.00000 | 25.00000 |
| seasonings / flavors: | 15.00000 | 30.00000 |
| snack foods: | 15.00000 | 30.00000 |
| soft candy: | 500.00000 | 750.00000 |
| soups: | 15.00000 | 25.00000 |
| sugar substitutes: | - | - |
| sweet sauces: | 25.00000 | 300.00000 |
Safety References:
European Food Safety Athority(EFSA):Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies...
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European Food Safety Authority (EFSA) reference(s):
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Flavouring Group Evaluation 9, Revision 1: (FGE.09 Rev1)[1] - Secondary alicyclic saturated and unsaturated alcohols, ketones and esters containing secondary alicyclic alcohols from chemical groups 8 and 30, and an ester of a phenol carboxylic acid from chemical group 25 - Scientific Opinion of the Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food
View page or View pdf
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Flavouring Group Evaluation 9, Revision 2 (FGE.09Rev2): Secondary alicyclic saturated and unsaturated alcohols, ketones and esters containing secondary alicyclic alcohols from chemical group 8 and 30, and an ester of a phenol derivative from chemical group 25
View page or View pdf
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Scientific Opinion on Flavouring Group Evaluation 96 (FGE.96): Consideration of 88 flavouring substances considered by EFSA for which EU production volumes / anticipated production volumes have been submitted on request by DG SANCO. Addendum to FGE. 51, 52, 53, 54, 56, 58, 61, 62, 63, 64, 68, 69, 70, 71, 73, 76, 77, 79, 80, 83, 84, 85 and 87.
View page or View pdf
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| EPI System: View |
| ClinicalTrials.gov:search |
| AIDS Citations:Search |
| Cancer Citations:Search |
| Toxicology Citations:Search |
| EPA ACToR:Toxicology Data |
| EPA Substance Registry Services (SRS):Registry |
| Laboratory Chemical Safety Summary :556998 |
| National Institute of Allergy and Infectious Diseases:Data |
| 2-(2-hydroxypropan-2-yl)-5-methylcyclohexan-1-ol |
| Chemidplus:0042822866 |
References:
Other Information:
Potential Blenders and core components note
Potential Uses:
| | hair conditioning |
| FR | herbal |
| FR | mint |
| | oral care agents |
| | skin conditioning |
Occurrence (nature, food, other): note
Synonyms:
| | citriodiol | | | coolact 38D (Takasago) | | | cubebaol | | | cyclohexanemethanol, 2-hydroxy-a,a,4-trimethyl- | | | cyclohexanol, 2-(2-hydroxy-2-propyl)-5-methyl- | | 2-(1- | hydroxy-1-methyl ethyl)-5-methyl cyclohexanol | | 2-(1- | hydroxy-1-methylethyl)-5-methylcyclohexanol | | 1- | hydroxy-2-(1-methyl-1-hydroxyethyl)-5-methyl cyclohexane | | 2- | hydroxy-a,a,4-trimethylcyclohexane methanol | | 2-(2- | hydroxypropan-2-yl)-5-methylcyclohexan-1-ol | | 2-(2- | hydroxypropan-2-yl)-5-methylcyclohexanol | | (1alpha,3beta,4beta)-p- | menthan-3,8-diol | | (1alpha,3beta,4beta)-para- | menthan-3,8-diol | | p- | menthan-3,8-diol | | para- | menthan-3,8-diol | | (1alpha,3beta,4beta)-p- | menthane-3,8-diol | | (1alpha,3beta,4beta)-para- | menthane-3,8-diol | | p- | menthane-3,8-diol | | | menthoglycol | | iso | pulegol hydrate |
Articles:
| PubMed:Assessing the efficacy of candidate mosquito repellents against the background of an attractive source that mimics a human host. |
| PubMed:A push-pull system to reduce house entry of malaria mosquitoes. |
| PubMed:The efficacy of repellents against Aedes, Anopheles, Culex and Ixodes spp. - a literature review. |
| PubMed:[Field efficacy of repellent formulation containing para-menthane-3,8-diol and lemongrass against Culicoides pachymerus (Diptera: Ceratopogonidae) in Colombia]. |
| PubMed:Efficacy testing of several Ixodes ricinus tick repellents: different results with different assays. |
| PubMed:Repellents and acaricides as personal protection measures in the prevention of tick-borne diseases. |
| PubMed:Efficacy of DEET and non-DEET-based insect repellents against bites of Simulium damnosum vectors of onchocerciasis. |
| PubMed:[Studies on anti-tumor metastatic constituents from Lindera glauca]. |
| PubMed:Metabolism of (+)- and (-)-menthols by CYP2A6 in human liver microsomes. |
| PubMed:Patent literature on mosquito repellent inventions which contain plant essential oils--a review. |
| PubMed:[Personal protection measures against blood-sucking insects and ticks]. |
| PubMed:Efficacy and safety of catnip (Nepeta cataria) as a novel filth fly repellent. |
| PubMed:Dihydronepetalactones deter feeding activity by mosquitoes, stable flies, and deer ticks. |
| PubMed:Percutaneous absorption of an insect repellent p-menthane-3,8-DIOL: a model for human dermal absorption. |
| PubMed:Effective insect repellent formulation in both surfactantless and classical microemulsions with a long-lasting protection for human beings. |
| PubMed:Acaricidal effects of Corymbia citriodora oil containing para-menthane-3,8-diol against nymphs of Ixodes ricinus (Acari: Ixodidae). |
| PubMed:Repellency of MyggA Natural spray (para-menthane-3,8-diol) and RB86 (neem oil) against the tick Ixodes ricinus (Acari: Ixodidae) in the field in east-central Sweden. |
| PubMed:PMD, a registered botanical mosquito repellent with deet-like efficacy. |
| PubMed:Repellency of oils of lemon eucalyptus, geranium, and lavender and the mosquito repellent MyggA natural to Ixodes ricinus (Acari: Ixodidae) in the laboratory and field. |
| PubMed:Efficacy of repellent products against caged and free flying Anopheles stephensi mosquitoes. |
| PubMed:[Extraction and determination of volatile constituents in leaves of Eucalyptus citriodora]. |
| PubMed:Laboratory and field tests of the effectiveness of the lemon-eucalyptus extract, Citridiol, as a repellent against land leeches of the genus Haemadipsa (Haemadipsidae). |
| PubMed:Laboratory evaluation of mosquito repellents against Aedes albopictus, Culex nigripalpus, and Ochierotatus triseriatus (Diptera: Culicidae). |
| PubMed:Enhancement effect of p-menthane-3,8-diol on in vitro permeation of antipyrine and indomethacin through Yucatan micropig skin. |
| PubMed:Repellency of IR3535, KBR3023, para-menthane-3,8-diol, and deet to black salt marsh mosquitoes (Diptera: Culicidae) in the Everglades National Park. |
| PubMed:Repellent activities of stereoisomers of p-menthane-3,8-diols against Anopheles gambiae (Diptera: Culicidae). |
| PubMed:Efficacy of three insect repellents against the malaria vector Anopheles arabiensis. |
| PubMed:Evaluation of a eucalyptus-based repellent against Anopheles spp. in Tanzania. |
| PubMed:Studies on the metabolism of l-menthol in rats. |
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3D/inchi