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methyl amine
aminomethane

Supplier Sponsors

Name:methanamine
CAS Number: 74-89-5Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:200-820-0
FDA UNII: BSF23SJ79E
Nikkaji Web:J1.431A
Beilstein Number:0741851
MDL:MFCD00008104
CoE Number:10483
XlogP3-AA:-0.70 (est)
Molecular Weight:31.05785000
Formula:C H5 N
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:flavoring agents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
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NCBI:Search
FDA Mainterm (IAUFC):74-89-5 ; METHYLAMINE
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Specific Gravity:1.08000 @ 25.00 °C.
Boiling Point: -21.10 °C. @ 760.00 mm Hg (est)
Vapor Pressure:2650.000000 mmHg @ 25.00 °C.
Flash Point: -87.00 °F. TCC ( -65.90 °C. ) (est)
logP (o/w): -0.570
Soluble in:
 water, 1e+006 mg/L @ 25 °C (est)
 water, 1.08E+06 mg/L @ 25 °C (exp)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
BASF
Monomethylamine
Odor: characteristic
Use: Monomethylamine (MMA) is used as an intermediate for example in the production of pesticides, solvents (i.e. N-Methylpyrrolidone), pharmaceuticals and refining applications.
Eastman Chemical
Monomethylamine anhydrous
sds
Odor: characteristic
Use: MMA is a versatile building block that is used in a wide variety of applications. We produce a number of MMA derivatives like NMP, metam sodium, MMEA and MDEA.
EMD Millipore
For experimental / research use only.
Methylamine
sds
Penta International
METHYLAMINE 40% AQUEOUS SOLUTION
Penta International
METHYLAMINE 40% IN WATER
Sigma-Aldrich: Aldrich
For experimental / research use only.
Methylamine anhydrous, ≥98%
sds
Silver Fern Chemical
Methylamine
Odor: characteristic
Use: Methylamine is used as an intermediate for accelerators, dyes, pharmaceuticals, insecticides, fungicides, textile dyes, fuel additive, component of paint removers, photographic developer, and a solvent.
Taminco (Eastman)
monomethylamine
TCI AMERICA
For experimental / research use only.
Methylamine (ca. 40% in Water, ca. 12mol/L)
sds
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-rat LD50 100 mg/kg
Inhalation Toxicology. Vol. 2, Pg. 29, 1990.

Dermal Toxicity:
subcutaneous-guinea pig LDLo 200 mg/kg
"Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1289, 1935.

subcutaneous-mouse LDLo 2500 mg/kg
"Merck Index; an Encyclopedia of Chemicals, Drugs, and Biologicals", 11th ed., Rahway, NJ 07065, Merck & Co., Inc. 1989Vol. 11, Pg. 949, 1989.

subcutaneous-rat LDLo 200 mg/kg
"Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1289, 1935.

Inhalation Toxicity:
inhalation-rat LC50 448 ppm/2.5H
SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE LUNGS, THORAX, OR RESPIRATION: DYSPNEA SKIN AND APPENDAGES (SKIN): "DERMATITIS, IRRITATIVE: AFTER SYSTEMIC EXPOSURE"
Journal of Environmental Biology. Vol. 13, Pg. 273, 1992.

inhalation-mouse LC50 2400 mg/m3/2H
Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982Vol. -, Pg. 81, 1982.

inhalation-mammal (species unspecified) LC50 2400 mg/m3
Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. Vol. 14, Pg. 80, 1975.

inhalation-mouse LC50 2400 mg/m3/2H
"Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982Vol. -, Pg. 81, 1982.
 
Safety in Use Information:
Category:
flavoring agents
Recommendation for methyl amine usage levels up to:
 not for fragrance use.
 
 
Safety References:
EPI System: View
NIOSH International Chemical Safety Cards:search
NIOSH Pocket Guide:search
Chemical Carcinogenesis Research Information System:Search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA Substance Registry Services (TSCA):74-89-5
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :6329
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:2
methanamine
Chemidplus:0000074895
EPA/NOAA CAMEO:hazardous materials
RTECS:74-89-5
 
References:
 methanamine
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:74-89-5
Pubchem (cid):6329
Pubchem (sid):134970572
Pherobase:View
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Indirect Additives used in Food Contact Substances:View
CHEBI:View
CHEMBL:View
UM BBD:Search
KEGG (GenomeNet):C00218
HMDB (The Human Metabolome Database):HMDB00164
FooDB:FDB003958
Export Tariff Code:2921.11.0000
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
Wikipedia:View
Formulations/Preparations:
•grades: technical (anhydrous; 30-40% soln). •available commercially as a 40% or 50% aqueous solution.
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 apple fruit
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 apple pericarp
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 banana fruit
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 barley seed
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 cabbage leaf
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 carrot root
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 celery stem
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 corn seed
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 grape fruit juice
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 herring
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 soybean seed
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 spinach leaf
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 tea leaf
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Synonyms:
 aminomethane
 carbinamine
 methanamine
 methyl-amine
 methylamine
monomethylamine
N-methylamine
 methylamine, anhydrous [UN1061] [Flammable gas]
 methylamine, aqueous solution [UN1235] [Flammable liquid]
 

Articles:

PubMed:Bi-functionality of Opisthorchis viverrini aquaporins.
PubMed:Palladium nanoparticles decorated on reduced graphene oxide rotating disk electrodes toward ultrasensitive hydrazine detection: effects of particle size and hydrodynamic diffusion.
PubMed:Efficient secretion of inulin fructotransferase in Pichia pastoris using the formaldehyde dehydrogenase 1 promoter.
PubMed:Mixed ligand copper(II) complexes of 2,9-dimethyl-1,10-phenanthroline: tridentate 3N primary ligands determine DNA binding and cleavage and cytotoxicity.
PubMed:Metabolomic analysis of amino acid and fat metabolism in rats with L-tryptophan supplementation.
PubMed:A new room temperature gas sensor based on pigment-sensitized TiO2 thin film for amines determination.
PubMed:1H-NMR-based profiling of organic components in leachate from animal carcasses disposal site with time.
PubMed:Titanium (III) cation selective electrode based on synthesized tris(2pyridyl) methylamine ionophore and its application in water samples.
PubMed:Production of salted and pressed anchovies (stolephorus sp.) and it's quality evaluation during storage.
PubMed:A survey of biogenic amines in vinegars.
PubMed:Effects of a Fusarium toxin-contaminated maize treated with sodium metabisulphite, methylamine and calcium hydroxide in diets for female piglets.
PubMed:Hydrothermal treatment of naturally contaminated maize in the presence of sodium metabisulfite, methylamine and calcium hydroxide; effects on the concentration of zearalenone and deoxynivalenol.
PubMed:Melatonin is formed during winemaking at safe levels of biogenic amines.
PubMed:Free amino acids and biogenic amines in Alicante Monastrell wines.
PubMed:Immobilization of tris(2 pyridyl) methylamine in a PVC-Membrane Sensor and Characterization of the Membrane Properties.
PubMed:Isolation of a bacteriocin-producing lactococcus lactis and application of its bacteriocin to manage spoilage bacteria in high-value marine fish under different storage temperatures.
PubMed:Effects of amines and aminoalcohols on bovine intestine alkaline phosphatase activity.
PubMed:Assessment of the genetic polymorphism and biogenic amine production of indigenous Oenococcus oeni strains isolated from Greek red wines.
PubMed:Gas chromatography-mass spectrometry assessment of amines in Port wine and grape juice after fast chloroformate extraction/derivatization.
PubMed:Regulation of mucosal addressin cell adhesion molecule 1 expression in human and mice by vascular adhesion protein 1 amine oxidase activity.
PubMed:The serotonin 5-HT(2A) receptor agonist TCB-2: a behavioral and neurophysiological analysis.
PubMed:A new ultra-pressure liquid chromatography method for the determination of biogenic amines in cheese.
PubMed:A method for benzoyl chloride derivatization of biogenic amines for high performance liquid chromatography.
PubMed:Metabolomic analysis of the response of growing pigs to dietary L-arginine supplementation.
PubMed:Nonlinear four-way kinetic-excitation-emission fluorescence data processed by a variant of parallel factor analysis and by a neural network model achieving the second-order advantage: malonaldehyde determination in olive oil samples.
PubMed:Modifications and insights into a method for the analysis of the nitrogen mustard mechlorethamine by high-performance liquid chromatography.
PubMed:Synthesis, herbicidal activities, and 3D-QSAR of 2-cyanoacrylates containing aromatic methylamine moieties.
PubMed:Reduction of fat deposition by combined inhibition of monoamine oxidases and semicarbazide-sensitive amine oxidases in obese Zucker rats.
PubMed:Hydration behavior of alkyl amines and their corresponding protonated forms. 1. Ammonia and methylamine.
PubMed:Antihyperglycemic effect of Cephalotaxus sinensis leaves and GLUT-4 translocation facilitating activity of its flavonoid constituents.
PubMed:Methylamine-dependent release of nitric oxide and dopamine in the CNS modulates food intake in fasting rats.
PubMed:The accumulation and synthesis of betaine in winter skate (Leucoraja ocellata).
PubMed:Formation of biogenic amines throughout the industrial manufacture of red wine.
PubMed:Mechanistic pathways of formation of acrylamide from different amino acids.
PubMed:Activity and expression of semicarbazide-sensitive benzylamine oxidase in a rodent model of diabetes: interactive effects with methylamine and alpha-aminoguanidine.
PubMed:Methylamine: a new endogenous modulator of neuron firing?
PubMed:Purification and characterization of glutamine synthetase of Pseudomonas taetrolens Y-30: an enzyme usable for production of theanine by coupling with the alcoholic fermentation system of baker's yeast.
PubMed:The role of creatine in the generation of N-methylacrylamide: a new toxicant in cooked meat.
PubMed:Semicarbazide sensitive amine oxidase overexpression has dual consequences: insulin mimicry and diabetes-like complications.
PubMed:Chemiluminescence determination of carbofuran and promecarb by flow injection analysis using two photochemical reactions.
PubMed:Isolation and characterization of water-soluble intermediates of blue pigments transformed from geniposide of Gardenia jasminoides.
PubMed:Deodorizing effects of tea catechins on amines and ammonia.
PubMed:Methylamine in human urine.
PubMed:A role for serotonin in lipopolysaccharide-induced anorexia in rats.
PubMed:New Melanoidin-like Maillard Polymers from 2-Deoxypentoses.
PubMed:Chemical and toxicological studies of products resulting from sorbic acid and methylamine interaction in food conditions.
PubMed:Flupyrsulfuron soil dissipation and mobility in winter wheat crops.
PubMed:Antibacterial efficacy against an in vivo Salmonella typhimurium infection model and pharmacokinetics of a liposomal ciprofloxacin formulation.
PubMed:Analysis of catalytic action of transglutaminase induced in human promyelocytic leukemia (HL-60) and human hepatoblastoma (HepG2) cells.
PubMed:Cleavage of oligodeoxyribonucleotides from controlled-pore glass supports and their rapid deprotection by gaseous amines.
PubMed:Nitrosatable amines and nitrosamide formation in natural stimulants: Cola acuminata, C. nitida and Garcinia cola.
PubMed:Activation of the ATP-ubiquitin-proteasome pathway in skeletal muscle of cachectic rats bearing a hepatoma.
PubMed:Glucocorticoids activate the ATP-ubiquitin-dependent proteolytic system in skeletal muscle during fasting.
PubMed:Increased exposure to dietary amines and nitrate in a population at high risk of oesophageal and gastric cancer in Kashmir (India).
PubMed:Chemical inactivation of aflatoxins in peanut protein ingredients.
PubMed:Detoxification of aflatoxin-polluted peanut cakes with monomethylamine/Ca(OH)2: pilot industrial application, nutrition experiments, toxicity evaluation.
PubMed:Evidence of peroxisomes and peroxisomal enzyme activities in the oleaginous yeast Apiotrichum curvatum.
PubMed:Iron- and manganese-containing superoxide dismutases from Methylomonas J: identity of the protein moiety and amino acid sequence.
PubMed:Trapping of reactive intermediates from the nitrosation of primary amines by a new type of scavenger reagent.
PubMed:Formation of aliphatic amine precursors of N-nitrosodimethylamine after oral administration of choline and choline analogues in the rat.
PubMed:Increase in human exposure to methylamine precursors of N-nitrosamines after eating fish.
PubMed:Digestion of the host erythrocyte by malaria parasites is the primary target for quinoline-containing antimalarials.
PubMed:Food-borne amines and amides as potential precursors of endogenous carcinogens.
PubMed:Susceptibility of human malaria parasites to chloroquine is pH dependent.
PubMed:Identification of the acidic compartment of Plasmodium falciparum-infected human erythrocytes as the target of the antimalarial drug chloroquine.
PubMed:Abundance of dimethylamine in seafoods: possible implications in the incidence of human cancer.
PubMed:High concentrations of dimethylamine and methylamine in squid and octopus and their implications in tumour aetiology.
PubMed:Intracellular alkalinization potentiates slow inward current and prolonged bursting in a molluscan neuron.
PubMed:Serum levels of dimenhydrinate. Determination by HPLC with UV detection after intake of dimenhydrinate in a coated chewing gum dragee.
PubMed:Importance of dietary amines in meal-induced gastrin release.
PubMed:N-Nitroso compounds from reactions of nitrite with methylamine.
PubMed:[On the problems in respect ot the formation of N-nitroso compound precursors when using alkylating agents in the fumigation of foodstuffs. I. Investigations of the formation of secondary amines by the action of ethylene oxide on primary amines and amino acids (author's transl)].
PubMed:pH Dependence and Cofactor Requirements of Photochemical Reactions in Maize Chloroplasts.
PubMed:Aflatoxin inactivation. Chemical and biological properties of ammonia and methylamine treated cottonseed meal.
 
Notes:
monovalent cation in pyruvate kinase catalysis. Methylamine is a colourless gas derivative of ammonia, but with one H atom replaced by a methyl group. It is the simplest primary amine. It has a strong odor similar to fish. Methylamine is used as a building block for the synthesis of many other commercially available compounds. Hundreds of millions of kilograms are produced annually. (Wikipedia)
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