EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes

sodium trimetaphosphate
1,3,5,2,4,6-trioxatriphosphorinane, 2,4,6-trihydroxy-, trisodium salt

Supplier Sponsors

Name:trisodium 2,4,6-trioxido-1,3,5,2lamda5,4lamda5,6lamda5-trioxatriphosphinane 2,4,6-trioxide
CAS Number: 7785-84-4Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:232-088-3
FDA UNII: 3IH6169RL0
Nikkaji Web:J268.687B
MDL:MFCD00867826
Molecular Weight:305.88339384
Formula:Na3 O9 P3
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:food additive and cosmetic agents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
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Google Patents:Search
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Pubchem Patents:Search
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 FDA/DG SANTE Petitions, Reviews, Notices:
1975 Sodium trimetaphosphate View - review
EU SANCO Sodium phosphates View - review
FDA Mainterm (IAUFC):7785-84-4 ; TRISODIUM TRIMETAPHOSPHATE
 
Physical Properties:
Appearance:white powder (est)
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Flash Point: 32.00 °F. TCC ( 0.00 °C. ) (est)
Soluble in:
 water
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: anticaking agents
buffering agents
chelating agents
 
Suppliers:
BOC Sciences
For experimental / research use only.
trimetaphosphate grade iii trisodium
Santa Cruz Biotechnology
For experimental / research use only.
Sodium Trimetaphosphate ≥95%
Sigma-Aldrich: Aldrich
For experimental / research use only.
Trisodium trimetaphosphate ≥95%
sds
Zhong Ya Chemical
Sodium Trimetaphosphate Food Grade
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intraperitoneal-rat LD50 3650 mg/kg
BEHAVIORAL: EXCITEMENT
Journal of Pharmacology and Experimental Therapeutics. Vol. 108, Pg. 117, 1953.

oral-mouse LD50 10300 mg/kg
Arzneimittel-Forschung. Drug Research. Vol. 7, Pg. 445, 1957.

intravenous-mouse LD50 1165 mg/kg
Arzneimittel-Forschung. Drug Research. Vol. 7, Pg. 445, 1957.

intravenous-rabbit LDLo 240 mg/kg
Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 169, Pg. 238, 1933.

Dermal Toxicity:
subcutaneous-mouse LD50 5940 mg/kg
Arzneimittel-Forschung. Drug Research. Vol. 7, Pg. 445, 1957.

skin-rabbit LD50 > 4640 mg/kg
National Technical Information Service. Vol. OTS0571153

Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
food additive and cosmetic agents
Recommendation for sodium trimetaphosphate usage levels up to:
 not for fragrance use.
 
Recommendation for sodium trimetaphosphate flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
Chemical Carcinogenesis Research Information System:Search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA Substance Registry Services (TSCA):7785-84-4
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :24579
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:2
trisodium 2,4,6-trioxido-1,3,5,2lamda5,4lamda5,6lamda5-trioxatriphosphinane 2,4,6-trioxide
Chemidplus:0007785844
EPA/NOAA CAMEO:hazardous materials
 
References:
 trisodium 2,4,6-trioxido-1,3,5,2lamda5,4lamda5,6lamda5-trioxatriphosphinane 2,4,6-trioxide
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:7785-84-4
Pubchem (cid):24579
Pubchem (sid):134991238
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Indirect Additives used in Food Contact Substances:View
CHEMBL:View
KEGG (GenomeNet):D02423
HMDB (The Human Metabolome Database):Search
FDA Listing of Food Additive Status:View
ChemSpider:View
Wikipedia:View
Formulations/Preparations:
•available from monsanto co as fine white powder, purified and technical grades purified grade meets fcc specifications on arsenic and heavy metals •toothpastes containing 0.5-95% silicon dioxide xerogel & 0.5-6% sodium trimetaphosphate are effective tooth polishing agents.
 
Potential Blenders and core components note
None Found
 
Potential Uses:
 buffering agents
 chelating agents
 
Occurrence (nature, food, other):note
 not found in nature
 
Synonyms:
metaphosphoric acid (H3P3O9), trisodium salt
metaphosphoric acid trisodium salt
metaphosphoric acid, trisodium salt
 sodium metaphosphate (Na3(P3O9))
 sodium phosphate ((NaPO3)3)
 sodiumtrimetaphosphate
 trimetaphosphoric acid (H3P3O9), trisodium salt
1,3,5,2,4,6-trioxatriphosphorinane, 2,4,6-trihydroxy-, trisodium salt
 trisodium 2,4,6-trioxido-1,3,5-trioxa-2
 trisodium 2,4,6-trioxido-1,3,5,2lamda5,4lamda5,6lamda5-trioxatriphosphinane 2,4,6-trioxide
 trisodium metaphosphate
 trisodium trimetaphosphate
 trisodium trimetaphosphate (Na3P3O9)
 

Articles:

PubMed:Polyaspartic acid enhances dentine remineralization bonded with a zinc-doped Portland-based resin cement.
PubMed:Cyclodextrin/dextran based hydrogels prepared by cross-linking with sodium trimetaphosphate.
PubMed:Level and position of substituents in cross-linked and hydroxypropylated sweet potato starches using nuclear magnetic resonance spectroscopy.
PubMed:Effectiveness of a Toothpaste with Low Fluoride Content Combined with Trimetaphosphate on Dental Biofilm and Enamel Demineralization in situ.
PubMed:In vitro effect of low-fluoride toothpastes containing sodium trimetaphosphate on enamel erosion.
PubMed:Synthesis of pH- and ionic strength-responsive microgels and their interactions with lysozyme.
PubMed:In situ remineralizing effect of fluoride varnishes containing sodium trimetaphosphate.
PubMed:Effect of toothpaste with nano-sized trimetaphosphate on dental caries: In situ study.
PubMed:Influence of phosphoproteins' biomimetic analogs on remineralization of mineral-depleted resin-dentin interfaces created with ion-releasing resin-based systems.
PubMed:Effects of the order of addition of reagents and alkali on modification of wheat starches.
PubMed:Preparation of cross-linked maize (Zea mays L.) starch in different reaction media.
PubMed:Preparation and characterization of carboxymethyl starch microgel with different crosslinking densities.
PubMed:In vitro effect of sodium trimetaphosphate additives to conventional toothpastes on enamel demineralization.
PubMed:In vitro enamel remineralization capacity of composite resins containing sodium trimetaphosphate and fluoride.
PubMed:Effect of trimetaphosphate and fluoride association on hydroxyapatite dissolution and precipitation in vitro.
PubMed:Roles of the antioxidant properties of icariin and its phosphorylated derivative in the protection against duck virus hepatitis.
PubMed:Preparation and evaluation of microspheres of xyloglucan and its thiolated xyloglucan derivative.
PubMed:Effect of resin composites with sodium trimetaphosphate with or without fluoride on hardness, ion release and enamel demineralization.
PubMed:Properties and characteristics of dual-modified rice starch based biodegradable films.
PubMed:Longitudinal evaluation of fluoride levels in nails of 18-30-month-old children that were using toothpastes with 500 and 1100 μg F/g.
PubMed:Type IV resistant starch increases cecum short chain fatty acids level in rats.
PubMed:Effect of fluoride varnish supplemented with sodium trimetaphosphate on enamel erosion and abrasion.
PubMed:Effect of fluoride gels supplemented with sodium trimetaphosphate on enamel erosion and abrasion: in vitro study.
PubMed:Preparation and characterization of starch crosslinked with sodium trimetaphosphate and hydrolyzed by enzymes.
PubMed:In vitro remineralizing effect of fluoride varnishes containing sodium trimetaphosphate.
PubMed:Effect of cross-linking on physicochemical properties of tapioca starch and its application in soup product.
PubMed:Physicochemical property of starch-pectin conjugates with resistance to enzymatic activity.
PubMed:Effect of fluoride varnish supplemented with sodium trimetaphosphate on enamel erosion and abrasion: an in situ/ex vivo study.
PubMed:Effect of fluoride gels supplemented with sodium trimetaphosphate in reducing demineralization.
PubMed:Novel phosphorus-containing cyclodextrin polymers and their affinity for calcium cations and hydroxyapatite.
PubMed:In vitro enamel remineralization by low-fluoride toothpaste with calcium citrate and sodium trimetaphosphate.
PubMed:Effect of sodium trimetaphosphate on hydroxyapatite solubility: an in vitro study.
PubMed:Biomimetic mineralisation of phosphorylated dentine by CPP-ACP.
PubMed:In vitro evaluation of the effect of mouth rinse with trimetaphosphate on enamel demineralization.
PubMed:In situ evaluation of a low fluoride concentration gel with sodium trimetaphosphate in enamel remineralization.
PubMed:A study of controlled uptake and release of anthocyanins by oxidized starch microgels.
PubMed:Effects of the order of addition of reagents and catalyst on modification of maize starches.
PubMed:Effect of pH on phosphorylation of potato protein isolate.
PubMed:Flow injection determination of carboxylate, phosphate, and sulfhydryl compounds using metal exchange complexation.
PubMed:Effect of drying technique on some physical properties of cross-linked high amylose/pectin mixtures.
PubMed:Anticaries effect of dentifrices with calcium citrate and sodium trimetaphosphate.
PubMed:Remineralization of partially demineralized dentine substrate based on a biomimetic strategy.
PubMed:Preparation and characterization of free films of high amylose/pectin mixtures cross-linked with sodium trimetaphosphate.
PubMed:Physical properties of pectin-high amylose starch mixtures cross-linked with sodium trimetaphosphate.
PubMed:Effect of mouth rinses with fluoride and trimetaphosphate on enamel erosion: an in vitro study.
PubMed:Preparation of cross-linked carboxymethyl jackfruit starch and evaluation as a tablet disintegrant.
PubMed:The use of sodium trimetaphosphate as a biomimetic analog of matrix phosphoproteins for remineralization of artificial caries-like dentin.
PubMed:Biomimetic analogs for collagen biomineralization.
PubMed:A chemical phosphorylation-inspired design for Type I collagen biomimetic remineralization.
PubMed:Fabrication of porous polysaccharide-based scaffolds using a combined freeze-drying/cross-linking process.
PubMed:Preparation and characterization of oxidized starch polymer microgels for encapsulation and controlled release of functional ingredients.
PubMed:Chemical characterization of a degradable polymeric bone adhesive containing hydrolysable fillers and interpretation of anomalous mechanical properties.
PubMed:In vitro evaluation of dentifrice with low fluoride content supplemented with trimetaphosphate.
PubMed:Modeling a system of phosphated cross-linked high amylose for controlled drug release. Part 2: physical parameters, cross-linking degrees and drug delivery relationships.
PubMed:17O solid-state NMR and first-principles calculations of sodium trimetaphosphate (Na3P3O9), tripolyphosphate (Na5P3O10), and pyrophosphate (Na4P2O7).
PubMed:Alpha-amino acid behaves differently from beta- or gamma-amino acids as treated by trimetaphosphate.
PubMed:Human endothelial progenitor cell attachment to polysaccharide-based hydrogels: a pre-requisite for vascular tissue engineering.
PubMed:High-resolution nuclear magnetic resonance spectroscopy studies of polysaccharides crosslinked by sodium trimetaphosphate: a proposal for the reaction mechanism.
PubMed:Pullulan-based hydrogel for smooth muscle cell culture.
PubMed:Phosphorylation of peptides derived from isolated soybean protein: effects on calcium binding, solubility and influx into Caco-2 cells.
PubMed:Retention of transforming growth factor beta1 using functionalized dextran-based hydrogels.
PubMed:A new vascular polyester prosthesis impregnated with cross-linked dextran.
PubMed:Final report on the safety assessment of Sodium Metaphosphate, Sodium Trimetaphosphate, and Sodium Hexametaphosphate.
PubMed:Polyphosphorylation and non-enzymatic template-directed ligation of oligonucleotides.
PubMed:Separation and determination of rare earth elements by Dowex 2-X8 resin using sodium trimetaphosphate as elution agent.
PubMed:Characterization of a crosslinked high amylose starch excipient.
PubMed:Composition and nutritive value of yeast biomass and yeast protein concentrates.
PubMed:The effect of sodium trimetaphosphate on caries: a 3-year clinical toothpaste trial.
PubMed:Role of models in assessing new agents for caries prevention--non-fluoride systems.
PubMed:The effect of NaF and SMFP toothpastes on three-year caries increments in adolescents.
PubMed:The location of the polyphosphate-binding sites on cytochrome c measured by NMR paramagnetic difference spectroscopy.
PubMed:Enzymatic preparation of seasoning 5'-nucleotides from baker's yeast.
PubMed:Caries preventive effects of toothpastes containing monofluorophosphate and trimetaphosphate: a 3-year clinical trial.
PubMed:Influence of combinations of oat hulls and sodium trimetaphosphate upon dental caries in the rat.
PubMed:Formation of the imidazolides of dinucleotides under potentially prebiotic conditions.
PubMed:The effect of sodium trimetaphosphate (TMP) as a chewing gum additive on caries increments in children.
PubMed:Effects of sodium trimetaphosphate supplementation of a high sucrose diet on the microbial and biochemical composition of four-day plaque and on urine calcium and phosphorus levels.
PubMed:Incorporation of 5'-amino-5'-deoxythymidine5'-phosphate in polynucleotides by use of DNA polymerase I and a phiX174 DNA template.
PubMed:Sodium trimetaphosphate as a bone-imaging agent. I. Animal studies.
PubMed:Purification and concentration of influenza types A and B by chromatography on calcium phosphate.
PubMed:Longitudinal study of cariostatic effects of sodium trimetaphosphate and sodium fluoride when fed separately and together in diets of rats.
PubMed:Sodium trimetaphosphate influence on the early development of rat caries and concurrent microbial changes.
PubMed:Cariostatic effects of sodium trimetaphosphate when fed to rats during different stages of tooth developent.
 
Notes:
None found
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