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Category: antimicrobial agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
Organoleptic Properties:
| Odor Type: balsamic |
| sweet fruity balsamic |
| Odor Description:at 100.00 %. mild sweet fruity balsam |
| Odor and/or flavor descriptions from others (if found). |
Cosmetic Information:
Suppliers:
Safety Information:
| Preferred SDS: View |
| European information : |
| Most important hazard(s): | | Xi - Irritant |
R 36/38 - Irritating to skin and eyes.
S 02 - Keep out of the reach of children.
S 24/25 - Avoid contact with skin and eyes.
S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S 36 - Wear suitable protective clothing.
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
oral-rat LD50 3000 mg/kg
Food and Cosmetics Toxicology. Vol. 14, Pg. 837, 1976.
intraperitoneal-mouse LD > 500 mg/kg
"Summary Tables of Biological Tests," National Research Council Chemical-Biological Coordination Center. Vol. 6, Pg. 149, 1954.
oral-rabbit LDLo 3000 mg/kg
SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Revue Medicale de la Suisse Romande. Vol. 15, Pg. 561, 1895.
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | | antimicrobial agents |
| RIFM Fragrance Material Safety Assessment: Search |
| IFRA Code of Practice Notification of the 49th Amendment to the IFRA Code of Practice |
| maximum skin levels for fine fragrances: | | | 0.0200 % and are based on the assumption that the fragrance mixture is used at 20% in a consumer product (IFRA Use Level Survey).
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| Recommendation for phenyl salicylate usage levels up to: | | | 2.0000 % in the fragrance concentrate.
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| use level in formulae for use in cosmetics: | | | 0.0200 %
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| Dermal Systemic Exposure in Cosmetic Products: | | | 0.0005 mg/kg/day
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| Maximised Survey-derived Daily Intakes (MSDI-EU): | 7.30 (μg/capita/day) |
| Maximised Survey-derived Daily Intakes (MSDI-USA): | 8.00 (μg/capita/day) |
| Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS). |
| The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library |
| publication number: 19 |
| Click here to view publication 19 |
| | average usual ppm | average maximum ppm |
| baked goods: | 40.00000 | 100.00000 |
| beverages(nonalcoholic): | 40.00000 | 100.00000 |
| beverages(alcoholic): | 40.00000 | 100.00000 |
| breakfast cereal: | 40.00000 | 100.00000 |
| cheese: | - | - |
| chewing gum: | 400.00000 | 1200.00000 |
| condiments / relishes: | - | - |
| confectionery froastings: | 40.00000 | 100.00000 |
| egg products: | - | - |
| fats / oils: | - | - |
| fish products: | - | - |
| frozen dairy: | - | - |
| fruit ices: | - | - |
| gelatins / puddings: | - | - |
| granulated sugar: | - | - |
| gravies: | - | - |
| hard candy: | 40.00000 | 100.00000 |
| imitation dairy: | - | - |
| instant coffee / tea: | - | - |
| jams / jellies: | - | - |
| meat products: | - | - |
| milk products: | 40.00000 | 100.00000 |
| nut products: | - | - |
| other grains: | - | - |
| poultry: | - | - |
| processed fruits: | - | - |
| processed vegetables: | - | - |
| reconstituted vegetables: | - | - |
| seasonings / flavors: | - | - |
| snack foods: | - | - |
| soft candy: | 40.00000 | 100.00000 |
| soups: | - | - |
| sugar substitutes: | - | - |
| sweet sauces: | - | - |
Safety References:
References:
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| | benzoic acid, 2-hydroxy-, phenyl ester | | 2- | hydroxybenzoic acid phenyl ester | | 2- | hydroxybenzoic acid, phenyl ester | | | musol | | | phenol salicylate | | 2- | phenoxycarbonyl phenol | | 2- | phenoxycarbonylphenol | | | phenyl 2-hydroxybenzoate | | | phenyl-alpha-hydroxybenzoate | | | salicylic acid phenyl ester | | | salicylic acid, phenyl ester | | | salol | | | salphenyl | | | seesorb 201 | | | seesorb K 201 |
Articles:
| PubMed:Kinetics and Mechanism of the Flexible Nanoparticle-Catalyzed Piperidinolysis of Anionic Phenyl Salicylate. |
| PubMed:Kinetics and mechanism of nanoparticles-catalyzed piperidinolysis of anionic phenyl salicylate. |
| PubMed:A universal modified van der Waals equation of state. Part I: Polymer and mineral glass formers. |
| PubMed:Transition from Arrhenius to non-Arrhenius temperature dependence of structural relaxation time in glass-forming liquids: continuous versus discontinuous scenario. |
| PubMed:Study of the transformation of two salicylates used in personal care products in chlorinated water. |
| PubMed:Screening alternative therapies to control Nosemosis type C in honey bee (Apis mellifera iberiensis) colonies. |
| PubMed:Simultaneous determination of the UV-filters benzyl salicylate, phenyl salicylate, octyl salicylate, homosalate, 3-(4-methylbenzylidene) camphor and 3-benzylidene camphor in human placental tissue by LC-MS/MS. Assessment of their in vitro endocrine activity. |
| PubMed:Phenyl salicylates - a new group of potential antituberculotics. |
| PubMed:Synthesis of biologically active and photostable rigid poly(vinyl chloride). |
| PubMed:Modeling dynamics of isotropic dielectrics in a laminar heterogeneous configuration. |
| PubMed:The estrogenic potential of salicylate esters and their possible risks in foods and cosmetics. |
| PubMed:Temperature dependence of the Landau-Placzek ratio in glass forming liquids. |
| PubMed:Positron annihilation response and broadband dielectric spectroscopy: salol. |
| PubMed:The role of nucleation in vitrification of supercooled liquids. |
| PubMed:Kinetic and rheological measurements of the effects of inert 2-, 3- and 4-bromobenzoate ions on the cationic micellar-mediated rate of piperidinolysis of ionized phenyl salicylate. |
| PubMed:A new semi-empirical kinetic method for the determination of ion exchange constants for the counterions of cationic micelles. |
| PubMed:Determination of an ion exchange constant by the use of a kinetic probe: a new semiempirical kinetic approach involving the effects of 3-F- and 4-F-substituted benzoates on the rate of piperidinolysis of anionic phenyl salicylate in aqueous cationic micelles. |
| PubMed:Infrared spectroscopy study of structural changes in glass-forming salol. |
| PubMed:Density scaling and dynamic correlations in viscous liquids. |
| PubMed:Kinetic evidence for the occurrence of independent ion-exchange processes in the cationic micellar-mediated reaction of piperidine with anionic phenyl salicylate. |
| PubMed:The temperature dependence of free volume in phenyl salicylate and its relation to structural dynamics: a positron annihilation lifetime and pressure-volume-temperature study. |
| PubMed:A direct test of the correlation between elastic parameters and fragility of ten glass formers and their relationship to elastic models of the glass transition. |
| PubMed:Facilitation, complexity growth, mode coupling, and activated dynamics in supercooled liquids. |
| PubMed:Preparation of lipophilic alkyl (hydroxy)benzoates by solvent-free lipase-catalyzed esterification and transesterification. |
| PubMed:Mass spectrometric identification of covalent adducts of the skin allergen 2,4-dinitro-1-chlorobenzene and model skin proteins. |
| PubMed:Fragrance material review on phenyl salicylate. |
| PubMed:Degradation kinetics of hydrolytically susceptible drugs in O/W emulsions--effects of interfacial area and lecithin. |
| PubMed:Investigating protein haptenation mechanisms of skin sensitisers using human serum albumin as a model protein. |
| PubMed:Depolarized light scattering versus optical Kerr effect spectroscopy of supercooled liquids: comparative analysis. |
| PubMed:Cole-Cole law for critical dynamics in glass-forming liquids. |
| PubMed:Pharmaceutical quality control of acid and neutral drugs based on competitive self-assembly in amphiphilic systems. |
| PubMed:Interfacial effects on vitrification of confined glass-forming liquids. |
| PubMed:Slow dynamics of salol: a pressure- and temperature-dependent light scattering study. |
| PubMed:Brillouin scattering study of salol: exploring the effects of rotation-translation coupling. |
| PubMed:Can experiments select the configurational component of excess entropy? |
| PubMed:Viscosity at the dynamic crossover in o-terphenyl and salol under high pressure. |
| PubMed:Nearly logarithmic decay of correlations in glass-forming liquids. |
| PubMed:Effect of ultraviolet light absorbers on photostabilization of azadirachtin-A in solution (part: II). |
| PubMed:[Determination of 4 antiseptics and 6 sunscreen agents in cosmetic products by reversed-phase high performance liquid chromatography]. |
| PubMed:Effect of some ultraviolet light absorbers on photo-stabilization of azadirachtin-A. |
| PubMed:Temperature and pressure dependence of the alpha relaxation and configurational entropy of a prototype glass former. |
| PubMed:[Determination of sunscreen agents in cosmetic products by reversed-phase high performance liquid chromatography]. |
| PubMed:Orientational dynamics in supercooled liquids near T(c) and comparison with ideal mode-coupling theory |
| PubMed:Effects of |
| PubMed:Effects of Nonionic, Cationic, and Mixed Nonionic-Cationic Surfactants on the Acid-Base Behavior of Phenyl Salicylate. |
| PubMed:Effects of [NaOH] and [KBr] on Intramolecular General Base-Catalyzed Methanolysis of Ionized Phenyl Salicylate in the Presence of Cationic Micelles. |
| PubMed:Screening of antiadherent activity on Streptococcus sobrinus culture. |
| PubMed:Neighboring group catalysis in the design of nucleotide prodrugs. |
| PubMed:The effectiveness of benzyl benzoate and different chemicals as acaricides. |
| PubMed:[Stability of phenyl salicylate in alcoholic-aqueous solution]. |
| PubMed:Biologic testing of leachable aromatic compounds from denture base materials. |
| PubMed:Tc of the mode coupling theory evaluated from impulsive stimulated light scattering on salol. |
| PubMed:Leaching from denture base materials in vitro. |
| PubMed:Reply to "Comment on 'Light-scattering investigation of alpha and beta relaxation near the liquid-glass transition of the molecular glass Salol' " and "Reexamination of the depolarized-light-scattering spectra of glass-forming liquids" |
| PubMed:Comment on "Light-scattering investigation of alpha and beta relaxation near the liquid-glass transition of the molecular glass Salol" |
| PubMed:Leaching of additives and degradation products from cold-cured orthodontic resins. |
| PubMed:Light-scattering spectroscopy of the liquid-glass transition in CaKNO3 and in the molecular glass Salol: Extended-mode-coupling-theory analysis. |
| PubMed:Brillouin scattering in salol: Determining Tc of the mode coupling theory. |
| PubMed:Light-scattering investigation of alpha and beta relaxation near the liquid-glass transition of the molecular glass Salol. |
| PubMed:Cross-sensitivity between resorcinol, resorcinol monobenzoate and phenyl salicylate. |
| PubMed:Specific-heat spectroscopy and dielectric susceptibility measurements of salol at the glass transition. |
| PubMed:Contact dermatitis from phenyl salicylate in a galenic cream. |
| PubMed:Direct observation of microbubbles in directional solidification of salol. |
| PubMed:Synthesis and evaluation of the analgesic and antiinflammatory activities of N,N'-bis(2-hydroxybenzoyl)-diaminoalkanes. |
| PubMed:Light scattering study of the glass transition in salol. |
| PubMed:Synthesis and evaluation of the analgesic and antiinflammatory activities of N-substituted salicylamides. |
| PubMed:Spectrophotometric determination of alkyl salicylate from the mixture of phenyl and alkyl salicylates by the use of the selective reactivity of phenyl salicylate toward secondary amines. |
| PubMed:Bile salt roles in bile-salt-stimulated lipase activity. |
| PubMed:Dermatitis from phenyl salicylate in safety spectacle frames. |
| PubMed:[Novel N-pyrazolylsalicylamides with antifungal activity]. |
| PubMed:Transesterification: an analytical and formulation problem. |
| PubMed:High-performance liquid chromatographic analysis of iodochlorhydroxyquin and hydrocortisone in ointments and creams. |
| PubMed:Allergic contact dermatitis to various salols (phenyl salicylates). A structure-activity relationship study in man and in animal (guinea pig). |
| PubMed:Allergy to phenyl salicylate. |
| PubMed:In vitro transformation of hamster embryo cells by 3-(N-salicyloyl)amino-1,2,4-triazole. |
| PubMed:Phenyl salicylate (Salol) in a lip salve. |
| PubMed:Potassium hydroxide solution 10% for the fast hydrolysis of esters for analysis. |
| PubMed:Elevated urinary phenol levels in beagle dogs treated with salol. |
| PubMed:Elevated urinary phenol levels not related to benzene exposure. |
| PubMed:Reactions to aspirin and food additives in patients with chronic urticaria, including the physical urticarias. |
| PubMed:Fluroescence of phenyl salicylate. |
| PubMed:[Aluminiumlactate and salol for the prevention of periodontal diseases, AGEPHA oral hygiene drugs]. |
| PubMed:[Assays of sodium noraminophenazone methanesulphonate, phenyl salicylate and papaverine hydrochloride in compound prescription forms]. |
| PubMed:Experimental production of malformations due to acetyl salicylate and phenyl salicylate in rats. |
| PubMed:[Effect of additional components and of the granulation method on some properties of salol tablets]. |
| PubMed:[Effect of aspirin and salol on gastrointestinal secretion in normal conditions and in experimental fever]. |
| PubMed:[Possibilities of determination of salol in combination with thymol and chloride of pilocarpine in combination with chloride of novocaine]. |
| PubMed:The salol reaction. |
| PubMed:THE INFLUENCE OF BILE ON METABOLISM. |
| PubMed:The Treatment of Small-Pox by Salol. |
| PubMed:Salol Calculi. |
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3D/inchi