Category: flavor and fragrance agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
Appearance: | colorless to pale yellow clear liquid (est) |
Assay: | 95.00 to 100.00 % sum of isomers
|
Food Chemicals Codex Listed: | Yes |
Specific Gravity: | 1.04700 to 1.05500 @ 25.00 °C.
|
Pounds per Gallon - (est).: | 8.712 to 8.779
|
Specific Gravity: | 1.04800 to 1.05600 @ 20.00 °C.
|
Pounds per Gallon - est.: | 8.731 to 8.797
|
Refractive Index: | 1.56500 to 1.57000 @ 20.00 °C.
|
Melting Point: | 16.00 to 17.00 °C. @ 760.00 mm Hg
|
Boiling Point: | 262.00 to 264.00 °C. @ 760.00 mm Hg
|
Vapor Pressure: | 0.011000 mmHg @ 25.00 °C. (est) |
Flash Point: | > 220.00 °F. TCC ( > 104.44 °C. )
|
logP (o/w): | 3.049 (est) |
Shelf Life: | 24.00 month(s) or longer if stored properly. |
Storage: | store in cool, dry place in tightly sealed containers, protected from heat and light. |
Soluble in: |
| fixed oils | | paraffin oil | | water, 169.1 mg/L @ 25 °C (est) |
Insoluble in: |
| glycerin | | propylene glycol |
Stability: |
| non-discoloring in most media |
Organoleptic Properties:
Odor Type: | spicy |
Odor Strength: | medium |
Odor Description: at 100.00 %. | spicy clove blossom carnation woody |
Substantivity: | 240 Hour(s) |
| |
Cosmetic Information:
Safety Information:
Most important hazard(s): | None - None found. |
|
S 02 - Keep out of the reach of children. S 24/25 - Avoid contact with skin and eyes.
|
Human Experience: | 8 % solution: no irritation or sensitization. |
Oral/Parenteral Toxicity: | |
oral-rat LD50 2500 mg/kg Food and Cosmetics Toxicology. Vol. 13, Pg. 865, 1975.
intravenous-mouse LD50 181 mg/kg LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE) Archives Internationales de Pharmacodynamie et de Therapie. Vol. 199, Pg. 226, 1972.
intraperitoneal-mouse LD50 570 mg/kg LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE) Archives Internationales de Pharmacodynamie et de Therapie. Vol. 199, Pg. 226, 1972.
|
Dermal Toxicity: | |
skin-rabbit LD50 > 5000 mg/kg Food and Cosmetics Toxicology. Vol. 13, Pg. 865, 1975.
|
Inhalation Toxicity: | |
Not determined
|
Safety in Use Information:
Category: | flavor and fragrance agents |
Recommendation for methyl isoeugenol usage levels up to: | | 8.0000 % in the fragrance concentrate.
|
|
Maximised Survey-derived Daily Intakes (MSDI-EU): | 109.00 (μg/capita/day) |
Maximised Survey-derived Daily Intakes (MSDI-USA): | 129.00 (μg/capita/day) |
Structure Class: | III |
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS). |
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library |
publication number: 3 |
Click here to view publication 3 |
| average usual ppm | average maximum ppm |
baked goods: | - | 18.00000 |
beverages(nonalcoholic): | - | 4.00000 |
beverages(alcoholic): | - | - |
breakfast cereal: | - | - |
cheese: | - | - |
chewing gum: | - | 110.00000 |
condiments / relishes: | - | - |
confectionery froastings: | - | - |
egg products: | - | - |
fats / oils: | - | - |
fish products: | - | - |
frozen dairy: | - | 7.70000 |
fruit ices: | - | 7.70000 |
gelatins / puddings: | - | 0.10000 |
granulated sugar: | - | - |
gravies: | - | - |
hard candy: | - | 13.00000 |
imitation dairy: | - | - |
instant coffee / tea: | - | - |
jams / jellies: | - | - |
meat products: | - | - |
milk products: | - | - |
nut products: | - | - |
other grains: | - | - |
poultry: | - | - |
processed fruits: | - | - |
processed vegetables: | - | - |
reconstituted vegetables: | - | - |
seasonings / flavors: | - | - |
snack foods: | - | - |
soft candy: | - | - |
soups: | - | - |
sugar substitutes: | - | - |
sweet sauces: | - | - |
Safety References:
References:
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| benzene, 1,2-dimethoxy-4-(1-propen-1-yl)- | 3,4- | dimethoxy-1,1-propen-1-yl benzene | 1,2- | dimethoxy-4-(1-propen-1-yl) benzene | 1,2- | dimethoxy-4-(1-propenyl) benzene | 1,2- | dimethoxy-4-(1-propenyl)-benzene | 1,2- | dimethoxy-4-(1-propenyl)benzene | 1,2- | dimethoxy-4-(prop-1-en-1-yl)benzene | 1,2- | dimethoxy-4-(prop-1-enyl)benzene | 1,2- | dimethoxy-4-prop-1-enylbenzene | 1,2- | dimethoxy-4-propen-1-yl benzene | 1-(3,4- | dimethoxyphenyl)-1-propene | 3-(3,4- | dimethoxyphenyl)-2-propene | 3,4- | dimethoxypropylbenzene | | ether, isoeugenyl methyl | iso | eugenol methyl | 1,3,4-iso | eugenol methyl ether | iso | eugenol methyl ether | iso- | eugenol methyl ether | iso | eugenyl methyl ether | | methyl iso eugenol | | methylisoeugenol | 4- | prop-1-enyl veratrole | 4- | prop-1-enylveratrole | 4- | propenyl veratrole | 4-(1- | propenyl)-1,2-dimethoxybenzene | 4- | propenylveratrole | 1- | veratryl-1-propene |
Articles:
PubMed: | Chemical compositions, phytotoxicity, and biological activities of Acorus calamus essential oils from Nepal. |
PubMed: | Characterization of a self-sufficient trans-anethole oxygenase from Pseudomonas putida JYR-1. |
PubMed: | Utility of rat liver S9 fractions to study skin-sensitizing prohaptens in a modified KeratinoSens assay. |
PubMed: | Synthesis, spectroscopic characterization and DFT calculations of β-O-4 type lignin model compounds. |
PubMed: | Neural coding of binary mixtures in a structurally related odorant pair. |
PubMed: | Production of natural fragrance aromatic acids by coexpression of trans-anethole oxygenase and p-anisaldehyde dehydrogenase genes of Pseudomonas putida JYR-1 in Escherichia coli. |
PubMed: | Isolation of a gene responsible for the oxidation of trans-anethole to para-anisaldehyde by Pseudomonas putida JYR-1 and its expression in Escherichia coli. |
PubMed: | Involvement of 5-HT1A in the anxiolytic-like effect of dichloromethane fraction of Pimenta pseudocaryophyllus. |
PubMed: | A hexane fraction of guava Leaves (Psidium guajava L.) induces anticancer activity by suppressing AKT/mammalian target of rapamycin/ribosomal p70 S6 kinase in human prostate cancer cells. |
PubMed: | Chemical composition of the essential oil of aerial parts of Haussknechtia elymaitica Boiss. from Iran: a good natural source for trans-asaron. |
PubMed: | Chemical composition, antinociceptive and anti-inflammatory properties of essential oil from the roots of Illicium lanceolatum. |
PubMed: | Major constituents and antimicrobial activity of Korean herb Acorus calamus. |
PubMed: | Terpenoid composition and antifungal activity of three commercially important essential oils against Aspergillus flavus and Aspergillus niger. |
PubMed: | Phosphoinositide 3-kinase-dependent antagonism in mammalian olfactory receptor neurons. |
PubMed: | Chemical composition of the essential oil of Feronia elephantum Correa. |
PubMed: | Natural compounds endowed with cholinergic or anticholinergic activity. Enhancement of acetylcholine release by a quaternary derivative of L-hyoscyamine. |
PubMed: | [Studies on constituents of rootsanel leaves from Desmodium blandum and their cytotoxic activity against growth of several tumor cells]. |
PubMed: | Nematicidal Activity of Plant Essential Oils and Components From Ajowan (Trachyspermum ammi), Allspice (Pimenta dioica) and Litsea (Litsea cubeba) Essential Oils Against Pine Wood Nematode (Bursaphelenchus Xylophilus). |
PubMed: | threo-2-(2,6-dimethoxyphenoxy)-1-(4-hydroxy-3,5-dimethoxyphenyl)propane-1,3-diol: a conformational study. |
PubMed: | Evidence for positive selection on the floral scent gene isoeugenol-O-methyltransferase. |
PubMed: | NTP Toxicology and Carcinogenesis Studies of Methyleugenol (CAS NO. 93-15-2) in F344/N Rats and B6C3F1 Mice (Gavage Studies). |
PubMed: | Inhibition of nicotinic acetylcholine receptors and calcium channels by clozapine in bovine adrenal chromaffin cells. |
PubMed: | Lignin peroxidase initiates O2-dependent self-propagating chemical reactions which accelerate the consumption of 1-(3',4'-dimethoxyphenyl)propene. |
PubMed: | Antiproliferative constituents in umbelliferae plants. IV. Constituents in the fruits of Anthriscus sylvestris Hoffm. |
PubMed: | Synthesis, structure and quantitative structure-activity relationships of sigma receptor ligands, 1-[2-(3,4-dimethoxyphenyl)ethyl]-4-(3-phenylpropyl) piperazines. |
PubMed: | A 28-day feeding study with methyl isoeugenol in rats. |
PubMed: | Semiochemical attractants ofDiabrotica undecimpunctata howardi barber, southern corn rootworm, andDiabrotica virgifera virgifera leconte, the western corn rootworm (Coleoptera: Chrysomelidae). |
PubMed: | Influence of vehicles on penetration through human epidermis of benzyl alcohol, isoeugenol and methyl isoeugenol. |
|