EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

piper betle leaf oil
volatile oil obtained by the steam distillation of the leaves of the pepper, piper betle l., piperaceae

Supplier Sponsors

CAS Number: 84775-81-5
ECHA EC Number:283-910-2
FDA UNII: Search
Category:fragrance agents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
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Google Patents:Search
US Patents:Search
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PubMed:Search
NCBI:Search
 
Physical Properties:
Appearance:yellow to brown clear liquid (est)
Food Chemicals Codex Listed: No
Soluble in:
 alcohol
Insoluble in:
 water
 
Organoleptic Properties:
Odor Type: phenolic
phenolic resinous smoky peppery ginger
Odor Description:at 0.10 % in dipropylene glycol. phenolic tar smoky mate leaves peppery ginger
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: deodorants
fragrance
oral care agents
skin conditioning
 
Suppliers:
Aromatic and Allied Chemicals
Betel Leaf Oil
Haldin International
Piper Betle Leaf Oil
Indenta Group
Betel Leaf Oil
India Essential Oils
Betel Leaf Oil
Kanta Enterprises
Piper Betle Leaf Oil
Lluch Essence
BETEL LEAF OIL
Noble Molecular Research
For experimental / research use only.
Betal Leaf Oil
Plant Lipids
Betel Leaf Oil
Ultra International
Betel Oil
Piper Betle
Crop Calendar
 
Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
fragrance agents
RIFM Fragrance Material Safety Assessment: Search
IFRA Code of Practice Notification of the 49th Amendment to the IFRA Code of Practice
IFRA Critical Effect:
Sensitization
contains the following IFRA (Annex) restricted components: (non-analysis max. level reference only)
eugenol Max. Found: <38.00 % and Reason: Sensitization
isoeugenol Max. Found: <12.00 % and Reason: Sensitization
geraniol Max. Found: <3.50 % and Reason: Sensitization
Recommendation for piper betle leaf oil usage levels up to:
  0.0100 % in the fragrance concentrate.
 
Recommendation for piper betle leaf oil flavor usage levels up to:
 not for flavor use.
 
Safety References:
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
National Institute of Allergy and Infectious Diseases:Data
piper betle leaf oil
Chemidplus:0084775815
 
References:
 piper betle leaf oil
Pubchem (sid):135279913
 
Other Information:
Export Tariff Code:3301.29.6000
Typical G.C.
Wikipedia:View
FAO:BASIC PRINCIPLES OF STEAM DISTILLATION
 
Potential Blenders and core components note
For Odor
animal
castoreum resinoid
FL/FR
castoreum resinoid replacer
FR
leather fragrance
FR
anise
anise seed oil
FL/FR
star
anise seed oil china
FL/FR
anise seed oil colombia
FL/FR
star
anise seed oil spain
FL/FR
anisic
ortho-
acetanisole
FL/FR
balsamic
sumatra
benzoin absolute
FL/FR
siam
benzoin CO2 extract
FL/FR
benzoin essence
FR
burnt
amber oil
FR
camphoreous
dextro-
camphor
FL/FR
chocolate
vanillyl ethyl ether
FL/FR
coffee
furfuryl mercaptan
FL/FR
coumarinic
phthalide
FL/FR
creamy
para-
vanillyl alcohol
FL/FR
floral
benzyl alcohol
FL/FR
para-
cresyl acetate
FL/FR
dimethyl anthranilate
FL/FR
ortho-
methyl acetophenone
FL/FR
fruity
ethyl 3-hydroxyhexanoate
FL/FR
para-
tolualdehyde
FL/FR
meta-
tolualdehyde
FL/FR
green
3,7-
dimethyl-6-octenoic acid
FL/FR
diphenyl oxide
FL/FR
seaweed absolute (fucus vesiculosus et serratus)
FL/FR
herbal
red
thyme oil india
FL/FR
red
thyme oil spain
FL/FR
thymol
FL/FR
yerba mate absolute
FL/FR
honey
phenyl pyruvic acid
FL/FR
leathery
castoreum absolute
FL/FR
leather specialty
FR
medicinal
2,6-
xylenol
FL/FR
minty
piperitenone
FL/FR
mossy
sea resorcylate
FR
veramoss (IFF)
FR
nutty
nutty cyclohexenone
FL/FR
phenolic
anisole
FL/FR
betel leaf oil replacer
FR
para-
cresol
FL/FR
ortho-
cresyl isobutyrate
FL/FR
2,3-
dimethyl benzofuran
FL/FR
para-alpha-
dimethyl styrene
FL/FR
ortho-
guaiacol
FL/FR
2'-
hydroxyacetophenone
FL/FR
methyl benzoate
FL/FR
4-
methyl-2,6-dimethoxyphenol
FL/FR
2-
propyl phenol
FL/FR
4-
propyl phenol
FL/FR
4-
vinyl phenol
FL/FR
2,5-
xylenol
FL/FR
2,3-
xylenol
FL/FR
smoky
birch tar oil
FL/FR
boswellia serrata wood tar oil
FR
cade oil
FR
2,6-
dimethoxyphenol
FL/FR
alpha-
ethoxy-ortho-cresol
FL/FR
4-
ethyl phenol
FL/FR
propyl paraben
CS
pyroligneous acids
FL/FR
pyroligneous acids hickory
FL/FR
spicy
clove bud absolute
FL/FR
cubeb oil
FL/FR
4-
ethyl guaiacol
FL/FR
4-
methyl guaiacol
FL/FR
pepper tree berry oil
FL/FR
zingerone
FL/FR
tobacco
methyl benzoxole
FL/FR
vanilla
ortho-
dimethyl hydroquinone
FL/FR
woody
guaiacyl acetate
FL/FR
beta-
thujaplicin
FR
For Flavor
No flavor group found for these
benzyl disulfide
FL
birch tar oil
FL/FR
chavicol
FL
ortho-
cresyl isobutyrate
FL/FR
2,4-
dihydroxybenzoic acid
FL
2,6-
dimethoxy-4-vinyl phenol
FL
ortho-
dimethyl hydroquinone
FL/FR
alpha-
ethoxy-ortho-cresol
FL/FR
3-
methyl crotonic acid
FL
1-
methyl pyrrole
FL
4-
methyl salicylaldehyde
FL
piperitenone
FL/FR
prenyl mercaptan
FL
2-
propyl phenol
FL/FR
4-
propyl phenol
FL/FR
para-
salicylic acid
FL
seaweed absolute (fucus vesiculosus et serratus)
FL/FR
animal
animal
castoreum resinoid
FL/FR
anise
anise seed oil
FL/FR
star
anise seed oil china
FL/FR
anise seed oil colombia
FL/FR
star
anise seed oil spain
FL/FR
anisic
ortho-
methyl acetophenone
FL/FR
aromatic
anisole
FL/FR
para-
cresyl acetate
FL/FR
burnt
2,6-
xylenol
FL/FR
chemical
2,3-
dimethyl benzofuran
FL/FR
coffee
furfuryl mercaptan
FL/FR
coumarinic
phthalide
FL/FR
creamy
para-
vanillyl alcohol
FL/FR
fishy
3-
penten-2-one
FL
floral
3,7-
dimethyl-6-octenoic acid
FL/FR
fruity
benzyl alcohol
FL/FR
dimethyl anthranilate
FL/FR
ethyl 3-hydroxyhexanoate
FL/FR
meta-
tolualdehyde
FL/FR
green
diphenyl oxide
FL/FR
herbal
red
thyme oil india
FL/FR
red
thyme oil spain
FL/FR
yerba mate absolute
FL/FR
leathery
castoreum absolute
FL/FR
meaty
4-
allyl-2,6-dimethoxyphenol
FL
2,6-
dimethyl thiophenol
FL
ortho-
thioguaiacol
FL
medicinal
dextro-
camphor
FL/FR
2,6-
dimethoxyphenol
FL/FR
musty
2-
ethoxythiazole
FL
2,5-
xylenol
FL/FR
naphthyl
2'-
hydroxyacetophenone
FL/FR
nutty
methyl benzoxole
FL/FR
nutty cyclohexenone
FL/FR
onion
2-
methyl-1,3-dithiolane
FL
phenolic
para-
cresol
FL/FR
methyl benzoate
FL/FR
4-
methyl-2,6-dimethoxyphenol
FL/FR
phenyl pyruvic acid
FL/FR
thymol
FL/FR
4-
vinyl phenol
FL/FR
2,3-
xylenol
FL/FR
powdery
ortho-
acetanisole
FL/FR
rummy
vanillyl ethyl ether
FL/FR
smoky
4-
ethyl phenol
FL/FR
pyroligneous acids
FL/FR
pyroligneous acids hickory
FL/FR
dextro-
xylose
FL
spicy
sumatra
benzoin absolute
FL/FR
siam
benzoin CO2 extract
FL/FR
chipotle chili oleoresin
FL
clove bud absolute
FL/FR
cubeb oil
FL/FR
para-alpha-
dimethyl styrene
FL/FR
4-
methyl guaiacol
FL/FR
pepper tree berry oil
FL/FR
para-
tolualdehyde
FL/FR
zingerone
FL/FR
vegetable
tyramine
FL
woody
4-
ethyl guaiacol
FL/FR
ortho-
guaiacol
FL/FR
guaiacyl acetate
FL/FR
 
Potential Uses:
FRbeeswax absolute replacer
FRbetel
FLcapsicum
FRcastoreum
FLcherry wild cherry
FRcigar
FLcloudberry bakeapple
FRcranberry
FRdeertongue absolute replacer
FRfig
FRgenet
FRhay new mown hay
FRleather
FRleather russian leather
FLmate
FLmustard
FLnectarine
CSpinus palustris tar
FRrhubarb
 tart
FRtobacco
FRtobacco
FRtobacco flower
FLwasabi
FRwisteria
FRwoodruff
 
Occurrence (nature, food, other):note
 piper betel
Search Trop Picture
 
Synonyms:
 betel leaf oil
 volatile oil obtained by the steam distillation of the leaves of the pepper, piper betle l., piperaceae
 

Articles:

PubMed:The phytochemistry, traditional uses and pharmacology of Piper Betel. linn (Betel Leaf): A pan-asiatic medicinal plant.
PubMed:Hydroxychavicol, a betel leaf component, inhibits prostate cancer through ROS-driven DNA damage and apoptosis.
PubMed:Effect of Sameera Pannaga Rasa (arsenomercurial formulation) in the management of Tamaka Shwasa (bronchial asthma) - Randomized double blind clinical study.
PubMed:Salivary ascorbic acid levels in betel quid chewers: A biochemical study.
PubMed:Piper betel leaf: a reservoir of potential xenohormetic nutraceuticals with cancer-fighting properties.
PubMed:Inhibitory effect of Piper betel leaf extracts on copper-mediated LDL oxidation and oxLDL-induced lipid accumulation via inducing reverse cholesterol transport in macrophages.
PubMed:Piper betel leaf extract: anticancer benefits and bio-guided fractionation to identify active principles for prostate cancer management.
PubMed:Effects of ionic surfactants on the morphology of silver nanoparticles using Paan (Piper betel) leaf petiole extract.
PubMed:Anti-microbial principles of selected remedial plants from Southern India.
PubMed:Biotransformation and cytotoxic effects of hydroxychavicol, an intermediate of safrole metabolism, in isolated rat hepatocytes.
PubMed:Antimicrobial Activity of Terminalia catappa, Manilkara zapota and Piper betel Leaf Extract.
PubMed:Cheilitis granulomatosa associated with allergic contact dermatitis to betel quid.
PubMed:Antioxidant activity of piper betel leaf extract and its constituents.
PubMed:Protection effect of piper betel leaf extract against carbon tetrachloride-induced liver fibrosis in rats.
PubMed:Increased sensitivity of Hep G2 cells toward the cytotoxicity of cisplatin by the treatment of piper betel leaf extract.
PubMed:Radioprotective property of the ethanolic extract of Piper betel Leaf.
PubMed:Epidemiology of betel quid usage.
PubMed:Paan without tobacco: an independent risk factor for oral cancer.
PubMed:Hydroxychavicol: a new anti-nitrosating phenolic compound from betel leaf.
PubMed:Nonmutagenicity of betel leaf and its antimutagenic action against environmental mutagens.
PubMed:The aetiology of oral submucous fibrosis: the stimulation of collagen synthesis by extracts of areca nut.
PubMed:Susceptibility characterisation of Candida spp. to four essential oils.
PubMed:Oral submucous fibrosis: a review article on etiopathogenesis.
 
Notes:
The essential oil is produced by steam distillation from the leaves of Piper Betle, a vine of the pepper family. The plant grows widely over the entire area between South Arabia and Southeast China.
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