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isopropyl palmitate
isopropyl hexadecanoate

Supplier Sponsors

Name:propan-2-yl hexadecanoate
CAS Number: 142-91-6Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:205-571-1
FDA UNII: 8CRQ2TH63M
Nikkaji Web:J11.002G
Beilstein Number:1786567
MDL:MFCD00008993
CoE Number:10732
XlogP3-AA:8.20 (est)
Molecular Weight:298.51026000
Formula:C19 H38 O2
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:solvents/deluents for flavor and/or fragrance agents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Perfumer and Flavorist:Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
DG SANTE Food Flavourings:09.606 isopropyl hexadecanoate
FDA Mainterm (SATF):142-91-6 ; ISOPROPYL PALMITATE
 
Physical Properties:
Appearance:colorless clear oily liquid (est)
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Specific Gravity:0.85200 to 0.85800 @ 25.00 °C.
Pounds per Gallon - (est).: 7.089 to 7.139
Refractive Index:1.43300 to 1.43900 @ 20.00 °C.
Melting Point: 13.00 °C. @ 760.00 mm Hg
Boiling Point: 342.00 °C. @ 760.00 mm Hg
Vapor Pressure:0.000084 mmHg @ 25.00 °C. (est)
Flash Point:> 230.00 °F. TCC ( > 110.00 °C. )
logP (o/w): 8.272 (est)
Soluble in:
 alcohol
 water, 0.001354 mg/L @ 25 °C (est)
Similar Items:note
isoamyl palmitate
butyl palmitate
isobutyl palmitate
carvyl palmitate
ethyl palmitate
3-hexen-1-yl palmitate
methyl palmitate
pentyl palmitate
propyl palmitate
 
Organoleptic Properties:
Odor Strength:none
Substantivity:208 Hour(s)
Odor Description:at 100.00 %. bland oily
Luebke, William tgsc, (1987)
Odor sample from: Ungerer & Company, Inc.
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: antistatic agents
binding agents
perfuming agents
skin conditioning
skin conditioning - emollient
solvents
 
Suppliers:
Acme-Hardesty
isoPropyl Palmitate
Odor: characteristic
Use: Topical Medicinal Preparations, Emollient, Moisturizer, Thickening Agent, Solvent, Binder, Diluent.
Allan Chemical
isoPropyl Palmitate
Alzo International
Dermol IPP
Alzo International
Wickenol 111
BOC Sciences
For experimental / research use only.
isoPropyl Palmitate
Charkit Chemical
ISOPROPYL PALMITATE
Chemical-navi - Nikkol
NIKKOL IPP-EX
Odor: characteristic
Use: Purity: 98% min; low viscosity; good penetration and spreading properties; non-oily feel.
Chemical-navi - Nikkol
NIKKOL IPP
Odor: characteristic
Use: Low viscosity; good penetration and spreading properties; non-oily feel.
Croda
Crestalan™
Odor: bland
Use: Non greasy, non- tacky emollient which spreads well and is rapidly absorbed . Excellent moisturiser, conditioner, plasticiser and super fatting agent. Skin creams, lotions and colour cosmetics.
Croda
Crodamol™ IPP
Odor: bland
Use: Branched chain, low viscosity, non-occlusive emollient with good spreading properties. Excellent dispersing medium. Suitable for all cosmetic applications.
ECSA Chemicals
ISOPROPYL PALMITATE
ECSA TRADE THE MOST UPDATED FINANCIAL PUBLICATION ON THE WORLD OF CHEMISTRY
H. Erhard Wagner
isoPropylpalmitate (Isopropyl Palmitate Ph. Eur. & USP/NF)
HallStar
HALLSTAR® IPP-NF
Odor: characteristic
Use: HallStar IPP-NF is an economical liquid ester made from the reaction of vegetal Palmitic Acid and petrochemical Isopropyl Alcohol. It conforms to the requirements of the National Formulary monograph for Isopropyl Palmitate. HallStar IPP-NF is a light non-occlusive emollient with a soft, dry, non-oily feel. It is used as pigment binder, diluent, and solubilizing agent for mineral oil, silicones, lanolin, and fragrances in many personal care product applications. HallStar IPP-NF is best stored in a cool dry place in the original sealed containers. Avoid prolonged storage above 32°C (90°F). Maintain above 15°C (59°F) to preclude freezing.
Jiangyin Healthway
Isopropyl Palmitate
New functional food ingredients
Kraft Chemical
isoPropyl Palmitate
Lipo Chemicals
Liponate® IPP
Odor: characteristic
Use: Liponate® IPP is a fast absorbing emollient and skin penetrant.
Lluch Essence
ISOPROPYL PALMITATE
Mosselman
isoPropyl Palmitate
Oleo Solutions
Edenor IEP 19
Odor: characteristic
Use: Flavours and Fragrances, Cosmetics and Personal Care, Cleaning and Detergents, Adhesives and Lubricants, Industrial, Inks and Coatings, Pharmaceutical and Veterinary
Penta International
ISOPROPYL PALMITATE NF
PerfumersWorld
IPP (iso-Propyl Palmitate)
Sigma-Aldrich
Isopropyl palmitate, ≥90%
sds
Certified Food Grade Products
SysKem Chemie
isoPropyl Palmitate
TCI AMERICA
For experimental / research use only.
isoPropyl Palmitate >97.0%(GC)
sds
Vigon International
Deltyl Prime NF (Isopropyl Palmitate)
 
Safety Information:
Preferred SDS: View
European information :
Most important hazard(s):
None - None found.
S 02 - Keep out of the reach of children.
S 24/25 - Avoid contact with skin and eyes.
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-rat LD50 [sex: M,F] > 40000 mg/kg
(FDA, 1976a)

oral-rat LD50 [sex: M,F] > 8000 mg/kg
(Kolmar Research Ctr, 1972)

oral-rat LD50 [sex: M,F] > 64000 mg/kg
(Bio-Toxicology Laboratories, 1982)

oral-rat LD50 > 5000 mg/kg
(Moreno, 1978c)

oral-rat LD50 > 5000 mg/kg
Food and Chemical Toxicology. Vol. 20, Pg. 727, 1982.

intraperitoneal-mouse LD50 100 mg/kg
National Technical Information Service. Vol. AD277-689

Dermal Toxicity:
skin-rabbit LD50 > 5000 mg/kg
Food and Chemical Toxicology. Vol. 20, Pg. 727, 1982.

Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
solvents/deluents for flavor and/or fragrance agents
RIFM Fragrance Material Safety Assessment: Search
IFRA Code of Practice Notification of the 49th Amendment to the IFRA Code of Practice
Recommendation for isopropyl palmitate usage levels up to:
  25.0000 % in the fragrance concentrate.
 
Maximised Survey-derived Daily Intakes (MSDI-EU): 0.012 (μg/capita/day)
Modified Theoretical Added Maximum Daily Intake (mTAMDI): 3900 (μg/person/day)
Threshold of Concern:1800 (μg/person/day)
Structure Class: I
 
Food categories according to Commission Regulation EC No. 1565/2000 (EC, 2000) in FGE.06 (EFSA, 2002a). According to the Industry the "normal" use is defined as the average of reported usages and "maximum use" is defined as the 95th percentile of reported usages (EFSA, 2002i).
Note: mg/kg = 0.001/1000 = 0.000001 = 1/1000000 = ppm.
 average usage mg/kgmaximum usage mg/kg
Dairy products, excluding products of category 02.0 (01.0): 7.0000035.00000
Fats and oils, and fat emulsions (type water-in-oil) (02.0): 5.0000025.00000
Edible ices, including sherbet and sorbet (03.0): 10.0000050.00000
Processed fruit (04.1): 7.0000035.00000
Processed vegetables (incl. mushrooms & fungi, roots & tubers, pulses and legumes), and nuts & seeds (04.2): --
Confectionery (05.0): 10.0000050.00000
Chewing gum (05.3): --
Cereals and cereal products, incl. flours & starches from roots & tubers, pulses & legumes, excluding bakery (06.0): 5.0000025.00000
Bakery wares (07.0): 10.0000050.00000
Meat and meat products, including poultry and game (08.0): 2.0000010.00000
Fish and fish products, including molluscs, crustaceans and echinoderms (MCE) (09.0): 2.0000010.00000
Eggs and egg products (10.0): --
Sweeteners, including honey (11.0): --
Salts, spices, soups, sauces, salads, protein products, etc. (12.0): 5.0000025.00000
Foodstuffs intended for particular nutritional uses (13.0): 10.0000050.00000
Non-alcoholic ("soft") beverages, excl. dairy products (14.1): 5.0000025.00000
Alcoholic beverages, incl. alcohol-free and low-alcoholic counterparts (14.2): 10.0000050.00000
Ready-to-eat savouries (15.0): 20.00000100.00000
Composite foods (e.g. casseroles, meat pies, mincemeat) - foods that could not be placed in categories 01.0 - 15.0 (16.0): 5.0000025.00000
 
Safety References:
European Food Safety Athority(EFSA):Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies...

European Food Safety Authority (EFSA) reference(s):

Opinion of the Scientific Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) related to Flavouring Group Evaluation 7 (FGE.07): Saturated and unsaturated aliphatic secondary alcohols, ketones and esters of secondary alcohols and saturated linear or branched-chain carboxylic acids from chemical group 5
View page or View pdf

Flavouring Group Evaluation 63 (FGE.63): Consideration of aliphatic secondary alcohols, ketones and related esters evaluated by JECFA (59th meeting) structurally related to saturated and unsaturated aliphatic secondary alcohols, ketones and esters of secondary alcohols and saturated linear or branched-chain carboxylic acids evaluated by EFSA in FGE.07 (2005) (Commission Regulation (EC) No 1565/2000 of 18 July 2000)
View page or View pdf

Flavouring Group Evaluation 7, Revision 1 (FGE.07Rev1): Saturated and unsaturated aliphatic secondary alcohols, ketones and esters of secondary alcohols and saturated linear or branched-chain carboxylic acids from chemical group 5 (Commission Regulation (EC) No 1565/2000 of 18 July 2000) - Scientific opinion of the Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC) on a request from the Commission
View page or View pdf

Flavouring Group Evaluation 7, Revision 2 (FGE.07Rev2) : Saturated and unsaturated aliphatic secondary alcohols, ketones and esters of secondary alcohols and saturated linear or branched-chain carboxylic acids from chemical group 5
View page or View pdf

Flavouring Group Evaluation 7, Revision 3 (FGE.07Rev3): Saturated and unsaturated aliphatic secondary alcohols, ketones and esters of secondary alcohols and saturated linear or branched-chain carboxylic acids from chemical group 5
View page or View pdf

Scientific Opinion on Flavouring Group Evaluation 7, Revision 4 (FGE.07Rev4): Saturated and unsaturated aliphatic secondary alcohols, ketones and esters of secondary alcohols and saturated linear or branched-chain carboxylic acids from chemical group 5
View page or View pdf

Scientific Opinion on Flavouring Group Evaluation 7, Revision 5 (FGE.07Rev5): saturated and unsaturated aliphatic secondary alcohols, ketones and esters of secondary alcohols and saturated linear or branched-chain carboxylic acids from chemical group 5
View page or View pdf

EPI System: View
Daily Med:search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA Substance Registry Services (TSCA):142-91-6
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :8907
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:nwg
propan-2-yl hexadecanoate
Chemidplus:0000142916
RTECS:RT4900000 for cas# 142-91-6
 
References:
 propan-2-yl hexadecanoate
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:142-91-6
Pubchem (cid):8907
Pubchem (sid):134973583
Flavornet:142-91-6
Pherobase:View
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Substances Added to Food (formerly EAFUS):View
CHEBI:View
CHEMBL:View
KEGG (GenomeNet):D04632
HMDB (The Human Metabolome Database):HMDB35474
FooDB:FDB014159
Export Tariff Code:2915.70.0150
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
Wikipedia:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
 antistatic agents
 binding agents
 emollients
 skin conditioning
 solvents
 
Occurrence (nature, food, other):note
 acacia concinna
Search Trop Picture
 buckwheat
Search Trop Picture
 citrus fruits
Search PMC Picture
 macadamia nut - up to 0.04 mg/kg
Search Trop Picture
 psidium salutare
Search Trop Picture
 
Synonyms:
 crestalan
 crodamol IPP
 deltyl
 deltyl prime NF
 dermol IPP
 edenor IEP 19
 emcol-IP
 emerest 2316
 hallstar IPP
 hallstar IPP-NF
 hexadecanoic acid 1-methyl ethyl ester
 hexadecanoic acid 1-methylethyl ester
 hexadecanoic acid isopropyl ester
 hexadecanoic acid, 1-methylethyl ester
 liponate IPP
1-methyl ethyl hexadecanoate
1-methylethyl hexadecanoate
 nikkol IPP
 nikkol IPP-EX
isopal
 palmitato de isopropila
 palmitic acid isopropyl ester
 propal
 propan-2-yl hexadecanoate
isopropyl hexadecanoate
isopropyl N-hexadecanoate
isopropyl palmitate NF
isopropylpalmitate
 sinnoester PIT
 unimate IPP
 wickenol 111
 

Articles:

PubMed:Anti-inflammatory effects of a novel ricinoleic acid poloxamer gel system for transdermal delivery.
PubMed:Evaluation of nicotinamide microemulsion on the skin penetration enhancement.
PubMed:Preparation and in vitro evaluation of a pluronic lecithin organogel containing ricinoleic acid for transdermal delivery.
PubMed:Permeation study through bacterial cellulose membrane.
PubMed:FA-loaded lipid drug delivery systems: preparation, characterization and biological studies.
PubMed:Propolis organogel as a novel topical delivery system for treating wounds.
PubMed:Mechanistic investigation and reversible effect of 2-isopropyl-5-methylcyclohexyl heptanoate on the in vitro percutaneous absorption of indomethacin.
PubMed:Chemical composition and antifungal activity of Matricaria recutita flower essential oil against medically important dermatophytes and soil-borne pathogens.
PubMed:Analysis of isopropyl para-toluenesulphonate in palm-based esters by gas chromatography with flame ionization detection and confirmed with mass spectrometry.
PubMed:Effect of the stability of hydrogen-bonded ion pairs with organic amines on transdermal penetration of teriflunomide.
PubMed:Polyglycerol fatty acid ester surfactant-based microemulsions for targeted delivery of ceramide AP into the stratum corneum: formulation, characterisation, in vitro release and penetration investigation.
PubMed:Effect of (E)-2-isopropyl-5-methylcyclohexyl octadec-9-enoate on transdermal delivery of Aconitum alkaloids.
PubMed:Topical delivery of flurbiprofen from pluronic lecithin organogel.
PubMed:Foreign body reaction to bone wax an unusual cause of persistent serous discharge from iliac crest graft donor site and the possible means to avoid such complication - a case report.
PubMed:Pluronic lecithin organogel as a topical drug delivery system.
PubMed:Aggregation pheromone compounds of the black larder beetle Dermestes haemorrhoidalis Kuster (Coleoptera: Dermestidae).
PubMed:Microemulsions as a surrogate carrier for dermal drug delivery.
PubMed:Aerosol OT microemulsions as carriers for transdermal delivery of hydrophobic and hydrophilic local anesthetics.
PubMed:The role of capillary force promoters in dry coating procedures--evaluation of acetylated monoglyceride, isopropyl myristate and palmitate.
PubMed:Preparation and evaluation of diltiazem hydrochloride diffusion-controlled transdermal delivery system.
PubMed:Comedogenicity in rabbit: some cosmetic ingredients/vehicles.
PubMed:[Screening of Panax notoginsenoside water in oil microemulsion formulations and their evaluation in vitro and in vivo].
PubMed:Enhancement of the skin permeation of clindamycin phosphate by Aerosol OT/1-butanol microemulsions.
PubMed:Assessment of oil polarity: comparison of evaluation methods.
PubMed:Transdermal delivery of hydrophobic and hydrophilic local anesthetics from o/w and w/o Brij 97-based microemulsions.
PubMed:Transdermal permeability of N-acetyl-D-glucosamine.
PubMed:Effect of penetration enhancers on skin permeation of trazodone hydrochloride from matrix type transdermal formulation through mouse and human cadaver epidermis.
PubMed:Lecithin organogels used as bioactive compounds carriers. A microdomain properties investigation.
PubMed:Characterisation of microstructures formed in isopropyl palmitate/water/Aerosol OT:1-butanol (2:1) system.
PubMed:Effects of isopropyl palmitate on the skin permeation of drugs.
PubMed:Microemulsions as transdermal drug delivery vehicles.
PubMed:Investigation of fatty acid esters to replace isopropyl myristate in the sterility test for ophthalmic ointments.
PubMed:The hairless guinea-pig as a model for treatment of acute irritation in humans.
PubMed:Characterization of microemulsion structures in the pseudoternary phase diagram of isopropyl palmitate/water/Brij 97:1-butanol.
PubMed:[Analysis of constituents of essential oil from the skin of water caltrop].
PubMed:Effect of oil phase lipophilicity on in vitro drug release from o/w microemulsions with low surfactant content.
PubMed:The hairless guinea-pig as a model for treatment of cumulative irritation in humans.
PubMed:Phase behavior of the microemulsions and the stability of the chloramphenicol in the microemulsion-based ocular drug delivery system.
PubMed:Biocompatible lecithin organogels: structure and phase equilibria.
PubMed:New microemulsion vehicle facilitates percutaneous penetration in vitro and cutaneous drug bioavailability in vivo.
PubMed:Microemulsions for dermal drug delivery studied by dynamic light scattering: effect of interparticle interactions in oil-in-water microemulsions.
PubMed:Effect of hydrophobic permeation enhancers on the release and skin permeation kinetics from matrix type transdermal drug delivery system of ketotifen fumarate.
PubMed:A repeat-batch membrane bioreactor with a phase inversion for the desaturation of isopropyl palmitate by a mutant Rhodococcus strain.
PubMed:Stable reversed vesicles in oil: characterization studies and encapsulation of model compounds.
PubMed:Direct micellar systems as a tool to improve the efficiency of aromatic substrate conversion for fine chemicals production.
PubMed:Production of isopropyl cis-6-hexadecenoate by regiospecific desaturation of isopropyl palmitate by a double mutant of a Rhodococcus strain.
PubMed:Studies on the kinetics of Isopropyl Palmitate synthesis in packed bed bioreactor using immobilized lipase.
PubMed:Skin healing preparations: compared in vitro diffusion of the active ingredients.
PubMed:Human skin irritation studies of a lecithin microemulsion gel and of lecithin liposomes.
PubMed:The adjuvancy of silicones: dependency on compartmentalization.
PubMed:[The effect of ibuprofen on the composition of tissue lipids in an experiment].
PubMed:Lecithin organogel as matrix for transdermal transport of drugs.
PubMed:Osseous regeneration in the presence of four common hemostatic agents.
PubMed:Solubilization and activity of yeast cells in water-in-oil microemulsion.
PubMed:Iatrogenic fenestration of a semicircular canal: a method of closure.
PubMed:Solubilization of bacterial cells in organic solvents via reverse micelles.
PubMed:Histological changes in rabbits after application of medicaments and cosmetic bases (III).
PubMed:Comedogenicity of current therapeutic products, cosmetics, and ingredients in the rabbit ear.
PubMed:Selection of the acceptor medium in in vitro measurements of drug release from dermatological ointments.
PubMed:Contact allergy to benzyl alcohol and isopropyl palmitate, ingredients of topical corticosteroid.
PubMed:Eye and skin irritation tests on the rabbit of several fatty acid esters.
 
Notes:
Used as a food additive [EAFUS]
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