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Category:natural substances and extractives
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Appearance: | colorless clear viscous liquid (est) |
| Assay: | 95.00 to 100.00
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| Food Chemicals Codex Listed: | No |
| Boiling Point: | 273.00 to 276.00 °C. @ 760.00 mm Hg
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| Vapor Pressure: | 0.011000 mmHg @ 25.00 °C. (est) |
| Flash Point: | 224.00 °F. TCC ( 106.67 °C. )
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| logP (o/w): | 6.434 (est) |
| Soluble in: |
| | alcohol | | | water, 0.08 mg/L @ 18C (exp) |
| Insoluble in: |
| | water |
Organoleptic Properties:
| Odor Type: woody |
| green woody |
| Odor Description:at 100.00 %. green woody |
| Odor and/or flavor descriptions from others (if found). |
Cosmetic Information:
Suppliers:
Safety Information:
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| Hazards identification |
| |
| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
| |
| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
|
Not determined
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | | natural substances and extractives |
| Recommendation for beta-cadinene usage levels up to: | | | not for fragrance use.
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| |
| Recommendation for beta-cadinene flavor usage levels up to: |
| | not for flavor use.
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Safety References:
References:
| | (1S,4aR,8aS)-4,7-dimethyl-1-propan-2-yl-1,2,4a,5,8,8a-hexahydronaphthalene |
| NIST Chemistry WebBook: | Search Inchi |
| Pubchem (cid): | 10657 |
| Pubchem (sid): | 134977794 |
| Pherobase: | View |
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| | cadine-3,9-diene | | (-)-beta- | cadinene | | b- | cadinene | | (1S,4aR,8aS)-4,7- | dimethyl-1-(1-methylethyl)-1,2,4a,5,8,8a-hexahydronaphthalene | | (1S,4aR,8aS)-4,7- | dimethyl-1-(propan-2-yl)-1,2,4a,5,8,8a-hexahydronaphthalene | | (1S,4aR,8aS)-4,7- | dimethyl-1-propan-2-yl-1,2,4a,5,8,8a-hexahydronaphthalene | | (1S- (1alpha,4abeta, 8aalpha))- 1,2,4a,5,8,8a- | hexahydro-4,7-dimethyl-1-(1-methyl ethyl) naphthalene | | (1S,4aR,8aS)-1,2,4a,5,8,8a- | hexahydro-4,7-dimethyl-1-(1-methylethyl)naphthalene | | [1S-(1a,4ab,8aa)]-1,2,4a,5,8,8a- | hexahydro-4,7-dimethyl-1-(1-methylethyl)naphthalene | | | naphthalene, 1,2,4a,5,8,8a-hexahydro-4,7-dimethyl-1-(1-methylethyl)-, (1S,4aR,8aS)- | | (1S,4aR,8aS)-1-iso | propyl-4,7-dimethyl-1,2,4a,5,8,8a-hexahydronaphthalene |
Articles:
| PubMed:Lavender (Lavandula stoechas L.) essential oils attenuate hyperglycemia and protect against oxidative stress in alloxan-induced diabetic rats. |
| PubMed:Screening of natural compounds as activators of the keap1-nrf2 pathway. |
| PubMed:Mechanism of ion transfer in supported liquid membrane systems: electrochemical control over membrane distribution. |
| PubMed:Analysis of essential oil constituents of three Dasymaschalon species (Annonaceae) from Vietnam. |
| PubMed:Absolute configuration of falcarinol (9Z-heptadeca-1,9-diene-4,6-diyn-3-ol) from Pastinaca sativa. |
| PubMed:Study on Gas Chromatography-Mass Spectrometry Fingerprint of Acanthopanax brachypus. |
| PubMed:Enhancement of 4-acetylantroquinonol B production by supplementation of its precursor during submerged fermentation of Antrodia cinnamomea. |
| PubMed:Mitigation of radiation-induced damage by targeting EGFR in noncancerous human epithelial cells. |
| PubMed:Characterization of posticlure and the structure-related sex pheromone candidates prepared by epoxidation of (6Z,9Z,11E)-6,9,11-trienes and (3Z,6Z,9Z,11E)-3,6,9,11-tetraenes. |
| PubMed:Photoinduced reactions of para-quinones with bicyclopropylidene leading to diverse polycyclic compounds with spirocyclopropanes. |
| PubMed:Chemical composition and anti-Trypanosoma cruzi activity of essential oils obtained from leaves of Xylopia frutescens and X. laevigata (Annonaceae). |
| PubMed:Cadinene sesquiterpenes from Eupatorium adenophorum and their antifungal activity. |
| PubMed:Chemical constituents and anticancer effects of the essential oil from leaves of Xylopia laevigata. |
| PubMed:A new eudesmane sesquiterpenoid lactone from Chloranthus japonicus. |
| PubMed:Analysis of chemical constituents and antinociceptive potential of essential oil of Teucrium Stocksianum bioss collected from the North West of Pakistan. |
| PubMed:Distillation time alters essential oil yield, composition, and antioxidant activity of male Juniperus scopulorum trees. |
| PubMed:Investigation of the volatile constituents of different Gynura species from two Chinese origins by SPME/GC-MS. |
| PubMed:Penta-cyclo-[9.3.1.1(2,6).1(4,8).1(9,13)]octa-deca-1(2),8(9)-diene. |
| PubMed:Validation of the multiple sensor mechanism of the Keap1-Nrf2 system. |
| PubMed:Methyl 2,2-dimeth-oxy-8-oxo-1-oxaspiro-[4.5]deca-6,9-diene-3-carboxyl-ate. |
| PubMed:Chemical composition, antimicrobial and antitumor activities of the essential oils and crude extracts of Euphorbia macrorrhiza. |
| PubMed:Influence of various growth parameters on fungal growth and volatile metabolite production by indoor molds. |
| PubMed:The use of in vitro technologies and high-resolution/accurate-mass LC-MS to screen for metabolites of 'designer' steroids in the equine. |
| PubMed:The use of in vitro technologiesand high-resolution/accurate-mass LC-MSto screen for metabolites of 'designer' steroids in the equine. |
| PubMed:Antiplasmodial volatile extracts from Cleistopholis patens Engler & Diels and Uvariastrum pierreanum Engl. (Engl. & Diels) (Annonaceae) growing in Cameroon. |
| PubMed:Immunotoxicity activity of sesquiterpenoids from black galingale (Kaempferia parviflora Wall. Ex. Baker) against Aedes aegypti L. |
| PubMed:Essential oil composition and insecticidal activity of Blumea perrottetiana growing in southwestern Nigeria. |
| PubMed:Biological activity of the essential oil of Kadsura longipedunculata (Schisandraceae) and its major components. |
| PubMed:Comparative in vitro metabolism of the 'designer' steroid estra-4,9-diene-3,17-dione between the equine, canine and human: identification of target metabolites for use in sports doping control. |
| PubMed:[Research on liposoluble ingredients of Quchiling]. |
| PubMed:5-Methyl-2,4-bis-(methyl-sulfan-yl)tricyclo-[6.2.1.0]undeca-4,9-diene-3,6-dione. |
| PubMed:Determination of cobalt ions at nano-level based on newly synthesized pendant armed macrocycle by polymeric membrane and coated graphite electrode. |
| PubMed:Fingerprint of selected Salvia species by HS-GC-MS analysis of their volatile fraction. |
| PubMed:Chemical composition and antimicrobial activity of the essential oil of Anaphalis nubigena var. monocephala. |
| PubMed:Crystal structure of (+)-delta-cadinene synthase from Gossypium arboreum and evolutionary divergence of metal binding motifs for catalysis. |
| PubMed:Sesquiterpenes from Laurencia similis. |
| PubMed:Instrumental analysis of terminal-conjugated dienes for reexamination of the sex pheromone secreted by a nettle moth, Parasa lepida lepida. |
| PubMed:(8S,9R,10S,11S,13S,14S,16S,17R)-4,4-Dichloro-16β-methyl-3,20-dioxo-17,21-bis-(propano-yloxy)-5β,8β-epoxy-pregna-1,9-diene. |
| PubMed:Cuticular hydrocarbons and soldier defense secretions of Reticulitermes in southern California: a critical analysis of the taxonomy of the genus in North America. |
| PubMed:Inhibition of mitochondrial metabolism by methyl-2-cyano-3,12-dioxooleana-1,9-diene-28-oate induces apoptotic or autophagic cell death in chronic myeloid leukemia cells. |
| PubMed:Tricyclo-[6.2.1.0]undeca-4,9-diene-3,6-dione. |
| PubMed:Suppressing the thermal metacyclophanediene to dihydropyrene isomerization: synthesis and rearrangement of 8,16-dicyano[2.2]metacyclophane-1,9-diene and evidence supporting the proposed biradicaloid mechanism. |
| PubMed:Two new xeniolides from a Taiwanese Xenia soft coral. |
| PubMed:A one-pot, microwave-influenced synthesis of diverse small molecules by multicomponent reaction cascades. |
| PubMed:Glucocorticoid receptor activation is involved in producing abnormal phenotypes of single-prolonged stress rats: a putative post-traumatic stress disorder model. |
| PubMed:Involvement of glucocorticoid receptor and pregnane X receptor in the regulation of mouse CYP3A44 female-predominant expression by glucocorticoid hormone. |
| PubMed:Synthesis and identification of novel oxa-steroids as progesterone receptor antagonists. |
| PubMed:Ab initio and DFT investigation of electrophilic addition reaction of bromine to endo,endo-tetracyclo[4.2.1.1(3,6).0 (2,7)]dodeca-4,9-diene. |
| PubMed:An evaluation of the allelopathic potential of selected perennial groundcovers: foliar volatiles of catmint (Nepeta x faassenii) inhibit seedling growth. |
| PubMed:Transport of a hydrophobic biosynthetic precursor by lipophorin in the hemolymph of a geometrid female moth which secretes an epoxyalkenyl sex pheromone. |
| PubMed:Xenicane-type diterpenes with cytotoxicity from Xenia florida. |
| PubMed:Analysis of atmospheric sesquiterpenes: sampling losses and mitigation of ozone interferences. |
| PubMed:Intramolecular hydrogen bonding in depsipeptides containing endo-3,6-tricyclo[6.2.1.0(2,7)]undeca-4,9-diene-3,6-endo-diol. |
| PubMed:A novel mechanism of action of methyl-2-cyano-3,12 dioxoolean-1,9 diene-28-oate: direct permeabilization of the inner mitochondrial membrane to inhibit electron transport and induce apoptosis. |
| PubMed:Panaxynol induces neurite outgrowth in PC12D cells via cAMP- and MAP kinase-dependent mechanisms. |
| PubMed:Sex pheromone and related compounds in the Ishigaki and Okinawa strains of the tussock moth Orgyia postica (Walker) (Lepidoptera: Lymantriidae). |
| PubMed:Identification of a sex pheromone component of the geometrid moth Milionia basalis pryeri. |
| PubMed:Identification of sex pheromone components of the painted apple moth: a tussock moth with a thermally labile pheromone component. |
| PubMed:Sesquiterpene constituents from the essential oils of the liverworts Mylia taylorii and Mylia nuda. |
| PubMed:Photochemical study of [3(3)](1,3,5)cyclophane and emission spectral properties of [3n]cyclophanes (n = 2-6). |
| PubMed:The sesquiterpene hydrocarbons of maize (Zea mays) form five groups with distinct developmental and organ-specific distributions. |
| PubMed:Oxygenated bisabolane fucosides from Carthamus lanatus L. |
| PubMed:Novel diterpenes from the heartwood of Chamaecyparis obtusa var. formosana. |
| PubMed:Three new sesquiterpenes from the black heartwood of Cryptomeria japonica. |
| PubMed:Development of the selective progesterone receptor modulator CDB-2914 for clinical indications. |
| PubMed:Pharmacologic properties of CDB(VA)-2914. |
| PubMed:Heats of formation of [2.2]paracyclophane-1-ene and [2.2]paracyclophane-1,9-diene - an experimental study. |
| PubMed:Hydrolytic behavior of 5alpha-hydroxy-11beta- and 5beta-hydroxy-11alpha-substituted 19-norsteroids. |
| PubMed:Structural and sensory characterization of compounds contributing to the bitter off-taste of carrots (Daucus carota L.) and carrot puree. |
| PubMed:Interspecific variation in terpenoid composition of defensive secretions of European Reticulitermes termites. |
| PubMed:Regulation of floral scent production in petunia revealed by targeted metabolomics. |
| PubMed:Aromadendrane transformations by Curvularia lunata ATCC 12017. |
| PubMed:Identification of epoxyhenicosadiene and novel diepoxy derivatives as sex pheromone components of the clear-winged tussock moth Perina nuda. |
| PubMed:The hetero-Diels-Alder addition of sulfur dioxide to 1-fluorobuta-1,3-dienes: the sofa conformations preferred by 6-fluorosultines (6-fluoro-3,6-dihydro-1,2-oxathiin-2-oxides) enjoy enthalpic and conformational Anomeric effects. |
| PubMed:Structural and mechanistic studies on the activation and propagation of a cationic allylpalladium procatalyst in 1,6-diene cycloisomerization. |
| PubMed:Sesquiterpenoid constituents of the liverworts Lepidozia fauriana and Lepidozia vitrea. |
| PubMed:Correspondence of soldier defense secretion mixtures with cuticular hydrocarbon phenotypes for chemotaxonomy of the termite genus Reticulitermes in North America. |
| PubMed:Two polycyclic compounds derived from a Diels-Alder reaction. |
| PubMed:A practical large-scale synthesis of 17alpha-acetoxy-11beta-(4-N, N-dimethylaminophenyl)-19-norpregna-4,9-diene-3,20-dione (CDB-2914). |
| PubMed:The steam volatile oil of Wollemia nobilis and its comparison with other members of the Araucariaceae (Agathis and Araucaria). |
| PubMed:Progesterone, oestrogen and glucocorticoid receptors in the uterus and mammary glands of mares from mid- to late gestation. |
| PubMed:Dienogest, a synthetic steroid, suppresses both embryonic and tumor-cell-induced angiogenesis. |
| PubMed:Lignans and polyacetylenes from bupleurum acutifolium |
| PubMed:The steroid promegestone is a noncompetitive antagonist of the Torpedo nicotinic acetylcholine receptor that interacts with the lipid-protein interface. |
| PubMed:Germacrene C synthase from Lycopersicon esculentum cv. VFNT cherry tomato: cDNA isolation, characterization, and bacterial expression of the multiple product sesquiterpene cyclase. |
| PubMed:11 beta-substituted 13 beta-ethyl gonane derivatives exhibit reversal of antiprogestational activity. |
| PubMed:Effects of two antiprogestins on early pregnancy in the long-tailed macaque (Macaca fascicularis). |
| PubMed:Antisense to the glucocorticoid receptor in hippocampal dentate gyrus reduces immobility in forced swim test. |
| PubMed:Steroid specificity of the human sperm membrane progesterone receptor. |
| PubMed:Antioxidant: a new role for RU-486 and related compounds. |
| PubMed:Synthesis of new 11 beta-substituted spirolactone derivatives. Relationship with affinity for mineralocorticoid and glucocorticoid receptors. |
| PubMed:Reactions of vitamin E and its model compound 2,2,5,7,8-pentamethylchroman-6-ol with ozone. |
| PubMed:Reversal of activity profile in analogs of the antiprogestin RU 486: effect of a 16 alpha-substituent on progestational (agonist) activity. |
| PubMed:Effect of the progestagen R5020 (promegestone) and of progesterone on the uptake and on the transformation of estrone sulfate in the MCF-7 and T-47d human mammary cancer cells: correlation with progesterone receptor levels. |
| PubMed:The effect of growth retardants on anthocyanin production in carrot cell suspension cultures. |
| PubMed:ZK98299--a new antiprogesterone: biochemical characterization of steroid binding parameters in the calf uterine cytosol. |
| PubMed:Synthesis of new 10 beta-propargylic and 11 beta-allenic steroidal spirolactones. |
| PubMed:Demonstration of putative membrane and cytosol steroid receptors for 17α, 20β-dihydroxy-4-pregnen-3-one in brook troutSalvelinus fontinalis oocytes by photoaffinity labelling using synthetic progestin 17,21-dimethyl-19-nor-pregn-4,9-diene-3,20-dione (R5020). |
| PubMed:Activation of thymocyte deoxyribonucleic acid degradation by endogenous glucocorticoids. |
| PubMed:Progesterone action in normal mouse mammary gland. |
| PubMed:Mechanism of action of a steroidal antiglucocorticoid in lymphoid cells. |
| PubMed:Kinetic pulse-chase labeling study of the glucocorticoid receptor in mouse lymphoma cells. Effect of glucocorticoid and antiglucocorticoid hormones on intracellular receptor half-life. |
| PubMed:Agonist-dependent phosphorylation and nuclear dephosphorylation of glucocorticoid receptors in intact cells. |
| PubMed:The chemistry of 9 alpha-hydroxysteroids. 1. Preparation of 9 alpha,17 beta-dihydroxy-17 alpha-ethynylandrost-4-en-3-one. |
| PubMed:Attenuation of preovulatory gonadotrophin surges by epostane: a new inhibitor of 3 beta-hydroxysteroid dehydrogenase. |
| PubMed:Ligand-modulated regulation of progesterone receptor messenger ribonucleic acid and protein in human breast cancer cell lines. |
| PubMed:RU486 is not an antiprogestin in the hamster. |
| PubMed:Role of progesterone in the modulation of the preovulatory surge of gonadotropins and ovulation in the pregnant mare's serum gonadotropin-primed immature rat and the adult rat. |
| PubMed:ORG-2058 as a ligand in the assay of progesterone receptor in breast cancer. |
| PubMed:Abbreviation of the period of sexual behavior in female guinea pigs by the progesterone antagonist RU 486. |
| PubMed:Antagonistic effect of glucocorticoids on retinoic acid induced growth inhibition and morphological alterations of a human cell line. |
| PubMed:Modulation of lactogenic receptors by progestins in cultured human breast cancer cells. |
| PubMed:Rapid in vivo effects of glucocorticoids on the integrity of rat lymphocyte genomic deoxyribonucleic acid. |
| PubMed:A-ring conformational stability and progesterone-receptor binding affinity of 4-en-3-one steroids. |
| PubMed:Zinc concentration and progestin receptor in human benign hyperplastic prostate. |
| PubMed:High affinity binding of [3H]R5020 and [3H]progesterone by putative progesterone receptors in cytosol and nuclear extract of turtle oviduct. |
| PubMed:Progestin binding in benign hyperplastic prostatic tissue. |
| PubMed:Assessment of structural similarities in chick oviduct progesterone receptor subunits by partial proteolysis of photoaffinity-labeled proteins. |
| PubMed:Estrogen and progesterone receptors in human uterus and oviduct. |
| PubMed:Progestin receptors in ovaries of 4-day cycling rats. An autoradiographic study. |
| PubMed:Presence of progesterone receptors and absence of oestrogen receptors in human intracranial meningioma cytosols. |
| PubMed:Photoaffinity labeling of the chick progesterone receptor proteins. Similar hormone binding domains detected after removal of proteolytic interference. |
| PubMed:Characterization of the cytosol androgen receptor of the human prostate. |
| PubMed:Plant cell suspension cultures as model systems for investigating growth regulating compounds. |
| PubMed:Progesterone receptors in mammary gland of the pregnant rat. |
| PubMed:Comparative studies of aromatase inhibitors in cultured human breast cancer cells. |
| PubMed:Hormone receptors of the baboon cardiovascular system. Biochemical characterization of aortic and myocardial cytoplasmic progesterone receptors. |
| PubMed:Identification of a steroid receptor on the surface of Xenopus oocytes by photoaffinity labeling. |
| PubMed:Photoaffinity labeling of glucocorticoid receptors. |
| PubMed:Purification of a human progesterone receptor. |
| PubMed:Direct inhibitory effect of glucocorticoids upon testicular luteinizing hormone receptor and steroidogenesis in vivo and in vitro. |
| PubMed:Absence of high-affinity binding of progesterone (R 5020) in human placenta and fetal membranes. |
| PubMed:Hormones modulate the concentration of cytoplasmic progestin receptors in the brain of male ring doves (Streptopelia risoria). |
| PubMed:Binding of medroxyprogesterone acetate in human breast cancer. |
| PubMed:Progestin receptors in rat brain: distribution and properties of cytoplasmic progestin-binding sites. |
| PubMed:Progesterone "receptor" in rat ovary. |
| PubMed:Assay of progesterone receptor binding sites with 17,21-dimethyl-19-norpregna-4,9-diene-3,20-dione and 16alpha-ethyl-21-hydroxy-19-nor-4-pregnene-3,20-dione as the radioactive ligands [proceedings]. |
| PubMed:[Specific binding of 3H-progesterone to a plasma protein in the guinea pig fetus]. |
| PubMed:Interaction of progestins with steroid receptors in human uterus. |
| PubMed:Comparison of [3H]progesterone and [6,7-3H]-17,21-dimethyl-19-norpregna-4,9-diene-3,20-dione for the measurement of progesterone receptors in human malignant tissue. |
| PubMed:Progestin binding in testes from three siblings with the syndrome of male pseudohermaphroditism with testicular feminization. |
| PubMed:Characterization of unoccupied (R) and occupied (RA) androgen binding components of the hyperplastic human prostate. |
| PubMed:Characterization and assay of the progesterone receptor in rat uterine cytosol. |
| PubMed:Progestin binding sites in the rat hypothalamus pituitary and uterus. |
| PubMed:N-(4-Acetamidophenyl)-anti-tricyclo [4.2.2.025-] deca-3, 9-diene-7, 8-endodicarboximide (1)--a chemically novel anticonvulsant. |
| PubMed:Characterization and assay of progesterone receptor in human mammary carcinoma. |
| PubMed:Specific progesterone receptors in dimethylbenzanthracene (DMBA)-induced mammary tumors. |
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Constit. of Pinus caribaea. Mixed cadinene isomers, with b-cadinene usually predominating, occur in several essential oils, esp. ylang-ylang, citronella and cade oil from Juniper spp. Cadinene isomers are used as a flavouring agent and/or flavour modifier
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3D/inchi