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11-dodecenoic acid
11-lauroleic acid

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CODE158743 CODE158743
Product(s):
65423-25-8 11-Dodecenoic Acid

Chemical sources Association Inc

Exchange of knowledge

Need This Item for Flavor? You can contact the Chemical Sources Association.

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CODE158743 CODE158743

Product(s):

CAS Number:	65423-25-8	3D/inchi
FDA UNII:	49K7IVS77N
Nikkaji Web:	J98.081A
XlogP3:	4.40 (est)
Molecular Weight:	198.30574000
Formula:	C12 H22 O2
NMR Predictor:	Predict (works with chrome, Edge or firefox)

Category:flavoring agents

US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:

Google Scholar:	Search
Google Books:	Search
Google Scholar: with word "volatile"	Search
Google Scholar: with word "flavor"	Search
Google Scholar: with word "odor"	Search
Perfumer and Flavorist:	Search
Google Patents:	Search
US Patents:	Search
EU Patents:	Search
Pubchem Patents:	Search
PubMed:	Search
NCBI:	Search
JECFA Food Flavoring:	1635 11-dodecenoic acid
FEMA Number:	4355 dodec-11-enoic acid
FDA:	No longer provide for the use of these seven synthetic flavoring substances
FDA Mainterm (SATF):	65423-25-8 ; 11-DODECENOIC ACID

Physical Properties:

Appearance:	colorless clear liquid (est)
Assay:	95.00 to 100.00
Food Chemicals Codex Listed:	No
Specific Gravity:	0.89000 to 0.89700 @ 25.00 °C.
Pounds per Gallon - (est).:	7.406 to 7.464
Refractive Index:	1.44700 to 1.45700 @ 20.00 °C.
Melting Point:	20.00 °C. @ 760.00 mm Hg
Boiling Point:	303.19 °C. @ 760.00 mm Hg (est)
Vapor Pressure:	0.000210 mmHg @ 25.00 °C. (est)
Flash Point:	392.00 °F. TCC ( 200.00 °C. )
logP (o/w):	4.365 (est)
Soluble in:
	alcohol
	water, 7.817 mg/L @ 25 °C (est)
Insoluble in:
	water

Organoleptic Properties:

Odor Type: fatty

fatty citrus aldehydic

Odor Description:at 10.00 % in dipropylene glycol. fatty citrus aldehydic

Odor and/or flavor descriptions from others (if found).

Cosmetic Information:

None found

Suppliers:

For experimental / research use only.

11-Dodecenoic acid

For experimental / research use only.

11-Dodecenoic Acid

11-dodecenoic acid

Chemical Sources Association

Need This Item for Flavor/Food?: You can contact the Chemical Sources Association

Safety Information:


Hazards identification

Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements

Pictogram

Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined

Safety in Use Information:

Category:
flavoring agents
Recommendation for 11-dodecenoic acid usage levels up to:
	not for fragrance use.

Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 23
Click here to view publication 23
		average usual ppm	average maximum ppm
baked goods:		0.20000	9.00000
beverages(nonalcoholic):		-	-
beverages(alcoholic):		-	-
breakfast cereal:		-	-
cheese:		-	-
chewing gum:		-	-
condiments / relishes:		-	-
confectionery froastings:		-	-
egg products:		-	-
fats / oils:		-	-
fish products:		-	-
frozen dairy:		-	-
fruit ices:		-	-
gelatins / puddings:		-	-
granulated sugar:		-	-
gravies:		-	-
hard candy:		-	-
imitation dairy:		-	-
instant coffee / tea:		-	-
jams / jellies:		-	-
meat products:		-	-
milk products:		0.01000	0.20000
nut products:		-	-
other grains:		-	-
poultry:		-	-
processed fruits:		-	-
processed vegetables:		-	-
reconstituted vegetables:		-	-
seasonings / flavors:		-	-
snack foods:		-	-
soft candy:		-	-
soups:		-	-
sugar substitutes:		-	-
sweet sauces:		-	-

Safety References:

EPI System: View

AIDS Citations:Search

Cancer Citations:Search

Toxicology Citations:Search

EPA ACToR:Toxicology Data

EPA Substance Registry Services (SRS):Registry

Laboratory Chemical Safety Summary :125207

National Institute of Allergy and Infectious Diseases:Data

dodec-11-enoic acid

Chemidplus:0065423258

References:

	dodec-11-enoic acid
NIST Chemistry WebBook:	Search Inchi
Canada Domestic Sub. List:	65423-25-8
Pubchem (cid):	125207
Pubchem (sid):	135081218

Other Information:

(IUPAC):	Atomic Weights of the Elements 2011 (pdf)
Videos:	The Periodic Table of Videos
tgsc:	Atomic Weights use for this web site
(IUPAC):	Periodic Table of the Elements
FDA Substances Added to Food (formerly EAFUS):	View
CHEBI:	View
HMDB (The Human Metabolome Database):	HMDB32248
FooDB:	FDB009340
VCF-Online:	VCF Volatile Compounds in Food
ChemSpider:	View

Potential Blenders and core components note

For Odor

aldehydic

citronellyl oxyacetaldehyde
FL/FR

dodecanal (aldehyde C-12 lauric)
FL/FR

(Z)-4-

dodecenal
FL/FR

green hexanal
FL/FR

citrus

citrus limon peel oil expressed
FL/FR

citrus paradisi peel extract
FL/FR

(E)-4-

4-

(Z)-4-

lemon oil c.p. california
FL/FR

lemon oil c.p. furocoumarin reduced
FL/FR

lemon specialty
FL/FR

orange fruit oil
FL/FR

blood

orange oil italy
FL/FR

(E)-2-

tetradecenal
FL/FR

tetrahydrocitral
FL/FR

fatty

decanoic acid
FL/FR

2-

decen-1-ol
FL/FR

(E)-2-

decen-1-ol
FL/FR

(E)-2-

floral

citronellal
FL/FR

fruity

decanal methyl enol ether
FL/FR

(E)-2-

undecenal
FL/FR

green

octanal diethyl acetal
FL/FR

waxy

myristic acid
FL/FR

For Flavor

No flavor group found for these

(E)-2-

decen-1-ol
FL/FR

4-

(Z)-4-

dodecenal
FL/FR

2,3-

epoxydecanal
FL

2,3-

epoxyheptanal
FL

2,3-

epoxyoctanal
FL

lemon specialty
FL/FR

tetrahydrocitral
FL/FR

decanal methyl enol ether
FL/FR

citrus

citrus

citronellyl oxyacetaldehyde
FL/FR

citrus limon peel oil expressed
FL/FR

citrus paradisi peel extract
FL/FR

(Z)-4-

lemon oil c.p. california
FL/FR

lemon oil c.p. furocoumarin reduced
FL/FR

orange fruit oil
FL/FR

blood

orange oil italy
FL/FR

fatty

2,4-

(E,E)-2,4-

dodecadienal
FL

floral

citronellal
FL/FR

green

(E)-4-

(E,E)-2,4-

(E)-2-

octanal diethyl acetal
FL/FR

herbal

green hexanal
FL/FR

soapy

decanoic acid
FL/FR

dodecanal (aldehyde C-12 lauric)
FL/FR

waxy

2-

decen-1-ol
FL/FR

myristic acid
FL/FR

(E)-2-

tetradecenal
FL/FR

(E)-2-

undecenal
FL/FR

Potential Uses:

FL	citrus
FL	fat
FL	meat

Occurrence (nature, food, other):note

	litsea lii var. nunkao-tahangensis Search Trop Picture
	macadamia oil Search Trop Picture
	persea bombycina (king ex hook. f.) kost Search Trop Picture
	persea duthiei Search Trop Picture

Synonyms:

	dodec-11-enoic acid
11-	lauroleic acid

Articles:

PubMed:Cytochrome P450-dependent desaturation of lauric acid: isoform selectivity and mechanism of formation of 11-dodecenoic acid.

PubMed:Effects of steric bulk and conformational rigidity on fatty acid omega hydroxylation by a cytochrome P450 4A1 fusion protein.

PubMed:In vitro hydroxylation and epoxidation of some isomeric lauric acid analogs by rat liver microsomes. Identification of metabolites and effects of clofibrate or phenobarbital pretreatment.

PubMed:Active site structure and substrate specificity of cytochrome P450 4A1: steric control of ligand approach perpendicular to heme plane.

PubMed:Fate of a terminal olefin with Drosophila microsomes and its inhibitory effects on some P-450 dependent activities.

PubMed:Cytochrome p-450-dependent hydroxylation of lauric Acid at the subterminal position and oxidation of unsaturated analogs in wheat microsomes.

PubMed:Regioselectivity of a plant lauric acid omega hydroxylase. Omega hydroxylation of cis and trans unsaturated lauric acid analogs and epoxygenation of the terminal olefin by plant cytochrome P-450.

PubMed:The catalytic site of rat hepatic lauric acid omega-hydroxylase. Protein versus prosthetic heme alkylation in the omega-hydroxylation of acetylenic fatty acids.

PubMed:Differential inactivation of plant lauric acid omega- and in-chain-hydroxylases by terminally unsaturated fatty acids.

PubMed:Autocatalytic inactivation of plant cytochrome P-450 enzymes: selective inactivation of the lauric acid in-chain hydroxylase from Helianthus tuberosus L. by unsaturated substrate analogs.

PubMed:Specific inactivation of hepatic fatty acid hydroxylases by acetylenic fatty acids.

Notes:

Used as a food additive [EAFUS]

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