|
Category: flavor and fragrance agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Appearance: | colorless to pale yellow clear liquid (est) |
| Assay: | 95.00 to 100.00 % sum of isomers
|
| Food Chemicals Codex Listed: | Yes |
| Specific Gravity: | 1.04700 to 1.05500 @ 25.00 °C.
|
| Pounds per Gallon - (est).: | 8.712 to 8.779
|
| Specific Gravity: | 1.04800 to 1.05600 @ 20.00 °C.
|
| Pounds per Gallon - est.: | 8.731 to 8.797
|
| Refractive Index: | 1.56500 to 1.57000 @ 20.00 °C.
|
| Melting Point: | 16.00 to 17.00 °C. @ 760.00 mm Hg
|
| Boiling Point: | 262.00 to 264.00 °C. @ 760.00 mm Hg
|
| Vapor Pressure: | 0.011000 mmHg @ 25.00 °C. (est) |
| Flash Point: | > 220.00 °F. TCC ( > 104.44 °C. )
|
| logP (o/w): | 3.049 (est) |
| Shelf Life: | 24.00 month(s) or longer if stored properly. |
| Storage: | store in cool, dry place in tightly sealed containers, protected from heat and light. |
| Soluble in: |
| | fixed oils | | | paraffin oil | | | water, 169.1 mg/L @ 25 °C (est) |
| Insoluble in: |
| | glycerin | | | propylene glycol |
| Stability: |
| | non-discoloring in most media |
Organoleptic Properties:
| Odor Type: | spicy |
| Odor Strength: | medium |
Odor Description: at 100.00 %. | spicy clove blossom carnation woody |
| Substantivity: | 240 Hour(s) |
| | |
Cosmetic Information:
Safety Information:
| Most important hazard(s): | | None - None found. |
| |
S 02 - Keep out of the reach of children. S 24/25 - Avoid contact with skin and eyes.
|
| Human Experience: | 8 % solution: no irritation or sensitization. |
| Oral/Parenteral Toxicity: | | |
oral-rat LD50 2500 mg/kg Food and Cosmetics Toxicology. Vol. 13, Pg. 865, 1975.
intravenous-mouse LD50 181 mg/kg LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE) Archives Internationales de Pharmacodynamie et de Therapie. Vol. 199, Pg. 226, 1972.
intraperitoneal-mouse LD50 570 mg/kg LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE) Archives Internationales de Pharmacodynamie et de Therapie. Vol. 199, Pg. 226, 1972.
|
| Dermal Toxicity: | | |
skin-rabbit LD50 > 5000 mg/kg Food and Cosmetics Toxicology. Vol. 13, Pg. 865, 1975.
|
| Inhalation Toxicity: | | |
Not determined
|
Safety in Use Information:
| Category: | flavor and fragrance agents |
| Recommendation for methyl isoeugenol usage levels up to: | | | 8.0000 % in the fragrance concentrate.
|
| |
| Maximised Survey-derived Daily Intakes (MSDI-EU): | 109.00 (μg/capita/day) |
| Maximised Survey-derived Daily Intakes (MSDI-USA): | 129.00 (μg/capita/day) |
| Structure Class: | III |
| Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS). |
| The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library |
| publication number: 3 |
| Click here to view publication 3 |
| | average usual ppm | average maximum ppm |
| baked goods: | - | 18.00000 |
| beverages(nonalcoholic): | - | 4.00000 |
| beverages(alcoholic): | - | - |
| breakfast cereal: | - | - |
| cheese: | - | - |
| chewing gum: | - | 110.00000 |
| condiments / relishes: | - | - |
| confectionery froastings: | - | - |
| egg products: | - | - |
| fats / oils: | - | - |
| fish products: | - | - |
| frozen dairy: | - | 7.70000 |
| fruit ices: | - | 7.70000 |
| gelatins / puddings: | - | 0.10000 |
| granulated sugar: | - | - |
| gravies: | - | - |
| hard candy: | - | 13.00000 |
| imitation dairy: | - | - |
| instant coffee / tea: | - | - |
| jams / jellies: | - | - |
| meat products: | - | - |
| milk products: | - | - |
| nut products: | - | - |
| other grains: | - | - |
| poultry: | - | - |
| processed fruits: | - | - |
| processed vegetables: | - | - |
| reconstituted vegetables: | - | - |
| seasonings / flavors: | - | - |
| snack foods: | - | - |
| soft candy: | - | - |
| soups: | - | - |
| sugar substitutes: | - | - |
| sweet sauces: | - | - |
Safety References:
References:
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| | benzene, 1,2-dimethoxy-4-(1-propen-1-yl)- | | 3,4- | dimethoxy-1,1-propen-1-yl benzene | | 1,2- | dimethoxy-4-(1-propen-1-yl) benzene | | 1,2- | dimethoxy-4-(1-propenyl) benzene | | 1,2- | dimethoxy-4-(1-propenyl)-benzene | | 1,2- | dimethoxy-4-(1-propenyl)benzene | | 1,2- | dimethoxy-4-(prop-1-en-1-yl)benzene | | 1,2- | dimethoxy-4-(prop-1-enyl)benzene | | 1,2- | dimethoxy-4-prop-1-enylbenzene | | 1,2- | dimethoxy-4-propen-1-yl benzene | | 1-(3,4- | dimethoxyphenyl)-1-propene | | 3-(3,4- | dimethoxyphenyl)-2-propene | | 3,4- | dimethoxypropylbenzene | | | ether, isoeugenyl methyl | | iso | eugenol methyl | | 1,3,4-iso | eugenol methyl ether | | iso | eugenol methyl ether | | iso- | eugenol methyl ether | | iso | eugenyl methyl ether | | | methyl iso eugenol | | | methylisoeugenol | | 4- | prop-1-enyl veratrole | | 4- | prop-1-enylveratrole | | 4- | propenyl veratrole | | 4-(1- | propenyl)-1,2-dimethoxybenzene | | 4- | propenylveratrole | | 1- | veratryl-1-propene |
Articles:
| PubMed: | Chemical compositions, phytotoxicity, and biological activities of Acorus calamus essential oils from Nepal. |
| PubMed: | Characterization of a self-sufficient trans-anethole oxygenase from Pseudomonas putida JYR-1. |
| PubMed: | Utility of rat liver S9 fractions to study skin-sensitizing prohaptens in a modified KeratinoSens assay. |
| PubMed: | Synthesis, spectroscopic characterization and DFT calculations of β-O-4 type lignin model compounds. |
| PubMed: | Neural coding of binary mixtures in a structurally related odorant pair. |
| PubMed: | Production of natural fragrance aromatic acids by coexpression of trans-anethole oxygenase and p-anisaldehyde dehydrogenase genes of Pseudomonas putida JYR-1 in Escherichia coli. |
| PubMed: | Isolation of a gene responsible for the oxidation of trans-anethole to para-anisaldehyde by Pseudomonas putida JYR-1 and its expression in Escherichia coli. |
| PubMed: | Involvement of 5-HT1A in the anxiolytic-like effect of dichloromethane fraction of Pimenta pseudocaryophyllus. |
| PubMed: | A hexane fraction of guava Leaves (Psidium guajava L.) induces anticancer activity by suppressing AKT/mammalian target of rapamycin/ribosomal p70 S6 kinase in human prostate cancer cells. |
| PubMed: | Chemical composition of the essential oil of aerial parts of Haussknechtia elymaitica Boiss. from Iran: a good natural source for trans-asaron. |
| PubMed: | Chemical composition, antinociceptive and anti-inflammatory properties of essential oil from the roots of Illicium lanceolatum. |
| PubMed: | Major constituents and antimicrobial activity of Korean herb Acorus calamus. |
| PubMed: | Terpenoid composition and antifungal activity of three commercially important essential oils against Aspergillus flavus and Aspergillus niger. |
| PubMed: | Phosphoinositide 3-kinase-dependent antagonism in mammalian olfactory receptor neurons. |
| PubMed: | Chemical composition of the essential oil of Feronia elephantum Correa. |
| PubMed: | Natural compounds endowed with cholinergic or anticholinergic activity. Enhancement of acetylcholine release by a quaternary derivative of L-hyoscyamine. |
| PubMed: | [Studies on constituents of rootsanel leaves from Desmodium blandum and their cytotoxic activity against growth of several tumor cells]. |
| PubMed: | Nematicidal Activity of Plant Essential Oils and Components From Ajowan (Trachyspermum ammi), Allspice (Pimenta dioica) and Litsea (Litsea cubeba) Essential Oils Against Pine Wood Nematode (Bursaphelenchus Xylophilus). |
| PubMed: | threo-2-(2,6-dimethoxyphenoxy)-1-(4-hydroxy-3,5-dimethoxyphenyl)propane-1,3-diol: a conformational study. |
| PubMed: | Evidence for positive selection on the floral scent gene isoeugenol-O-methyltransferase. |
| PubMed: | NTP Toxicology and Carcinogenesis Studies of Methyleugenol (CAS NO. 93-15-2) in F344/N Rats and B6C3F1 Mice (Gavage Studies). |
| PubMed: | Inhibition of nicotinic acetylcholine receptors and calcium channels by clozapine in bovine adrenal chromaffin cells. |
| PubMed: | Lignin peroxidase initiates O2-dependent self-propagating chemical reactions which accelerate the consumption of 1-(3',4'-dimethoxyphenyl)propene. |
| PubMed: | Antiproliferative constituents in umbelliferae plants. IV. Constituents in the fruits of Anthriscus sylvestris Hoffm. |
| PubMed: | Synthesis, structure and quantitative structure-activity relationships of sigma receptor ligands, 1-[2-(3,4-dimethoxyphenyl)ethyl]-4-(3-phenylpropyl) piperazines. |
| PubMed: | A 28-day feeding study with methyl isoeugenol in rats. |
| PubMed: | Semiochemical attractants ofDiabrotica undecimpunctata howardi barber, southern corn rootworm, andDiabrotica virgifera virgifera leconte, the western corn rootworm (Coleoptera: Chrysomelidae). |
| PubMed: | Influence of vehicles on penetration through human epidermis of benzyl alcohol, isoeugenol and methyl isoeugenol. |
|