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Category:flavoring agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00
|
| Food Chemicals Codex Listed: | No |
| Melting Point: | 33.00 °C. @ 760.00 mm Hg
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| Boiling Point: | 225.00 to 227.00 °C. @ 760.00 mm Hg (est)
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| Boiling Point: | 280.00 °C. @ 760.00 mm Hg
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| Vapor Pressure: | 0.069000 mmHg @ 25.00 °C. (est) |
| Flash Point: | 204.00 °F. TCC ( 95.40 °C. ) (est)
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| logP (o/w): | 0.447 (est) |
| Soluble in: |
| | alcohol | | | water, 6.241e+004 mg/L @ 25 °C (est) |
| Insoluble in: |
| | water |
| Similar Items:note |
| 2-acetyl-3-methyl pyrazine |
| 2-acetyl-5-methyl pyrazine |
Organoleptic Properties:
Cosmetic Information:
Suppliers:
Safety Information:
| |
| Hazards identification |
| |
| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
| |
| Pictogram | |
| |
| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
|
Not determined
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
|
Not determined
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Safety in Use Information:
| Category: | | flavoring agents |
| Recommendation for 2-acetyl-6-methyl pyrazine usage levels up to: | | | not for fragrance use.
|
| |
| Maximised Survey-derived Daily Intakes (MSDI-EU): | 0.028 (μg/capita/day) |
| Modified Theoretical Added Maximum Daily Intake (mTAMDI): | 270 (μg/person/day) |
| Threshold of Concern: | 540 (μg/person/day) |
| Structure Class: | II |
| |
| Food categories according to Commission Regulation EC No. 1565/2000 (EC, 2000) in FGE.06 (EFSA, 2002a). According to the Industry the "normal" use is defined as the average of reported usages and "maximum use" is defined as the 95th percentile of reported usages (EFSA, 2002i). |
| Note: mg/kg = 0.001/1000 = 0.000001 = 1/1000000 = ppm. |
| | average usage mg/kg | maximum usage mg/kg |
| Dairy products, excluding products of category 02.0 (01.0): | 0.40000 | 2.00000 |
| Fats and oils, and fat emulsions (type water-in-oil) (02.0): | 0.10000 | 0.50000 |
| Edible ices, including sherbet and sorbet (03.0): | 0.40000 | 2.00000 |
| Processed fruit (04.1): | 0.40000 | 2.00000 |
| Processed vegetables (incl. mushrooms & fungi, roots & tubers, pulses and legumes), and nuts & seeds (04.2): | - | - |
| Confectionery (05.0): | 1.00000 | 5.00000 |
| Chewing gum (05.3): | - | - |
| Cereals and cereal products, incl. flours & starches from roots & tubers, pulses & legumes, excluding bakery (06.0): | 0.20000 | 1.00000 |
| Bakery wares (07.0): | 1.00000 | 5.00000 |
| Meat and meat products, including poultry and game (08.0): | 0.10000 | 0.40000 |
| Fish and fish products, including molluscs, crustaceans and echinoderms (MCE) (09.0): | 0.10000 | 0.40000 |
| Eggs and egg products (10.0): | - | - |
| Sweeteners, including honey (11.0): | - | - |
| Salts, spices, soups, sauces, salads, protein products, etc. (12.0): | 0.10000 | 0.50000 |
| Foodstuffs intended for particular nutritional uses (13.0): | 0.20000 | 1.00000 |
| Non-alcoholic ("soft") beverages, excl. dairy products (14.1): | 0.20000 | 1.00000 |
| Alcoholic beverages, incl. alcohol-free and low-alcoholic counterparts (14.2): | 1.00000 | 5.00000 |
| Ready-to-eat savouries (15.0): | 1.00000 | 5.00000 |
| Composite foods (e.g. casseroles, meat pies, mincemeat) - foods that could not be placed in categories 01.0 - 15.0 (16.0): | 0.20000 | 1.00000 |
Safety References:
European Food Safety Athority(EFSA):Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies...
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European Food Safety Authority (EFSA) reference(s):
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Opinion of the Scientific Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) on a request from the Commission related to Flavouring Group Evaluation 17 (FGE.17): Pyrazine derivatives from chemical group 24 (Commission Regulation (EC) No 1565/2000 of 18 July 2000)
View page or View pdf
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Flavouring Group Evaluation 50 (FGE.50): Consideration of pyrazine derivatives evaluated by JECFA (57th meeting) structurally related to pyrazine derivatives evaluated by EFSA in FGE.17 (2005) (Commission Regulation (EC) No 1565/2000 of 18 July 2000) - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC)
View page or View pdf
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Flavouring Group Evaluation 17, Revision 1 (FGE.17Rev1): Pyrazine derivatives from chemical group 24 - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC) [1]
View page or View pdf
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Scientific Opinion on Flavouring Group Evaluation 17, Revision 2 (FGE.17Rev2): Pyrazine derivatives from chemical group 24
View page or View pdf
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Scientific Opinion on Flavouring Group Evaluation 50, Revision 1 (FGE.50Rev1): Consideration of pyrazine derivatives evaluated by JECFA (57th meeting) structurally related to pyrazine derivatives evaluated by EFSA in FGE.17Rev2 (2010)
View page or View pdf
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Scientific Opinion on Flavouring Group Evaluation 17, Revision 3 (FGE.17Rev3): Pyrazine derivatives from chemical group 24
View page or View pdf
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| EPI System: View |
| AIDS Citations:Search |
| Cancer Citations:Search |
| Toxicology Citations:Search |
| EPA ACToR:Toxicology Data |
| EPA Substance Registry Services (SRS):Registry |
| Laboratory Chemical Safety Summary :527821 |
| National Institute of Allergy and Infectious Diseases:Data |
| 1-(6-methylpyrazin-2-yl)ethanone |
References:
Other Information:
Potential Blenders and core components note
| For Odor |
| No odor group found for these |
sulfuryl octanoate
FL/FR |
|
sulfuryl butyrate
FL/FR |
sulfuryl decanoate
FL/FR |
sulfuryl hexanoate
FL/FR |
sulfuryl isobutyrate
FL/FR |
sulfuryl propionate
FL/FR |
| alliaceous |
| alliaceous |
methyl furfuryl disulfide
FL/FR |
| balsamic |
2- acetyl furan
FL/FR |
| caramellic |
caramel furanone solution
FL/FR |
coffee dione
FL/FR |
cyclotene
FL/FR |
fenugreek oleoresin
FL/FR |
5- methyl furfural
FL/FR |
| chocolate |
cocoa oleoresin
FL/FR |
2,5- dimethyl pyrazine
FL/FR |
2,6- dimethyl pyrazine
FL/FR |
2,4,5- trimethyl thiazole
FL/FR |
| cocoa |
2- methyl butyraldehyde
FL/FR |
| coffee |
cichorium intybus root extract
FL/FR |
cichorium intybus root solid extract
FL/FR |
coffea arabica seed extract
FL/FR |
roasted coffea arabica seed extract
FL/FR |
coffea arabica seed oil
FL/FR |
coffee absolute
FL/FR |
arabica coffee bean butter
FL/FR |
roasted arabica coffee bean essence
FL/FR |
roasted coffee bean extract
FL/FR |
roasted arabica coffee bean oil
FL/FR |
roasted arabica coffee bean oil CO2 extract
FL/FR |
coffee bean oil extract
FL/FR |
coffee difuran
FL/FR |
coffee resinoid
FL/FR |
furfuryl mercaptan
FL/FR |
1- hydroxy-2-butanone
FL/FR |
2- methyl-3-,5 or 6-(furfuryl thio) pyrazine
FL/FR |
| corn chip |
popcorn pyrimidine
FL/FR |
| earthy |
nutty pyrazine
FL/FR |
| fruity |
tropical thiazole
FL/FR |
| green |
2- heptyl furan
FL/FR |
| herbal |
wormwood oil america
FL/FR |
wormwood oil italy
FL/FR |
wormwood oil poland
FL/FR |
| medicinal |
2,6- xylenol
FL/FR |
| moldy |
strawberry furanone methyl ether
FL/FR |
| musty |
menthofuran
FL/FR |
| nutty |
3- acetyl pyridine
FL/FR |
2- acetyl-3-ethyl pyrazine
FL/FR |
2- acetyl-3-methyl pyrazine
FL/FR |
2- acetyl-3,5(or 6)-dimethyl pyrazine
FL/FR |
3,5- cocoa pyrazine
FL/FR |
3,6- cocoa pyrazine
FL/FR |
2,3- dimethyl pyrazine
FL/FR |
4,5- dimethyl-2-ethyl-3-thiazoline
FL/FR |
2- ethyl pyrazine
FL/FR |
2- ethyl-4-methyl thiazole
FL/FR |
filbert heptenone
FL/FR |
filbert heptenone B
FL/FR |
filbert pyrazine
FL/FR |
5- methyl quinoxaline
FL/FR |
nutty quinoxaline
FL/FR |
sesame absolute
FL/FR |
sesame absolute CO2 extract
FL/FR |
2,3,5,6- tetramethyl pyrazine
FL/FR |
| phenolic |
para-alpha- dimethyl styrene
FL/FR |
| popcorn |
2- acetyl pyrazine
FL/FR |
2- acetyl pyridine
FL/FR |
2- acetyl thiazole
FL/FR |
| roasted |
fenugreek resinoid
FL/FR |
trigonella foenum-graecum seed oil CO2 extract
FL/FR |
| sulfurous |
benzothiazole
FL/FR |
dimethyl sulfide
FL/FR |
furfuryl thioacetate
FL/FR |
S- furfuryl thioformate
FL/FR |
2- methyl 5-(methyl thio) furan
FL/FR |
3- thiohexanol
FL/FR |
| sweet |
2- hydroxy-3,4,5-trimethyl-2-cyclopenten-1-one
FL/FR |
| vegetable |
1- furfuryl pyrrole
FL/FR |
| woody |
juniper berry oleoresin
FL/FR |
| For Flavor |
| No flavor group found for these |
6,7- dihydro-2,3-dimethyl-5H-cyclopentapyrazine
FL |
dimethyl dihydrocyclopentapyrazine
FL |
2,5- dimethyl thiazole
FL |
2,5- dimethyl-3-thiofuroyl furan
FL |
ethyl dimethyl pyrazine
FL |
2- formyl pyrrole
FL |
2- hydroxy-3,4,5-trimethyl-2-cyclopenten-1-one
FL/FR |
3- mercapto-3-methyl butyl formate
FL |
methyl 2-(methyl thio) acetate
FL |
2- methyl-3-,5 or 6-(furfuryl thio) pyrazine
FL/FR |
2- propionyl pyrrole
FL |
pyrazines mixture
FL |
sulfuryl butyrate
FL/FR |
sulfuryl decanoate
FL/FR |
sulfuryl hexanoate
FL/FR |
sulfuryl isobutyrate
FL/FR |
|
sulfuryl formate
FL |
sulfuryl octanoate
FL/FR |
sulfuryl propionate
FL/FR |
| alliaceous |
| alliaceous |
benzyl mercaptan
FL |
dicyclohexyl disulfide
FL |
tropical thiazole
FL/FR |
| ammoniacal |
2- methyl piperidine
FL |
| bready |
2- propionyl thiazole
FL |
| brown |
fenugreek oleoresin
FL/FR |
1- hydroxy-2-butanone
FL/FR |
5- methyl furfural
FL/FR |
| burnt |
furfuryl alcohol
FL |
2- methyl quinoxaline
FL |
2,6- xylenol
FL/FR |
| caramellic |
caramel furanone
FL |
caramel furanone solution
FL/FR |
cyclotene
FL/FR |
fenugreek resinoid
FL/FR |
| chocolate |
cocoa oleoresin
FL/FR |
| coffee |
cichorium intybus root extract
FL/FR |
cichorium intybus root solid extract
FL/FR |
coffea arabica seed extract
FL/FR |
roasted coffea arabica seed extract
FL/FR |
coffea arabica seed oil
FL/FR |
coffee absolute
FL/FR |
arabica coffee bean butter
FL/FR |
roasted arabica coffee bean essence
FL/FR |
roasted coffee bean extract
FL/FR |
roasted arabica coffee bean oil CO2 extract
FL/FR |
coffee bean oil extract
FL/FR |
coffee difuran
FL/FR |
coffee dione
FL/FR |
coffee distillates
FL |
coffee pyrazine
FL |
coffee resinoid
FL/FR |
difurfuryl ether
FL |
diisoamyl thiomalate
FL |
2,4- dimethyl thiazole
FL |
2- ethyl-4-methyl thiazole
FL/FR |
furfuryl mercaptan
FL/FR |
methyl furfuryl disulfide
FL/FR |
methyl furfuryl thiol
FL |
2- thiophene thiol
FL |
| corn |
2- acetyl pyridine
FL/FR |
2- acetyl thiazole
FL/FR |
2- acetyl-2-thiazoline
FL |
popcorn pyrimidine
FL/FR |
| earthy |
difurfuryl sulfide
FL |
| fatty |
2- heptyl furan
FL/FR |
| fishy |
4,5- dimethyl thiazole
FL |
| fruity |
furfuryl isobutyrate
FL |
furfuryl isovalerate
FL |
furfuryl propionate
FL |
| fusel |
2- methyl butyraldehyde
FL/FR |
| green |
2- methyl-5-isopropyl pyrazine
FL |
| herbal |
wormwood oil america
FL/FR |
wormwood oil italy
FL/FR |
wormwood oil poland
FL/FR |
| malty |
yeast thiazoline
FL |
| meaty |
benzothiazole
FL/FR |
2,6- dimethyl pyrazine
FL/FR |
3- mercapto-2-butanone
FL |
2- methyl 3-(methyl thio) furan
FL |
| molasses |
molasses blackstrap
FL |
| moldy |
strawberry furanone methyl ether
FL/FR |
| mustard |
furfuryl methyl ether
FL |
| musty |
2,5- dimethyl pyrazine
FL/FR |
2- ethoxythiazole
FL |
menthofuran
FL/FR |
2- methyl 5-(methyl thio) furan
FL/FR |
| nutty |
2- acetyl furan
FL/FR |
3- acetyl pyridine
FL/FR |
2- acetyl-3-ethyl pyrazine
FL/FR |
2- acetyl-3-methyl pyrazine
FL/FR |
2- acetyl-3,5(or 6)-dimethyl pyrazine
FL/FR |
3,5- cocoa pyrazine
FL/FR |
3,6- cocoa pyrazine
FL/FR |
2,3- dimethyl pyrazine
FL/FR |
4,5- dimethyl-2-ethyl-3-thiazoline
FL/FR |
2- ethyl pyrazine
FL/FR |
1- ethyl-2-acetyl pyrrole
FL |
filbert heptenone
FL/FR |
filbert heptenone B
FL/FR |
filbert pyrazine
FL/FR |
5- methyl quinoxaline
FL/FR |
nutty pyrazine
FL/FR |
nutty quinoxaline
FL/FR |
nutty thiazole
FL |
sesame absolute
FL/FR |
sesame absolute CO2 extract
FL/FR |
2,3,5,6- tetramethyl pyrazine
FL/FR |
2,4,5- trimethyl thiazole
FL/FR |
| onion |
furfuryl isopropyl sulfide
FL |
| popcorn |
2- propionyl-2-thiazoline
FL |
| roasted |
2- acetyl pyrazine
FL/FR |
roasted arabica coffee bean oil
FL/FR |
ethyl 3-(furfuryl thio) propionate
FL |
furfuryl thioacetate
FL/FR |
trigonella foenum-graecum seed oil CO2 extract
FL/FR |
| solvent |
2- ethyl furan
FL |
| spicy |
para-alpha- dimethyl styrene
FL/FR |
| sulfurous |
2,3- butane dithiol
FL |
butyl mercaptan
FL |
dimethyl sulfide
FL/FR |
ethyl methyl sulfide
FL |
S- ethyl thioacetate
FL |
S- furfuryl thioformate
FL/FR |
furfuryl thiopropionate
FL |
3- methyl-2-butane thiol
FL |
2- thienyl mercaptan
FL |
3- thiohexanol
FL/FR |
| vegetable |
1- furfuryl pyrrole
FL/FR |
| woody |
juniper berry oleoresin
FL/FR |
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| 2- | acetyl-6-methylpyrazine | | | ethanone, 1-(6-methyl-2-pyrazinyl)- | | 1-(6- | methyl-2-pyrazinyl) ethanone | | 1-(6- | methyl-2-pyrazinyl)-1-ethanone | | 1-(6- | methyl-2-pyrazinyl)ethanone | | 1-(6- | methylpyrazin-2-yl)ethanone | | | pyrazine, 2-acetyl-6-methyl- |
Articles:
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3D/inchi