| Name: | (2E,4E)-dodeca-2,4-dienal |
| CAS Number: | 21662-16-8 |  3D/inchi
|
| ECHA EINECS - REACH Pre-Reg: | 244-517-1 |
| FDA UNII: | VO340RJ9LU |
| Nikkaji Web: | J126.514H |
| Beilstein Number: | 1776172 |
| CoE Number: | 11758 |
| XlogP3-AA: | 4.30 (est) |
| Molecular Weight: | 180.29060000 |
| Formula: | C12 H20 O |
| NMR Predictor: | Predict (works with chrome, Edge or firefox) |
| Also(can) Contains: | (E,Z)-2,4-dodecadienal |
| EFSA/JECFA Comments: |
| At least 85%; secondary component 11-12% 2-trans-4-cis isomer. (EFSA)
The chemical name in the UL should be changed to Dodeca-(2E,4E)-dienal, in accordance with the CAS nr and the most recent speci?cations on stereoisomeric composition (Documentation provided to EFSA nr.10) |
Category:flavoring agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Appearance: | pale yellow to yellow clear liquid (est) |
| Assay: | 97.00 to 100.00 sum of isomers
|
| Food Chemicals Codex Listed: | No |
| Specific Gravity: | 0.98300 to 0.98900 @ 25.00 °C.
|
| Pounds per Gallon - (est).: | 8.180 to 8.229
|
| Refractive Index: | 1.47000 to 1.47600 @ 20.00 °C.
|
| Boiling Point: | 130.00 °C. @ 6.00 mm Hg
|
| Acid Value: | 3.00 max. KOH/g
|
| Vapor Pressure: | 0.005000 mmHg @ 25.00 °C. (est) |
| Flash Point: | 220.00 °F. TCC ( 104.44 °C. )
|
| logP (o/w): | 4.438 (est) |
| Soluble in: |
| | alcohol | | | water, 11.33 mg/L @ 25 °C (est) |
| Insoluble in: |
| | water |
Organoleptic Properties:
| Odor Type: fatty |
| Odor Strength:medium |
| Substantivity: > 168 hour(s) at 100.00 % |
| grapefruit orange fatty citrus |
| Odor Description:at 100.00 %. grapefruit orange fatty citrus |
| Flavor Type: fatty |
| fatty waxy citrus peel chicken |
| Taste Description: fatty waxy citrus peel chicken skin |
| Odor and/or flavor descriptions from others (if found). |
| Bedoukian Research |
| 2,4-DODECADIEN-1-AL ≥90.0% (trans,trans), Kosher |
| Odor Description:An oily, fatty, dairy odor with a hint of citrus |
Taste Description:Fatty, waxy, citrus peel, with slight chicken skin notes
Peel notes of most citrus flavors, specifically orange and grapefruit. |
| Alfrebro |
| 2,4-DODECADIENAL NATURAL 10% IN MCTG |
| Odor Description:Powerful, Vegetable |
Cosmetic Information:
Suppliers:
| Alfrebro |
| 2,4-DODECADIENAL NATURAL 10% IN ETHYL ACETATE
Odor: Powerful, Vegetable |
| Alfrebro |
| 2,4-DODECADIENAL NATURAL 10% IN MCTG
Odor: Powerful, Vegetable |
| Bedoukian Research |
| 2,4-DODECADIEN-1-AL
≥90.0% (trans,trans), Kosher Odor: An oily, fatty, dairy odor with a hint of citrus Flavor: Fatty, waxy, citrus peel, with slight chicken skin notes Peel notes of most citrus flavors, specifically orange and grapefruit. |
| BOC Sciences |
| For experimental / research use only. |
| 2,4-DODECADIEN-1-AL 97.0% (sum of isomers)
|
| Parchem |
| (E,E)-2,4-dodecadien-1-al
|
| Penta International |
| TRANS-2-TRANS-4-DODECADIENAL
|
Safety Information:
| Preferred SDS: View |
| European information : |
| Most important hazard(s): | | Xi - Irritant |
R 38 - Irritating to skin.
S 02 - Keep out of the reach of children.
S 24 - Avoid contact with skin.
S 36 - Wear suitable protective clothing.
|
| |
| Hazards identification |
| |
| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
| |
| Pictogram | |
| |
| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
|
Not determined
|
| Dermal Toxicity: |
|
Not determined
|
| Inhalation Toxicity: |
|
Not determined
|
Safety in Use Information:
| Category: | | flavoring agents |
| IFRA Critical Effect: | | Insufficient data |
| | View the IFRA Standard |
| Recommendation for (E,E)-2,4-dodecadienal usage levels up to: | | | PROHIBITED: Should not be used as a fragrance ingredient.
|
| |
| Maximised Survey-derived Daily Intakes (MSDI-EU): | 0.095 (μg/capita/day) |
| Maximised Survey-derived Daily Intakes (MSDI-USA): | 0.10 (μg/capita/day) |
| Modified Theoretical Added Maximum Daily Intake (mTAMDI): | 82 (μg/person/day) |
| Threshold of Concern: | 1800 (μg/person/day) |
| Structure Class: | I |
| Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS). |
| The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library |
| publication number: 13 |
| Click here to view publication 13 |
| | average usual ppm | average maximum ppm |
| baked goods: | - | 1.00000 |
| beverages(nonalcoholic): | - | - |
| beverages(alcoholic): | - | - |
| breakfast cereal: | - | - |
| cheese: | - | - |
| chewing gum: | - | - |
| condiments / relishes: | - | 0.50000 |
| confectionery froastings: | - | - |
| egg products: | - | - |
| fats / oils: | - | - |
| fish products: | - | - |
| frozen dairy: | - | - |
| fruit ices: | - | - |
| gelatins / puddings: | - | - |
| granulated sugar: | - | - |
| gravies: | - | 0.50000 |
| hard candy: | - | - |
| imitation dairy: | - | - |
| instant coffee / tea: | - | - |
| jams / jellies: | - | - |
| meat products: | - | 0.50000 |
| milk products: | - | - |
| nut products: | - | - |
| other grains: | - | - |
| poultry: | - | - |
| processed fruits: | - | - |
| processed vegetables: | - | - |
| reconstituted vegetables: | - | - |
| seasonings / flavors: | - | - |
| snack foods: | - | 0.50000 |
| soft candy: | - | - |
| soups: | - | 0.50000 |
| sugar substitutes: | - | - |
| sweet sauces: | - | - |
| |
| Food categories according to Commission Regulation EC No. 1565/2000 (EC, 2000) in FGE.06 (EFSA, 2002a). According to the Industry the "normal" use is defined as the average of reported usages and "maximum use" is defined as the 95th percentile of reported usages (EFSA, 2002i). |
| Note: mg/kg = 0.001/1000 = 0.000001 = 1/1000000 = ppm. |
| | average usage mg/kg | maximum usage mg/kg |
| Dairy products, excluding products of category 02.0 (01.0): | 0.01000 | 1.00000 |
| Fats and oils, and fat emulsions (type water-in-oil) (02.0): | 0.50000 | 5.00000 |
| Edible ices, including sherbet and sorbet (03.0): | 0.01000 | 1.00000 |
| Processed fruit (04.1): | - | - |
| Processed vegetables (incl. mushrooms & fungi, roots & tubers, pulses and legumes), and nuts & seeds (04.2): | 0.01000 | 1.00000 |
| Confectionery (05.0): | 0.05000 | 1.00000 |
| Chewing gum (05.3): | - | - |
| Cereals and cereal products, incl. flours & starches from roots & tubers, pulses & legumes, excluding bakery (06.0): | 0.05000 | 1.00000 |
| Bakery wares (07.0): | 0.50000 | 3.00000 |
| Meat and meat products, including poultry and game (08.0): | 0.50000 | 3.00000 |
| Fish and fish products, including molluscs, crustaceans and echinoderms (MCE) (09.0): | 0.50000 | 3.00000 |
| Eggs and egg products (10.0): | 0.01000 | 1.00000 |
| Sweeteners, including honey (11.0): | 1.00000 | - |
| Salts, spices, soups, sauces, salads, protein products, etc. (12.0): | 0.05000 | 1.00000 |
| Foodstuffs intended for particular nutritional uses (13.0): | - | - |
| Non-alcoholic ("soft") beverages, excl. dairy products (14.1): | 0.01000 | 1.00000 |
| Alcoholic beverages, incl. alcohol-free and low-alcoholic counterparts (14.2): | 0.01000 | 1.00000 |
| Ready-to-eat savouries (15.0): | 0.50000 | 3.00000 |
| Composite foods (e.g. casseroles, meat pies, mincemeat) - foods that could not be placed in categories 01.0 - 15.0 (16.0): | 0.01000 | 1.00000 |
Safety References:
European Food Safety Athority(EFSA):Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies...
|
European Food Safety Authority (EFSA) reference(s):
|
Flavouring Group Evaluation 203: alpha,beta-Unsaturated aliphatic aldehydes and precursors from chemical subgroup 1.1.4 of FGE.19 with two or more conjugated double bonds and with or without additional non-conjugated double bonds
View page or View pdf
|
Scientific Opinion on Flavouring Group Evaluation 203, Revision 1 (FGE.203Rev1): a,ß-Unsaturated aliphatic aldehydes and precursors from chemical subgroup 1.1.4 of FGE.19 with two or more conjugated double-bonds and with or without additional non-conjugated double-bonds
View page or View pdf
|
Scientific Opinion on Flavouring Group Evaluation 203, Revision 2 (FGE.203Rev2): a,ß-unsaturated aliphatic aldehydes and precursors from chemical subgroup 1.1.4 of FGE.19 with two or more conjugated double-bonds and with or without additional non-conjugated double-bonds
View page or View pdf
|
Scientific Opinion on Flavouring Group Evaluation 70, Revision 1 (FGE.70Rev1): consideration of aliphatic, linear, a,ß-unsaturated, di- and trienals and related alcohols, acids and esters evaluated by JECFA (61st-68th-69th meeting)
View page or View pdf
|
| EPI System: View |
| AIDS Citations:Search |
| Cancer Citations:Search |
| Toxicology Citations:Search |
| EPA Substance Registry Services (TSCA):21662-16-8 |
| EPA ACToR:Toxicology Data |
| EPA Substance Registry Services (SRS):Registry |
| Laboratory Chemical Safety Summary :5367530 |
| National Institute of Allergy and Infectious Diseases:Data |
| WGK Germany:2 |
| (2E,4E)-dodeca-2,4-dienal |
| Chemidplus:0021662168 |
References:
Other Information:
Potential Blenders and core components note
| For Odor |
| aldehydic |
acetyl nonyryl
FL/FR |
decanal (aldehyde C-10)
FL/FR |
dodecanal (aldehyde C-12 lauric)
FL/FR |
2- methyl undecanal (aldehyde C-12 mna)
FL/FR |
tridecanal
FL/FR |
| buttery |
butyl butyryl lactate
FL/FR |
| citrus |
benzyl anthranilate
FR |
4- decenal
FL/FR |
(E)-4- decenal
FL/FR |
dimethyl octenone
FR |
2,4- dimethyl-3-cyclohexene-1-methanyl acetate
FR |
grapefruit indene
FR |
grapefruit mercaptan
FL/FR |
grapefruit nitrile
FR |
grapefruit oil c.p. california
FL/FR |
grapefruit oil CO2 extract (citrus paradisi macf. var. falvedo)
FL/FR |
grapefruit oil terpeneless
FL/FR |
grapefruit pentanol
FR |
myrmac aldehyde
FR |
(+)- nootkatone
FL/FR |
rhubafuran
FR |
alpha- terpinyl methyl ether
FL/FR |
(±)-2,4,8- trimethyl-7-nonen-2-ol
FL/FR |
valencene
FL/FR |
| coconut |
gamma- nonalactone (aldehyde C-18 (so-called))
FL/FR |
delta- undecalactone
FL/FR |
| fatty |
(Z)- dairy lactone
FL/FR |
decanoic acid
FL/FR |
(E)-2- decenal
FL/FR |
ethyl undecylenate
FL/FR |
delta- juniper lactone
FL/FR |
4- methyl octanoic acid
FL/FR |
| floral |
cassis oxime 10%
FR |
para- cresyl laurate
FL/FR |
3- decanol
FL/FR |
2- decanone
FL/FR |
dimethyl octanol
FL/FR |
gardenia amide
FR |
gardenia decalone
FR |
gardenia pentyl acetate
FR |
jasmin pyranone
FL/FR |
magnolia indene
FR |
neryl acetate
FL/FR |
nonanol
FL/FR |
peony acetonitrile
FR |
phenethyl anthranilate
FL/FR |
| fresh |
10- undecen-1-yl acetate
FL/FR |
| fruity |
iso butyl methyl anthranilate
FL/FR |
decyl butyrate
FL/FR |
grapefruit acetal
FR |
octyl formate
FL/FR |
2- undecenal
FL/FR |
| green |
cilantro leaf oil
FL/FR |
ethyl (E)-4-decenoate
FL/FR |
heptanal dimethyl acetal
FL/FR |
heptyl formate
FL/FR |
(Z)-3- hexen-1-yl propionate
FL/FR |
(E)-2- octen-1-ol
FL/FR |
| herbal |
6- acetoxydihydrotheaspirane
FL/FR |
2- dodecenal
FL/FR |
linalyl acetate
FL/FR |
3- octyl acetate
FL/FR |
| musk |
iso ambrettolide
FL/FR |
| oily |
butter acids
FL/FR |
| sulfurous |
grapefruit menthane
FL/FR |
| waxy |
iso amyl decanoate
FL/FR |
heptyl octanoate
FL/FR |
methyl octanoate
FL/FR |
myristic acid
FL/FR |
nonanoic acid
FL/FR |
(E)-2- tridecenal
FL/FR |
| For Flavor |
| No flavor group found for these |
6- acetoxydihydrotheaspirane
FL/FR |
iso butyl methyl anthranilate
FL/FR |
3- decanol
FL/FR |
4- decenal
FL/FR |
dihydronootkatone
FL |
11- dodecenoic acid
FL |
4- mercapto-4-methyl-2-pentanol
FL |
| aldehydic |
| aldehydic |
acetyl nonyryl
FL/FR |
| bitter |
glyceryl tributyrate
FL |
| citrus |
cilantro leaf oil
FL/FR |
grapefruit mercaptan
FL/FR |
grapefruit oil c.p. california
FL/FR |
grapefruit oil CO2 extract (citrus paradisi macf. var. falvedo)
FL/FR |
grapefruit oil terpeneless
FL/FR |
(+)- nootkatone
FL/FR |
(±)-2,4,8- trimethyl-7-nonen-2-ol
FL/FR |
valencene
FL/FR |
| coconut |
gamma- nonalactone (aldehyde C-18 (so-called))
FL/FR |
| creamy |
butyl butyryl lactate
FL/FR |
jasmin pyranone
FL/FR |
delta- undecalactone
FL/FR |
| fatty |
butter acids
FL/FR |
(Z)- dairy lactone
FL/FR |
dimethyl octanol
FL/FR |
2- dodecenal
FL/FR |
ethyl (E)-4-decenoate
FL/FR |
ethyl undecylenate
FL/FR |
heptyl formate
FL/FR |
delta- juniper lactone
FL/FR |
4- methyl octanoic acid
FL/FR |
2,4- nonadienal
FL |
(E,E)-2,4- nonadienal
FL |
nonanoic acid
FL/FR |
(E)-2- octen-1-ol
FL/FR |
(E,E)-2,4- undecadienal
FL |
| fermented |
2- decanone
FL/FR |
| floral |
linalyl acetate
FL/FR |
neryl acetate
FL/FR |
phenethyl anthranilate
FL/FR |
| fruity |
decyl butyrate
FL/FR |
| greasy |
10- undecen-1-yl acetate
FL/FR |
| green |
(E)-4- decenal
FL/FR |
heptanal dimethyl acetal
FL/FR |
(Z)-3- hexen-1-yl propionate
FL/FR |
methyl octanoate
FL/FR |
3- octyl acetate
FL/FR |
octyl formate
FL/FR |
| musk |
iso ambrettolide
FL/FR |
| soapy |
decanoic acid
FL/FR |
dodecanal (aldehyde C-12 lauric)
FL/FR |
| sulfurous |
grapefruit menthane
FL/FR |
| waxy |
iso amyl decanoate
FL/FR |
para- cresyl laurate
FL/FR |
decanal (aldehyde C-10)
FL/FR |
(E)-2- decenal
FL/FR |
heptyl octanoate
FL/FR |
2- methyl undecanal (aldehyde C-12 mna)
FL/FR |
myristic acid
FL/FR |
nonanol
FL/FR |
octyl 2-furoate
FL |
tridecanal
FL/FR |
(E)-2- tridecenal
FL/FR |
2- undecenal
FL/FR |
| woody |
alpha- terpinyl methyl ether
FL/FR |
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| (2E,4E)- | dodeca-2,4-dienal | | (2trans,4trans)- | dodeca-2,4-dienal | | (E,E)- | dodeca-2,4-dienal | | (E,E)-2,4- | dodecadien-1-al | | (E)-2,(E)-4- | dodecadien-1-al | | trans-2,trans-4- | dodecadien-1-al | | trans,trans-2,4- | dodecadien-1-al | | (2E,4E)-2,4- | dodecadienal | | (5E,7E)- | dodecadienal | | (6E,8E)- | dodecadienal | | (7E,9E)- | dodecadienal | | (trans,trans)-2,4- | dodecadienal | | trans-2-trans-4- | dodecadienal | | trans,trans-2,4- | dodecadienal | | 2,4- | dodecadienal, (2E,4E)- | | 2,4- | dodecadienal, (E,E)- | | 2,4- | dodecadienal, trans,trans- |
Articles:
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