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Category:flavor and fragrance agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Appearance: | colorless clear oily liquid (est) |
| Assay: | 98.00 to 100.00
|
| Food Chemicals Codex Listed: | No |
| Specific Gravity: | 1.05200 to 1.05600 @ 20.00 °C.
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| Pounds per Gallon - (est).: | 8.764 to 8.797
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| Refractive Index: | 1.44100 to 1.44400 @ 20.00 °C.
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| Melting Point: | -76.00 to -75.00 °C. @ 760.00 mm Hg
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| Boiling Point: | 172.00 to 173.00 °C. @ 1.00 mm Hg
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| Vapor Pressure: | 0.800000 mmHg @ 170.00 °C. |
| Vapor Density: | 14.1 ( Air = 1 ) |
| Flash Point: | > 230.00 °F. TCC ( > 110.00 °C. )
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| logP (o/w): | 5.227 (est) |
| Soluble in: |
| | alcohol | | | oils | | | water, 0.6464 mg/L @ 25 °C (est) | | | water, 5 mg/L @ C (exp) |
| Similar Items:note |
| acetyl triethyl citrate |
Organoleptic Properties:
| Odor Type: herbal |
| Odor Strength:low |
| Substantivity:204 hour(s) at 100.00 % |
| herbal winey sweet |
Odor Description:at 100.00 %. very faint herbal wine sweet
Luebke, William tgsc, (1993) |
| Odor sample from: Morflex Chemical Company, Inc. |
| Odor and/or flavor descriptions from others (if found). |
Cosmetic Information:
Suppliers:
Safety Information:
| Preferred SDS: View |
| European information : |
| Most important hazard(s): | | None - None found. |
S 02 - Keep out of the reach of children.
S 24/25 - Avoid contact with skin and eyes.
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| |
| Hazards identification |
| |
| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
| |
| Pictogram | |
| |
| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
gavage-rat LD50 > 30000 mg/kg
Value represents the maximum dose level tested. Animals dosed at 30,000 mg/kg had 100% survival rate.
(Finkelstein & Gold, 1959)
intraperitoneal-mouse LD50 > 4000 mg/kg
Journal of Pharmaceutical Sciences. Vol. 53, Pg. 774, 1964.
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | | flavor and fragrance agents |
| RIFM Fragrance Material Safety Assessment: Search |
| IFRA Code of Practice Notification of the 49th Amendment to the IFRA Code of Practice |
| Recommendation for acetyl tributyl citrate usage levels up to: | | | 15.0000 % in the fragrance concentrate.
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| |
| Maximised Survey-derived Daily Intakes (MSDI-EU): | ND (μg/capita/day) |
| Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS). |
| The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library |
| publication number: 3 |
| Click here to view publication 3 |
| | average usual ppm | average maximum ppm |
| baked goods: | - | - |
| beverages(nonalcoholic): | - | 0.40000 |
| beverages(alcoholic): | - | - |
| breakfast cereal: | - | - |
| cheese: | - | - |
| chewing gum: | - | - |
| condiments / relishes: | - | - |
| confectionery froastings: | - | - |
| egg products: | - | - |
| fats / oils: | - | - |
| fish products: | - | - |
| frozen dairy: | - | - |
| fruit ices: | - | - |
| gelatins / puddings: | - | - |
| granulated sugar: | - | - |
| gravies: | - | - |
| hard candy: | - | - |
| imitation dairy: | - | - |
| instant coffee / tea: | - | - |
| jams / jellies: | - | - |
| meat products: | - | - |
| milk products: | - | - |
| nut products: | - | - |
| other grains: | - | - |
| poultry: | - | - |
| processed fruits: | - | - |
| processed vegetables: | - | - |
| reconstituted vegetables: | - | - |
| seasonings / flavors: | - | - |
| snack foods: | - | - |
| soft candy: | - | - |
| soups: | - | - |
| sugar substitutes: | - | - |
| sweet sauces: | - | - |
Safety References:
European Food Safety Athority(EFSA):Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies...
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European Food Safety Authority (EFSA) reference(s):
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Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC) on a request from the Commission related to - Flavouring Group Evaluation 10: Aliphatic primary and secondary saturated and unsaturated alcohols, aldehydes, acetals, carboxylic acids and esters containing an additional oxygenated functional group and lactones from chemical groups 9, 13 and 30 - (Commission Regulation (EC) No 1565/2000 of 18 July 2000)
View page or View pdf
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Opinion of the Scientific Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) related to a 10th list of substances for food contact materials
View page or View pdf
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Flavouring Group Evaluation 10, Revision 1 (FGE10 Rev1)[1] - Aliphatic primary and secondary saturated and unsaturated alcohols, aldehydes, acetals, carboxylic acids and esters containing an additional oxygenated functional group and lactones from chemical groups 9, 13 and 30 - Scientific Opinion of the Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food (AFC)
View page or View pdf
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Scientific Opinion on Flavouring Group Evaluation 10, Revision 2 (FGE.10Rev2): Aliphatic primary and secondary saturated and unsaturated alcohols, aldehydes, acetals, carboxylic acids and esters containing an additional oxygenated functional group and lactones from chemical groups 9, 13 and 30
View page or View pdf
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| EPI System: View |
| Chemical Carcinogenesis Research Information System:Search |
| AIDS Citations:Search |
| Cancer Citations:Search |
| Toxicology Citations:Search |
| EPA Substance Registry Services (TSCA):77-90-7 |
| EPA ACToR:Toxicology Data |
| EPA Substance Registry Services (SRS):Registry |
| Laboratory Chemical Safety Summary :6505 |
| National Institute of Allergy and Infectious Diseases:Data |
| WGK Germany:3 |
| tributyl 2-acetyloxypropane-1,2,3-tricarboxylate |
| Chemidplus:0000077907 |
| RTECS:TZ8330000 for cas# 77-90-7 |
References:
| | tributyl 2-acetyloxypropane-1,2,3-tricarboxylate |
| NIST Chemistry WebBook: | Search Inchi |
| Canada Domestic Sub. List: | 77-90-7 |
| Pubchem (cid): | 6505 |
| Pubchem (sid): | 134972804 |
Other Information:
Potential Blenders and core components note
Potential Uses:
| | film formers |
| FR | herbal |
| | plasticisers |
| | solvents |
Occurrence (nature, food, other): note
Synonyms:
| 2- | acetoxy-1,2,3-propane tricarboxylic acid tributyl ester | | 2- | acetoxy-1,2,3-propanetricarboxylic acid tributyl ester | | | acetyl citric acid tributyl ester | | 2-( | acetyl oxy)-1,2,3-propane tricarboxylic acid tributyl ester | | 2- | acetyl tributyl citrate | | | acetyl tributyl citrate NF USP | | | acetyl tributylcitrate | | | acetylcitric acid, tributyl ester | | 2-( | acetyloxy)-1,2,3-propanetricarboxylic acid, tributyl ester | | | acetyltributyl citrate | | | blo-trol | | | caswell no. 005ab | | | citric acid tributyl ester acetate | | | citric acid, O-acetyl-, tributyl ester | | | citric acid, tributyl ester, acetate | | | citroflex A 4 | | | citroflex A-4 | | | dibutyl 3-acetyloxy-3-(butoxycarbonyl)pentane-1,5-dioate | | 1,2,3- | propanetricarboxylic acid, 2- (acetyloxy)-, tributyl ester | | 1,2,3- | propanetricarboxylic acid, 2-(acetyloxy)-, tributyl ester | | | TEC | | | tributyl 2-(acetyl oxy)-1,2,3-propane tricarboxylate | | | tributyl 2-(acetyloxy)-1,2, 3-propanetricarboxylic acid | | | tributyl 2-(acetyloxy)-1,2,3-propanetricarboxylate | | | tributyl 2-(acetyloxy)propane-1,2,3-tricarboxylate | | | tributyl 2-acetoxy-1,2, 3-propanetricarboxylate | | | tributyl 2-acetoxy-1,2,3-propane tricarboxylate | | | tributyl 2-acetoxy-1,2,3-propanetricarboxylate | | | tributyl 2-acetoxypropane-1,2,3-tricarboxylate | | | tributyl 2-acetylcitrate | | 1,2,3- | tributyl 2-acetyloxypropane-1,2,3-tricarboxylate | | | tributyl acetyl citrate | | | tributyl acetylcitrate | | | tributyl citrate acetate | | | tributyl O-acetyl citrate | | | tributyl O-acetylcitrate | | | uniplex 84 |
Articles:
| PubMed:Pharmacokinetic Properties of Acetyl Tributyl Citrate, a Pharmaceutical Excipient |
| PubMed:Final report on the safety assessment of acetyl triethyl citrate, acetyl tributyl citrate, acetyl trihexyl citrate, and acetyl trioctyl citrate |
| PubMed:Acetyl tributyl citrate, the most widely used phthalate substitute plasticizer, induces cytochrome p450 3a through steroid and xenobiotic receptor |
| PubMed:Structural characterization of potential endocrine disrupting activity of alternate plasticizers di-(2-ethylhexyl) adipate (DEHA), acetyl tributyl citrate (ATBC) and 2,2,4-trimethyl 1,3-pentanediol diisobutyra |
| PubMed:Acetyl tributyl citrate and dibutyl sebacate inhibit the growth of cultured mammalian cells |
| PubMed:Effects of in vitro exposure to dibutyl phthalate, mono-butyl phthalate, and acetyl tributyl citrate on ovarian antral follicle growth and viability |
| PubMed:Development of new tissue conditioner using acetyl tributyl citrate and novel hyperbranched polyester to improve viscoelastic stability |
| PubMed:Effects of oral exposure to the phthalate substitute acetyl tributyl citrate on female reproduction in mice |
| PubMed:Toxicology of the citric acid esters: tributyl citrate, acetyl tributyl citrate, triethyl citrate, and acetyl triethyl citrate |
| PubMed:Preparation and Characterization of Bioplastic-Based Green Renewable Composites from Tapioca with Acetyl Tributyl Citrate as a Plasticizer |
| PubMed:Fabrication and characterization of poly(lactic acid)/acetyl tributyl citrate/carbon black as conductive polymer composites |
| PubMed:Citrate ester substitutes for di-2-ethylhexyl phthalate: In vivo reproductive and in vitro cytotoxicity assessments |
| PubMed:Assessment of endocrine-disrupting activities of alternative chemicals for bis(2-ethylhexyl)phthalate |
| PubMed:Dermal bioaccessibility of plasticizers in indoor dust and clothing |
| PubMed:Biocompatibility of wollastonite-poly(N-butyl-2-cyanoacrylate) composites |
| PubMed:Occurrence, toxicity and risk assessment of plastic additives in Besos river, Spain |
| PubMed:Influence of monomer type, plasticizer content, and powder/liquid ratio on setting characteristics of acrylic permanent soft denture liners based on poly(ethyl methacrylate/butyl methacrylate) and acetyl tribu |
| PubMed:Plasticizer Degradation by Marine Bacterial Isolates: A Proteogenomic and Metabolomic Characterization |
| PubMed:Hybrid Biocomposites Based on Poly(Lactic Acid) and Silica Aerogel for Food Packaging Applications |
| PubMed:Influence of Composition and Plasma Power on Properties of Film from Biodegradable Polymer Blends |
| PubMed:Biodiscovery of antibacterial constituents from the endolichenic fungi isolated from Parmotrema rampoddense |
| PubMed:Dermal exposure to plasticizers in nail polishes: An alternative major exposure pathway of phosphorus-based compounds |
| PubMed:Estimates of dietary exposure of Spanish population to packaging contaminants from cereal based foods contained in plastic materials |
| PubMed:Estimation of Dietary Exposure to Contaminants Transferred from the Packaging in Fatty Dry Foods Based on Cereals |
| PubMed:In Silico Investigation of First-Pass Effect on Selected Small Molecule Excipients and Structural Dynamics of P-glycoprotein |
| PubMed:Bionanocomposite films based on plasticized PLA-PHB/cellulose nanocrystal blends |
| PubMed:Effect of Extrusion Screw Speed and Plasticizer Proportions on the Rheological, Thermal, Mechanical, Morphological and Superficial Properties of PLA |
| PubMed:Cytocompatibility of new phthalate ester-free tissue conditioners in vitro |
| PubMed:GC-MS Screening Analysis for the Identification of Potential Migrants in Plastic and Paper-Based Candy Wrappers |
| PubMed:Identification of intentionally and non-intentionally added substances in plastic packaging materials and their migration into food products |
| PubMed:Novel Sustainable Composites Based on Poly(hydroxybutyrate-co-hydroxyvalerate) and Seagrass Beach-CAST Fibers: Performance and Degradability in Marine Environments |
| PubMed:The effect of crude drugs on the angiogenic property and dynamic viscoelasticity of PEMA-based soft polymer materials |
| PubMed:Processing Conditions, Thermal and Mechanical Responses of Stretchable Poly (Lactic Acid)/Poly (Butylene Succinate) Films |
| PubMed:Migration levels of PVC plasticisers: Effect of ionising radiation treatment |
| PubMed:Plasticized poly(lactic acid)-poly(hydroxybutyrate) (PLA-PHB) blends incorporated with catechin intended for active food-packaging applications |
| PubMed:Quantification of five plasticizers used in PVC tubing through high performance liquid chromatographic-UV detection |
| PubMed:Investigation of the interactions of enteric and hydrophilic polymers to enhance dissolution of griseofulvin following hot melt extrusion processing |
| PubMed:Target and non-target analysis of migrants from PVC-coated cans using UHPLC-Q-Orbitrap MS: evaluation of long-term migration testing |
| PubMed:The Effect of Reactive Ionic Liquid or Plasticizer Incorporation on the Physicochemical and Transport Properties of Cellulose Acetate Propionate-Based Membranes |
| PubMed:Occurrence of extractable ink residuals in packaging materials used in the Czech Republic |
| PubMed:Variables that affect the mechanism of drug release from osmotic pumps coated with acrylate/methacrylate copolymer latexes |
| PubMed:Effect of ionising radiation treatment on the specific migration characteristics of packaging-food simulant combinations: effect of type and dose of radiation |
| PubMed:Self-adhesive thin films for topical delivery of 5-aminolevulinic acid |
| PubMed:[Survey of plasticizers in polyvinyl chloride toys] |
| PubMed:Analysis of phthalic acid diesters, monoester, and other plasticizers in polyvinyl chloride household products in Japan |
| PubMed:[Examination of sex-hormonal activity of some additives for PVDC film] |
| PubMed:Migration and hydrolysis of hydrophobic polylactide plasticizer |
| PubMed:Determination of diethylhexyladipate and acetyltributylcitrate in aqueous extracts after cloud point extraction coupled with microwave assisted back extraction and gas chromatographic separation |
| PubMed:[Contents of plasticizers in cap-sealing for bottled food and their migration into food] |
| PubMed:Optimization of focused ultrasonic extraction of propellant components determined by gas chromatography/mass spectrometry |
| PubMed:[Material labeling of soft plastic toys and plasticizers in polyvinyl chloride products] |
| PubMed:Estimated daily intake of plasticizers in 1-week duplicate diet samples following regulation of DEHP-containing PVC gloves in Japan |
| PubMed:Development of a gas chromatographic/mass spectrometric method for determination of phthalates in oily foods |
| PubMed:Local demixion in plasticized polylactide probed by electron spin resonance |
| PubMed:Effect of high-dose electron beam irradiation on the migration of DOA and ATBC plasticizers from food-grade PVC and PVDC/PVC films, respectively, into olive oil |
| PubMed:Migration from plasticized films into foods. 3. Migration of phthalate, sebacate, citrate and phosphate esters from films used for retail food packaging |
| PubMed:Enhanced oxygen barrier properties of poly(lactic acid) via oxygen scavenging strategy combining with uniaxial stretching |
| PubMed:Biodegradation of Poly(Lactic Acid) Biocomposites under Controlled Composting Conditions and Freshwater Biotope |
| PubMed:Calculation of the dimensions of drug-polymer devices based on diffusion parameters |
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