2-furoic acid
a-furancarboxylic acid

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  CODE104016 CODE104016
  Product(s):
  88-14-2 Furan-2-carboxylic acid >98%

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  CJ Latta & Associates, LLC

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  F0081 2-Furancarboxylic Acid >98.0%(GC)(T)
  SDS

Name: furan-2-carboxylic acid CAS Number: 88-14-2 3D/inchi ECHA EINECS - REACH Pre-Reg: 201-803-0 FDA UNII: P577F6494A Nikkaji Web: J4.288I Beilstein Number: 0110149 MDL: MFCD00003238 CoE Number: 10098 XlogP3: 0.50 (est) Molecular Weight: 112.08448000 Formula: C5 H4 O3 BioActivity Summary: listing NMR Predictor: Predict (works with chrome, Edge or firefox) Category:flavoring agents   US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information: Google Scholar: Search Google Books: Search Google Scholar: with word "volatile" Search Google Scholar: with word "flavor" Search Google Scholar: with word "odor" Search Perfumer and Flavorist: Search Google Patents: Search US Patents: Search EU Patents: Search Pubchem Patents: Search PubMed: Search NCBI: Search DG SANTE Food Flavourings: 13.136 2-furoic acid   Physical Properties: Assay: 95.00 to 100.00 Food Chemicals Codex Listed: No Melting Point: 130.00 to 133.00 °C. @ 760.00 mm Hg Boiling Point: 230.00 to 232.00 °C. @ 760.00 mm Hg Vapor Pressure: 0.033000 mmHg @ 25.00 °C. (est) Flash Point: 201.00 °F. TCC ( 93.89 °C. ) logP (o/w): 0.640 Soluble in:   alcohol   water, 37100 mg/L @ 15 °C (exp)   Organoleptic Properties: Odor Type: odorless Odor Description:odorless Flavor Type: acidic acidic caramellic earthy Taste Description: acidic caramellic earthy Odor and/or flavor descriptions from others (if found).   Cosmetic Information: None found   Suppliers: BOC Sciences For experimental / research use only. Furan-2-carboxylic acid >98% CJ Latta & Associates FUROIC ACID Nagar Haveli Perfumes & Aromatics 2 - Furoic Acid Natural Odor: acidic caramellic earthy Nagar Haveli Perfumes & Aromatics Furoic Acid Penta International 2-FUROIC ACID Santa Cruz Biotechnology For experimental / research use only. 2-Furoic Acid Sigma-Aldrich: Aldrich For experimental / research use only. 2-Furoic acid 98% sds TCI AMERICA For experimental / research use only. 2-Furancarboxylic Acid >98.0%(GC)(T) sds   Safety Information: Preferred SDS: View European information : Most important hazard(s): Xi - Irritant R 36/37/38 - Irritating to eyes, respiratory system, and skin. S 02 - Keep out of the reach of children. S 24/25 - Avoid contact with skin and eyes. S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S 36 - Wear suitable protective clothing.   Hazards identification   Classification of the substance or mixture GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) None found. GHS Label elements, including precautionary statements   Pictogram   Hazard statement(s) None found. Precautionary statement(s) None found. Oral/Parenteral Toxicity: intraperitoneal-mouse LD50 100 mg/kg Pharmaceutical Research. Vol. 2, Pg. 233, 1985. Dermal Toxicity: Not determined Inhalation Toxicity: Not determined   Safety in Use Information: Category: flavoring agents Recommendation for 2-furoic acid usage levels up to:   not for fragrance use.   Maximised Survey-derived Daily Intakes (MSDI-EU): 0.013 (μg/capita/day) Modified Theoretical Added Maximum Daily Intake (mTAMDI): 1400 (μg/person/day) Adequate NOAEL exists: Yes Threshold of Concern: 540 (μg/person/day) Structure Class: II   Food categories according to Commission Regulation EC No. 1565/2000 (EC, 2000) in FGE.06 (EFSA, 2002a). According to the Industry the "normal" use is defined as the average of reported usages and "maximum use" is defined as the 95th percentile of reported usages (EFSA, 2002i). Note: mg/kg = 0.001/1000 = 0.000001 = 1/1000000 = ppm.   average usage mg/kg maximum usage mg/kg Dairy products, excluding products of category 02.0 (01.0): 3.00000 15.00000 Fats and oils, and fat emulsions (type water-in-oil) (02.0): 2.00000 10.00000 Edible ices, including sherbet and sorbet (03.0): 3.00000 15.00000 Processed fruit (04.1): 2.00000 10.00000 Processed vegetables (incl. mushrooms & fungi, roots & tubers, pulses and legumes), and nuts & seeds (04.2): - - Confectionery (05.0): 5.00000 25.00000 Chewing gum (05.3): - - Cereals and cereal products, incl. flours & starches from roots & tubers, pulses & legumes, excluding bakery (06.0): 2.00000 10.00000 Bakery wares (07.0): - - Meat and meat products, including poultry and game (08.0): 1.00000 5.00000 Fish and fish products, including molluscs, crustaceans and echinoderms (MCE) (09.0): 1.00000 5.00000 Eggs and egg products (10.0): - - Sweeteners, including honey (11.0): - - Salts, spices, soups, sauces, salads, protein products, etc. (12.0): 2.00000 10.00000 Foodstuffs intended for particular nutritional uses (13.0): 3.00000 15.00000 Non-alcoholic ("soft") beverages, excl. dairy products (14.1): 2.00000 10.00000 Alcoholic beverages, incl. alcohol-free and low-alcoholic counterparts (14.2): 5.00000 25.00000 Ready-to-eat savouries (15.0): 5.00000 25.00000 Composite foods (e.g. casseroles, meat pies, mincemeat) - foods that could not be placed in categories 01.0 - 15.0 (16.0): 2.00000 10.00000   Safety References: European Food Safety Athority(EFSA):Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies... European Food Safety Authority (EFSA) reference(s): Opinion of the Scientific Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) related to Flavouring Group Evaluation 13 (FGE.13); Furfuryl and furan derivatives with and without additional side-chain substituents and heteroatoms from chemical group 14 (Commission Regulation (EC) No 1565/2000 of 18 View page or View pdf Flavouring Group Evaluation 66 (FGE.66)[1]:Consideration of furfuryl alcohol and related flavouring substances evaluated by JECFA (55th meeting) structurally related to Furfuryl and furan derivatives with and without additional side chain substituents and heteroatoms evaluated by EFSA in FGE.13 (2005) View page or View pdf Scientific Opinion on Flavouring Group Evaluation 13Rev1: Furfuryl and furan derivatives with and without additional side-chain substituents and heteroatoms from chemical group 14 View page or View pdf Consideration of sulfur-substituted furan derivatives used as flavouring agents evaluated by JECFA (59th meeting) structurally related to a subgroup of substances within the group of “Furfuryl and furan derivatives with and without additional side-chain substituents and heteroatoms from chemical group 14” evaluated by EFSA in FGE.13Rev1 (2009) View page or View pdf Flavouring Group Evaluation 67 (FGE.67): Consideration of 40 furan-substituted aliphatic hydrocarbons, alcohols, aldehydes, ketones, carboxylic acids and related esters, sulfides, disulfides and ethers evaluated by JECFA at the 65th meeting (JECFA, 2006b) and re-evaluated at the 69th meeting (JECFA, 2009c) View page or View pdf Scientific Opinion on Flavouring Group Evaluation 13, Revision 2 (FGE.13Rev2): Furfuryl and furan derivatives with and without additional side-chain substituents and heteroatoms from chemical group 14 View page or View pdf Scientific Opinion on Flavouring Group Evaluation 67, Revision 1 (FGE.67Rev.1): Consideration of 40 furan-substituted aliphatic hydrocarbons, alcohols, aldehydes, ketones, carboxylic acids and related esters, sulfides, disulfides and ethers evaluated by JECFA at the 65th meeting (JECFA, 2006b) and re-evaluated at the 69th meeting (JECFA, 2009c) View page or View pdf Scientific Opinion on Flavouring Group Evaluation 13 Revision 3 (FGE.13Rev3): furfuryl and furan derivatives with and without additional side-chain substituents and heteroatoms from chemical group 14 View page or View pdf EPI System: View Chemical Carcinogenesis Research Information System:Search AIDS Citations:Search Cancer Citations:Search Toxicology Citations:Search EPA Substance Registry Services (TSCA):88-14-2 EPA ACToR:Toxicology Data EPA Substance Registry Services (SRS):Registry Laboratory Chemical Safety Summary :6919 National Institute of Allergy and Infectious Diseases:Data WGK Germany:3 furan-2-carboxylic acid Chemidplus:0000088142 RTECS:LV1763000 for cas# 88-14-2   References:   furan-2-carboxylic acid NIST Chemistry WebBook: Search Inchi Canada Domestic Sub. List: 88-14-2 Pubchem (cid): 6919 Pubchem (sid): 134972020   Other Information: (IUPAC): Atomic Weights of the Elements 2011 (pdf) Videos: The Periodic Table of Videos tgsc: Atomic Weights use for this web site (IUPAC): Periodic Table of the Elements CHEBI: View CHEMBL: View Metabolomics Database: Search UM BBD: Search KEGG (GenomeNet): C01546 HMDB (The Human Metabolome Database): HMDB00617 FooDB: FDB000951 Export Tariff Code: 2932.19.5100 VCF-Online: VCF Volatile Compounds in Food ChemSpider: View EFSA Update of results on the monitoring of furan levels in food: Read Report EFSA Previous report: Results on the monitoring of furan levels in food: Read Report EFSA Report of the CONTAM Panel on provisional findings on furan in food: Read Report   Potential Blenders and core components note For Odor For Flavor malty malt distillates FL   Potential Uses: FL coffee FL guava FL papaya FL rum FL vegetable   Occurrence (nature, food, other):note   asparagus cooked asparagus - 0.01 mg/kg Search Trop Picture   beer - up to 0.8 mg/kg Search PMC Picture   coffee - up to 80 mg/kg Search PMC Picture   guava fruit - less than 0.05 mg/kg Search Trop Picture   papaya fruit - less than 0.05 mg/kg Search Trop Picture   rum - 0.4 mg/kg Search PMC Picture   wood oak wood Search Picture   Synonyms: 2- carboxyfuran 2- furan carboxylic acid alpha- furan carboxylic acid   furan-2-carboxylic acid 2- furancarboxylic acid a- furancarboxylic acid alpha- furancarboxylic acid b- furancarboxylic acid 2- furanoic acid a- furoic acid alpha- furoic acid 2- furoicacid   pyromucic acid   Articles:   None found yet. 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Notes: Isol. from roots of Phaseolus vulgaris (kidney bean) Furoic acid is a metabolite that appears in the urine of workers occupationally exposed to furfural and is marker of exposure to this compound. Furfural is a heterocyclic aldehyde that is commonly used as a solvent in industry. It is readily absorbed into the body via the lungs and has significant skin absorption. Furfural is an irritant of the eyes, mucous membranes, and skin and is a central nervous system depressant. Furfural as a confirmed animal carcinogen with unknown relevance to humans (It has been suggested that is a substance that produces hepatic cirrhosis). Once in the body, furfural is metabolized rapidly via oxidation to the metabolite furoic acid, which is then conjugated with glycine and excreted in the urine in both free and conjugated forms. (PMID: 3751566, 4630229, 12587683)