|
Category:flavor and fragrance agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Appearance: | colorless clear oily liquid (est) |
| Assay: | 98.00 to 100.00
|
| Food Chemicals Codex Listed: | No |
| Specific Gravity: | 1.00400 to 1.01400 @ 20.00 °C.
|
| Pounds per Gallon - (est).: | 8.364 to 8.447
|
| Refractive Index: | 1.52100 to 1.53100 @ 20.00 °C.
|
| Melting Point: | 18.00 to 20.00 °C. @ 760.00 mm Hg
|
| Boiling Point: | 218.00 to 219.00 °C. @ 760.00 mm Hg
|
| Vapor Pressure: | 0.129000 mmHg @ 25.00 °C. (est) |
| Flash Point: | 210.00 °F. TCC ( 98.89 °C. )
|
| logP (o/w): | 2.190 |
| Soluble in: |
| | alcohol | | | water, 2000 mg/L @ 20 °C (exp) |
Organoleptic Properties:
| Odor Type: floral |
| hawthorn lilac floral aromatic cherry herbal |
| Odor Description:at 10.00 % in dipropylene glycol. hawthorn lilac floral aromatic cherry herbal |
| Flavor Type: fruity |
| fruity |
| Taste Description: fruity |
| Odor and/or flavor descriptions from others (if found). |
| Alfrebro |
| PROPIOPHENONE NATURAL |
| Odor Description:Sweet, Floral, Aromatic |
| Pell Wall Perfumes |
| Propiophenone |
Odor Description:Floral-lilac and hawthorne, sweet, fruity-cherry. Powerful
Arctander discusses both its uses and limitations: “has found some use in perfume compositions for its powerful, herbaceous-floral effect, and for an overall character less pungent and less chemical than Acetophenone.
Its odor has some similarity to that of Ethylbenzoate, and it can be used in discrete amounts in Lilac, higher proportions in Hawthorne, Wisteria, Fougere, etc. It blends well with Cananga, Amylsalicylate, Anisaldehyde, Lavandin oil, etc. and it is relatively inexpensive. |
| Taste Description:fruity |
Cosmetic Information:
Suppliers:
| Alfrebro |
| PROPIOPHENONE NATURAL
Odor: Sweet, Floral, Aromatic |
| BOC Sciences |
| For experimental / research use only. |
| Propiophenone > 95%
|
| EMD Millipore |
| For experimental / research use only. |
| Propiophenone
|
| Pell Wall Perfumes |
| Propiophenone
Odor: Floral-lilac and hawthorne, sweet, fruity-cherry. Powerful Use: Arctander discusses both its uses and limitations: “has found some use in perfume compositions for its powerful, herbaceous-floral effect, and for an overall character less pungent and less chemical than Acetophenone.
Its odor has some similarity to that of Ethylbenzoate, and it can be used in discrete amounts in Lilac, higher proportions in Hawthorne, Wisteria, Fougere, etc. It blends well with Cananga, Amylsalicylate, Anisaldehyde, Lavandin oil, etc. and it is relatively inexpensive. |
| Penta International |
| PROPIOPHENONE
|
| Sigma-Aldrich |
| Propiophenone, ≥99%
Odor: cherry |
| Certified Food Grade Products |
| TCI AMERICA |
| For experimental / research use only. |
| Propiophenone >98.0%(GC)
|
Safety Information:
| Preferred SDS: View |
| European information : |
| Most important hazard(s): | | Xi - Irritant |
R 36/38 - Irritating to skin and eyes.
S 02 - Keep out of the reach of children.
S 24/25 - Avoid contact with skin and eyes.
S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S 36 - Wear suitable protective clothing.
|
| |
| Hazards identification |
| |
| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
| |
| Pictogram | |
| |
| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
oral-rat LD50 4.49 ml/kg
(Carpenter et al., 1974)
intraperitoneal-mouse LD50 100 mg/kg
National Technical Information Service. Vol. AD277-689
oral-rat LD50 4490 uL/kg
Toxicology and Applied Pharmacology. Vol. 28, Pg. 313, 1974.
|
| Dermal Toxicity: |
skin-rabbit LD50 4490 ul/kg
Toxicology and Applied Pharmacology. Vol. 28, Pg. 313, 1974.
subcutaneous-mouse LD50 2250 mg/kg
Arzneimittel-Forschung. Drug Research. Vol. 5, Pg. 559, 1955.
|
| Inhalation Toxicity: |
|
Not determined
|
Safety in Use Information:
| Category: | | flavor and fragrance agents |
| RIFM Fragrance Material Safety Assessment: Search |
| IFRA Code of Practice Notification of the 49th Amendment to the IFRA Code of Practice |
| Recommendation for propiophenone usage levels up to: | | | 1.0000 % in the fragrance concentrate.
|
| |
| Maximised Survey-derived Daily Intakes (MSDI-EU): | 0.012 (μg/capita/day) |
| Maximised Survey-derived Daily Intakes (MSDI-USA): | 0.03 (μg/capita/day) |
| Threshold of Concern: | 1800 (μg/person/day) |
| Structure Class: | I |
| Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS). |
| The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library |
| publication number: 9 |
| Click here to view publication 9 |
| | average usual ppm | average maximum ppm |
| baked goods: | - | 1.00000 |
| beverages(nonalcoholic): | - | 0.20000 |
| beverages(alcoholic): | - | - |
| breakfast cereal: | - | - |
| cheese: | - | - |
| chewing gum: | - | - |
| condiments / relishes: | - | - |
| confectionery froastings: | - | 1.00000 |
| egg products: | - | - |
| fats / oils: | - | - |
| fish products: | - | - |
| frozen dairy: | - | 1.00000 |
| fruit ices: | - | 1.00000 |
| gelatins / puddings: | - | 1.00000 |
| granulated sugar: | - | - |
| gravies: | - | - |
| hard candy: | - | - |
| imitation dairy: | - | - |
| instant coffee / tea: | - | - |
| jams / jellies: | - | - |
| meat products: | - | - |
| milk products: | - | - |
| nut products: | - | - |
| other grains: | - | - |
| poultry: | - | - |
| processed fruits: | - | - |
| processed vegetables: | - | - |
| reconstituted vegetables: | - | - |
| seasonings / flavors: | - | - |
| snack foods: | - | - |
| soft candy: | - | - |
| soups: | - | - |
| sugar substitutes: | - | - |
| sweet sauces: | - | - |
Safety References:
European Food Safety Athority(EFSA):Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies...
|
European Food Safety Authority (EFSA) reference(s):
|
Opinion of the Scientific Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) related to Flavouring Group Evaluation 16 (FGE.16): Aromatic ketones from chemical group 21 (Commission Regulation (EC) No 1565/2000 of 18 July 2000)
View page or View pdf
|
Flavouring Group Evaluation 16, Revision 1 (FGE.16Rev1)[1]: Aromatic ketones from chemical group 21- Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food
View page or View pdf
|
Flavouring Group Evaluation 69, (FGE.69)[1] - Consideration of aromatic substituted secondary alcohols, ketones and related esters evaluated by JECFA (57th meeting) structurally related to aromatic ketones from chemical group 21 evaluated by EFSA in FGE.16 (2006) - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food
View page or View pdf
|
Flavouring Group Evaluation 16, Revision 2 (FGE.16Rev2): Aromatic ketones from chemical group 21
View page or View pdf
|
Scientific Opinion on Flavouring Group Evaluation 69, Revision 1 (FGE.69Rev1): consideration of aromatic substituted secondary alcohols, ketones and related esters evaluated by JECFA (57th meeting), structurally related to aromatic ketones from chemical group 21 evaluated by EFSA in FGE.16Rev2
View page or View pdf
|
| EPI System: View |
| AIDS Citations:Search |
| Cancer Citations:Search |
| Toxicology Citations:Search |
| EPA Substance Registry Services (TSCA):93-55-0 |
| EPA ACToR:Toxicology Data |
| EPA Substance Registry Services (SRS):Registry |
| Laboratory Chemical Safety Summary :7148 |
| National Institute of Allergy and Infectious Diseases:Data |
| WGK Germany:2 |
| 1-phenylpropan-1-one |
| Chemidplus:0000093550 |
| RTECS:UG7175000 for cas# 93-55-0 |
References:
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| | benzoylethane | | | ethyl phenyl ketone | | | hawthorn ketone | | | ketone, ethyl phenyl | | | phenyl ethyl ketone | | 1- | phenyl propan-1-one | | 1- | phenyl-1-propanone | | 1- | phenyl-propan-1-one | | 1- | phenylpropan-1-one | | 1- | propanone, 1-phenyl- | | | propionphenone | | | propionyl benzene | | | propionylbenzene | | | USAF EK-1235 |
Articles:
| Google Patents:Production of propiophenone |
| US Patents:3,952,024 - Furfurylthioacetone |
| PubMed:3-Methyl-2-phenyl-1-substituted-indole derivatives as indomethacin analogs: design, synthesis and biological evaluation as potential anti-inflammatory and analgesic agents. |
| US Patents:Certain 2,5-dimethyl-3-thiopyrazines |
| PubMed:Benzothiazoline: versatile hydrogen donor for organocatalytic transfer hydrogenation. |
| PubMed:[Chemical constituents from Pholidota cantonensis]. |
| PubMed:[Chemical constituents from Pholidota cantonensis]. |
| PubMed:A determinant of odorant specificity is located at the extracellular loop 2-transmembrane domain 4 interface of an Anopheles gambiae odorant receptor subunit. |
| PubMed:Anxiolytic-like effect of Illicium verum fruit oil, trans-anethole and related compounds in mice. |
| PubMed:Hypervalent iodine-promoted α-fluorination of acetophenone derivatives with a triethylamine·HF complex. |
| PubMed:Chiral phosphoric-acid-catalyzed transfer hydrogenation of ethyl ketimine derivatives by using benzothiazoline. |
| PubMed:Synthesis and in vitro cytotoxic activity of novel chalcone-like agents. |
| PubMed:Steric vs. electronic effects in the Lactobacillus brevis ADH-catalyzed bioreduction of ketones. |
| PubMed:Very high pressure liquid chromatography using fully porous particles: quantitative analysis of fast gradient separations without post-run times. |
| PubMed:Pd-catalyzed carbonylative α-arylation of aryl bromides: scope and mechanistic studies. |
| PubMed:Measurement of ionic resonances in alkyl phenyl ketone cations via infrared strong field mass spectrometry. |
| PubMed:Measurement of stable isotope ratios in methylamphetamine: a link to its precursor source. |
| PubMed:[(3)H]metyrapol and 4-[(131)i]iodometomidate label overlapping, but not identical, binding sites on rat adrenal membranes. |
| PubMed:NIS-catalyzed reactions: amidation of acetophenones and oxidative amination of propiophenones. |
| PubMed:Hydrogenolysis of β-O-4 lignin model dimers by a ruthenium-xantphos catalyst. |
| PubMed:Candida tenuis xylose reductase catalyzed reduction of aryl ketones for enantioselective synthesis of active oxetine derivatives. |
| PubMed:Evaluation of an immunochromatographic test for discrimination between Mycobacterium tuberculosis complex & non tuberculous mycobacteria in clinical isolates from extra-pulmonary tuberculosis. |
| PubMed:Effect of column dimension on observed column efficiency in very high pressure liquid chromatography. |
| PubMed:Synthesis of propiophenone derivatives as new class of antidiabetic agents reducing body weight in db/db mice. |
| PubMed:Enhancement of cypermethrin degradation by a coculture of Bacillus cereus ZH-3 and Streptomyces aureus HP-S-01. |
| PubMed:Phloretin inhibits phorbol ester-induced tumor promotion and expression of cyclooxygenase-2 in mouse skin: extracellular signal-regulated kinase and nuclear factor-κB as potential targets. |
| PubMed:The analysis of substituted cathinones. Part 2: an investigation into the phenylacetone based isomers of 4-methylmethcathinone and N-ethylcathinone. |
| PubMed:2,5-Bis[4-(dimethyl-amino)-phen-yl]-3,6-dimethyl-pyrazine. |
| PubMed:Unusual compounds from exudates of Dionysia diapensifolia and D. gaubae var. megalantha (Primulaceae). |
| PubMed:Comparison of Mycobacterium tuberculosis culture using liquid culture medium and Lowenstein Jensen medium in abdominal tuberculosis. |
| PubMed:Synthesis and X-ray structure determination of highly active Pd(II), Pd(I), and Pd(0) complexes of di(tert-butyl)neopentylphosphine (DTBNpP) in the arylation of amines and ketones. |
| PubMed:On-chip integrated multi-thermo-actuated microvalves of poly(N-isopropylacrylamide) for microflow injection analysis. |
| PubMed:Two new sesquiterpene derivatives from the Tunisian endemic Ferula tunetana Pom. |
| PubMed:Asymmetric synthesis of (S)-3-chloro-1-phenyl-1-propanol using Saccharomyces cerevisiae reductase with high enantioselectivity. |
| PubMed:Ultrasound promoted efficient method for the cleavage of 3-aryl-2,3-epoxyl-1-phenyl-1-propanone with indole. |
| PubMed:Phloretin induces apoptosis in H-Ras MCF10A human breast tumor cells through the activation of p53 via JNK and p38 mitogen-activated protein kinase signaling. |
| PubMed:A convenient and efficient protocol for the synthesis of 5-aryl-1,3-diphenylpyrazole catalyzed by hydrochloric acid under ultrasound irradiation. |
| PubMed:Characterization of pncA mutations of pyrazinamide-resistant Mycobacterium tuberculosis in Turkey. |
| PubMed:Nickel-catalyzed formation of a carbon-nitrogen bond at the beta position of saturated ketones. |
| PubMed:Dramatic effect of aggregation on rates and thermodynamics of stereoisomerization of magnesium enolates. |
| PubMed:The consolidation of neuroleptic therapy: Janssen, the discovery of haloperidol and its introduction into clinical practice. |
| PubMed:Polymer-immobilized catalyst for asymmetric hydrogenation of racemic alpha-(N-benzoyl-N-methylamino)propiophenone. |
| PubMed:Variability in essential-oil composition of Piper marginatum sensu lato. |
| PubMed:Purification and characterization of 2-aminoacetophenone reductase of newly isolated Burkholderia sp. YT. |
| PubMed:Selective formation of triplet alkyl nitrenes from photolysis of beta-azido-propiophenone and their reactivity. |
| PubMed:alpha-arylation of ketones using highly active, air-stable (DtBPF)PdX2 (X = Cl, Br) catalysts. |
| PubMed:Inhibition of carbonyl reductase activity in pig heart by alkyl phenyl ketones. |
| PubMed:Determination of six bioactive components of Saussurea katochaete by capillary electrophoresis. |
| PubMed:The effects of non-medically used psychoactive drugs on monoamine neurotransmission in rat brain. |
| PubMed:Kinetics and mechanism of ketone enolization mediated by magnesium bis(hexamethyldisilazide). |
| PubMed:Oxidations of secondary alcohols to ketones using easily recyclable bis(trifluoroacetate) adducts of fluorous alkyl iodides, CF3(CF2)(n-1)I(OCOCF3)2. |
| PubMed:Design, synthesis, and biochemical evaluation of novel cruzain inhibitors with potential application in the treatment of Chagas' disease. |
| PubMed:Lewis base catalyzed Mannich-type reactions between trimethylsilyl enol ethers and aldimines. |
| PubMed:Beccaridiol, an unusual 28-nortriterpenoid from the leaves of Diplectria beccariana. |
| PubMed:Studies of the condensation of sulfones with ketones and aldehydes. |
| PubMed:Structural effects on the beta-scission reaction of tertiary arylcarbinyloxyl radicals. The role of alpha-cyclopropyl and alpha-cyclobutyl groups. |
| PubMed:Hollow colloidal particles obtained by nano-extrusion in the presence of phospholipids. |
| PubMed:Dynamic structural change of the self-assembled lanthanum complex induced by lithium triflate for direct catalytic asymmetric aldol-Tishchenko reaction. |
| PubMed:Evaluation of antimicrobial activities of several mannich bases and their derivatives. |
| PubMed:Metabolism of designer drugs of abuse. |
| PubMed:Alkylthiol gold nanoparticles in sol-gel-based open tubular capillary electrochromatography. |
| PubMed:Stereoselective enolizations mediated by magnesium and calcium bisamides: contrasting aggregation behavior in solution and in the solid state. |
| PubMed:Isolation and antifungal activity of kakuol, a propiophenone derivative from Asarum sieboldii rhizome. |
| PubMed:Interactions of Rh(III)-dihydrido-bis(phosphine) complexes with semicarbazones. |
| PubMed:Stereoselective metabolic activation of alpha-hydroxy-N-desmethyltamoxifen: the R-isomer forms more DNA adducts in rat liver cells. |
| PubMed:Synthesis of [O-methyl-11C]1-(2-chlorophenyl)-5-(4-methoxyphenyl)-4-methyl-1H-pyrazole-3-carboxylic acid piperidin-1-ylamide: a potential PET ligand for CB1 receptors. |
| PubMed:(E,E)-1,4-Diethyl-1,4-diphenyl-2,3-diazabutadiene. |
| PubMed:A DFT investigation of the addition reaction of monomeric lithium enolate derived from propiophenone to propene oxide: examination of the possible transition structures. |
| PubMed:Characterization of surfactant and phospholipid vesicles for use as pseudostationary phases in electrokinetic chromatography. |
| PubMed:Preliminary study on rapid identification of Mycobacterium tuberculosis complex isolates by the BD ProbeTec ET system. |
| PubMed:Microbial degradation of illicit drugs, their precursors, and manufacturing by-products: implications for clandestine drug laboratory investigation and environmental assessment. |
| PubMed:Highly efficient chiral metal cluster systems derived from Ru3(CO)12 and chiral diiminodiphosphines for the asymmetric transfer hydrogenation of ketones. |
| PubMed:A hybrid microdevice for electrophoresis and electrochromatography using UV detection. |
| PubMed:Quantitative and structural determination of pseudoephedrine sulfate and its related compounds in pharmaceutical preparations using high-performance liquid chromatography. |
| PubMed:A silica gel-supported ruthenium complex of 1,4,7-trimethyl-1,4,7-triazacyclononane as recyclable catalyst for chemoselective oxidation of alcohols and alkenes by tert-butyl hydroperoxide. |
| PubMed:Rearrangement of 2-aryl-3,3-dichloroazetidines: intermediacy of 2-azetines. |
| PubMed:Resolution of alpha-hydroxytamoxifen; R-isomer forms more DNA adducts in rat liver cells. |
| PubMed:High-performance liquid chromatographic method development and validation for the simultaneous quantitation of naproxen sodium and pseudoephedrine hydrochloride impurities. |
| PubMed:New minor constituents from Anethum sowa. |
| PubMed:Anti-leishmanial activity of neolignans from Virola species and synthetic analogues. |
| PubMed:Synthesis and reactivity of a potential carcinogenic metabolite of tamoxifen: 3,4-dihydroxytamoxifen-o-quinone. |
| PubMed:Enantioseparation of amfepramone (rac-diethylpropion): preparative separation of the enantiomers and enantioselective analysis. |
| PubMed:Optically active antifungal azoles. IX. An alternative synthetic route for 2-[(1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4- triazol-1-yl)propyl]-4-[4-(2,2,3,3-tetrafluoropropoxy)phenyl]- 3(2H,4H)-1,2,4-triazolone and its analogs. |
| PubMed:Kinetics of racemization of (+)- and (-)-diethylpropion: studies in aqueous solution, with and without the addition of cyclodextrins, in organic solvents and in human plasma. |
| PubMed:Antineoplastic and cytotoxic activity of beta-alkylamino-(para-substituted)propiophenone and beta-alkylamino-(6-methyl)-naphthone derivatives in murine and human tissue culture cells. |
| PubMed:Specific identification of Mycobacterium tuberculosis with the luciferase reporter mycobacteriophage: use of p-nitro-alpha-acetylamino-beta-hydroxy propiophenone. |
| PubMed:[New, previously unavailable on the illegal drug market amphetamine derivatives with a partial propiophenone structure]. |
| PubMed:Asymmetric Electroreduction of Ketone and Aldehyde Derivatives to the Corresponding Alcohols Using Alcohol Dehydrogenase as an Electrocatalyst. |
| PubMed:New catalytic roles for serine esterases: a 19F-NMR study of the interaction of 3,3,3-trifluoro-2,2-dihydroxy-1-phenyl-1-propanone with chicken liver carboxylesterase. |
| PubMed:Inward transport of 3H-MPP+ in freshly isolated rat hepatocytes: evidence for interaction with catecholamines. |
| PubMed:Synthesis and hypolipidemic evaluation of beta-alkylaminopropiophenone and beta-alkylaminopropio-2'-naphthone derivatives in rodents. |
| PubMed:Microencapsulation of yeast cells and their use as a biocatalyst in organic solvents. |
| PubMed:Fatty acids and other compounds with nematicidal activity from cultures of Basidiomycetes. |
| PubMed:[Rapid diagnosis of mycobacteria, especially Mycobacterium tuberculosis and Mycobacterium avium complex, using MB Check system]. |
| PubMed:Purines. LII. Synthesis and biological evaluation of 8-methylguanine 7-oxide and its 9-arylmethyl derivatives. |
| PubMed:[Rapid diagnosis of mycobacteria, especially Mycobacterium tuberculosis and Mycobacterium avium complex, using BACTEC 460 TB system]. |
| PubMed:Studies of the pharmacokinetics and metabolism of 4-amino-propiophenone (PAPP) in rats, dogs and cynomolgus monkeys. |
| PubMed:Antiarrhythmic effects of two new propafenone related drugs. A study on four animal models of arrhythmia. |
| PubMed:Accumulation and release of adrenaline, and the modulation by adrenaline of noradrenaline release from rabbit blood vessels in vitro. |
| PubMed:Physiological pharmacokinetics of a new muscle-relaxant, inaperisone, combined with its pharmacological effect on blood flow rate. |
| PubMed:Degradation kinetics of (+/-)-4'-ethyl-2-methyl-3-(1-pyrrolidinyl)propiophenone hydrochloride (HY-770) and structure-stability relationship among its analogues in aqueous solution. |
| PubMed:[Effects of (+/-)-4'-ethyl-2-methyl-3-(l-pyrrolidinyl) propiophenone hydrochloride (HY-770) on the bladder function]. |
| PubMed:Evaluation of some azines of aminomethylacetophenones and related quaternary ammonium compounds versus the EMT6 tumour. |
| PubMed:The guinea-pig trachea O-methylating system is more effective in modulating beta 2- than beta 1-adrenoceptor-mediated responses to isoprenaline. |
| PubMed:Effects of anoxia and ischemia on uptake2 of catecholamines in perfused rat heart. |
| PubMed:2-(N-nitroso-N-methylamino)propiophenone, a direct acting bacterial mutagen found in nitrosated Ephedra altissima tea. |
| PubMed:Altered metabolism of [18F]-6-fluorodopa in the hooded rat following inhibition of catechol-O-methyltransferase with U-0521. |
| PubMed:Local anaesthetic effects of benzene and structurally related molecules, including benzocaine, on the squid giant axon. |
| PubMed:Nitrosation products from the plant Ephedra altissima and their potential endogenous formation. |
| PubMed:[Central muscle relaxant activities of 2-methyl-3-aminopropiophenone derivatives]. |
| PubMed:Down regulation of beta-receptors by bupropion and its major metabolite in mouse brain. |
| PubMed:Liquid chromatographic determination of bendiocarb in technical materials and wettable powder formulations: collaborative study. |
| PubMed:Studies on the metabolism of propafenone. 3rd Comm.: Isolation of the conjugated metabolites in the dog and identification using fast atom bombardment mass spectrometry. |
| PubMed:Carbonyl reductase activity of sepiapterin reductase from rat erythrocytes. |
| PubMed:Mechanism of inactivation of monoamine oxidase by 1-phenylcyclopropylamine. |
| PubMed:Accumulation of 3H-adrenaline by rabbit aorta. |
| PubMed:Rapid radiometric methods to detect and differentiate Mycobacterium tuberculosis/M. bovis from other mycobacterial species. |
| PubMed:Studies on the metabolism of propafenone. 2nd comm.: studies on the biotransformation in the dog. |
| PubMed:Studies on the metabolism of propafenone. 1st Comm.: synthesis and chromatographic/mass spectrometric properties of the labelled compound and of the reference substances. |
| PubMed:Immunopharmacological studies on mydocalm and related compounds as an antagonist of slow reacting substance of anaphylaxis (SRS-A). |
| PubMed:[Experimental observations on the iodination of phenols in the preparation of intermediates of pharmaceutical interest]. |
| PubMed:Stereospecific metabolic reduction of ketones. |
| PubMed:Diethylstilbestrol: placental transfer, metabolism, covalent binding and fetal distribution in the Wistar rat. |
| PubMed:Simultaneous determination of tetracaine and its degradation product, p-n-butylaminobenzoic acid, by high-performance liquid chromatography. |
| PubMed:[Effects of muscle relaxant E.M.P.P. on afferent discharges of muscle spindle in man--an microneurographic analysis (author's transl)]. |
| PubMed:The effects of cofactor and species differences on the in vitro metabolism of propiophenone and phenylacetone. |
| PubMed:Uptake and metabolism of noradrenaline by blood vessels of perinephritic hypertensive dogs. |
| PubMed:Testing propafenone hydrochloride in the Ames Salmonella microsome system and in mammalian cytogenetic systems (bone marrow, spermatogonia). |
| PubMed:[Pharmacological studies of 2-methyl-3(2-phenyl-3-methyl-tetrahydrooxazino)-propiophenone hydrochloride and 1-phenoxycarboxy-1-phenyl-2-methyl-3(2-phenyl-3-methyl-tetrahydrooxazino)-propane hydrochloride compounds]. |
| PubMed:Altered inotropic and chronotropic effects of noradrenaline on isolated rat atria exposed to chagasic sera. Influences of cocaine, normetanephrine and U-0521 (3'-4'-dihydroxy-2-methyl propiophenone. |
| PubMed:Structure-activity relationship of 5-hydroxykynurenamine analogues in isolated dog cerebral arteries. |
| PubMed:Pharmacology of 4'fluoro-3-(1-piperidyl) propiophenone (compound CN), a new centrally acting skeletal muscle relaxant. |
| PubMed:Central muscle relaxant activity of 4'-fluoro-3-(1-piperidyl) propiophenone (compound CN). |
| PubMed:The indirect sympathomimetic activity of etilefrine--a comparison with tyramine and ephedrine using [3H] noradrenaline. |
| PubMed:Test for differentiation of M. tuberculosis and M. bovis from other mycobacteria. |
| PubMed:A positive influence of frequency on the inotrophic response of isolated rat atria to certain adrenergic amines. Effects of cocaine and U-0521 (3',4'-dihydroxy-2-methyl propiophenone. |
| PubMed:New inhibitors of steroid 11beta-hydroxylase. Structure--activity relationship studies of metyrapone-like compounds. |
| PubMed:The role played by the extraneuronal system in the disposition of noradrenaline and adrenaline in vessels. |
| PubMed:Synthesis and antitussive activity of 3-azabicyclo[3.2.2]nonane derivatives. |
| PubMed:Reversible adrenergic alpha-receptor blocking action of 2,4'-dimethyl-3-piperidino-propiophenone (tolperisone). |
| PubMed:Inhibitory actions of polyphloretin phosphate and related compounds on the response to prostaglandin in the smooth muscle of guinea-pig stomach. |
| PubMed:The effect of etafenone on the subcellular distribution of calcium and some oligoelements in heart muscle. Ultracytochemical and x-ray microanalytical study. |
| PubMed:A comparative study of the role played by some inactivation pathways in the disposition of the transmitter in the rabbit aorta and the saphenous vein of the dog. |
| PubMed:Adamantanamine derivatives. Antimicrobial activities of certain Mannich bases. |
| PubMed:Positive and negative chronotropic response of the S-A node to oxyfedrine. |
| PubMed:Supersensitivity to catecholamines after impairment of extraneuronal uptake or catechol-O-methyl transferase. |
| PubMed:[Stability of oxyfedrine in pharmacological experiments in vitro]. |
| PubMed:[The effect of oxyfedrine on cardiac performance in coronary patients. Tests using electrocardiographic and metabolic parameters in atrial stimulation]. |
| PubMed:[Pharmacologic effects in combined use of oxyfedrine and beta-acetyldiogoxin]. |
| PubMed:Estrogenic & antiestrogenic properties of e-492, a nonsteroidal compound. |
| PubMed:Relation between the amount of smooth muscle of venous tissue and the degree of supersensitivity to isoprenaline caused by inhibition of catechol-O-methyl transferase. |
| PubMed:Inhibition of chlorination in Streptomyces aureofaciens by nitriles and related compounds. |
| PubMed:[Photochemistry of 3-piperidino-2-phenyl-propiophenone]. |
| PubMed:Reduced side effects following administration of a new anorectic agent, 4'-chloro-2-(ethylamino)propiophenone, in timed-release form. |
| PubMed:Effects of chloroform, diethyl ether and a propiophenone derivative, 3-dimethylamino-2-methyl-2-phenoxypropiophenone hydrochloride, upon cyclic 3',5'-nucleotide phosphodiesterase. |
| PubMed:Beta-adrenergic blocking property of l-3-methoxy-omega-(1-hydroxy-1-phenylisopropylamino)-propiophenone-HCL (D 563) in femoral circulation. |
| PubMed:[4n-buthoxy-beta(I-piperidil) propiophenone chlorhydrate in the local anesthesia in ophthalmoloy and its antimicrobial properties]. |
| PubMed:[Psychomotor disorders with audio-visual hallucinations probably caused by the use of a new coronary dilator or L-3 methoxy-W-(hydroxy-1-phenyl-isopropylamine) propiophenone hydrochloride. Record of the case]. |
| PubMed:Quantitative analysis of 4'-chloro-2-ethyl-aminopropiophenone, 4'-chloro-2-amino-propiophenone and the corresponding amino-alcohols in a mixture of the four compounds. |
| PubMed:Effects of 1,3,5-trihydroxybenzene and 2,4,6-trihydroxy-1-propiophenone on the smooth muscle organs. |
| PubMed:[Behavior of free fatty acids and glucose in serum under effect of L-3-methoxy-omega-(1-hydroxy-1-phenylisopropylamino)-propiophenone hydrochloride (oxyfedrine)]. |
| PubMed:[Baeyer-Villiger rearrangement of propiophenone derivatives]. |
| PubMed:The catechol-O-methyl transferase activity and endogenous catecholamine content of various tissues in the rat and the effect of administration of U-0521 (3',4'-dihydroxy-2-methyl propiophenone). |
| PubMed:Pharmacological properties of a propiophenone derivative. |
| PubMed:[Studies of the cardiac toxicity of a derivative of propiophenone in the rabbit]. |
| PubMed:Studies on the potentiation of the inotropic actions of certain catecholamines by U-0521 (3',4'-dihydroxy-alpha-methyl propiophenone). |
| PubMed:[Effect of trihydroxy propiophenone on subjective symptoms (especially in bile duct diseases)]. |
| PubMed:[Anti-arrhythmic property of a derivative of propiophenone]. |
| PubMed:[Biochemical studies on L-3-methoxy-omega-(1-hydroxy-1-phenyl-isopropyl-amino)-propiophenone hydrochloride]. |
| PubMed:[Treatment of angina pectoris with the association of a duodenal heparinoid and )O-(beta-diethylaminoethoxy)phenyl propiophenone]. |
| PubMed:[The treatment of hormone-dependent tumors with "paroxy-propiophenone", a hypophysio-diencephalic inhibiting drug]. |
| PubMed:[PHARMACOLOGICAL STUDY OF 2,4-DICHLORO-ALPHA-(DIMETHYLAMINO)-PROPIOPHENONE]. |
| PubMed:[MANNICH BASES OF PHARMACEUTICAL INTEREST AND THEIR DERIVATIVES. II. DERIVATIVES OF PHARMACOLOGICALLY ACTIVE PROPIOPHENONE]. |
| PubMed:Influence of p-hydroxy-propiophenone on liver tumorigenesis in rats ingesting ethionine and N-2-fluorenylacetamide. |
| PubMed:[Acetolysis of omega-N-piperidino-propiophenone and 1-N-piperidino-3-butanone]. |
| PubMed:[Pharmacological study of trihydroxy-2,4,6-propiophenone]. |
| PubMed:Sensitization of the pigeon to epinephrine-induced ventricular fibrillation by a substituted propiophenone. |
| PubMed:[Local anesthetic action of propiophenone derivatives. 2. Pharmacological studies of no. 25, one of the propiophenone derivatives]. |
| PubMed:[Synthesis of alpha-diethylamino-propiophenone hydroploride]. |
| PubMed:[4-alkoxy-(respectively 4-alkyl)-3-pipecolino]-propiophenone and-thienone]. |
| PubMed:[On some new derivatives of p-hydroxy-propiophenone with local anesthetic activity]. |
| PubMed:The use of p-nitro-alpha-acetylamino-beta-hydroxy-propiophenone (NAP) in the differentiation of mycobacteria. |
| PubMed:Sensitization to ventricular fibrillation. I Sensitization by a substituted propiophenone, U-0882. |
| PubMed:Bronchography using dyclonine hydrochloride anesthesia (4 N-butoxy-beta-piperidino-propiophenone-hydrochloride). |
| PubMed:[Effect of paraoxy-propiophenone on the course of tuberculosis in animal experiment]. |
| PubMed:The pharmacology of a new potent analgesic, R 951 2-[N-(4-carbethoxy-4-phenyl)-piperidino]-propiophenone HCI. |
| PubMed:[Chemotherapeutic activity of p-nitro-alpha-acylamino-propiophenone & p-nitro-alpha-acylamino-acrylophenone]. |
| PubMed:[Studies on local anesthetics. XIII. Basic substituted propiophenone]. |
| PubMed:Local anesthetic and pharmacologic properties of 4n-butoxy beta-(1-piperidyl) propiophenone HCl and beta-diethylaminoethyl p-n-hexyloxybenzilate HCl. |
| PubMed:[Various local anesthetics derived from propiophenone]. |
| PubMed:[Para-oxy-propiophenone and the genital system]. |
| PubMed:[Series of propiophenone derivatives as local anesthetics]. |
| PubMed:[Effect of para-oxy-propiophenone on the urinary excretion of 17-ketosteroidi]. |
| PubMed:[Effect of p-hydroxy-propiophenone on the islands of Langerhans]. |
| PubMed:[Effect of para-oxy-propiophenone on gonadostimuline A and B]. |
| PubMed:[P-hydroxy-propiophenone therapy of vitiligo]. |
| PubMed:[Effect of p-hydroxy-propiophenone on some forms of arterial hypertension]. |
| PubMed:[Effect of para-oxy-propiophenone on pregnancy]. |
| PubMed:[Action of para-oxy-propiophenone on growth of tadpole fed with fresh thyroid, and on germination and development of Triticum sativum Lm. seeds treated with suspended in water pulverized thyroid]. |
| PubMed:[Effect of associated methylthiouracil with para-oxy-propiophenone]. |
| PubMed:[Effect of para-oxy-propiophenone on pregnancy]. |
| PubMed:The pituitary action and estrogenic effect of parahydroxy-propiophenone. |
| PubMed:A study of the friendship fluctuations of preadolescents. |
| PubMed:[Lack of inhibiting action of paraoxypropiophenone (H-365) on pituitary secretion]. |
| PubMed:[Para-oxypropiophenone]. |
| PubMed:[Mechanism of action of the biochemical level of p-oxypropiophenone]. |
| PubMed:[Melanoconstrictor effect of para-oxypropiophenone on Rana temporaria tadpoles]. |
| PubMed:[Endocrine effect of 4-hydroxy-propiophenone in the adult male rat]. |
| PubMed:[Hypothalamus-hypophyseal system after treatment with paraoxypropiophenone]. |
| PubMed:[Present status of H-365, para-oxypropiophenone, synthetic pituitary inhibitor]. |
| PubMed:The effect of the continuous administration of p-amino-propiophenone on the blood in man. |
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