EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

lepidine
p-methylquinoline

Supplier Sponsors

Fragrance Demo Formulas
Name:4-methylquinoline
CAS Number: 491-35-0Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:207-734-2
FDA UNII: 116169T3O8
Nikkaji Web:J1.552K
Beilstein Number:0110926
MDL:MFCD00006784
CoE Number:488
XlogP3:2.60 (est)
Molecular Weight:143.18873000
Formula:C10 H9 N
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
EFSA/JECFA Comments:
No longer supported by Industry (EFSA, 2011).
Category:flavor and fragrance agents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Perfumer and Flavorist:Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
FDA Mainterm (SATF):491-35-0 ; LEPIDINE
FDA Regulation:
FDA PART 172 -- FOOD ADDITIVES PERMITTED FOR DIRECT ADDITION TO FOOD FOR HUMAN CONSUMPTION
Subpart F--Flavoring Agents and Related Substances
Sec. 172.515 Synthetic flavoring substances and adjuvants.
 
Physical Properties:
Appearance:colorless to yellow clear liquid (est)
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Specific Gravity:1.08300 to 1.08900 @ 25.00 °C.
Pounds per Gallon - (est).: 9.012 to 9.062
Refractive Index:1.61500 to 1.62100 @ 20.00 °C.
Melting Point: 9.00 °C. @ 760.00 mm Hg
Boiling Point: 264.00 °C. @ 760.00 mm Hg
Vapor Pressure:0.018000 mmHg @ 25.00 °C. (est)
Flash Point:> 230.00 °F. TCC ( > 110.00 °C. )
logP (o/w): 2.610
Soluble in:
 alcohol
 water, 479.2 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor Type: burnt
burnt oily herbal floral sweet
Odor Description:at 100.00 %. burnt oily herbal floral sweet
Flavor Type: floral
sweet floral oily burnt
Taste Description: at 5.00 ppm in water. sweet floral oily slightly burnt
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: perfuming agents
 
Suppliers:
Demand And Supply Chem
For experimental / research use only.
Lepidine
Penta International
4-METHYL QUINOLINE
R C Treatt & Co Ltd
para-Methyl Quinoline
Santa Cruz Biotechnology
For experimental / research use only.
Lepidine
Sigma-Aldrich
4-Methylquinoline, ≥99%
Certified Food Grade Products
Synerzine
4-Methyl Quinoline
TCI AMERICA
For experimental / research use only.
Lepidine >97.0%(GC)(T)
 
Safety Information:
Preferred SDS: View
European information :
Most important hazard(s):
Xi - Irritant
R 36/37/38 - Irritating to eyes, respiratory system, and skin.
S 02 - Keep out of the reach of children.
S 24/25 - Avoid contact with skin and eyes.
S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S 36 - Wear suitable protective clothing.
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-rat LD50 1260 mg/kg
(Moreno, 1976y)

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
flavor and fragrance agents
RIFM Fragrance Material Safety Assessment: Search
IFRA Code of Practice Notification of the 49th Amendment to the IFRA Code of Practice
Recommendation for lepidine usage levels up to:
  0.6000 % in the fragrance concentrate.
 
Maximised Survey-derived Daily Intakes (MSDI-EU): 0.12 (μg/capita/day)
Modified Theoretical Added Maximum Daily Intake (mTAMDI): 160 (μg/person/day)
Threshold of Concern:90 (μg/person/day)
Structure Class: III
 
Food categories according to Commission Regulation EC No. 1565/2000 (EC, 2000) in FGE.06 (EFSA, 2002a). According to the Industry the "normal" use is defined as the average of reported usages and "maximum use" is defined as the 95th percentile of reported usages (EFSA, 2002i).
Note: mg/kg = 0.001/1000 = 0.000001 = 1/1000000 = ppm.
 average usage mg/kgmaximum usage mg/kg
Dairy products, excluding products of category 02.0 (01.0): 0.400002.00000
Fats and oils, and fat emulsions (type water-in-oil) (02.0): 0.200001.00000
Edible ices, including sherbet and sorbet (03.0): 0.400002.00000
Processed fruit (04.1): 0.300001.50000
Processed vegetables (incl. mushrooms & fungi, roots & tubers, pulses and legumes), and nuts & seeds (04.2): --
Confectionery (05.0): 0.400002.00000
Chewing gum (05.3): --
Cereals and cereal products, incl. flours & starches from roots & tubers, pulses & legumes, excluding bakery (06.0): 0.200001.00000
Bakery wares (07.0): 0.400002.00000
Meat and meat products, including poultry and game (08.0): 0.100000.40000
Fish and fish products, including molluscs, crustaceans and echinoderms (MCE) (09.0): 0.100000.40000
Eggs and egg products (10.0): --
Sweeteners, including honey (11.0): --
Salts, spices, soups, sauces, salads, protein products, etc. (12.0): 0.200001.00000
Foodstuffs intended for particular nutritional uses (13.0): 0.400002.00000
Non-alcoholic ("soft") beverages, excl. dairy products (14.1): 0.200001.00000
Alcoholic beverages, incl. alcohol-free and low-alcoholic counterparts (14.2): --
Ready-to-eat savouries (15.0): 1.000005.00000
Composite foods (e.g. casseroles, meat pies, mincemeat) - foods that could not be placed in categories 01.0 - 15.0 (16.0): 0.200001.00000
 
Safety References:
European Food Safety Athority(EFSA):Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies...

European Food Safety Authority (EFSA) reference(s):

Opinion of the Scientific Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) related to Flavouring Group Evaluation 24 (FGE.24): Pyridine, pyrrole, indole and quinoline derivatives from chemical group 28 (Commission Regulation (EC) No 1565/2000 of 18 July 2000)
View page or View pdf

Pyridine, pyrrole, indole and quinoline derivatives from chemical group 28 Flavouring Group Evaluation 24, Revision 1 - Scientific Opinion of the Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC)
View page or View pdf

Flavouring Group Evaluation 77 (FGE77) [1] - Consideration of Pyridine, Pyrrole and Quinoline Derivatives evaluated by JECFA (63rd meeting) structurally related to Pyridine, Pyrrole, Indole and Quinoline Derivatives evaluated by EFSA in FGE.24Rev1 (2008)
View page or View pdf

Scientific opinion on Flavouring Group Evaluation 24, Revision 2 (FGE.24Rev2): Pyridine, pyrrole, indole and quinoline derivatives from chemical group 28
View page or View pdf

EPI System: View
Chemical Carcinogenesis Research Information System:Search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA GENetic TOXicology:Search
EPA Substance Registry Services (TSCA):491-35-0
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :10285
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
4-methylquinoline
Chemidplus:0000491350
RTECS:OH0316000 for cas# 491-35-0
 
References:
 4-methylquinoline
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:491-35-0
Pubchem (cid):10285
Pubchem (sid):134976471
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Substances Added to Food (formerly EAFUS):View
CHEBI:View
CHEMBL:View
HMDB (The Human Metabolome Database):HMDB33437
FooDB:FDB011475
Export Tariff Code:2933.40.7050
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
Wikipedia:View
 
Potential Blenders and core components note
For Odor
balsamic
benzyl benzoate
FL/FR
benzyl salicylate
FL/FR
cyclohexyl benzoate
FL/FR
citrus
acetaldehyde citronellyl methyl acetal
FR
agrestic specialty
FR
beta-
bisabolol
FL/FR
2-
heptanol
FL/FR
litsea cubeba oil terpeneless
FL/FR
floral
ortho-
acetyl-para-cresol
FL/FR
amyl salicylate
FL/FR
iso
amyl salicylate
FL/FR
benzyl pivalate
FL/FR
bois de rose fragrance
FR
bois de rose oil brazil
FL/FR
bois de rose oil replacer
FR
butyl tiglate
FR
cassie absolute replacer
FL/FR
cassis cyclohexene
FR
citronellal
FL/FR
clover fragrance
FR
coriander seed oil
FL/FR
cyclohexyl ethyl alcohol
FL/FR
cymbopogon validus leaf oil
FR
dihydroisojasmonate methyl ester
FR
dihydromyrcene
FR
2,4-
dimethyl-3-cyclohexene-1-methanol
FR
eau de brouts absolute
FR
elder flower fragrance
FR
ethyl linalool
FR
ethyl linalyl acetal
FR
geranyl acetate
FL/FR
heather fragrance
FR
heliotrope absolute
FR
herbal pyran
FR
hexahydrofarnesyl acetone
FL/FR
ho leaf oil
FR
ilex paraguariensis oleoresin
FL/FR
beta-
ionol
FL/FR
jasmin acetate
FL/FR
(Z)-
jasmone
FL/FR
iso
jasmone
FL/FR
karo karounde absolute
FR
karo karounde absolute replacer
FR
lavandin concrete decolorized
FR
lavandin oil
FL/FR
lavandula angustifolia flower oil
FL/FR
lavender absolute replacer
FR
lavender oil
FL/FR
lavender oil bulgaria
FL/FR
lavender oil france
FL/FR
lavender oil greece
FL/FR
lavender oil replacer
FR
nonisyl propionate
FR
(Z)-beta-
ocimene
FL/FR
pelargonium graveolens flower water
FR
iso
phytol
FL/FR
prenyl salicylate
FL/FR
reseda absolute
FR
reseda absolute replacer
FR
sambucus nigra flower oil CO2 extract
FR
terpinyl isobutyrate
FL/FR
tetrahydrolinalyl acetate
FR
fruity
myrtle oil replacer
FR
sambucus canadensis fruit absolute
FL/FR
green
acetaldehyde di-(Z)-3-hexen-1-yl acetal
FL/FR
acetaldehyde ethyl phenethyl acetal
FL/FR
iso
butyl benzyl carbinol
FL/FR
decanal propylene glycol acetal
FL/FR
heptyl formate
FL/FR
(Z)-3-
hexen-1-ol
FL/FR
(Z)-3-
hexen-1-yl angelate
FR
hexyl tiglate
FL/FR
marigold pot absolute
FL/FR
herbal
alpha-
amyl cinnamyl formate
FL/FR
calendula officinalis flower oil CO2 extract
FR
cananga fruit oil
FR
carrot seed oil (daucus carota ssp. gummifer hook. fil.) spain
FR
chamomile isobutyrate
FR
chrysanthemum ketone
FR
coriander seed absolute
FL/FR
inula root oil
FR
lavandin flower water
FR
abrialis
lavandin oil
FL/FR
lavender absolute bulgaria
FL/FR
lavender absolute france
FL/FR
lavender fragrance
FR
lavender oil australia
FL/FR
lavender oil terpeneless
FL/FR
lavender specialty
FR
lavender stem oil lithuania
FR
marigold pot flower oil
FL/FR
laevo-
menthyl propionate
FL/FR
methyl cyclogeranate (Firmenich)
FR
methyl ortho-anisate
FL/FR
5-
methyl-3-heptanone
FL/FR
myrtle oil
FL/FR
myrtle oil morocco
FL/FR
nonisyl acetate
FR
minty
homo
menthyl acetate
FL/FR
spicy
cardamom seed oil CO2 extract
FL/FR
carnation absolute
FR
carnation absolute replacer
FR
ginger root oil cochin
FL/FR
hollyberry fragrance
FR
origanum majorana leaf oil
FL/FR
woody
2-
decalinyl acetate
FR
woody acetate
FR
woody amber specialty
FR
zdravetz absolute
FR
zdravetz oil
FL/FR
For Flavor
No flavor group found for these
acetaldehyde di-(Z)-3-hexen-1-yl acetal
FL/FR
ortho-
acetyl-para-cresol
FL/FR
alpha-
amyl cinnamyl formate
FL/FR
benzyl pivalate
FL/FR
cassie absolute replacer
FL/FR
cyclohexyl benzoate
FL/FR
decanal propylene glycol acetal
FL/FR
8,9-
dehydrotheaspirone
FL
ilex paraguariensis oleoresin
FL/FR
marigold pot flower oil
FL/FR
laevo-
menthyl propionate
FL/FR
methyl ortho-anisate
FL/FR
myrtle oil morocco
FL/FR
origanum majorana leaf oil
FL/FR
3-
pentanol
FL
terpinyl isobutyrate
FL/FR
(E)-4-
undecenal
FL
zdravetz oil
FL/FR
amber
amber
iso
butyl benzyl carbinol
FL/FR
aromatic
amyl salicylate
FL/FR
balsamic
benzyl benzoate
FL/FR
benzyl salicylate
FL/FR
citrus
beta-
bisabolol
FL/FR
cooling
homo
menthyl acetate
FL/FR
fatty
heptyl formate
FL/FR
floral
bois de rose oil brazil
FL/FR
citronellal
FL/FR
elderflower distillates
FL
beta-
ionol
FL/FR
jasmin acetate
FL/FR
fruity
2-
heptanol
FL/FR
5-
methyl-3-heptanone
FL/FR
sambucus canadensis fruit absolute
FL/FR
green
acetaldehyde ethyl phenethyl acetal
FL/FR
iso
amyl salicylate
FL/FR
cyclohexyl ethyl alcohol
FL/FR
geranyl acetate
FL/FR
hexahydrofarnesyl acetone
FL/FR
(Z)-3-
hexen-1-ol
FL/FR
hexyl tiglate
FL/FR
iso
jasmone
FL/FR
marigold pot absolute
FL/FR
(Z)-beta-
ocimene
FL/FR
sorbyl acetate
FL
herbal
coriander seed absolute
FL/FR
coriander seed oil
FL/FR
abrialis
lavandin oil
FL/FR
lavandin oil
FL/FR
lavandula angustifolia flower oil
FL/FR
lavender absolute bulgaria
FL/FR
lavender absolute france
FL/FR
lavender oil
FL/FR
lavender oil australia
FL/FR
lavender oil bulgaria
FL/FR
lavender oil france
FL/FR
lavender oil greece
FL/FR
lavender oil terpeneless
FL/FR
prenyl salicylate
FL/FR
lemon
litsea cubeba oil terpeneless
FL/FR
oily
iso
phytol
FL/FR
spicy
cardamom seed oil CO2 extract
FL/FR
cumin oleoresin
FL
ginger root oil cochin
FL/FR
myrtle oil
FL/FR
woody
(Z)-
jasmone
FL/FR
 
Potential Uses:
FRanimal
FRchypre
FRleather
FRrose
FRwoody
 
Occurrence (nature, food, other):note
 cress garden cress seed
Search Trop Picture
 peppermint oil - up to 0.1 mg/kg
Search Trop Picture
 
Synonyms:
 cincholepidine
 lepidine
4-lepidine
4-methyl quinoline
gamma-methyl quinoline
p-methyl quinoline
para-methyl quinoline
4-methylquinoline
gamma-methylquinoline
p-methylquinoline
para-methylquinoline
 quinoline, 4-methyl-
 

Articles:

PubMed:Dehydrogenative cross-coupling reaction by cooperative transition-metal and Brønsted acid catalysis for the synthesis of β-quinolinyl α-amino acid esters.
PubMed:Biofunctional constituent isolated from Citrullus colocynthis fruits and structure-activity relationships of its analogues show acaricidal and insecticidal efficacy.
PubMed:Antinociceptive effect of some biuret derivatives on formalin test in mice.
PubMed:TiO₂ nanotube arrays prepared by anodization as an adsorbent in micro-solid-phase extraction to preconcentrate and determine nitrogen-containing polycyclic aromatic hydrocarbons in water samples.
PubMed:Antimicrobial potentials of active component isolated from Citrullus colocynthis fruits and structure-activity relationships of its analogues against foodborne bacteria.
PubMed:Tafenoquine and NPC-1161B require CYP 2D metabolism for anti-malarial activity: implications for the 8-aminoquinoline class of anti-malarial compounds.
PubMed:Anion effects on the structures and magnetic properties of binuclear lanthanide single-molecule magnets.
PubMed:Genotoxicity risk assessment of diversely substituted quinolines using the SOS chromotest.
PubMed:7-Hydroxyquinoline-8-carbaldehydes. 1. Ground- and excited-state long-range prototropic tautomerization.
PubMed:A novel approach to the pyridoacridine ring system: synthesis of the topoisomerase inhibitor 13-deazaascididemin.
PubMed:Integrated organic-aqueous biocatalysis and product recovery for quinaldine hydroxylation catalyzed by living recombinant Pseudomonas putida.
PubMed:One-pot synthesis of pyranocoumarins via microwave-assisted pseudo multicomponent reactions and their molecular switching properties.
PubMed:Synthesis, DNA binding, and oxidative cleavage studies of Fe(II) and Co(III) complexes containing bioactive ligands.
PubMed:Synthesis, antidepressant and antifungal evaluation of novel 2-chloro-8-methylquinoline amine derivatives.
PubMed:Physicochemical characterization of NPC 1161C, a novel antimalarial 8-aminoquinoline, in solution and solid state.
PubMed:Separation and preconcentration of trace amounts of aluminum ions in surface water samples using different analytical techniques.
PubMed:Spectroscopic studies on 2-[2-(4-methylquinolin-2-yl)hydrazono]-1,2-diphenylethanone molecule and its metal complexes.
PubMed:A bistable molecular switch driven by photoinduced hydrogen-atom transfer.
PubMed:An ATP-sensitive potassium channel blocker suppresses sodium-induced hypertension through increased secretion of urinary kallikrein.
PubMed:Thiazole Orange derivatives: synthesis, fluorescence properties, and labeling cancer cells.
PubMed:Toxicity in rhesus monkeys following administration of the 8-aminoquinoline 8-[(4-amino-l-methylbutyl)amino]- 5-(l-hexyloxy)-6-methoxy-4-methylquinoline (WR242511).
PubMed:Selenium-containing heterocycles: synthesis and pharmacological activities of some new 4-methylquinoline-2(1H) selenone derivatives.
PubMed:Facile, one-step production of niacin (vitamin B3) and other nitrogen-containing pharmaceutical chemicals with a single-site heterogeneous catalyst.
PubMed:Evaluation of the Spanish hot dip galvanising sector as a source of polychlorinated dibenzo-p-dioxins and polychlorinated dibenzofurans.
PubMed:Detection of methylquinoline transformation products in microcosm experiments and in tar oil contaminated groundwater using LC-NMR.
PubMed:Synthesis of para-methoxybenzyl (PMB) ethers under neutral conditions.
PubMed:Insertion reactions of alkynes and organic isocyanides into the palladium-carbon bond of dimetallic Fe-Pd alkoxysilyl complexes.
PubMed:Development and validation of a stability-indicating reversed-phase high performance liquid chromatography method for NPC 1161C, a novel 8-aminoquinoline anti-malarial drug.
PubMed:Ruthenium-catalyzed intermolecular coupling reactions of arylamines with ethylene and 1,3-dienes: mechanistic insight on hydroamination vs ortho-C-H bond activation.
PubMed:Modulation of Ca(2+)-dependent and Ca(2+)-independent miniature endplate potentials by phorbol ester and adenosine in frog.
PubMed:Simultaneous determination of NSO-heterocycles, homocycles and their metabolites in groundwater of tar oil contaminated sites using LC with diode array UV and fluorescence detection.
PubMed:[Antimicrobial effect of hydrazides and ilidenhydrazides of (quinoline-2-ilthio)carboxylic acids].
PubMed:Ring-substituted quinolines. Part 2: Synthesis and antimycobacterial activities of ring-substituted quinolinecarbohydrazide and ring-substituted quinolinecarboxamide analogues.
PubMed:Water-soluble molecular capsules: self-assembly and binding properties.
PubMed:Synthesis and antimycobacterial activities of ring-substituted quinolinecarboxylic acid/ester analogues. Part 1.
PubMed:Modular and tunable chemosensor scaffold for divalent zinc.
PubMed:Gene cluster of Arthrobacter ilicis Ru61a involved in the degradation of quinaldine to anthranilate: characterization and functional expression of the quinaldine 4-oxidase qoxLMS genes.
PubMed:Preparation of 7-alkylamino-2-methylquinoline-5,8-diones.
PubMed:N-(2-hydroxypropyl)methacrylamide (HPMA) copolymers for targeted delivery of 8-aminoquinoline antileishmanial drugs.
PubMed:Synthesis, characterization and reactions of 2-deoxo-5-deazaalloxazines.
PubMed:A fluorometric assay for the determination of 1-deoxy-D-xylulose 5-phosphate synthase activity.
PubMed:Derivatives of 8-hydroxy-2-methylquinoline are powerful prototypes for zinc sensors in biological systems.
PubMed:A P450 BM-3 mutant hydroxylates alkanes, cycloalkanes, arenes and heteroarenes.
PubMed:Synthesis and in vitro cytotoxicity of 2-alkylaminosubstituted quinoline derivatives.
PubMed:Anti-mutagenic structural modification by fluorine-substitution in highly mutagenic 4-methylquinoline derivatives.
PubMed:Sphingomonas sp. strain Lep1: an aerobic degrader of 4-methylquinoline.
PubMed:Synthesis of Pyrrolo[4,3,2-de]quinolines from 6,7-Dimethoxy-4-methylquinoline. Formal Total Syntheses of Damirones A and B, Batzelline C, Isobatzelline C, Discorhabdin C, and Makaluvamines A-D.
PubMed:Evaluation of selected antiprotozoal drugs in the Babesia microti-hamster model.
PubMed:Aerobic biodegradation of 4-methylquinoline by a soil bacterium.
PubMed:Potent mutagenic potential of 4-methylquinoline: metabolic and mechanistic considerations.
PubMed:Potential use of WR6026 as prophylaxis against transfusion-transmitted American trypanosomiasis.
PubMed:Side-chain hydroxylation in the metabolism of 8-aminoquinoline antiparasitic agents.
PubMed:Phase 2 efficacy trial of an oral 8-aminoquinoline (WR6026) for treatment of visceral leishmaniasis.
PubMed:Hydroxylation and biodegradation of 6-methylquinoline by pseudomonads in aqueous and nonaqueous immobilized-cell bioreactors.
PubMed:Microbial metabolism of quinoline and related compounds. XIX. Degradation of 4-methylquinoline and quinoline by Pseudomonas putida K1.
PubMed:Microbial metabolism of quinoline and related compounds. XV. Quinoline-4-carboxylic acid oxidoreductase from Agrobacterium spec.1B: a molybdenum-containing enzyme.
PubMed:Comparison of methemoglobin formers in protection against the toxic effects of cyanide.
PubMed:Genotoxicity of fluoroquinolines and methylquinolines.
PubMed:Pharmacokinetics of the anti-leishmanian agent WR 6026 in dogs.
PubMed:Quinoline esters as potential antimalarial drugs: effect on relapses of Plasmodium cynomolgi infections in monkeys.
PubMed:Microbial degradation of quinoline and methylquinolines.
PubMed:Carcinogenicity of quinoline, 4- and 8-methylquinoline and benzoquinolines in newborn mice and rats.
PubMed:2,2-Dialkyl-1,2-dihydroquinolines: cytochrome P-450 catalyzed N-alkylporphyrin formation, ferrochelatase inhibition, and induction of 5-aminolevulinic acid synthase activity.
PubMed:Fungal metabolism of 4-methylprimaquine.
PubMed:Metabolism of a potential 8-aminoquinoline antileishmanial drug in rat liver microsomes.
PubMed:High-performance liquid chromatographic method for the analysis of a candidate 8-aminoquinoline antileishmanial drug using oxidative electrochemical detection.
PubMed:Tumor-initiating activity of quinoline and methylated quinolines on the skin of SENCAR mice.
PubMed:Study of artificial flavouring substances for mutagenicity in the Salmonella/microsome, Basc and micronucleus tests.
PubMed:Quinoline and methylquinolines in cigarette smoke: comparative data and the effect of filtration.
PubMed:Effect of carcinogenic components of cigarette smoke on in vivo production of murine interferon.
PubMed:On the metabolism of quinoline and isoquinoline: possible molecular basis for differences in biological activities.
PubMed:Microbial transformation of nitroaromatic compounds in sewage effluent.
PubMed:Effect of sidestream tobacco smoke components on alpha/beta interferon production.
PubMed:[Antimalarial 6-aminoquinolines. XIV. 6-(4-Diethylamino-1-methylbutylamino)-4-methoxy-2-methyl- and -2,4-dimethylquinolines with variations of substituents in positions 5 and 8].
PubMed:Synthesis and antimalarial activity of 8-[(1-alkyl-4-aminobutyl)amino]-6-methoxy-4-methylquinolines.
PubMed:[Antimalarial 6-aminoquinolines. XIII. 5,8-Dialkoxyderivatives of 6-(4-diethylamino-1-methylbutylamino)-2-methyl- and 6-(4-diethylamino-1-methylbutylamino)-2,4-dimethylquinoline (author's transl)].
PubMed:Analogues of 8-[[6-(diethylamino) hexyl]amino]-6-methoxy-4-methylquinoline as candidate antileishmanial agents.
PubMed:Synthesis of 2,4-disubstituted 6-methoxy-8-aminoquinoline analogues as potential antiparasitics.
PubMed:Leishmaniasis: in search of new chemotherapeutic agents.
PubMed:Primaquine analogues: derivatives of 4-amino-2-methoxyacridine.
PubMed:[The reaction of heteroaromatic N-oxide with acid chloride and cyanide. IX. On p-tolylsulfonylation on side-chain carbon in 2-methylquinoline 1-oxide and related compounds (author's transl)].
PubMed:The antileishmanial activity of lepidines.
PubMed:Toxic interaction of mixtures of two coal conversion effluent components (resorcinol and 6-methylquinoline) to Daphnia magna.
PubMed:Antimalarials. 11. 2-Vinylogs of substituted 2-aryl-4-quinoline amino alcohols.
PubMed:Chichibabin reaction. 3. Chichibabin reaction of 7-methylquinoline and migration of the methyl group in Friedel-Crafts reaction of N-(m-tolyl)- and N-)p-tolyl)-beta-chloropropionamide (studies on the syntheses of heterocyclic compounds. CCXV.
 
Notes:
Alkaloid from the seeds of Lepidium sativum (garden cress) Lepidine, or 4-methylquinoline, is a heterocyclic aromatic organic compound. Its methyl group is fairly acidic, allowing for condensations to occur at this position, especially when the nitrogen is quaternized. It is used in the preparation of certain dyes.
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