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Category:information only not used for fragrances or flavors
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00
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| Food Chemicals Codex Listed: | No |
| Specific Gravity: | 1.01600 @ 25.00 °C.
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| Refractive Index: | 1.61300 @ 20.00 °C.
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| Melting Point: | 7.60 °C. @ 760.00 mm Hg
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| Boiling Point: | 268.00 °C. @ 760.00 mm Hg
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| Boiling Point: | 267.00 to 268.00 °C. @ 760.00 mm Hg (est)
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| Vapor Pressure: | 0.013000 mmHg @ 25.00 °C. (est) |
| Flash Point: | > 230.00 °F. TCC ( > 110.00 °C. )
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| logP (o/w): | 4.370 |
| Soluble in: |
| | alcohol | | | water, 11.4 mg/L @ 25 °C (exp) |
| Insoluble in: |
| | water |
Organoleptic Properties:
| Flavor Type: moldy |
| moldy resinous |
| Taste Description: mouldy tarry |
| Odor and/or flavor descriptions from others (if found). |
Cosmetic Information:
Suppliers:
Safety Information:
| Preferred SDS: View |
| |
| Hazards identification |
| |
| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
| |
| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
|
Not determined
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| Dermal Toxicity: |
|
Not determined
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| Inhalation Toxicity: |
|
Not determined
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Safety in Use Information:
| Category: | | information only not used for fragrances or flavors |
| Recommendation for 1,4-dimethyl naphthalene usage levels up to: | | | not for fragrance use.
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| |
| Recommendation for 1,4-dimethyl naphthalene flavor usage levels up to: |
| | not for flavor use.
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Safety References:
European Food Safety Authority (EFSA) reference(s):
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Conclusion on the peer review of the pesticide risk assessment of the active substance 1,4-dimethylnaphthalene
View page or View pdf
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Reasoned opinion on the setting of a new MRL for 1,4-dimethylnaphthalene in potatoes
View page or View pdf
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Outcome of the consultation with Member States, the applicant and EFSA on the pesticide risk assessment for 1,4-dimethylnaphthalene in light of confirmatory data
View page or View pdf
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Review of the existing maximum residue levels for 1,4-dimethylnaphthalene according to Article 12 of Regulation (EC) No 396/2005
View page or View pdf
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| EPI System: View |
| AIDS Citations:Search |
| Cancer Citations:Search |
| Toxicology Citations:Search |
| EPA ACToR:Toxicology Data |
| EPA Substance Registry Services (SRS):Registry |
| Laboratory Chemical Safety Summary :11304 |
| National Institute of Allergy and Infectious Diseases:Data |
| WGK Germany:3 |
| 1,4-dimethylnaphthalene |
| Chemidplus:0000571584 |
References:
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| 1,4- | dimethyl-naphthalene | | 1,4- | dimethylnaphthalene | | 1,4- | DMN | | | naphthalene, 1,4-dimethyl- |
Articles:
| US Patents:3,931,166 - Certain 2,5-dimethyl-3-thiopyrazines |
| PubMed:The Paleobiosphere: a novel device for the in vivo testing of hydrocarbon producing-utilizing microorganisms. |
| US Patents:3,961,095 - Flavoring agent |
| PubMed:Triplet excited state behavior of naphthalene-based pseudopeptides in the presence of energy donors. |
| PubMed:Functionalized derivatives of 1,4-dimethylnaphthalene as precursors for biomedical applications: synthesis, structures, spectroscopy and photochemical activation in the presence of dioxygen. |
| PubMed:The sprout inhibitor 1,4-dimethylnaphthalene induces the expression of the cell cycle inhibitors KRP1 and KRP2 in potatoes. |
| PubMed:Ralstonia sp. U2 naphthalene dioxygenase and Comamonas sp. JS765 nitrobenzene dioxygenase show differences in activity towards methylated naphthalenes. |
| PubMed:Liquid phase separation of polyaromatics on [Cu2(BDC)2(dabco)]. |
| PubMed:Electron donor-acceptor interaction of 3,4-dimethylaniline with 2,3-dicyano-1,4-naphthoquinone. |
| PubMed:Dexmedetomidine induces both relaxations and contractions, via different {alpha}2-adrenoceptor subtypes, in the isolated mesenteric artery and aorta of the rat. |
| PubMed:Analogues of (3R)-7-hydroxy-N-[(1S)-1-{[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethyl-1-piperidinyl]methyl}-2-methylpropyl)-1,2,3,4-tetrahydro-3-isoquinolinecarboxamide (JDTic). Synthesis and in vitro and in vivo opioid receptor antagonist activity. |
| PubMed:Steric effects on the control of endo/exo-selectivity in the asymmetric cycloaddition reaction of 3,4-dimethyl-1-phenylarsole. |
| PubMed:The sprout inhibitors chlorpropham and 1,4-dimethylnaphthalene elicit different transcriptional profiles and do not suppress growth through a prolongation of the dormant state. |
| PubMed:(1R*,2R*)-1-(4-Chloro-phen-yl)-4-dimethyl-amino-1-(3-meth-oxy-2-naphth-yl)-2-(1-naphth-yl)butan-2-ol. |
| PubMed:(1R*,2R*)-1-(7-Bromo-3-methoxy-naphthalen-2-yl)-4-(dimethyl-amino)-2-(naphthalen-1-yl)-1-phenyl-butan-2-ol. |
| PubMed:Yields of glyoxal and ring-cleavage co-products from the OH radical-initiated reactions of naphthalene and selected alkylnaphthalenes. |
| PubMed:Metal-organic frameworks as high-potential adsorbents for liquid-phase separations of olefins, alkylnaphthalenes and dichlorobenzenes. |
| PubMed:Generation of cholesterol carboxyaldehyde by the reaction of singlet molecular oxygen [O2 (1Delta(g))] as well as ozone with cholesterol. |
| PubMed:Soft-hydrothermal processing of red cedar bedding reduces its induction of cytochrome P450 in mouse liver. |
| PubMed:The pH effect on the naphthoquinone-photosensitized oxidation of 5-methylcytosine. |
| PubMed:Multidimensional gas chromatography with capillary flow technology and LTM-GC. |
| PubMed:Selective oxidation and reduction of trinuclear titanium(II) hexaazatrinaphthylene complexes-synthesis, structure, and electrochemical investigations. |
| PubMed:On the effect of 1,4-diazabicyclo[2.2.2]octane on the singlet-oxygen dimol emission: chemical generation of 1O2)2 in peroxide reactions. |
| PubMed:A widely used retinoic acid receptor antagonist induces peroxisome proliferator-activated receptor-gamma activity. |
| PubMed:Disorder-to-order transition of 1,4-dimethylnaphthalene: Formation of molecular complex with water and p-xylene on Al2O3 (0001). |
| PubMed:Volatile biomarkers of pulmonary tuberculosis in the breath. |
| PubMed:Oximetry of oxygen supersaturated solutions using nitroxides as EPR probe. |
| PubMed:Effects of 9,10-dihydroxy-4,4-dimethyl-5,8-dihydro-1(4H)-anthracenone derivatives on tumor cell respiration. |
| PubMed:Enantioselective addition of vinylzinc reagents to aldehydes catalyzed by modular ligands derived from amino acids. |
| PubMed:Synthesis and antidepressant activity of some 1,3,5-triphenyl-2-pyrazolines and 3-(2''-hydroxy naphthalen-1''-yl)-1,5-diphenyl-2-pyrazolines. |
| PubMed:A redox active and electrochemiluminescent threading bis-intercalator and its applications in DNA assays. |
| PubMed:Application of cyclodextrin-mediated capillary electrophoresis to determine the apparent binding constants and thermodynamic parameters of the alkylnaphthalene derivatives. |
| PubMed:Characterization of Sphingomonas aldehyde dehydrogenase catalyzing the conversion of various aromatic aldehydes to their carboxylic acids. |
| PubMed:Estimates of internal energies of vaporisation of some room temperature ionic liquids. |
| PubMed:Identification of a new scaffold for opioid receptor antagonism based on the 2-amino-1,1-dimethyl-7-hydroxytetralin pharmacophore. |
| PubMed:Synthesis, antiprotozoal and cytotoxic activities of new N-(3,4-dimethyl-5-isoxazolyl)-1,2-naphthoquinone-4-amino derivatives. |
| PubMed:A retinoid-related molecule that does not bind to classical retinoid receptors potently induces apoptosis in human prostate cancer cells through rapid caspase activation. |
| PubMed:Synthesis of conformationally stable 1,8-diarylnaphthalenes: development of new photoluminescent sensors for ion-selective recognition. |
| PubMed:Chemical composition of the essential oils of two Chinese endemic Meconopsis species. |
| PubMed:Singlet molecular oxygen generated from lipid hydroperoxides by the russell mechanism: studies using 18(O)-labeled linoleic acid hydroperoxide and monomol light emission measurements. |
| PubMed:Direct evidence of singlet molecular oxygen [O2(1Deltag)] production in the reaction of linoleic acid hydroperoxide with peroxynitrite. |
| PubMed:Effects of hydroxypropyl-beta-cyclodextrin on the chemical stability of a naphthoquinone in aqueous solutions. |
| PubMed:Sensitized photoxygenation of piroxicam in neat solvents and solvent mixtures. |
| PubMed:Differential effects of U46619 on renal regional hemodynamics in the rat: involvement of endothelin. |
| PubMed:Disposition and metabolism of 1,4-dimethylnaphthalene in rat. |
| PubMed:Effect of experimental diabetes on the fatty acid composition, molecular species of phosphatidyl-choline and physical properties of hepatic microsomal membranes. |
| PubMed:Effect of hydroxypropyl-beta-cyclodextrin on the solubility of an antibacterial isoxazolyl-naphthoquinone. |
| PubMed:Cytochrome P450 omega/omega-1 hydroxylase-derived eicosanoids contribute to endothelin(A) and endothelin(B) receptor-mediated vasoconstriction to endothelin-1 in the rat preglomerular arteriole. |
| PubMed:Mechanism of antibacterial and degradation behavior of a chlorinated isoxazolylnaphthoquinone. |
| PubMed:Antimutagenic effects and possible mechanisms of action of vitamins and related compounds against genotoxic heterocyclic amines from cooked food. |
| PubMed:An aqueous concentration model for riverine spills. |
| PubMed:Effects of endothelin-1 on capsaicin-induced nociception in mice. |
| PubMed:Inactivation of enveloped viruses by singlet oxygen thermally generated from a polymeric naphthalene derivative. |
| PubMed:Oxidative stress in Staphylococcus aureus associated to the cleavage of an isoxazolylnaphthoquinoneimine with antibacterial capacity. |
| PubMed:An "in vitro" system simulates in membranes the antibacterial mechanism postulated for the action of isoxazolylnaphtoquinoneimine in Staphylococcus aureus. |
| PubMed:Activation of 5-HT1A receptors potentiates the clonidine inhibitory effect in the locus coeruleus. |
| PubMed:Singlet Oxygen and the Production of Sulfur Oxygenates of Nickel(II) and Palladium(II) Thiolates. |
| PubMed:New non-peptide endothelin-A receptor antagonists: synthesis, biological properties, and structure-activity relationships of 5-(dimethylamino)-N-pyridyl-,-N-pyrimidinyl-,-N-pyridazinyl-, and -N-pyrazinyl-1-naphthalenesulfonamides. |
| PubMed:Antibacterial effect of 2-hydroxy-N-(3,4-dimethyl-5-isoxazolyl)-1, 4-naphthoquinone-4-imine on Staphylococcus aureus. |
| PubMed:Formation of singlet oxygen in the thermal decomposition of 3-hydroxymethyl-3,4,4-trimethyl-1,2-dioxetane, a chemical source of triplet-excited ketones. |
| PubMed:A role for endothelin ETA receptors in regulation of renal function in spontaneously hypertensive rats. |
| PubMed:Glucocorticoid receptor-mediated inhibition by corticosterone of 5-HT1A autoreceptor functioning in the rat dorsal raphe nucleus. |
| PubMed:Mutagenic activity of isoxazolylnaphthoquinoneimines assayed by micronucleus bone marrow test. |
| PubMed:Diurnal rhythm of beta-carotene in photosynthetic alga Gonyaulax polyedra. |
| PubMed:Discovery and structure-activity relationships of sulfonamide ETA-selective antagonists. |
| PubMed:Antibiotic activity of isoxazolylnaphthoquinone imines on mice infected with Staphylococcus aureus. |
| PubMed:BMS-182874 is a selective, nonpeptide endothelin ETA receptor antagonist. |
| PubMed:Stability determination of 3-bromo-2-hydroxy-N-(3,4-dimethyl-5-isoxazolyl)- 1,4-naphthoquinon-4-imine in ethanol by first-derivative spectrophotometry. |
| PubMed:Isoxazoles. 8. Preformulation studies of an isoxazolylnaphthoquinone derivative. |
| PubMed:Synthesis and some physiochemical properties of 2-hydroxy-N-(3,4-dimethyl-5-isoxazolyl)-1,4-naphthoquinone 4-imine derivatives. |
| PubMed:The discovery of sulfonamide endothelin antagonists and the development of the orally active ETA antagonist 5-(dimethylamino)-N-(3,4-dimethyl-5-isoxazolyl)-1-naphthalenesulf onamide. |
| PubMed:Energy-transfer measurements of the Cys35-Cys84 distance in bovine cardiac troponin C. |
| PubMed:Effect of Plumbagin on some glucose metabolising enzymes studied in rats in experimental hepatoma. |
| PubMed:[In vitro antibacterial activity of isoxazolyl++ naphthoquinones. I]. |
| PubMed:The in vitro and in vivo cytotoxicity of menadione (vitamin K3) against rat transplantable hepatoma induced by 3'-methyl-4-dimethyl-aminoazobenzene. |
| PubMed:Isoxazolylnaphthoquinone effects on the growth of Trypanosoma cruzi. |
| PubMed:Isoxazoles. VI: Aspects of the chemical stability of a new naphthoquinone-amine in acidic aqueous solution. |
| PubMed:Substrate interactions during aerobic biodegradation of benzene. |
| PubMed:[Effect of naphthoquinone-imines on the production of hydrogen peroxide by Crithidia fasciculata and Leptomonas seymouri]. |
| PubMed:Palladium(0)-assisted synthesis of C-glycopyranosyl compounds. |
| PubMed:Structure-activity relationships among DNA gyrase inhibitors. Synthesis and biological evaluation of 1,2-dihydro-4, 4-dimethyl-1-oxo-2-naphthalenecarboxylic acids as 1-carba bioisosteres of oxolinic acid. |
| PubMed:High-dose chemotherapy and autologous bone marrow transplantation for the treatment of small cell lung carcinoma. |
| PubMed:Different protein-lipid interaction in human red blood cell membrane of Rh positive and Rh negative blood compared with Rhnull. |
| PubMed:Inhibition of DMBA carcinogenesis of hamster buccal pouch by phenanthrene and dimethylnaphthalene. |
| PubMed:Treatment of malignant gliomas and brain metastases in adults using a combination of adriamycine, VM 26, and CCNU. Results of a type II trial. |
| PubMed:Treatment of malignant gliomas and brain metastases in adults with a combination of adriamycin, VM 26, and CCNU. Results of a phase II trail. |
| PubMed:[Trial treatment of glioblastomas in adults and cerebral metastais by adriamycin, VM 26 and CCNU combination. Result of a type II trial]. |
| PubMed:The cardioactive and related properties of N-methyl-N-( -phenylethyl)-1,2,3,4-tetrahydro-6-methoxy-4,4-dimethyl-2-naphthylamine hydrochloride (2-AT-1). |
| PubMed:Microbial hydrocarbon co-oxidation. I. Oxidation of mono- and dicyclic hydrocarbons by soil isolates of the genus Nocardia. |
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3D/inchi