Articles:
Notes:
Isol. from ylang-ylang, cananga and other essential oils. Also present in tomato and Camembert cheese. Flavouring ingredient
| Fragrance Demo Formulas Flavor Demo Formulas | ||
| Name: | 1-methoxy-4-methylbenzene | |
| CAS Number: | 104-93-8 |  3D/inchi
|
| Other: | 1071687-44-9 | |
| ECHA EINECS - REACH Pre-Reg: | 203-253-7 | |
| FDA UNII: | 10FAI0OR9W | |
| Nikkaji Web: | J10.114A | |
| Beilstein Number: | 1237336 | |
| MDL: | MFCD00008413 | |
| FEMA Number: | 2681 | |
| CoE Number: | 188 | |
| XlogP3: | 2.70 (est) | |
| Molecular Weight: | 122.16690000 | |
| Formula: | C8 H10 O | |
| BioActivity Summary: | listing | |
| NMR Predictor: | Predict (works with chrome or firefox) | |
Category: flavor and fragrance agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
| Google Scholar: | Search |
| Google Books: | Search |
| Google Scholar: with word "volatile" | Search |
| Google Scholar: with word "flavor" | Search |
| Google Scholar: with word "odor" | Search |
| Perfumer and Flavorist: | Search |
| Google Patents: | Search |
| US Patents: | Search |
| EU Patents: | Search |
| Pubchem Patents: | Search |
| PubMed: | Search |
| NCBI: | Search |
| JECFA Food Flavoring: | 1243 p-methylanisole |
| Flavis Number: | 04.015 (Old) |
| DG SANTE Food Flavourings: | 04.015 1-methoxy-4-methylbenzene |
| FEMA Number: | 2681 p-methylanisole |
| FDA Mainterm: | P-METHYLANISOLE |
| FDA Regulation: | |
| FDA PART 172 -- FOOD ADDITIVES PERMITTED FOR DIRECT ADDITION TO FOOD FOR HUMAN CONSUMPTION Subpart F--Flavoring Agents and Related Substances Sec. 172.515 Synthetic flavoring substances and adjuvants. | |
Physical Properties:
| Appearance: | colorless clear liquid (est) |
| Assay: | 99.00 to 100.00 % |
| Food Chemicals Codex Listed: | Yes |
| Specific Gravity: | 0.96700 to 0.96900 @ 25.00 °C. |
| Pounds per Gallon - (est).: | 8.046 to 8.063 |
| Refractive Index: | 1.51200 to 1.51400 @ 20.00 °C. |
| Boiling Point: | 174.00 °C. @ 760.00 mm Hg |
| Vapor Pressure: | 2.029000 mmHg @ 25.00 °C. (est) |
| Flash Point: | 128.00 °F. TCC ( 53.33 °C. ) |
| logP (o/w): | 2.609 (est) |
| Shelf Life: | 24.00 month(s) or longer if stored properly. |
| Storage: | store in cool, dry place in tightly sealed containers, protected from heat and light. |
| Soluble in: | |
| alcohol | |
| dipropylene glycol | |
| fixed oils | |
| water, 527.1 mg/L @ 25 °C (est) | |
| Insoluble in: | |
| glycerin | |
| propylene glycol | |
| water | |
| Stability: | |
| non-discoloring in most media | |
Organoleptic Properties:
| Odor Type: | naphthyl |
| Odor Strength: | high , recommend smelling in a 1.00 % solution or less |
| Odor Description: at 1.00 % in dipropylene glycol. | naphthyl cresol ylang powdery nutty |
| Substantivity: | 8 Hour(s) |
Cosmetic Information:
| CosIng: | cosmetic data |
| Cosmetic Uses: |
perfuming agents |
Safety Information:
| Most important hazard(s): | |
| Xn - Harmful. | |
|
R 10 - Flammable. R 22 - Harmful if swallowed. R 38 - Irritating to skin. S 02 - Keep out of the reach of children. S 16 - Keep away from sources of ignition - No Smoking. S 24/25 - Avoid contact with skin and eyes. S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S 37/39 - Wear suitable gloves and eye/face protection. | |
| Human Experience: | 2 % solution: no irritation or sensitization. |
| Oral/Parenteral Toxicity: | |
|
oral-rat LD50 [sex: M,F] 1920 mg/kg (Wong & Hart, 1971) intraperitoneal-mouse LD > 500 mg/kg "Summary Tables of Biological Tests," National Research Council Chemical-Biological Coordination Center. Vol. 6, Pg. 214, 1954. oral-rat LD50 1920 mg/kg Food and Cosmetics Toxicology. Vol. 12, Pg. 393, 1974. | |
| Dermal Toxicity: | |
|
skin-rabbit LD50 > 5000 mg/kg Food and Cosmetics Toxicology. Vol. 12, Pg. 393, 1974. | |
| Inhalation Toxicity: | |
| Not determined | |
Safety in Use Information:
| Category: | flavor and fragrance agents | ||
| Recommendation for para-methyl anisole usage levels up to: | |||
| 2.0000 % in the fragrance concentrate. | |||
| Maximised Survey-derived Daily Intakes (MSDI-EU): | 0.49 (μg/capita/day) | ||
| Maximised Survey-derived Daily Intakes (MSDI-USA): | 15.00 (μg/capita/day) | ||
| Structure Class: | I | ||
| Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS). | |||
| The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library | |||
| publication number: 3 | |||
| Click here to view publication 3 | |||
| average usual ppm | average maximum ppm | ||
| baked goods: | - | 7.60000 | |
| beverages(nonalcoholic): | - | 2.70000 | |
| beverages(alcoholic): | - | - | |
| breakfast cereal: | - | - | |
| cheese: | - | - | |
| chewing gum: | - | - | |
| condiments / relishes: | - | 2.00000 | |
| confectionery froastings: | - | - | |
| egg products: | - | - | |
| fats / oils: | - | - | |
| fish products: | - | - | |
| frozen dairy: | - | 2.70000 | |
| fruit ices: | - | 2.70000 | |
| gelatins / puddings: | 0.50000 | 4.00000 | |
| granulated sugar: | - | - | |
| gravies: | - | - | |
| hard candy: | - | 4.80000 | |
| imitation dairy: | - | - | |
| instant coffee / tea: | - | - | |
| jams / jellies: | - | - | |
| meat products: | - | - | |
| milk products: | - | - | |
| nut products: | - | - | |
| other grains: | - | - | |
| poultry: | - | - | |
| processed fruits: | - | - | |
| processed vegetables: | - | - | |
| reconstituted vegetables: | - | - | |
| seasonings / flavors: | - | - | |
| snack foods: | - | - | |
| soft candy: | - | - | |
| soups: | - | - | |
| sugar substitutes: | - | - | |
| sweet sauces: | - | - | |
Safety References:
| European Food Safety Athority(efsa): | Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies... |
| European Food Safety Authority (EFSA) reference(s): | |
| Opinion of the Scientific Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) related to Flavouring Group Evaluation 23 (FGE.23): Aliphatic, alicyclic and aromatic ethers including anisole derivatives From chemical groups 15, 16 and 26 (Commission Regulation (EC) No 1565/2000 of 18 July 2000 View page or View pdf | |
| Flavouring Group Evaluation 59 (FGE.59): Consideration of aliphatic and aromatic ethers evaluated by JECFA (61st meeting) structurally related to aliphatic, alicyclic and aromatic ethers including anisole derivatives evaluated by EFSA in FGE.23 (2006) (Commission Regulation (EC) No 1565/2000 of 18 July 2000) - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC) View page or View pdf | |
| Flavouring Group Evaluation 23, Revision 1 (FGE.23Rev1): Aliphatic, alicyclic and aromatic ethers including anisole derivatives from chemical groups 15, 16, 26 and 30[1] - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food View page or View pdf | |
| Scientific Opinion on Flavouring Group Evaluation 59, Revision 1 (FGE.59Rev1): Consideration of aliphatic and aromatic ethers evaluated by JECFA (61st meeting and 63rd meeting) structurally related to aliphatic, alicyclic and aromatic ethers including anisole derivatives evaluated by EFSA in FGE.23 Rev2 (2010) View page or View pdf | |
| Scientific Opinion on the safety and efficacy of aromatic ethers including anisole derivatives (chemical group 26) when used as feed additives for all animal species View page or View pdf | |
| EPI System: | View |
| NLM Hazardous Substances Data Bank: | Search |
| Cancer Citations: | Search |
| Toxicology Citations: | Search |
| Env. Mutagen Info. Center: | Search |
| EPA Substance Registry Services (TSCA): | 104-93-8 |
| EPA ACToR: | Toxicology Data |
| EPA Substance Registry Services (SRS): | Registry |
| Laboratory Chemical Safety Summary : | 7731 |
| National Institute of Allergy and Infectious Diseases: | Data |
| WISER: | UN 1993 |
| WGK Germany: | 1 |
| 1-methoxy-4-methylbenzene | |
| Chemidplus: | 0000104938 |
| RTECS: | BZ8780000 for cas# 104-93-8 |
References:
| 1-methoxy-4-methylbenzene | |
| NIST Chemistry WebBook: | Search Inchi |
| Canada Domestic Sub. List: | 104-93-8 |
| Pubchem (cid): | 7731 |
| Pubchem (sid): | 134970835 |
| Pherobase: | View |
Other Information:
| (IUPAC): | Atomic Weights of the Elements 2009 |
| (IUPAC): | Atomic Weights of the Elements 2009 (pdf) |
| Videos: | The Periodic Table of Videos |
| tgsc: | Atomic Weights use for this web site |
| (IUPAC): | Periodic Table of the Elements |
| FDA Everything Added to Food in the United States (EAFUS): | View |
| CHEMBL: | View |
| HMDB (The Human Metabolome Database): | HMDB32076 |
| FooDB: | FDB008791 |
| Export Tariff Code: | 2909.30.6000 |
| Haz-Map: | View |
| VCF-Online: | VCF Volatile Compounds in Food |
| ChemSpider: | View |
| Wikipedia: | View |
| RSC Learn Chemistry: | View |
| Formulations/Preparations: grades: fcc; technical. | |
Potential Blenders and core components note
Potential Uses:
| champaca | FR | |
| cherry blossom | FR | |
| currant black currant | FR | |
| floral | FR | |
| genet | FR | |
| grape | FR | |
| hay new mown hay | FR | |
| hyacinth | FR | |
| jasmin | FR | |
| jonquil | FR | |
| lilac | FR | |
| lily | FR | |
| mulberry | FR | |
| narcissus | FR | |
| nut | FL | |
| rose | FR | |
| sandalwood | FR | |
| tide | ||
| tuberose | FR | |
| wallflower | FR | |
| walnut | FL | |
| wisteria | FR | |
| ylang ylang | FR |
Occurrence (nature, food, other): note
| cananga Search Trop Picture | |
| cananga odorata oil java @ 2.14% Data GC Search Trop Picture | |
| cananga oil china @ 2.05% Data GC Search Trop Picture | |
| champaca concrete @ trace% Data GC Search Trop Picture | |
| cheese Search PMC Picture | |
| cheese gorgonzola cheese Search PMC Picture | |
| croton flavens l. (welensali) leaf oil curacao @ trace% Data GC Search Trop Picture | |
| hyacinthus orientalis absolute @ 0.01-0.02% Data GC Search Trop Picture | |
| lavender oil spike spain @ 0.009% Data GC Search Trop Picture | |
| tomato Search Trop Picture | |
| ylang ylang Search Trop Picture | |
| ylang ylang oil @ 0.34% Data GC Search Trop Picture | |
| ylang ylang oil CO2 extract @ 2.00% Data GC Search Trop Picture | |
| ylang ylang oil I (cananga odorata hook. f. and thomas.) @ 5.75% Data GC Search Trop Picture | |
| ylang ylang oil II (cananga odorata hook. f. and thomas.) @ 1.19% Data GC Search Trop Picture | |
| ylang ylang oil III @ 0.39% Data GC Search Trop Picture |
Synonyms:
| anisole, p-methyl- | |
| benzene, 1-methoxy-4-methyl- | |
| p- | cresol methyl ether |
| para- | cresol methyl ether |
| p- | cresyl methyl ether |
| para- | cresyl methyl ether |
| p- | cresyl methyl ether ( p – cresol ) |
| p- | cresyl methyl ether FCC |
| cresyl methyl ether para | |
| cresyl methyl ether para FCC | |
| 1- | methoxy-4-methyl benzene |
| 1- | methoxy-4-methyl-benzene |
| 1- | methoxy-4-methylbenzene |
| 4- | methoxytoluene |
| p- | methoxytoluene |
| para- | methoxytoluene |
| methyl 4-methyl phenyl ether | |
| methyl 4-methylphenyl ether | |
| 4- | methyl anisole |
| p- | methyl anisole |
| para- | methyl anisole |
| para- | methyl cresol |
| methyl p-cresol | |
| o- | methyl p-cresol |
| methyl p-cresyl ether | |
| methyl p-methylphenyl ether | |
| methyl p-tolyl ether | |
| methyl para cresol | |
| ortho- | methyl para-cresol |
| methyl para-cresyl ether | |
| methyl para-methyl phenyl ether | |
| methyl para-tolyl ether | |
| 4- | methyl phenol methyl ether |
| 4- | methyl-1-methoxybenzene |
| 1- | methyl-4-methoxybenzene |
| methyl-para-cresol | |
| 4- | methylanisole |
| p- | methylanisole |
| para- | methylanisole |
| 4- | methylcresol |
| p- | methylcresol |
| 4- | methylphenol methyl ether |
| toluene, 4-methoxy- | |
| p- | tolyl methyl ether |
| para- | tolyl methyl ether |