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Category:natural substances and extractives
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Appearance: | bluish green clear liquid (est) |
| Assay: | 97.00 to 100.00
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| Food Chemicals Codex Listed: | No |
| Specific Gravity: | 0.98810 @ 25.00 °C.
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| Boiling Point: | 159.00 °C. @ 11.00 mm Hg
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| Boiling Point: | 298.00 to 300.00 °C. @ 760.00 mm Hg
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| Vapor Pressure: | 0.002000 mmHg @ 25.00 °C. (est) |
| Flash Point: | 279.00 °F. TCC ( 137.22 °C. )
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| logP (o/w): | 5.510 |
| Soluble in: |
| | alcohol | | | water, 0.2979 mg/L @ 25 °C (est) |
| Insoluble in: |
| | water |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). |
Cosmetic Information:
Suppliers:
Safety Information:
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
intramuscular-mouse LD50 3000 mg/kg
Rastitel'nye Resursy. Plant Resources. Vol. 3, Pg. 67, 1967.
intravenous-rabbit LDLo 600 mg/kg
LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Rastitel'nye Resursy. Plant Resources. Vol. 3, Pg. 67, 1967.
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | | natural substances and extractives |
| Recommendation for chamazulene usage levels up to: | | | not for fragrance use.
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| Recommendation for chamazulene flavor usage levels up to: |
| | not for flavor use.
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Safety References:
References:
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| | azulene, 7-ethyl-1,4-dimethyl- | | | camazulene | | | dimethulene | | 1,4- | dimethyl-7-(1-methylethyl) azulene | | 1,4- | dimethyl-7-ethyl azulene | | 1,4- | dimethyl-7-ethylazulene | | 7- | ethyl-1,4-dimethyl azulene | | 7- | ethyl-1,4-dimethylazulene | | | lindazulene |
Articles:
| PubMed:Antinociceptive and anti-edematous activities of the essential oils of two Balkan endemic Laserpitium species. |
| PubMed:Chemopreventive and antioxidant activity of the chamazulene-rich essential oil obtained from Artemisia arborescens L. growing on the Isle of La Maddalena, Sardinia, Italy. |
| PubMed:Chemical composition and antifungal activity of Matricaria recutita flower essential oil against medically important dermatophytes and soil-borne pathogens. |
| PubMed:Pelargonium graveolens L'Her. and Artemisia arborescens L. essential oils: chemical composition, antifungal activity against Rhizoctonia solani and insecticidal activity against Rhysopertha dominica. |
| PubMed:The organ-specific expression of terpene synthase genes contributes to the terpene hydrocarbon composition of chamomile essential oils. |
| PubMed:Fast quality assessment of German chamomile (Matricaria chamomilla L.) by headspace solid-phase microextraction: influence of flower development stage. |
| PubMed:Guaianolides and volatile compounds in chamomile tea. |
| PubMed:Activity of Matricaria chamomilla essential oil against anisakiasis. |
| PubMed:Anglo-Saxon pharmacopoeia revisited: a potential treasure in drug discovery. |
| PubMed:Chemical composition and antibacterial potential of Artemisia arborescens L. essential oil. |
| PubMed:Variability of the essential oil content and composition of chamomile (Matricaria recutita L.) affected by weather conditions. |
| PubMed:Effect of Matricaria chamomilla L. flower essential oil on the growth and ultrastructure of Aspergillus niger van Tieghem. |
| PubMed:Content and composition of the essential oil of Chamomilla recutita (L.) Rauschert from some European countries. |
| PubMed:Chemical composition, antioxidant and antibacterial properties of Achillea collina Becker ex Heimerl s.l. and A. pannonica Scheele essential oils. |
| PubMed:Genotoxicity of Achillea millefolium essential oil in diploid cells of Aspergillus nidulans. |
| PubMed:Induction of mitochondrial-dependent apoptosis by an essential oil from Tanacetum gracile. |
| PubMed:Chemical composition and antibacterial activity of essential oil from Artemisia feddei. |
| PubMed:Trypanosoma cruzi: activity of essential oils from Achillea millefolium L., Syzygium aromaticum L. and Ocimum basilicum L. on epimastigotes and trypomastigotes. |
| PubMed:Phytochemical analysis of the essential oil of Achillea millefolium L. from various European Countries. |
| PubMed:Determination of chamazulene carboxylic acid in serum by high-performance liquid chromatography. Development and validation. |
| PubMed:Qualitative and quantitative analysis of the active components of the essential oil from Brickellia veronicaefolia by nuclear magnetic resonance spectroscopy. |
| PubMed:Chamazulene carboxylic acid and matricin: a natural profen and its natural prodrug, identified through similarity to synthetic drug substances. |
| PubMed:Comparative analysis of the oil and supercritical CO(2) extract of Artemisia arborescens L. and Helichrysum splendidum (Thunb.) Less. |
| PubMed:A review of the bioactivity and potential health benefits of chamomile tea (Matricaria recutita L.). |
| PubMed:Inhibitory effects of the essential oil of chamomile (Matricaria recutita L.) and its major constituents on human cytochrome P450 enzymes. |
| PubMed:Smooth muscle relaxant action of benzyl benzoates and salicylic acid derivatives from Brickellia veronicaefolia on isolated guinea-pig ileum. |
| PubMed:Screening of chemical composition and antifungal and antioxidant activities of the essential oils from three Turkish artemisia species. |
| PubMed:Effect of magnesium on essential oil formation of genetically transformed and non-transformed chamomile cultures. |
| PubMed:[Pharmacognostic research of some species of Achillea. Note 1. Volatile oils analysis]. |
| PubMed:New terpenoids in cultivated and wild chamomile (in vivo and in vitro). |
| PubMed:Inhibitory effect of chamomile essential oil on the sister chromatid exchanges induced by daunorubicin and methyl methanesulfonate in mouse bone marrow. |
| PubMed:Synthesis of new azulene derivatives and study of their effect on lipid peroxidation and lipoxygenase activity. |
| PubMed:Absolute stereochemistry of guaianolides, of matricin and its epimers, of yarrow proazulenes, and of chamazulene carboxylic acid. |
| PubMed:On the absolute configuration of matricin. |
| PubMed:Antifungal activity of the essential oil of flowerheads of garland chrysanthemum (Chrysanthemum coronarium) against agricultural pathogens. |
| PubMed:Production of yarrow (Achillea millefolium L.) in Norway: essential oil content and quality. |
| PubMed:In vitro study on the transfer of volatile oil components. |
| PubMed:A study of the production of essential oils in chamomile hairy root cultures. |
| PubMed:Incorporation of 1-[1-(13)C]Deoxy-D-xylulose in chamomile sesquiterpenes. |
| PubMed:Investigation of the effect of chamazulene on lipid peroxidation and free radical processes. |
| PubMed:Effects of some components of the essential oil of chamomile, Chamomilla recutita, on histamine release from rat mast cells. |
| PubMed:Chamazulene: an antioxidant-type inhibitor of leukotriene B4 formation. |
| PubMed:Management of oral mucositis during local radiation and systemic chemotherapy: a study of 98 patients. |
| PubMed:Studies on the Origin of (-)-alpha-Bisabolol and Chamazulene in Chamomile Preparations; Part I. Investigations by Isotope Ratio Mass Spectrometry (IRMS). |
| PubMed:[Observations and research on an extract of Inula viscosa Ait ]. |
| PubMed:[Pharmacologic studies on chamomile compounds. VI. Studies on the antiphlogistic effect of chamazulene and matricine]. |
| PubMed:Constituents of Essential Oil of Artemisia arborescens. |
| PubMed:[A chemical study of the essential oil from Artemisia arborescens]. |
| PubMed:[Determination of bisabolol, spiroether and chamazulene in Anthodium Chamomillae]. |
| PubMed:On the quantitative determination of chamazulene and prochamazulenes in essential oils and crude drugs from yarrow (Achillea sp.--Compositae). II.: A new colorimetric method of high sensitivity for determination of chamazulene in the essential oils. |
| PubMed:[A method for the determination of the chamazulene content of chamomile oil]. |
| PubMed:Quantitative determination of essential oil, total azulenes and chamazulene in German chamomile (Matricaria chamomilla) cultivated in Argentina. |
| PubMed:[Change in the content of essential oil and chamazulene in German camomile (Matricaria chamomilla L.) during vegetative period]. |
| PubMed:Chamazulene from Artemesia caruthii. |
| PubMed:[Comparative toxicity of S-guaiazulene, chamazulene and their 3-monosulfone derivatives in white rat]. |
| PubMed:[Studies on the effect of chamazulene on the human skin]. |
| PubMed:[Contribution to the presence and amount of chamazulene in solitary growing plants of the species Achillea millefolium L..]. |
| PubMed:[New possibilities of preparation of chamazulene]. |
| PubMed:Studies on seven-membered ring derivatives. III. Partial synthesis of 1,4-dimethyl-7-ethylazulene (lindazulene). |
| PubMed:[Antipyretic action of chamazulene]. |
| PubMed:[Further results with chamazulene in the treatment of asthmatic diseases in infancy and childhood]. |
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3D/inchi