|
Category:natural substances and extractives
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Appearance: | colorless to yellow green clear liquid (est) |
| Assay: | 95.00 to 100.00
|
| Food Chemicals Codex Listed: | No |
| Specific Gravity: | 1.12400 to 1.43500 @ 25.00 °C.
|
| Pounds per Gallon - (est).: | 9.353 to 11.941
|
| Refractive Index: | 1.53600 to 1.53800 @ 20.00 °C.
|
| Melting Point: | 29.00 to 30.00 °C. @ 760.00 mm Hg
|
| Boiling Point: | 294.00 to 295.00 °C. @ 760.00 mm Hg
|
| Boiling Point: | 159.00 to 160.00 °C. @ 10.00 mm Hg
|
| Vapor Pressure: | 0.003000 mmHg @ 25.00 °C. (est) |
| Flash Point: | 243.00 °F. TCC ( 117.20 °C. ) (est)
|
| logP (o/w): | 3.481 (est) |
| Soluble in: |
| | alcohol | | | acetone | | | ether | | | acetic acid | | | water, 27.68 mg/L @ 25 °C (est) |
| Insoluble in: |
| | water |
Organoleptic Properties:
| Odor Type: herbal |
| Odor Strength:low |
| parsley herbal |
| Odor Description:at 100.00 %. parsley faint |
| Odor and/or flavor descriptions from others (if found). |
Cosmetic Information:
Suppliers:
Safety Information:
| |
| Hazards identification |
| |
| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
| |
| Pictogram | |
| |
| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
|
Not determined
|
| Dermal Toxicity: |
subcutaneous-frog LDLo 1515 mg/kg
PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE
LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 35, Pg. 342, 1895.
subcutaneous-mouse LDLo 1000 mg/kg
Bolletino della Societe Italiana di Biologia Sperimentale. Vol. 14, Pg. 291, 1939.
|
| Inhalation Toxicity: |
|
Not determined
|
Safety in Use Information:
| Category: | | natural substances and extractives |
| Recommendation for apiole (parsley) usage levels up to: | | | not for fragrance use.
|
| |
| Recommendation for apiole (parsley) flavor usage levels up to: |
| | not for flavor use.
|
Safety References:
References:
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| | allyl dimethoxymethylene dioxybenzene | | 1- | allyl-2,5-dimethoxy-3,4-methylene dioxybenzene | | 1- | allyl-2,5-dimethoxy-3,4-methylenedioxybenzene | | 5- | allyl-4,7-dimethoxy-1,3-benzodioxol | | | apiol (parsley) | | | apioline (parsley) | | 1,3- | benzodioxole, 4,7-dimethoxy-5-(2-propen-1-yl)- | | 1,3- | benzodioxole, 4,7-dimethoxy-5-(2-propenyl)- | | 4,7- | dimethoxy-5-(2-propenyl)-1,3-benzodioxole | | 4,7- | dimethoxy-5-(prop-2-en-1-yl)-1,3-benzodioxole | | 4,7- | dimethoxy-5-prop-2-enyl-1,3-benzodioxole | | 4,7- | dimethoxy-5-prop-2-enyl-2H-benzo[d]1,3-dioxolene | | 1,2- | methylene dioxy-3,6-dimethoxy-4-allyl benzene | | | parsley apiol | | | parsley apiole | | | parsley camphor |
Articles:
| PubMed:The in vivo antitumor effects on human COLO 205 cancer cells of the 4,7-dimethoxy-5-(2-propen-1-yl)-1,3-benzodioxole (apiole) derivative of 5-substituted 4,7-dimethoxy-5-methyl-l,3-benzodioxole (SY-1) isolated from the fruiting body of Antrodia camphorate. |
| PubMed:Age-dependent changes from allylphenol to prenylated benzoic acid production in Piper gaudichaudianum Kunth. |
| PubMed:Chemical composition, antimicrobial and antioxidant activities of the essential oil of Psammogeton canescens. |
| PubMed:[Poisoning by apiole. 3. Toxicological studies: Labat reaction and determination with chromotropic acid]. |
| PubMed:[Poisoning by apiole. II. Histopathological aspects and pathogenetic discussion]. |
| PubMed:[Quantitative determination of apiole]. |
| PubMed:Psychotrophic phenylisopropylamines derived from apiole and dillapiole. |
| PubMed:Study of the Anti-Proliferative Activity of 5-Substituted 4,7-Dimethoxy-1,3-Benzodioxole Derivatives of SY-1 from Antrodia camphorata on Human COLO 205 Colon Cancer Cells. |
| PubMed:Medicinal plants from the genus Acalypha (Euphorbiaceae)--a review of their ethnopharmacology and phytochemistry. |
| PubMed:Endemic Balkan parsnip Pastinaca hirsuta: the chemical profile of essential oils, headspace volatiles and extracts. |
| PubMed:Critique of medicinal conspicuousness of Parsley(Petroselinum crispum): a culinary herb of Mediterranean region. |
| PubMed:Chemical composition of the essential oil of Pituranthos scoparius. |
| PubMed:Chemical and biological evaluation of essential oils from two species of Myrtaceae - Eugenia uniflora L. and Plinia trunciflora (O. Berg) Kausel. |
| PubMed:Antioxidant capacity and larvicidal and antifungal activities of essential oils and extracts from Piper krukoffii. |
| PubMed:Acaricidal activities of apiol and its derivatives from Petroselinum sativum seeds against Dermatophagoides pteronyssinus, Dermatophagoides farinae, and Tyrophagus putrescentiae. |
| PubMed:Chemical composition and antioxidant activities of the essential oil and methanol extracts of Psammogeton canescens. |
| PubMed:Antimicrobial activities of essential oil and hexane extract of Florence fennel [Foeniculum vulgare var. azoricum (Mill.) Thell.] against foodborne microorganisms. |
| PubMed:Comparative essential oil composition of flowers, leavesand stems of basil (Ocimum basilicum L.) used as herb. |
| PubMed:Biotransformation of menthol and geraniol by hairy root cultures of Anethum graveolens: effect on growth and volatile components. |
| PubMed:Essential oil composition of three Peperomia species from the Amazon, Brazil. |
| PubMed:Chemical composition and antimicrobial activities of the essential oil from the seeds of Enterolobium contortisiliquum (leguminosae). |
| PubMed:Chemical composition and antimicrobial activity of Momordica charantia seed essential oil. |
| PubMed:Comparative analysis of the oil and supercritical CO2 extract of Ridolfia segetum (L.) Moris. |
| PubMed:Inhibition of oxidation of human low-density lipoproteins by phenolic substances in different essential oils varieties. |
| PubMed:Compartive study of volatile components and fatty acids of plants and in vitro cultures of parsley (Petroselinum crispum (Mill) nym ex hill). |
| PubMed:Volatile chemical constituents of Piper aduncum L and Piper gibbilimbum C. DC (Piperaceae) from Papua New Guinea. |
| PubMed:Dillapiol and Apiol as specific inhibitors of the biosynthesis of aflatoxin G1 in Aspergillus parasiticus. |
| PubMed:Plant-derived natural products exhibiting activity against formosan subterranean termites (Coptotermes formosanus). |
| PubMed:Enzyme activity in the flesh fly Parasarcophaga dux Thomson influenced by dill compounds, myristicin and apiol. |
| PubMed:Toxicological efficacy of some indigenous dill compounds against the flesh fly, Parasarcophaga dux Thomson. |
| PubMed:Anaerobic utilization of essential oils by denitrifying bacteria. |
|
crystalline essential oil isolated directly from commercial oil of parsley. Occurs in Sassafras albidum (sassafras) and Anethum graveolens (dill)
Apiol is an organic chemical compound, also known as parsley apiol, apiole or parsley camphor. It is found in celery, parsley seeds, and the essential oil of parsley. Heinrich Christoph Link, an apothecary in Leipzig, discovered the substance in 1715 as greenish crystals reduced by steam from oil of parsley. In 1855 Joret and Homolle discovered that apiol was an effective treatment of amenorrea or lack of menstruation.; In medicine it has been used, as essential oil or in purified form, for the treatment of menstrual disorders. It is an irritant and in high doses it is toxic and can cause liver and kidney damage.
|
3D/inchi