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Category:flavor and fragrance agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Appearance: | white crystalline solid (est) |
| Assay: | 96.00 to 100.00 sum of isomers
|
| Food Chemicals Codex Listed: | No |
| Melting Point: | 50.00 to 53.00 °C. @ 760.00 mm Hg
|
| Boiling Point: | 293.00 to 295.00 °C. @ 760.00 mm Hg
|
| Vapor Pressure: | 0.001000 mmHg @ 25.00 °C. (est) |
| Flash Point: | 260.00 °F. TCC ( 126.67 °C. )
|
| logP (o/w): | 3.658 (est) |
| Soluble in: |
| | alcohol | | | water, 4.081 mg/L @ 25 °C (est) |
| Insoluble in: |
| | water |
Organoleptic Properties:
Cosmetic Information:
Suppliers:
Safety Information:
| European information : |
| Most important hazard(s): | | Xi - Irritant |
R 36/37/38 - Irritating to eyes, respiratory system, and skin.
S 02 - Keep out of the reach of children.
S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S 36 - Wear suitable protective clothing.
|
| |
| Hazards identification |
| |
| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
| |
| Pictogram | |
| |
| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
|
Not determined
|
| Dermal Toxicity: |
|
Not determined
|
| Inhalation Toxicity: |
|
Not determined
|
Safety in Use Information:
| Category: | | flavor and fragrance agents |
| RIFM Fragrance Material Safety Assessment: Search |
| IFRA Code of Practice Notification of the 49th Amendment to the IFRA Code of Practice |
| Recommendation for 6-acetoxydihydrotheaspirane usage levels up to: | | | 0.1000 % in the fragrance concentrate.
|
| |
| Maximised Survey-derived Daily Intakes (MSDI-EU): | 0.12 (μg/capita/day) |
| Maximised Survey-derived Daily Intakes (MSDI-USA): | ND (μg/capita/day) |
| Modified Theoretical Added Maximum Daily Intake (mTAMDI): | 940 (μg/person/day) |
| Threshold of Concern: | 540 (μg/person/day) |
| Structure Class: | II |
| Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS). |
| The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library |
| publication number: 13 |
| Click here to view publication 13 |
| | average usual ppm | average maximum ppm |
| baked goods: | - | 0.50000 |
| beverages(nonalcoholic): | - | - |
| beverages(alcoholic): | - | - |
| breakfast cereal: | - | - |
| cheese: | - | - |
| chewing gum: | - | - |
| condiments / relishes: | - | 0.30000 |
| confectionery froastings: | - | - |
| egg products: | - | - |
| fats / oils: | - | - |
| fish products: | - | - |
| frozen dairy: | - | - |
| fruit ices: | - | - |
| gelatins / puddings: | - | - |
| granulated sugar: | - | - |
| gravies: | - | 0.20000 |
| hard candy: | - | - |
| imitation dairy: | - | - |
| instant coffee / tea: | - | 0.05000 |
| jams / jellies: | - | - |
| meat products: | - | 0.50000 |
| milk products: | - | - |
| nut products: | - | - |
| other grains: | - | - |
| poultry: | - | - |
| processed fruits: | - | - |
| processed vegetables: | - | - |
| reconstituted vegetables: | - | - |
| seasonings / flavors: | - | 0.10000 |
| snack foods: | - | 0.50000 |
| soft candy: | - | - |
| soups: | - | 0.20000 |
| sugar substitutes: | - | - |
| sweet sauces: | - | - |
| |
| Food categories according to Commission Regulation EC No. 1565/2000 (EC, 2000) in FGE.06 (EFSA, 2002a). According to the Industry the "normal" use is defined as the average of reported usages and "maximum use" is defined as the 95th percentile of reported usages (EFSA, 2002i). |
| Note: mg/kg = 0.001/1000 = 0.000001 = 1/1000000 = ppm. |
| | average usage mg/kg | maximum usage mg/kg |
| Dairy products, excluding products of category 02.0 (01.0): | 1.00000 | 8.00000 |
| Fats and oils, and fat emulsions (type water-in-oil) (02.0): | - | - |
| Edible ices, including sherbet and sorbet (03.0): | 1.00000 | 80.00000 |
| Processed fruit (04.1): | - | - |
| Processed vegetables (incl. mushrooms & fungi, roots & tubers, pulses and legumes), and nuts & seeds (04.2): | - | - |
| Confectionery (05.0): | 10.00000 | 20.00000 |
| Chewing gum (05.3): | - | - |
| Cereals and cereal products, incl. flours & starches from roots & tubers, pulses & legumes, excluding bakery (06.0): | 2.00000 | 7.00000 |
| Bakery wares (07.0): | 2.00000 | 6.00000 |
| Meat and meat products, including poultry and game (08.0): | - | - |
| Fish and fish products, including molluscs, crustaceans and echinoderms (MCE) (09.0): | - | - |
| Eggs and egg products (10.0): | - | - |
| Sweeteners, including honey (11.0): | - | - |
| Salts, spices, soups, sauces, salads, protein products, etc. (12.0): | 1.00000 | 10.00000 |
| Foodstuffs intended for particular nutritional uses (13.0): | - | - |
| Non-alcoholic ("soft") beverages, excl. dairy products (14.1): | 1.00000 | 5.00000 |
| Alcoholic beverages, incl. alcohol-free and low-alcoholic counterparts (14.2): | 2.00000 | 10.00000 |
| Ready-to-eat savouries (15.0): | 1.00000 | 5.00000 |
| Composite foods (e.g. casseroles, meat pies, mincemeat) - foods that could not be placed in categories 01.0 - 15.0 (16.0): | - | - |
Safety References:
European Food Safety Athority(EFSA):Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies...
|
European Food Safety Authority (EFSA) reference(s):
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Scientific Opinion on Flavouring Group Evaluation 90 (FGE.90): Consideration of Aliphatic, acyclic and alicyclic terpenoid tertiary alcohols and structurally related substances evaluated by JECFA (68th meeting)FGE.18Rev1 (2009)
View page or View pdf
|
Statement on List of Representative Substances for Testing.
The current Statement lays down a list of substances in sub-groups with representative substances for which additional data are required prior to their evaluation through the Procedure (Regulation (EC) No 1565/2000).
View page or View pdf
|
Scientific Opinion on Flavouring Group Evaluation 90, Revision 1 (FGE.90Rev1): consideration of six substances evaluated by JECFA (68th meeting) structurally related to aliphatic, alicyclic and aromatic saturated and unsaturated tertiary alcohols, aromatic tertiary alcohols and their esters evaluated by EFSA in FGE.18Rev1 and FGE.75Rev1
View page or View pdf
|
| EPI System: View |
| AIDS Citations:Search |
| Cancer Citations:Search |
| Toxicology Citations:Search |
| EPA Substance Registry Services (TSCA):57893-27-3 |
| EPA ACToR:Toxicology Data |
| EPA Substance Registry Services (SRS):Registry |
| Laboratory Chemical Safety Summary :93838 |
| National Institute of Allergy and Infectious Diseases:Data |
| WGK Germany:3 |
| [2a,5a(S*)]-2,6,10,10-tetramethyl-1-oxaspiro[4.5]decan-6-yl acetate |
| Chemidplus:0057893273 |
| [(2R,5S,10R)-2,6,6,10-tetramethyl-1-oxaspiro[4.5]decan-10-yl] acetate |
| Chemidplus:0057967723 |
| [(2R,5R,10R)-2,6,6,10-tetramethyl-1-oxaspiro[4.5]decan-10-yl] acetate |
| Chemidplus:0057967734 |
| [(2R,5R,10S)-2,6,6,10-tetramethyl-1-oxaspiro[4.5]decan-10-yl] acetate |
| Chemidplus:0057967745 |
| (2,6,6,10-tetramethyl-1-oxaspiro[4.5]decan-10-yl) acetate |
| Chemidplus:0072541094 |
References:
| | [2a,5a(S*)]-2,6,10,10-tetramethyl-1-oxaspiro[4.5]decan-6-yl acetate |
| NIST Chemistry WebBook: | Search Inchi |
| Canada Domestic Sub. List: | 57893-27-3 |
| Pubchem (cid): | 93838 |
| Pubchem (sid): | 135050797 |
| | [(2R,5S,10R)-2,6,6,10-tetramethyl-1-oxaspiro[4.5]decan-10-yl] acetate |
| NIST Chemistry WebBook: | Search Inchi |
| Canada Domestic Sub. List: | 57967-72-3 |
| Pubchem (cid): | 108785 |
| Pubchem (sid): | 135065556 |
| | [(2R,5R,10R)-2,6,6,10-tetramethyl-1-oxaspiro[4.5]decan-10-yl] acetate |
| NIST Chemistry WebBook: | Search Inchi |
| Canada Domestic Sub. List: | 57967-73-4 |
| Pubchem (cid): | 108786 |
| Pubchem (sid): | 135065557 |
| | [(2R,5R,10S)-2,6,6,10-tetramethyl-1-oxaspiro[4.5]decan-10-yl] acetate |
| NIST Chemistry WebBook: | Search Inchi |
| Canada Domestic Sub. List: | 57967-74-5 |
| Pubchem (cid): | 108787 |
| Pubchem (sid): | 135065558 |
| | (2,6,6,10-tetramethyl-1-oxaspiro[4.5]decan-10-yl) acetate |
| NIST Chemistry WebBook: | Search Inchi |
| Canada Domestic Sub. List: | 72541-09-4 |
| Pubchem (cid): | 93838 |
| Pubchem (sid): | 135268079 |
Other Information:
Potential Blenders and core components note
| For Odor |
| No odor group found for these |
curcuma amada roxb. rhizome oil
CS |
| aldehydic |
| aldehydic |
tridecanal
FL/FR |
2- tridecenal
FL/FR |
| balsamic |
guaiacyl phenyl acetate
FL/FR |
guaiyl acetate
FL/FR |
| caramellic |
ethyl maltol
FL/FR |
| citrus |
benzyl anthranilate
FR |
(S)-(-)- citronellal
FL/FR |
citrus unshiu peel oil
FL/FR |
dimethyl octenone
FR |
2,4- dimethyl-3-cyclohexene-1-methanyl acetate
FR |
dipentene
FL/FR |
grapefruit indene
FR |
grapefruit mercaptan
FL/FR |
grapefruit nitrile
FR |
grapefruit oil c.p. california
FL/FR |
grapefruit oil CO2 extract (citrus paradisi macf. var. falvedo)
FL/FR |
grapefruit oil terpeneless
FL/FR |
grapefruit pentanol
FR |
myrmac aldehyde
FR |
(+)- nootkatone
FL/FR |
ocimene quintoxide
FL/FR |
blood orange oil italy
FL/FR |
rhubafuran
FR |
tangerine acetate
FR |
tangerine nitrile
FR |
tangerine oil america
FL/FR |
tangerine oil terpeneless
FL/FR |
alpha- terpinyl methyl ether
FL/FR |
tetrahydromyrcenyl acetate
FR |
(±)-2,4,8- trimethyl-7-nonen-2-ol
FL/FR |
valencene
FL/FR |
verbena absolute france
FL/FR |
| floral |
cassis oxime 10%
FR |
champaca absolute
FR |
cilantro herb oil egypt
FL/FR |
dihydromyrcene
FR |
dimethyl benzyl carbinyl propionate
FR |
ethyl ethyl anthranilate
FL/FR |
gardenia amide
FR |
gardenia decalone
FR |
gardenia pentyl acetate
FR |
geranyl formate
FL/FR |
geranyl tiglate
FL/FR |
magnolia indene
FR |
alpha-iso methyl ionone (90% min.)
FL/FR |
neryl acetate
FL/FR |
peony acetonitrile
FR |
phenethyl isobutyrate
FL/FR |
2- phenyl propyl isobutyrate
FL/FR |
tea acetate
FR |
tetrahydrolinalool
FL/FR |
| fruity |
iso butyl methyl anthranilate
FL/FR |
grapefruit acetal
FR |
heptyl butyrate
FL/FR |
ocimen-1-yl acetate
FR |
osmanthus flower absolute
FL/FR |
| green |
agrumen aldehyde
FR |
cilantro leaf oil
FL/FR |
galbanum oil
FL/FR |
3,5- ivy carbaldehyde
FL/FR |
ivy carbaldehyde
FL/FR |
3,6- ivy carbaldehyde
FL/FR |
2,4- ivy carbaldehyde
FL/FR |
magnolia flower oil
FL/FR |
| herbal |
acorus calamus rhizome oil
FR |
arnica flower oil
FR |
(R)-(+)- citronellal
FL/FR |
citrus ocimenol acetate
FR |
clary sage absolute
FL/FR |
clary sage oil france
FL/FR |
eucalyptus citriodora oil
FR |
freesia heptanol
FL/FR |
geranic oxide
FL/FR |
jambu oleoresin
FL/FR |
3- octyl acetate
FL/FR |
petitgrain heptane
FR |
saffron pyranone
FR |
oswego tea specialty
FR |
| licorice |
sweet basil oleoresin
FL/FR |
| musty |
ketoiso phorone
FL/FR |
| pine |
dipentene terpene hydrocarbon byproducts
FR |
| spicy |
cubeb oil CO2 extract (piper cubeba)
FL/FR |
(-)- cubenol
FL/FR |
ginger oleoresin africa
FL/FR |
ginger root oil cochin
FL/FR |
| sulfurous |
grapefruit menthane
FL/FR |
| terpenic |
gamma- terpinene
FL/FR |
| tropical |
cis- galbanum oxathiane
FL/FR |
genet absolute
FL/FR |
| waxy |
(E)-2- tridecenal
FL/FR |
| woody |
cyperus root oil (cyperus rotundus)
FR |
alpha- farnesene
FL/FR |
(-)- guaiol
FR |
polylimonene
FL/FR |
| For Flavor |
| No flavor group found for these |
(E)-alpha- bergamotene
FL |
iso butyl methyl anthranilate
FL/FR |
(S)-(-)- citronellal
FL/FR |
(R)-(+)- citronellal
FL/FR |
citrus unshiu peel oil
FL/FR |
dihydronootkatone
FL |
dipentene
FL/FR |
ethyl ethyl anthranilate
FL/FR |
guaiyl acetate
FL/FR |
2- heptyl cyclopropane carboxylic acid
FL |
3,5- ivy carbaldehyde
FL/FR |
ivy carbaldehyde
FL/FR |
magnolia flower oil
FL/FR |
4- mercapto-4-methyl-2-pentanol
FL |
3- octyl butyrate
FL |
2- phenyl propyl isobutyrate
FL/FR |
polylimonene
FL/FR |
(E)-4- undecenal
FL |
| aldehydic |
| aldehydic |
2- tridecenal
FL/FR |
| camphoreous |
geranic oxide
FL/FR |
| caramellic |
ethyl maltol
FL/FR |
| citrus |
cilantro leaf oil
FL/FR |
freesia heptanol
FL/FR |
grapefruit mercaptan
FL/FR |
grapefruit oil c.p. california
FL/FR |
grapefruit oil CO2 extract (citrus paradisi macf. var. falvedo)
FL/FR |
grapefruit oil terpeneless
FL/FR |
(+)- nootkatone
FL/FR |
blood orange oil italy
FL/FR |
ketoiso phorone
FL/FR |
tangerine oil america
FL/FR |
tangerine oil terpeneless
FL/FR |
(±)-2,4,8- trimethyl-7-nonen-2-ol
FL/FR |
valencene
FL/FR |
verbena absolute france
FL/FR |
| coffee |
2,4- dimethyl thiazole
FL |
| cooling |
jambu oleoresin
FL/FR |
| fatty |
(E,E)-2,4- dodecadienal
FL |
| floral |
geranyl tiglate
FL/FR |
alpha-iso methyl ionone (90% min.)
FL/FR |
neryl acetate
FL/FR |
tetrahydrolinalool
FL/FR |
| fruity |
osmanthus flower absolute
FL/FR |
| green |
alpha- farnesene
FL/FR |
galbanum oil
FL/FR |
cis- galbanum oxathiane
FL/FR |
geranyl formate
FL/FR |
heptyl butyrate
FL/FR |
2,4- ivy carbaldehyde
FL/FR |
3,6- ivy carbaldehyde
FL/FR |
ocimene quintoxide
FL/FR |
3- octyl acetate
FL/FR |
| hay |
genet absolute
FL/FR |
| herbal |
cilantro herb oil egypt
FL/FR |
clary sage absolute
FL/FR |
clary sage oil france
FL/FR |
| honey |
phenethyl isobutyrate
FL/FR |
| licorice |
sweet basil oleoresin
FL/FR |
| phenolic |
guaiacyl phenyl acetate
FL/FR |
| spicy |
cubeb oil CO2 extract (piper cubeba)
FL/FR |
(-)- cubenol
FL/FR |
ginger oleoresin africa
FL/FR |
ginger root oil cochin
FL/FR |
| sulfurous |
grapefruit menthane
FL/FR |
| terpenic |
gamma- terpinene
FL/FR |
| waxy |
tridecanal
FL/FR |
(E)-2- tridecenal
FL/FR |
| woody |
alpha- terpinyl methyl ether
FL/FR |
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| 6- | dihydrotheaspirane acetate | | iso | spirene | | 1-oxa | spiro[4.5]decan-6-ol, 2,6,10,10-tetramethyl-, acetate | | 2RS,5SR,6SR-2,6,10,10- | tetramethyl-1-oxaspiro 4,5 dec-6-yl acetate | | (2,6,10,10- | tetramethyl-1-oxaspiro(4.5)dec-6-yl) acetate | | (2a,5a(S*))-2,6,10,10- | tetramethyl-1-oxaspiro(4.5)decan-6-yl acetate | | (2alpha,5alpha(S*))-2,6,10,10- | tetramethyl-1-oxaspiro(4.5)decan-6-yl acetate | | 2,6,10,10- | tetramethyl-1-oxaspiro(4.5)decan-6-yl acetate | | 2,6,10,10- | tetramethyl-1-oxaspiro[4.5]dec-6-yl acetate | | [(2R,5R,10R)-2,6,6,10- | tetramethyl-1-oxaspiro[4.5]decan-10-yl] acetate | | [(2R,5R,10S)-2,6,6,10- | tetramethyl-1-oxaspiro[4.5]decan-10-yl] acetate | | [(2R,5S,10R)-2,6,6,10- | tetramethyl-1-oxaspiro[4.5]decan-10-yl] acetate | | [2a,5a(S*)]-2,6,10,10- | tetramethyl-1-oxaspiro[4.5]decan-6-yl acetate | | 2,6,10,10- | tetramethyl-1-oxaspiro[4.5]decan-6-yl acetate |
Articles:
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