Category: flavor and fragrance agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
Appearance: | pale yellow to amber yellow clear liquid (est) |
Assay: | 98.00 to 100.00
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Food Chemicals Codex Listed: | No |
Specific Gravity: | 1.10600 to 1.11300 @ 25.00 °C.
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Pounds per Gallon - (est).: | 9.203 to 9.261
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Refractive Index: | 1.52800 to 1.53200 @ 20.00 °C.
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Boiling Point: | 212.00 °C. @ 760.00 mm Hg
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Vapor Pressure: | 0.003000 mmHg @ 25.00 °C. (est) |
Flash Point: | 248.00 °F. TCC ( 120.00 °C. )
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logP (o/w): | 1.571 (est) |
Soluble in: |
| alcohol | | water, 2262 mg/L @ 25 °C (est) |
Organoleptic Properties:
Odor Type: chocolate |
Odor Strength:medium |
Substantivity: > 400 hour(s) at 20.00 % in ethyl alcohol |
alcoholic rummy sweet chocolate creamy vanilla spicy nutmeg smoky |
Odor Description:at 20.00 % in ethyl alcohol. alcoholic rum sweet chocolate creamy vanilla spicy nutmeg smoky Luebke, William tgsc, (2009) |
Odor sample from: Alfrebro LLC/ Archer Daniels Midland Company |
Flavor Type: rummy |
rummy chocolate creamy vanilla |
Taste Description: sweet rummy chocolate creamy vanilla Luebke, William tgsc, (2009) |
Odor and/or flavor descriptions from others (if found). |
Alfrebro |
VANILLYL ETHYL ETHER SYNTH 20% IN EtOH |
Odor Description:alcoholic rum sweet chocolate creamy vanilla spicy nutmeg smoky Luebke, William tgsc, (2009) |
Taste Description:sweet rummy chocolate creamy vanilla Luebke, William tgsc, (2009) |
Cosmetic Information:
Suppliers:
Safety Information:
Preferred SDS: View |
European information : |
Most important hazard(s): | Xi - Irritant |
R 36/38 - Irritating to skin and eyes. S 02 - Keep out of the reach of children. S 24/25 - Avoid contact with skin and eyes. S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S 36 - Wear suitable protective clothing.
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Hazards identification |
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Classification of the substance or mixture |
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
None found. |
GHS Label elements, including precautionary statements |
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Pictogram | |
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Hazard statement(s) |
None found. |
Precautionary statement(s) |
None found. |
Oral/Parenteral Toxicity: |
oral-rat LD50 > 2000 mg/kg (Dufour, 1994)
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Dermal Toxicity: |
Not determined
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Inhalation Toxicity: |
Not determined
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Safety in Use Information:
Category: | flavor and fragrance agents |
RIFM Fragrance Material Safety Assessment: Search |
IFRA Code of Practice Notification of the 49th Amendment to the IFRA Code of Practice |
Recommendation for vanillyl ethyl ether usage levels up to: | | 0.6000 % in the fragrance concentrate.
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Maximised Survey-derived Daily Intakes (MSDI-EU): | 20.00 (μg/capita/day) |
Maximised Survey-derived Daily Intakes (MSDI-USA): | 22.00 (μg/capita/day) |
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS). |
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library |
publication number: 17. Update in publication number(s): 22 |
Click here to view publication 17 |
| average usual ppm | average maximum ppm |
baked goods: | 5.00000 | 15.00000 |
beverages(nonalcoholic): | 30.00000 | 300.00000 |
beverages(alcoholic): | 30.00000 | 300.00000 |
breakfast cereal: | 5.00000 | 10.00000 |
cheese: | - | - |
chewing gum: | 200.00000 | 600.00000 |
condiments / relishes: | - | - |
confectionery froastings: | 100.00000 | 500.00000 |
egg products: | - | - |
fats / oils: | - | - |
fish products: | - | - |
frozen dairy: | 3.00000 | 5.00000 |
fruit ices: | - | - |
gelatins / puddings: | - | - |
granulated sugar: | - | - |
gravies: | - | - |
hard candy: | 100.00000 | 500.00000 |
imitation dairy: | - | - |
instant coffee / tea: | 3.00000 | 10.00000 |
jams / jellies: | - | - |
meat products: | - | - |
milk products: | 20.00000 | 200.00000 |
nut products: | - | - |
other grains: | - | - |
poultry: | - | - |
processed fruits: | - | - |
processed vegetables: | - | - |
reconstituted vegetables: | - | - |
seasonings / flavors: | - | - |
snack foods: | 50.00000 | 500.00000 |
soft candy: | 100.00000 | 500.00000 |
soups: | - | - |
sugar substitutes: | - | - |
sweet sauces: | - | - |
Safety References:
European Food Safety Athority(EFSA):Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies...
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European Food Safety Authority (EFSA) reference(s):
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Opinion of the Scientific Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) on a request from the Commission related to Flavouring Group Evaluation 20 (FGE.20): Benzyl alcohols, benzaldehydes, a related acetal, benzoic acids, and related esters from chemical group 23 View page or View pdf
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Flavouring Group Evaluation 52 (FGE.52): Consideration of hydroxy- and alkoxy-substituted benzyl derivatives evaluated by JECFA (57th meeting) structurally related to benzyl alcohols, benzaldehydes, a related acetal, benzoic acids, and related esters evaluated by EFSA in FGE.20 (2005) (Commission Regulation (EC) No 1565/2000 of 18 July 2000) - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC) View page or View pdf
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Flavouring Group Evaluation 20, Revision 1 (FGE.20Rev1): Benzyl alcohols, benzaldehydes, a related acetal, benzoic acids and related esters from chemical group 23 View page or View pdf
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Scientific Opinion on Flavouring Group Evaluation 20, Revision 2 (FGE.20Rev2): Benzyl alcohols, benzaldehydes, a related acetal, benzoic acids, and related esters from chemical groups 23 and 30 View page or View pdf
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Scientific Opinion on Flavouring Group Evaluation 20, Revision 3(FGE.20Rev3): Benzyl alcohols, benzaldehydes, a related acetal, benzoic acids, and related esters from chemical groups 23 and 30 View page or View pdf
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EPI System: View |
AIDS Citations:Search |
Cancer Citations:Search |
Toxicology Citations:Search |
EPA ACToR:Toxicology Data |
EPA Substance Registry Services (SRS):Registry |
Laboratory Chemical Safety Summary :61586 |
National Institute of Allergy and Infectious Diseases:Data |
WGK Germany:3 |
4-(ethoxymethyl)-2-methoxyphenol |
Chemidplus:0013184866 |
References:
Other Information:
Potential Blenders and core components note
For Odor |
aldehydic |
acetyl nonyryl FL/FR |
anisic |
para- anisaldehyde FL/FR |
methyl para-anisate FL/FR |
balsamic |
amyl phenyl acetate FL/FR |
sumatra benzoin resin FL/FR |
sumatra benzoin resinoid FL/FR |
prenyl benzoate FL/FR |
terpinyl cinnamate FL/FR |
buttery |
acetoin FL/FR |
acetyl butyryl FL/FR |
acetyl isobutyryl FL/FR |
acetyl propionyl FL/FR |
butyl butyryl lactate FL/FR |
caramellic |
2-oxo butyric acid FL/FR |
strawberry furanone acetate FL/FR |
cheesy |
butyric acid FL/FR |
chocolate |
iso amyl phenyl acetate FL/FR |
iso butyl phenyl acetate FL/FR |
chocolate pyrazine A FL/FR |
cocoa oleoresin FL/FR |
2,4,5- trimethyl thiazole FL/FR |
citrus |
1- methyl-4-methyl ethenyl cyclohexene sulfurized FL/FR |
coconut |
coconut decanone methyl FR |
delta- decalactone FL/FR |
delta-2- dodecenolactone FL/FR |
delta- nonalactone FL/FR |
gamma- octalactone FL/FR |
delta- undecalactone FL/FR |
creamy |
gamma- butyrolactone FL/FR |
creamy lactone FL/FR |
geranyl ethyl acetal FR |
3- heptyl dihydro-5-methyl-2(3H)-furanone FL/FR |
para- vanillic acid FL/FR |
para- vanillyl alcohol FL/FR |
earthy |
1- nonen-3-ol FL/FR |
fatty |
(Z)- dairy lactone FL/FR |
ethyl undecylenate FL/FR |
4- methyl octanoic acid FL/FR |
fermented |
butyl laevo-lactate FL/FR |
floral |
alpha- amyl cinnamyl acetate FL/FR |
amyl salicylate FL/FR |
benzyl phenyl acetate FL/FR |
heliotropin FL/FR |
fruity |
acetoin acetate FL/FR |
gamma- decalactone FL/FR |
farnesyl acetone FL/FR |
methyl (Z)-5-octenoate FL/FR |
gamma- undecalactone (aldehyde C-14 (so-called)) FL/FR |
green |
bark carbaldehyde FR |
iso butyl benzyl carbinol FL/FR |
butyl lactate FL/FR |
(Z)-4- hepten-1-ol FL/FR |
(Z)-4- heptenal FL/FR |
(Z)-4- heptenal diethyl acetal FL/FR |
herbal |
tricyclodecenyl isobutyrate FR |
honey |
butyl phenyl acetate FL/FR |
phenyl acetic acid FL/FR |
medicinal |
meta- dimethyl hydroquinone FL/FR |
mushroom |
3- octen-2-ol FL/FR |
naphthyl |
2,4- dimethyl benzaldehyde FL/FR |
nutty |
4,5- dimethyl-2-ethyl-3-thiazoline FL/FR |
2- methyl pyrazine FL/FR |
resorcinol FR |
2,3,5,6- tetramethyl pyrazine FL/FR |
popcorn |
2- acetyl pyrazine FL/FR |
powdery |
para- anisyl alcohol FL/FR |
spicy |
allspice berry oil terpeneless FL/FR |
para- anisyl formate FL/FR |
sweet |
vanilla oleoresin bali FL/FR |
tonka |
6- amyl-alpha-pyrone FL/FR |
dihydrocoumarin FL/FR |
gamma- hexalactone FL/FR |
mint lactone FL/FR |
vanilla |
ortho- dimethyl hydroquinone FL/FR |
ethyl vanillin FL/FR |
ethyl vanillin hexylene glycol acetal FR |
ethyl vanillin isobutyrate FL/FR |
ethyl vanillin propylene glycol acetal FL/FR |
propenyl guaethol FL/FR |
vanillin FL/FR |
vanillin propylene glycol acetal FL/FR |
vanillyl acetate FL/FR |
vanillyl isobutyrate FL/FR |
vanillylidene acetone FL/FR |
vegetable |
methional FL/FR |
waxy |
allyl nonanoate FL/FR |
ethyl palmitate FL/FR |
methyl laurate FL/FR |
2- nonanol FL/FR |
octyl isobutyrate FL/FR |
delta- tetradecalactone FL/FR |
undecanoic acid FL/FR |
For Flavor |
No flavor group found for these |
allyl methyl trisulfide FL |
amyl phenyl acetate FL/FR |
chocolate pyrazine A FL/FR |
6- decenoic acid FL |
ortho- dimethyl hydroquinone FL/FR |
delta-2- dodecenolactone FL/FR |
farnesyl acetone FL/FR |
methyl para-anisate FL/FR |
prenyl benzoate FL/FR |
aldehydic |
aldehydic |
acetyl nonyryl FL/FR |
amber |
iso butyl benzyl carbinol FL/FR |
aromatic |
amyl salicylate FL/FR |
balsamic |
sumatra benzoin resin FL/FR |
sumatra benzoin resinoid FL/FR |
vanillylidene acetone FL/FR |
bitter |
methyl ethoxypyrazine FL |
brown |
2-oxo butyric acid FL/FR |
buttery |
butter cream frosting flavor FL |
butyl laevo-lactate FL/FR |
diacetyl FL |
cabbage |
methyl 2-thiofuroate FL |
caramellic |
strawberry furanone acetate FL/FR |
chemical |
meta- dimethyl hydroquinone FL/FR |
cherry |
heliotropin FL/FR |
chocolate |
cocoa oleoresin FL/FR |
creme de cocoa flavor FL |
citrus |
1- methyl-4-methyl ethenyl cyclohexene sulfurized FL/FR |
cocoa |
iso butyl phenyl acetate FL/FR |
butyraldehyde FL |
cocoa distillates FL |
2- methyl furan FL |
coconut |
delta- decalactone FL/FR |
(R)- massoia lactone FL |
6- methyl coumarin FL |
creamy |
acetoin FL/FR |
acetyl butyryl FL/FR |
acetyl isobutyryl FL/FR |
6- amyl-alpha-pyrone FL/FR |
para- anisaldehyde FL/FR |
butyl butyryl lactate FL/FR |
creamy lactone FL/FR |
dihydrocoumarin FL/FR |
gamma- hexalactone FL/FR |
mint lactone FL/FR |
delta- nonalactone FL/FR |
octyl isobutyrate FL/FR |
delta- undecalactone FL/FR |
gamma- undecalactone (aldehyde C-14 (so-called)) FL/FR |
para- vanillic acid FL/FR |
para- vanillyl alcohol FL/FR |
dairy |
methyl (Z)-5-octenoate FL/FR |
earthy |
alpha- amyl cinnamyl acetate FL/FR |
1- nonen-3-ol FL/FR |
fatty |
(Z)- dairy lactone FL/FR |
ethyl undecylenate FL/FR |
4- methyl octanoic acid FL/FR |
2,4- octadien-1-ol FL |
floral |
iso amyl phenyl acetate FL/FR |
phenyl acetic acid FL/FR |
fruity |
acetoin acetate FL/FR |
acetyl isovaleryl FL |
para- anisyl alcohol FL/FR |
gamma- decalactone FL/FR |
3- heptyl dihydro-5-methyl-2(3H)-furanone FL/FR |
terpinyl cinnamate FL/FR |
green |
butyl lactate FL/FR |
heptanal 2,3-butane diol acetal FL |
(Z)-4- hepten-1-ol FL/FR |
(Z)-4- heptenal FL/FR |
(Z)-4- heptenal diethyl acetal FL/FR |
honey |
benzyl phenyl acetate FL/FR |
butyl phenyl acetate FL/FR |
lactonic |
gamma- octalactone FL/FR |
meaty |
4- allyl-2,6-dimethoxyphenol FL |
milky |
gamma- butyrolactone FL/FR |
mushroom |
3- octen-2-ol FL/FR |
naphthyl |
2,4- dimethyl benzaldehyde FL/FR |
nutty |
4,5- dimethyl-2-ethyl-3-thiazoline FL/FR |
2- methyl pyrazine FL/FR |
2,3,5,6- tetramethyl pyrazine FL/FR |
2,4,5- trimethyl thiazole FL/FR |
roasted |
2- acetyl pyrazine FL/FR |
sour |
butyric acid FL/FR |
spicy |
allspice berry oil terpeneless FL/FR |
para- anisyl formate FL/FR |
benzylidene acetone FL |
cinnamon vanilla cream flavor FL |
root beer float flavor FL |
sweet |
ethyl 3-(2-hydroxyphenyl) propionate FL |
orange vanilla cream flavor FL |
vanilla oleoresin bali FL/FR |
toasted |
acetyl propionyl FL/FR |
tomato |
methional FL/FR |
vanilla |
ethyl vanillin FL/FR |
ethyl vanillin isobutyrate FL/FR |
ethyl vanillin propylene glycol acetal FL/FR |
vanilla ice cream flavor FL |
propenyl guaethol FL/FR |
vanillin FL/FR |
vanillin propylene glycol acetal FL/FR |
vanillyl acetate FL/FR |
vanillyl isobutyrate FL/FR |
waxy |
allyl nonanoate FL/FR |
ethyl palmitate FL/FR |
methyl laurate FL/FR |
2- nonanol FL/FR |
octyl 2-furoate FL |
delta- tetradecalactone FL/FR |
undecanoic acid FL/FR |
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
p- | cresol, a-ethoxy-2-methoxy- | alpha- | ethoxy-2-methoxy-p-cresol | alpha- | ethoxy-2-methoxy-para-cresol | 4-( | ethoxymethyl)-2-methoxyphenol | | ethyl 4-hydroxy-3-methoxybenzyl ether | | ethyl vanillyl ether | 4- | hydroxy-3-methoxybenzyl ethyl ether | | phenol, 4-(ethoxymethyl)-2-methoxy- | | vanillin ethyl ether |
Articles:
US Patents:4,657,700 - Fragrance compositions containing benzyl ethers |
PubMed:[Chemical constituents from tubers of Cremastra appendiculata]. |
PubMed:[Chemical constituents of Cudrania cochinchinensis]. |
PubMed:[Phenolic derivatives from Wisteria sinensis sweet caulis]. |
PubMed:Inhibition of arachidonic acid metabolism by the Andean crude drug Parastrephia lucida (Meyen) Cabrera. |
PubMed:Inhibition of arachidonic acid metabolism by the Andean crude drug Parastrephia lucida (Meyen) Cabrera. |
PubMed:A study on anticancer activity of Caulis Spatholobi extract on human osteosarcoma Saos-2 cells. |
PubMed:Biodegradation of 2,4-dichlorophenol by shiitake mushroom (Lentinula edodes) using vanillin as an activator. |
PubMed:[Chemical constituents from aqueous extract of Gastrodia elata]. |
PubMed:Effects of glucam P-20, vanillin, and fixolide on mosquito repellency of citronella oil lotions. |
PubMed:Simultaneous determination of five active compounds in chimonanthus nitens by double-development HPTLC and scanning densitometry. |
PubMed:Lignin structural variation in hardwood species. |
PubMed:Triacylglyceride measurement in small quantities of homogenised insect tissue: comparisons and caveats. |
PubMed:Artificial aging of Uva di Troia and Primitivo wines using oak chips inoculated with Penicillium purpurogenum. |
PubMed:Identification of DypB from Rhodococcus jostii RHA1 as a lignin peroxidase. |
PubMed:Improved iterative synthesis of linearly disassembling dendrons. |
PubMed:Physicochemical, nutritional, and functional characterization of fruits xoconostle (Opuntia matudae) pears from Central-México Region. |
PubMed:Total synthesis of (+)-schweinfurthins B and E. |
PubMed:A rapid and precise method for determination of D/H ratios of plant methoxyl groups. |
PubMed:[Studies on the chemical constituents of Litsea lancifolia]. |
PubMed:Qualitative and quantitative analysis of four species of Curcuma rhizomes using twice development thin layer chromatography. |
PubMed:Oxidation of lignin using aqueous polyoxometalates in the presence of alcohols. |
PubMed:Evaluation of a Hypocrea jecorina enzyme preparation for hydrolysis of Tifton 85 bermudagrass. |
PubMed:Vanillin, 4-hydroxybenzyl aldehyde and 4-hydroxybenzyl alcohol prevent hippocampal CA1 cell death following global ischemia. |
PubMed:Protective effects of several components of Gastrodia elata on lipid peroxidation in gerbil brain homogenates. |
PubMed:[Chemical constituents from roots of Ardisia punctata]. |
PubMed:In vitro androgenicity in pulp and paper mill effluents. |
PubMed:The effects of sample preparation and gas chromatograph injection techniques on the accuracy of measuring guaiacol, 4-methylguaiacol and other volatile oak compounds in oak extracts by stable isotope dilution analyses. |
PubMed:Application of solid-phase extraction for determination of phenolic compounds in barrique wines. |
PubMed:Guaiacylglycerol-7'-O-methyl 8'-vanillic acid ether and related compounds from Boreava orientalis. |
PubMed:Chemical analysis and antifungal activity of the essential oil of Calea clematidea. |
PubMed:Maturing wines in oak barrels. Effects of origin, volume, and age of the barrel on the wine volatile composition. |
PubMed:Production of oxychemicals from precipitated hardwood lignin. |
PubMed:Formation and Degradation of Furfuryl Alcohol, 5-Methylfurfuryl Alcohol, Vanillyl Alcohol, and Their Ethyl Ethers in Barrel-Aged Wines. |
PubMed:Inhibition of oxidation of human low-density lipoproteins by phenolic substances in different essential oils varieties. |
PubMed:Network of C-H...O interactions in 4-benzyloxy-3-methoxybenzaldehyde (vanillin benzyl ether). |
PubMed:Characterization of the key aroma compounds in dried fruits of the West African peppertree Xylopia aethiopica (Dunal) A. Rich (Annonaceae) using aroma extract dilution analysis. |
PubMed:Concentrations of salinomycin in eggs and tissues of laying chickens fed medicated feed for 14 days followed by withdrawal for 3 days. |
PubMed:Oxidation of phenolic arylglycerol beta-aryl ether lignin model compounds by manganese peroxidase from Phanerochaete chrysosporium: oxidative cleavage of an alpha-carbonyl model compound. |
PubMed:Degradation of non-phenolic beta-o-4 lignin substructure model compounds by Acinetobacter sp. |
PubMed:Devil's-claw (Proboscidea louisianica), essential oil and its components : Potential allelochemical agents on cotton and wheat. |
PubMed:Thiol-mediated oxidation of nonphenolic lignin model compounds by manganese peroxidase of Phanerochaete chrysosporium. |
PubMed:Isolation and characterization of an anaerobic dehydrodivanillin-degrading bacterium. |
PubMed:[Simultaneous analysis of aromatic aldehydes and coumarins with high pressure liquid chromatography. Application to wines and brandies stored in oak barrels]. |
PubMed:Anaerobic degradation of veratrylglycerol-beta-guaiacyl ether and guaiacoxyacetic acid by mixed rumen bacteria. |
PubMed:Alarm substances of the stingless bee,Trigona silvestriana. |
PubMed:Catabolism of arylglycerol-beta-aryl ethers lignin model compounds by Pseudomonas cepacia 122. |
PubMed:Whole-cell bioconversion of vanillin to vanillic acid by Streptomyces viridosporus. |
PubMed:Biosynthesis, deposition, and partial characterization of potato suberin phenolics. |
PubMed:Gas-chromatographic estimation of 3-methoxy-4-hydroxy phenylglycol after transformation to vanillin methoxime trimethylsilyl ether. |
PubMed:Gas-chromatographic estimation of urinary vanillylmandelic acid after transformation to vanillin methoxime trimethylsilyl ether. |
PubMed:[Benzoins, benzils and benzilic acids of o-vanillin- and o-novovanillin ether]. |
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