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Category:flavoring agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Appearance: | colorless to yellow clear liquid (est) |
| Assay: | 95.00 to 100.00
|
| Food Chemicals Codex Listed: | No |
| Specific Gravity: | 0.71500 to 0.72100 @ 25.00 °C.
|
| Pounds per Gallon - (est).: | 5.950 to 5.999
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| Refractive Index: | 1.38700 to 1.39300 @ 20.00 °C.
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| Melting Point: | -72.00 °C. @ 760.00 mm Hg
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| Boiling Point: | 62.00 to 63.00 °C. @ 760.00 mm Hg
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| Vapor Pressure: | 178.000000 mmHg @ 25.00 °C. |
| Flash Point: | -3.00 °F. TCC ( -19.44 °C. )
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| logP (o/w): | 0.740 |
| Soluble in: |
| | propylene glycol | | | water, 1.12E+05 mg/L @ 20 °C (exp) |
Organoleptic Properties:
| Odor Description:at 0.10 % in propylene glycol. fishy ammonia |
| Odor and/or flavor descriptions from others (if found). |
Cosmetic Information:
Suppliers:
Safety Information:
| Preferred SDS: View |
| European information : |
| Most important hazard(s): | | Xn N - Harmful, Dangerous for the environment. |
R 20/22 - Harmful by inhalation and if swallowed.
R 35 - Causes severe burns.
R 50 - Very toxic to aquatic organisms.
S 02 - Keep out of the reach of children.
S 09 - Keep container in a well-ventilated place.
S 16 - Keep away from sources of ignition - No Smoking.
S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S 28 - After contact with skin, wash immediately with plenty of water.
S 36/37/39 - Wear suitable clothing, gloves and eye/face protection.
S 45 - In case of accident or if you feel unwell seek medical advice immediately.
S 61 - Avoid release to the environment. Refer to special instructions/safety data sheet.
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| |
| Hazards identification |
| |
| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
| |
| Pictogram | |
| |
| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
oral-rat LD50 152 mg/kg
LUNGS, THORAX, OR RESPIRATION: DYSPNEA
BEHAVIORAL: ATAXIA
BEHAVIORAL: ANTIPSYCHOTIC
Toxicology and Applied Pharmacology. Vol. 63, Pg. 150, 1982.
oral-chicken LD50 250 mg/kg
Pesticide Manual. Vol. 9, Pg. 112, 1991
oral-dog LD50 225 mg/kg
Pesticide Manual. Vol. 9, Pg. 112, 1991.
|
| Dermal Toxicity: |
skin-rabbit LD50 2500 mg/kg
Pesticide Manual. Vol. 9, Pg. 112, 1991.
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| Inhalation Toxicity: |
|
Not determined
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Safety in Use Information:
| Category: | | flavoring agents |
| Recommendation for (±)-sec-butyl amine usage levels up to: | | | not for fragrance use.
|
| |
| Maximised Survey-derived Daily Intakes (MSDI-EU): | 0.012 (μg/capita/day) |
| Maximised Survey-derived Daily Intakes (MSDI-USA): | 2.00 (μg/capita/day) |
| Modified Theoretical Added Maximum Daily Intake (mTAMDI): | 340 (μg/person/day) |
| Threshold of Concern: | 1800 (μg/person/day) |
| Structure Class: | 1 |
| Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS). |
| The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library |
| publication number: 22 |
| Click here to view publication 22 |
| | average usual ppm | average maximum ppm |
| baked goods: | 2.00000 | 10.00000 |
| beverages(nonalcoholic): | - | - |
| beverages(alcoholic): | - | - |
| breakfast cereal: | 0.20000 | 1.00000 |
| cheese: | 0.40000 | 2.00000 |
| chewing gum: | - | - |
| condiments / relishes: | 0.10000 | 0.50000 |
| confectionery froastings: | 1.00000 | 5.00000 |
| egg products: | - | - |
| fats / oils: | 0.10000 | 0.50000 |
| fish products: | 0.20000 | 1.00000 |
| frozen dairy: | 0.40000 | 2.00000 |
| fruit ices: | 0.40000 | 2.00000 |
| gelatins / puddings: | - | - |
| granulated sugar: | - | - |
| gravies: | 0.10000 | 0.50000 |
| hard candy: | - | - |
| imitation dairy: | - | - |
| instant coffee / tea: | - | - |
| jams / jellies: | - | - |
| meat products: | 0.20000 | 1.00000 |
| milk products: | 0.40000 | 2.00000 |
| nut products: | - | - |
| other grains: | 0.20000 | 1.00000 |
| poultry: | 0.20000 | 1.00000 |
| processed fruits: | 0.40000 | 2.00000 |
| processed vegetables: | - | - |
| reconstituted vegetables: | - | - |
| seasonings / flavors: | 0.10000 | 0.50000 |
| snack foods: | 1.00000 | 5.00000 |
| soft candy: | - | - |
| soups: | 0.10000 | 0.50000 |
| sugar substitutes: | - | - |
| sweet sauces: | - | - |
| |
| Food categories according to Commission Regulation EC No. 1565/2000 (EC, 2000) in FGE.06 (EFSA, 2002a). According to the Industry the "normal" use is defined as the average of reported usages and "maximum use" is defined as the 95th percentile of reported usages (EFSA, 2002i). |
| Note: mg/kg = 0.001/1000 = 0.000001 = 1/1000000 = ppm. |
| | average usage mg/kg | maximum usage mg/kg |
| Dairy products, excluding products of category 02.0 (01.0): | 0.40000 | 2.00000 |
| Fats and oils, and fat emulsions (type water-in-oil) (02.0): | 0.10000 | 0.50000 |
| Edible ices, including sherbet and sorbet (03.0): | 0.40000 | 2.00000 |
| Processed fruit (04.1): | 0.40000 | 2.00000 |
| Processed vegetables (incl. mushrooms & fungi, roots & tubers, pulses and legumes), and nuts & seeds (04.2): | - | - |
| Confectionery (05.0): | 1.00000 | 5.00000 |
| Chewing gum (05.3): | - | - |
| Cereals and cereal products, incl. flours & starches from roots & tubers, pulses & legumes, excluding bakery (06.0): | 0.20000 | 1.00000 |
| Bakery wares (07.0): | 2.00000 | 10.00000 |
| Meat and meat products, including poultry and game (08.0): | 0.20000 | 1.00000 |
| Fish and fish products, including molluscs, crustaceans and echinoderms (MCE) (09.0): | 0.20000 | 1.00000 |
| Eggs and egg products (10.0): | - | - |
| Sweeteners, including honey (11.0): | - | - |
| Salts, spices, soups, sauces, salads, protein products, etc. (12.0): | 0.10000 | 0.50000 |
| Foodstuffs intended for particular nutritional uses (13.0): | 0.20000 | 1.00000 |
| Non-alcoholic ("soft") beverages, excl. dairy products (14.1): | - | - |
| Alcoholic beverages, incl. alcohol-free and low-alcoholic counterparts (14.2): | 1.00000 | 5.00000 |
| Ready-to-eat savouries (15.0): | 1.00000 | 5.00000 |
| Composite foods (e.g. casseroles, meat pies, mincemeat) - foods that could not be placed in categories 01.0 - 15.0 (16.0): | 0.20000 | 1.00000 |
Safety References:
References:
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| (±)-2- | aminobutane | | 2- | aminobutane | | | butafume | | | butan-2-amine | | | butan-2-yl amine | | (±)-2- | butanamine | | 2- | butanamine | | (±)-2- | butyl amine | | (RS)-sec- | butyl amine | | 2- | butyl amine | | dextro,laevo-2- | butyl amine | | dextro,laevo-sec- | butyl amine | | (±)-2- | butylamine | | (±)-sec- | butylamine | | (RS)-sec- | butylamine | | ±-sec- | butylamine | | 2- | butylamine | | D,L-2- | butylamine | | D,L-sec- | butylamine | | sec- | butylamine | | 1- | methyl propanamine | | 1- | methyl propyl amine | | 1- | methylpropanamine | | 1- | methylpropylamine | | | propylamine, 1-methyl | | | propylamine, 1-methyl- | | | tutane |
Articles:
| Info:aliphatic and aromatic amines and amides |
| PubMed:[Synthesis of particle-free silver conductive ink and investigation of fabrication of conductive film by printing]. |
| PubMed:Enantioselective supramolecular carriers for nucleoside drugs. A thermodynamic and kinetic gas phase investigation. |
| PubMed:Unprecedented gas-phase chiroselective logic gates. |
| PubMed:Transition metal catalysed dehydrogenation of amine-borane fuel blends. |
| PubMed:Interaction of antitumor platinum complexes with human liver microsomal cytochromes P450. |
| PubMed:Protonation and silver(I) complex-formation equilibria of some amino-alcohols. |
| PubMed:A kinetic study of guest displacement reactions on a host-guest complex with a photoswitchable calixarene. |
| PubMed:Modelling amphetamine/receptor interactions: a gas-phase study of complexes formed between amphetamine and Some chiral amido[4]resorcinarenes. |
| PubMed:Induced-fit in the gas phase: conformational effects on the enantioselectivity of chiral tetra-amide macrocycles. |
| PubMed:Monosolvation of R-1-phenyl-2,2,2-trifluoroethanol with amines: configurational effects on the excitation, ionization, and fragmentation of diastereomeric complexes. |
| PubMed:Pharmacokinetics and metabolism of 3,4-dichlorophenyl-propenoyl-sec.-butylamine in rats by high performance liquid chromatography-ion trap mass spectrometry. |
| PubMed:Gas-phase enantioselectivity of chiral amido[4]resorcinarene receptors. |
| PubMed:Purification and characterization of a novel cyclohexylamine oxidase from the cyclohexylamine-degrading Brevibacterium oxydans IH-35A. |
| PubMed:Microbial synthesis of chiral amines by (R)-specific transamination with Arthrobacter sp. KNK168. |
| PubMed:Elementary supramolecular chemistry in the gas phase: ligand exchange reactions of proton-bound clusters of aliphatic amides and diamides with amines. |
| PubMed:Effect of chelating vs. bridging coordination of chiral short-bite P-X-P (X=C, N, O) ligands in enantioselective palladium-catalysed allylic substitution reactions. |
| PubMed:Chiral recognition by resorcin[4]arene receptors: intrinsic kinetics and dynamics. |
| PubMed:Kinetic resolution of (R,S)-sec-butylamine using omega-transaminase from Vibrio fluvialis JS17 under reduced pressure. |
| PubMed:The Direct catalytic asymmetric cross-Mannich reaction: a highly enantioselective route to 3-amino alcohols and alpha-amino acid derivatives. |
| PubMed:DNA interactions of new antitumor platinum complexes with trans geometry activated by a 2-metylbutylamine or sec-butylamine ligand. |
| PubMed:Microbial synthesis of (R)- and (S)-3,4-dimethoxyamphetamines through stereoselective transamination. |
| PubMed:The effect of ligand charge on the coordination geometry of an Fe(III)ion: five- and six-coordinate Fe(III) complexes of tris(2-benzimidazolylmethyl)amine. |
| PubMed:Comparison of the omega-transaminases from different microorganisms and application to production of chiral amines. |
| PubMed:PMMA-stimulus generalization to the optical isomers of MBDB and 3,4-DMA. |
| PubMed:N-methyl-1-(1,3-benzodioxol-5-yl)-2-butanamine (MBDB): its properties and possible risks. |
| PubMed:Effect of common food preservatives on mycelial growth and spore germination of Fusarium oxysporum. |
| PubMed:[The degradation of glycoproteins with lithium borohydride. Isolation and analysis of O-glycopeptides with reduced C-terminal amino acid residue]. |
| PubMed:Indan analogs of fenfluramine and norfenfluramine have reduced neurotoxic potential. |
| PubMed:[Study on ion chromatography (IC) for the low-molecular weight amines]. |
| PubMed:Thermometric titrations of amines with nitrosyl perchlorate in acetonitrile solvent. |
| PubMed:High-performance liquid chromatographic method for the simultaneous determination of pentisomide and its major metabolite N-desisopropylpentisomide in plasma, urine and tissues using solid-phase extraction. |
| PubMed:Stereoselective LSD-like activity in d-lysergic acid amides of (R)- and (S)-2-aminobutane. |
| PubMed:Postharvest-applied agrochemicals and their residues in fresh fruits and vegetables. |
| PubMed:[3H]monoamine releasing and uptake inhibition properties of 3,4-methylenedioxymethamphetamine and p-chloroamphetamine analogues. |
| PubMed:Behavioral, biochemical and neurotoxicological actions of the alpha-ethyl homologue of p-chloroamphetamine. |
| PubMed:Resolution of enantiomeric amides on a Pirkle-type chiral stationary phase. A comparison of subcritical fluid and liquid chromatographic approaches. |
| PubMed:Evaluation of the genetic activity profiles of 65 pesticides. |
| PubMed:Determination of coumarin anticoagulant rodenticide residues in animal tissue by high-performance liquid chromatography. I. Fluorescence detection using post-column techniques. |
| PubMed:Carcinogenicity of methylated derivatives of N-nitrosodiethylamine and related compounds in Sprague-Dawley rats. |
| PubMed:Synthesis and body distribution of several iodine-131 labeled centrally acting drugs. |
| PubMed:Approach to the quantitative analysis of di-sec.butylamine stereoisomeric mixtures by means of N.M.R. |
| PubMed:An evaluation of 1-(4-methyl) 2, 5-dimethoxyphenyl-2-aminobutane (MDPA-1) as an enhancer of memory and learning. |
| PubMed:Control of potato gangrene and skin spot diseases by fumigation of tubers with sec-butylamine. |
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3D/inchi