Articles:
Notes:
Constit. of mandarin peel oil (Citrus madurensis), petitgrain oil and other citrus spp. oils. Flavouring agent
| Fragrance Demo Formulas Flavor Demo Formulas | ||
| Name: | methyl 2-methylaminobenzoate | |
| CAS Number: | 85-91-6 |  3D/inchi
|
| ECHA EINECS - REACH Pre-Reg: | 201-642-6 | |
| FDA UNII: | 5Z37T562P9 | |
| Nikkaji Web: | J2.411B | |
| Beilstein Number: | 0607217 | |
| MDL: | MFCD00017183 | |
| FEMA Number: | 2718 | |
| CoE Number: | 756 | |
| XlogP3: | 2.30 (est) | |
| Molecular Weight: | 165.19207000 | |
| Formula: | C9 H11 N O2 | |
| BioActivity Summary: | listing | |
| NMR Predictor: | Predict (works with chrome or firefox) | |
Category: flavor and fragrance agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
| Google Scholar: | Search |
| Google Books: | Search |
| Google Scholar: with word "volatile" | Search |
| Google Scholar: with word "flavor" | Search |
| Google Scholar: with word "odor" | Search |
| Perfumer and Flavorist: | Search |
| Google Patents: | Search |
| US Patents: | Search |
| EU Patents: | Search |
| Pubchem Patents: | Search |
| PubMed: | Search |
| NCBI: | Search |
| JECFA Food Flavoring: | 1545 methyl N-methylanthranilate |
| Flavis Number: | 09.781 (Old) |
| DG SANTE Food Flavourings: | 09.781 methyl N-methylanthranilate |
| FEMA Number: | 2718 methyl N-methylanthranilate |
| FDA Mainterm: | METHYL N-METHYLANTHRANILATE |
| FDA Regulation: | |
| FDA PART 172 -- FOOD ADDITIVES PERMITTED FOR DIRECT ADDITION TO FOOD FOR HUMAN CONSUMPTION Subpart F--Flavoring Agents and Related Substances Sec. 172.515 Synthetic flavoring substances and adjuvants. | |
Physical Properties:
| Appearance: | pale yellow to amber clear liquid to solid (est) |
| Assay: | 98.00 to 100.00 % sum of isomers |
| Food Chemicals Codex Listed: | Yes |
| Specific Gravity: | 1.12500 to 1.13000 @ 25.00 °C. |
| Pounds per Gallon - (est).: | 9.361 to 9.403 |
| Refractive Index: | 1.57900 to 1.58100 @ 20.00 °C. |
| Melting Point: | 17.00 to 19.00 °C. @ 760.00 mm Hg |
| Boiling Point: | 255.00 to 256.00 °C. @ 760.00 mm Hg |
| Boiling Point: | 130.00 to 131.00 °C. @ 13.00 mm Hg |
| Congealing Point: | 12.00 °C. |
| Acid Value: | 1.00 max. KOH/g |
| Vapor Pressure: | 0.007000 mmHg @ 25.00 °C. (est) |
| Vapor Density: | >1 ( Air = 1 ) |
| Flash Point: | > 230.00 °F. TCC ( > 110.00 °C. ) |
| logP (o/w): | 2.530 (est) |
| Shelf Life: | 24.00 month(s) or longer if stored properly. |
| Storage: | store in cool, dry place in tightly sealed containers, protected from heat and light. |
| Soluble in: | |
| alcohol | |
| dipropylene glycol | |
| fixed oils | |
| water, 475 mg/L @ 20 °C (exp) | |
| Insoluble in: | |
| glycerin | |
| Stability: | |
| bath foam | |
| cream | |
| hair spray | |
| lotion | |
| powder | |
| shampoo | |
| soap | |
Organoleptic Properties:
| Odor Type: | floral |
| Odor Strength: | medium |
| Odor Description: at 100.00 %. | fruity musty sweet neroli powdery phenolic wine |
| Substantivity: | 48 Hour(s) |
Cosmetic Information:
| Cosmetic Uses: |
perfuming agents |
Safety Information:
| Most important hazard(s): | |
| Xi - Irritant | |
|
R 36/38 - Irritating to skin and eyes. R 42 - May cause sensitisation by inhalation. R 42/43 - May cause sensitization by inhalation and skin contact. R 43 - May cause sensitisation by skin contact. S 02 - Keep out of the reach of children. S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S 36 - Wear suitable protective clothing. | |
| Human Experience: | 10 % solution: no irritation or sensitization. |
| Oral/Parenteral Toxicity: | |
|
oral-rat LD50 3380 mg/kg BEHAVIORAL: ANALGESIA BEHAVIORAL: GENERAL ANESTHETIC BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) Food and Cosmetics Toxicology. Vol. 8, Pg. 359, 1970. intravenous-mouse LD50 180 mg/kg U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#07000 | |
| Dermal Toxicity: | |
|
skin-rabbit LD50 5000 mg/kg U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#07000 | |
| Inhalation Toxicity: | |
| Not determined | |
Safety in Use Information:
| Category: | flavor and fragrance agents | ||
| IFRA Critical Effect: | Phototoxicity and potential for nitrosam | ||
| IFRA fragrance material specification: | |||
| For applications on areas of the skin exposed to sunlight, excluding bath preparations, soaps and other wash-off products, limit to 10% in the finished cosmetic product. Based on the phototoxic potential and on the observed no-effect level of approximately 2 mg/cm2 of the hairless mouse (Food and Chemical Toxicology 17, 273 (1979)). The material has been identified for having the potential of forming nitrosamines in nitrosating systems. Downstream users therefore have to be notified of the presence of the material and its potential to be able to consider adequate protective measures. | |||
| IFRA: | View Standard | ||
| limits in the finished product for - "leave on the skin contact": | |||
| 0.1000 % Restriction. | |||
| Recommendation for dimethyl anthranilate usage levels up to: | |||
| 8.0000 % in the fragrance concentrate. | |||
| Maximised Survey-derived Daily Intakes (MSDI-EU): | 51.00 (μg/capita/day) | ||
| Maximised Survey-derived Daily Intakes (MSDI-USA): | 120.00 (μg/capita/day) | ||
| Threshold of Concern: | 1800 (μg/person/day) | ||
| Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS). | |||
| The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library | |||
| publication number: 3 | |||
| Click here to view publication 3 | |||
| average usual ppm | average maximum ppm | ||
| baked goods: | - | 17.00000 | |
| beverages(nonalcoholic): | - | 5.10000 | |
| beverages(alcoholic): | - | - | |
| breakfast cereal: | - | - | |
| cheese: | - | - | |
| chewing gum: | - | - | |
| condiments / relishes: | - | - | |
| confectionery froastings: | - | - | |
| egg products: | - | - | |
| fats / oils: | - | - | |
| fish products: | - | - | |
| frozen dairy: | - | 5.00000 | |
| fruit ices: | - | 5.00000 | |
| gelatins / puddings: | - | - | |
| granulated sugar: | - | - | |
| gravies: | - | - | |
| hard candy: | - | 18.00000 | |
| imitation dairy: | - | - | |
| instant coffee / tea: | - | - | |
| jams / jellies: | - | 4.00000 | |
| meat products: | - | - | |
| milk products: | - | - | |
| nut products: | - | - | |
| other grains: | - | - | |
| poultry: | - | - | |
| processed fruits: | - | - | |
| processed vegetables: | - | - | |
| reconstituted vegetables: | - | - | |
| seasonings / flavors: | - | - | |
| snack foods: | - | - | |
| soft candy: | - | - | |
| soups: | - | - | |
| sugar substitutes: | - | - | |
| sweet sauces: | - | - | |
Safety References:
| European Food Safety Athority(efsa): | Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies... |
| European Food Safety Authority (EFSA) reference(s): | |
| Flavouring Group Evaluation 84, (FGE.84)[1] - Consideration of Anthranilate derivatives evaluated by JECFA (65th meeting) - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food View page or View pdf | |
| Scientific Opinion on the safety and efficacy of anthranilate derivatives (chemical group 27) when used as flavourings for all animal species View page or View pdf | |
| EPI System: | View |
| NLM Hazardous Substances Data Bank: | Search |
| Chemical Carcinogenesis Research Information System: | Search |
| Env. Mutagen Info. Center: | Search |
| NLM Developmental and Reproductive Toxicity: | Search |
| EPA Substance Registry Services (TSCA): | 85-91-6 |
| EPA ACToR: | Toxicology Data |
| EPA Substance Registry Services (SRS): | Registry |
| Laboratory Chemical Safety Summary : | 6826 |
| National Institute of Allergy and Infectious Diseases: | Data |
| SCCNFP: | opinion |
| WGK Germany: | 1 |
| methyl 2-methylaminobenzoate | |
| Chemidplus: | 0000085916 |
| RTECS: | CB3500000 for cas# 85-91-6 |
References:
| methyl 2-methylaminobenzoate | |
| NIST Chemistry WebBook: | Search Inchi |
| Canada Domestic Sub. List: | 85-91-6 |
| Pubchem (cid): | 6826 |
| Pubchem (sid): | 134970606 |
| Pherobase: | View |
Other Information:
| (IUPAC): | Atomic Weights of the Elements 2009 |
| (IUPAC): | Atomic Weights of the Elements 2009 (pdf) |
| Videos: | The Periodic Table of Videos |
| tgsc: | Atomic Weights use for this web site |
| (IUPAC): | Periodic Table of the Elements |
| FDA Everything Added to Food in the United States (EAFUS): | View |
| CHEMBL: | View |
| HMDB (The Human Metabolome Database): | HMDB34169 |
| FooDB: | FDB012455 |
| Export Tariff Code: | 2922.49.1000 |
| Haz-Map: | View |
| VCF-Online: | VCF Volatile Compounds in Food |
| ChemSpider: | View |
Potential Blenders and core components note
Potential Uses:
| acacia | FR | |
| amber | FR | |
| apple green apple | FR | |
| apricot | FR | |
| beer birch beer | FL | |
| berry | FR | |
| blackberry | FR | |
| cabochard | ||
| cherry | FR | |
| cinq fleurs forvil | ||
| citrus | FR | |
| cranberry | FR | |
| currant | FR | |
| enhancer | ||
| fern | FR | |
| floral | FR | |
| fruit punch | FL | |
| gooseberry | FR | |
| grape | FR | |
| heather | FR | |
| honey | FR | |
| huckleberry | FR | |
| hyacinth | FR | |
| jasmin | FR | |
| jonquil | FR | |
| linden flower | FR | |
| lux beauty shower soap | ||
| mandarin | FR | |
| mimosa | FR | |
| mulberry | FR | |
| neroli | FR | |
| orange blossom | FR | |
| oriental | FR | |
| peach | FR | |
| petitgrain mandarin oil replacer | FL/FR | |
| petitgrain orange petitgrain | FR | |
| petitgrain tangerine petitgrain | FL/FR | |
| plum | FR | |
| raspberry | FR | |
| root beer | FR | |
| rue | FL/FR | |
| sarsaparilla | FL | |
| strawberry | FR | |
| tangerine | FR | |
| tea | FL | |
| tuberose | FR | |
| wintergreen | FR | |
| wisteria | FR |
Occurrence (nature, food, other): note
| bergamot oil @ trace% Data GC Search Trop Picture | |
| broom absolute Search Trop Picture | |
| champaca concrete @ 0.05% Data GC Search Trop Picture | |
| hyacinth Search Trop Picture | |
| hyacinthus orientalis absolute @ trace% Data GC Search Trop Picture | |
| mandarin fruit Search Trop Picture | |
| mandarin oil @ 0.50% Data GC Search Trop Picture | |
| mandarin oil avana @ 0.46% Data GC Search Trop Picture | |
| mandarin oil avana @ 0.48% Data GC Search Trop Picture | |
| mandarin oil italy @ 0.45% Data GC Search Trop Picture | |
| mandarin oil italy @ 0.50% Data GC Search Trop Picture | |
| mushroom giant puffball mushroom Search PMC Picture | |
| orange fruit Search Trop Picture | |
| petitgrain Search Trop Picture | |
| petitgrain lemon oil @ 0.25% Data GC Search Trop Picture | |
| rue Search Trop Picture | |
| yuzu leaf oil @ 45.36-58.50% Data GC Search Trop Picture | |
| zanthoxylum tingoassuiba PbMd Search Trop Picture |
Synonyms:
| 2- | amino-3-methyl-benzoic acid methyl ester |
| benzoic acid, 2-amino-3-methyl-, methyl ester | |
| di methyl anthranilate | |
| dimethyl anthranilate | |
| dimethyl anthranilate (natural) | |
| dimethyl anthranilate FCC | |
| dimethyl anthranilate natural | |
| dimethyl anthranilate, natural | |
| methyl 2-(methyl amino) benzoate | |
| methyl 2-(methylamino) benzoate | |
| methyl 2-amino-3-methylbenzenecarboxylate | |
| methyl 2-amino-3-methylbenzoate | |
| methyl 2-methylaminobenzoate | |
| methyl 3-methylanthranilate | |
| 2-( | methyl amino) benzoic acid methyl ester |
| 2- | methyl aminomethyl benzoate |
| methyl anthranilic acid methyl ester | |
| N- | methyl anthranilic acid methyl ester |
| methyl anthranylate methyl nat | |
| methyl methanthranilate | |
| methyl methyl aminobenzoate | |
| methyl methyl anthranilate | |
| methyl methylanthranilate | |
| methyl methylanthranilate egypt, natural isolated constituent | |
| methyl N-methyl anthranilate | |
| methyl N-methyl-2-aminobenzoate | |
| methyl N-methyl-ho-anthranilate | |
| methyl N-methyl-ortho-anthranilate | |
| methyl N-methylanthranilate | |
| methyl o-(methylamino) benzoate | |
| methyl o-methylaminobenzoate | |
| methyl ortho-(methyl amino) benzoate | |
| methyl ortho-methyl aminobenzoate | |
| 2-( | methylamino)benzoic acid methyl ester |