Category:flavor enhancers, flavoring agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
Appearance: | white crystalline solid (est) |
Assay: | 95.00 to 100.00
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Food Chemicals Codex Listed: | No |
Melting Point: | 186.00 to 188.00 °C. @ 760.00 mm Hg
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Boiling Point: | 549.00 to 550.00 °C. @ 760.00 mm Hg (est)
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Flash Point: | 547.00 °F. TCC ( 286.20 °C. ) (est)
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logP (o/w): | 3.745 (est) |
Soluble in: |
| alcohol | | water, 7.276 mg/L @ 25 °C (est) |
Insoluble in: |
| water |
Organoleptic Properties:
Flavor Type: cooling |
cooling bitter |
Taste Description: at 10.00 ppm in water. moderate throat and mouth cooling that lingers with some bitter notes in background. Cooling lasts with breath in for 30 minutes. |
Odor and/or flavor descriptions from others (if found). |
Cosmetic Information:
Suppliers:
Safety Information:
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Hazards identification |
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Classification of the substance or mixture |
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
None found. |
GHS Label elements, including precautionary statements |
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Pictogram | |
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Hazard statement(s) |
None found. |
Precautionary statement(s) |
None found. |
Oral/Parenteral Toxicity: |
Not determined
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Dermal Toxicity: |
Not determined
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Inhalation Toxicity: |
Not determined
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Safety in Use Information:
Category: | flavor enhancers, flavoring agents |
Recommendation for (2S,5R)-N-[4-(2-amino-2-oxoethyl)phenyl]-5-methyl-2-(propan-2-yl)cyclohexanecarboxamide usage levels up to: | | not for fragrance use.
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Maximised Survey-derived Daily Intakes (MSDI-EU): | 6.10 (μg/capita/day) |
Modified Theoretical Added Maximum Daily Intake (mTAMDI): | 7800 (μg/person/day) |
Threshold of Concern: | 90 (μg/person/day) |
Structure Class: | III |
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS). |
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library |
publication number: 25. Update in publication number(s): 28 |
Click here to view publication 25 |
| average usual ppm | average maximum ppm |
baked goods: | - | - |
beverages(nonalcoholic): | 10.00000 | 50.00000 |
beverages(alcoholic): | - | - |
breakfast cereal: | - | - |
cheese: | - | - |
chewing gum: | 400.00000 | 800.00000 |
condiments / relishes: | - | - |
confectionery froastings: | 25.00000 | 100.00000 |
egg products: | - | - |
fats / oils: | - | - |
fish products: | - | - |
frozen dairy: | - | - |
fruit ices: | - | - |
gelatins / puddings: | - | - |
granulated sugar: | - | - |
gravies: | - | - |
hard candy: | 25.00000 | 100.00000 |
imitation dairy: | - | - |
instant coffee / tea: | - | - |
jams / jellies: | 25.00000 | 100.00000 |
meat products: | - | - |
milk products: | - | - |
nut products: | - | - |
other grains: | - | - |
poultry: | - | - |
processed fruits: | - | - |
processed vegetables: | - | - |
reconstituted vegetables: | - | - |
seasonings / flavors: | - | - |
snack foods: | - | - |
soft candy: | 25.00000 | 100.00000 |
soups: | - | - |
sugar substitutes: | - | - |
sweet sauces: | - | - |
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Food categories according to Commission Regulation EC No. 1565/2000 (EC, 2000) in FGE.06 (EFSA, 2002a). According to the Industry the "normal" use is defined as the average of reported usages and "maximum use" is defined as the 95th percentile of reported usages (EFSA, 2002i). |
Note: mg/kg = 0.001/1000 = 0.000001 = 1/1000000 = ppm. |
| average usage mg/kg | maximum usage mg/kg |
Dairy products, excluding products of category 02.0 (01.0): | - | - |
Fats and oils, and fat emulsions (type water-in-oil) (02.0): | - | - |
Edible ices, including sherbet and sorbet (03.0): | - | - |
Processed fruit (04.1): | 20.00000 | 100.00000 |
Processed vegetables (incl. mushrooms & fungi, roots & tubers, pulses and legumes), and nuts & seeds (04.2): | 20.00000 | 100.00000 |
Confectionery (05.0): | 70.00000 | 300.00000 |
Chewing gum (05.3): | - | - |
Cereals and cereal products, incl. flours & starches from roots & tubers, pulses & legumes, excluding bakery (06.0): | - | - |
Bakery wares (07.0): | - | - |
Meat and meat products, including poultry and game (08.0): | - | - |
Fish and fish products, including molluscs, crustaceans and echinoderms (MCE) (09.0): | - | - |
Eggs and egg products (10.0): | - | - |
Sweeteners, including honey (11.0): | - | - |
Salts, spices, soups, sauces, salads, protein products, etc. (12.0): | - | - |
Foodstuffs intended for particular nutritional uses (13.0): | - | - |
Non-alcoholic ("soft") beverages, excl. dairy products (14.1): | 10.00000 | 50.00000 |
Alcoholic beverages, incl. alcohol-free and low-alcoholic counterparts (14.2): | - | - |
Ready-to-eat savouries (15.0): | - | - |
Composite foods (e.g. casseroles, meat pies, mincemeat) - foods that could not be placed in categories 01.0 - 15.0 (16.0): | - | - |
Safety References:
References:
Other Information:
Potential Blenders and core components note
For Odor |
balsamic |
iso bornyl formate FL/FR |
dextro- fenchone FL/FR |
camphoreous |
beta-homo cyclocitral FL/FR |
fenchol FL/FR |
laevo- fenchone FL/FR |
citrus |
ocimene quintoxide FL/FR |
earthy |
(-)-alpha- fenchol FL/FR |
ethereal |
cyclohexyl formate FL/FR |
floral |
iso butyl salicylate FL/FR |
dihydrocarvyl acetate FL/FR |
fruity |
cyclohexyl acetate FL/FR |
pineapple pentenoate FL/FR |
tropical trithiane FL/FR |
vanilla carboxylate FL/FR |
green |
manzanate (Givaudan) FL/FR |
3,5,5- trimethyl hexanol FL/FR |
herbal |
1,4- cineole FL/FR |
1,8- cineole FL/FR |
geranic oxide FL/FR |
6- hydroxydihydrotheaspirane (mixture of isomers) FL/FR |
hyssop oil FL/FR |
jambu oleoresin FL/FR |
spike lavender oil FL/FR |
myrtenol FL/FR |
sabinene hydrate FL/FR |
theaspirane FL/FR |
medicinal |
meta- dimethyl hydroquinone FL/FR |
mentholic |
cornmint oil china FL/FR |
cornmint oil terpeneless FL/FR |
(±)- menthol FL/FR |
laevo- menthol FL/FR |
dextro,laevo- menthol FL/FR |
dextro-neo menthol FL/FR |
(±)-iso menthone FL/FR |
menthyl acetate FL/FR |
laevo- menthyl acetate FL/FR |
peppermint cyclohexanone FL/FR |
minty |
betula lenta bark oil america FL/FR |
cornmint oil japan FL/FR |
(-)- menthone FL/FR |
(±)- menthone FL/FR |
homo menthyl acetate FL/FR |
laevo- menthyl lactate FL/FR |
pennyroyal oil fractions FL/FR |
peppermint absolute FL/FR |
peppermint oil america FL/FR |
peppermint oil idaho FL/FR |
iso pulegol FL/FR |
spearmint oil america FL/FR |
WS-23 FL/FR |
naphthyl |
para- methyl anisole FL/FR |
odorless |
dextro,laevo- menthone glycerine acetal FL/FR |
spicy |
4- carvomenthenol FL/FR |
myrtenal FL/FR |
sulfurous |
mango thiol FL/FR |
woody |
(+)- camphene FL/FR |
camphene FL/FR |
For Flavor |
No flavor group found for these |
(+)- camphene FL/FR |
camphoreous |
camphoreous |
camphene FL/FR |
fenchol FL/FR |
(-)-alpha- fenchol FL/FR |
laevo- fenchone FL/FR |
geranic oxide FL/FR |
6- hydroxydihydrotheaspirane (mixture of isomers) FL/FR |
chemical |
meta- dimethyl hydroquinone FL/FR |
cooling |
iso butyl salicylate FL/FR |
4- carvomenthenol FL/FR |
1,4- cineole FL/FR |
beta-homo cyclocitral FL/FR |
1,3- dihydroxyacetone (dimer) FL |
dextro- fenchone FL/FR |
1-(2- hydroxy-4-methyl cyclohexyl) ethanone FL |
jambu oleoresin FL/FR |
spike lavender oil FL/FR |
manzanate (Givaudan) FL/FR |
laevo- menthol FL/FR |
iso menthol FL |
dextro,laevo- menthol FL/FR |
laevo- menthone 1,2-glycerol ketal FL |
dextro,laevo- menthone glycerine acetal FL/FR |
menthyl acetate FL/FR |
homo menthyl acetate FL/FR |
laevo- menthyl lactate FL/FR |
mono menthyl succinate FL |
2-(4- methylphenoxy)-N-(1H-pyrazol-3-yl)-N-(thiophen-2-ylmethyl)acetamide FL |
peppermint oil america FL/FR |
N-(2-( pyridin-2-yl)ethyl)-3-para-menthane carboxamide FL |
sabinene hydrate FL/FR |
theaspirane FL/FR |
WS-12 FL |
WS-3 FL |
WS-5 FL |
earthy |
panax quinquefolius root extract FL |
floral |
dihydrocarvyl acetate FL/FR |
fruity |
pineapple pentenoate FL/FR |
tropical trithiane FL/FR |
vanilla carboxylate FL/FR |
green |
cyclohexyl formate FL/FR |
ocimene quintoxide FL/FR |
iso phorone FL |
3,5,5- trimethyl hexanol FL/FR |
herbal |
hyssop oil FL/FR |
mentholic |
cornmint oil terpeneless FL/FR |
(±)- menthol FL/FR |
dextro-neo menthol FL/FR |
peppermint cyclohexanone FL/FR |
minty |
betula lenta bark oil america FL/FR |
1,8- cineole FL/FR |
cornmint oil china FL/FR |
cornmint oil japan FL/FR |
limonene glycol FL |
(-)- menthone FL/FR |
(±)-iso menthone FL/FR |
(±)- menthone FL/FR |
laevo- menthyl acetate FL/FR |
myrtenal FL/FR |
myrtenol FL/FR |
pennyroyal oil fractions FL/FR |
peppermint absolute FL/FR |
peppermint oil idaho FL/FR |
iso pulegol FL/FR |
spearmint oil america FL/FR |
WS-23 FL/FR |
naphthyl |
para- methyl anisole FL/FR |
solvent |
cyclohexyl acetate FL/FR |
sulfurous |
mango thiol FL/FR |
woody |
iso bornyl formate FL/FR |
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
(2S,5R)-N-[4-(2- | amino-2-oxo-ethyl)phenyl]-2-isopropyl-5-methyl-cyclohexanecarboxamide | (2S,5R)-N-[4-(2- | amino-2-oxo-ethyl)phenyl]-2-isopropyl-5-methylcyclohexanecarboxamide | (2S,5R)-N-[4-(2- | amino-2-oxoethyl)phenyl]-5-methyl-2-(propan-2-yl)cyclohexanecarboxamiide | 4-[[[(2S,5R)-5- | methyl-2-(1-methylethyl)cyclohexyl]carbonyl]amino]-benzeneacetamide |
Articles:
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