EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

shark liver oil
fats and glyceridic oils, shark-liver

Supplier Sponsors

CAS Number: 68990-63-6
ECHA EC Number:273-616-2
FDA UNII: 4B24275HEU
Category:cosmetic agents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
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PubMed:Search
NCBI:Search
 
Physical Properties:
Food Chemicals Codex Listed: No
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: skin conditioning
skin protecting agents
solvents
 
Suppliers:
Charkit Chemical
SHARK LIVER OIL 20%
Charkit Chemical
SHARK LIVER OIL 30,000 A
 
Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intraperitoneal-mouse LD50 > 30000 mg/kg
Kiso to Rinsho. Clinical Report. Vol. 12, Pg. 775, 1978.

intravenous-mouse LD50 2450 mg/kg
Kiso to Rinsho. Clinical Report. Vol. 12, Pg. 775, 1978.

oral-mouse LD50 > 30000 mg/kg
Kiso to Rinsho. Clinical Report. Vol. 12, Pg. 775, 1978.

intraperitoneal-rat LD50 > 20000 mg/kg
Kiso to Rinsho. Clinical Report. Vol. 12, Pg. 775, 1978.

oral-rat LD50 > 20000 mg/kg
Kiso to Rinsho. Clinical Report. Vol. 12, Pg. 775, 1978.

Dermal Toxicity:
subcutaneous-mouse LD50 > 30000 mg/kg
Kiso to Rinsho. Clinical Report. Vol. 12, Pg. 775, 1978.

subcutaneous-rat LD50 > 20000 mg/kg
Kiso to Rinsho. Clinical Report. Vol. 12, Pg. 775, 1978.

Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
cosmetic agents
Recommendation for shark liver oil usage levels up to:
 not for fragrance use.
 
Recommendation for shark liver oil flavor usage levels up to:
 not for flavor use.
 
Safety References:
Daily Med:search
EPA Substance Registry Services (TSCA):68990-63-6
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
National Institute of Allergy and Infectious Diseases:Data
Chemidplus:0068990636
 
References:
Pubchem (sid):135356858
 
Other Information:
 
Potential Blenders and core components note
None Found
 
Potential Uses:
 emollients
 
Occurrence (nature, food, other):note
 found in nature
 
Synonyms:
 fats and glyceridic oils, shark-liver
 oils, shark-liver
 

Articles:

PubMed:Jurassic surgery and immunity enhancement by alkyglycerols of shark liver oil.
PubMed:Alkylglycerols modulate the proliferation and differentiation of non-specific agonist and specific antigen-stimulated splenic lymphocytes.
PubMed:[Nonspecific immunomodulation in obstetrics and gynecology with Ecomer preliminary report].
PubMed:Antitumor and anti-cachectic effects of shark liver oil and fish oil: comparison between independent or associative chronic supplementation in Walker 256 tumor-bearing rats.
PubMed:Oral administration of alkylglycerols differentially modulates high-fat diet-induced obesity and insulin resistance in mice.
PubMed:[Anti-tumor activity of 1-O-alkylglycerols--the main component of shark liver oil].
PubMed:Discrimination against diacylglycerol ethers in lipase-catalysed ethanolysis of shark liver oil.
PubMed: Shark liver oil: hidden dangers.
PubMed:Biological importance and applications of squalene and squalane.
PubMed:Chronic supplementation with shark liver oil for reducing tumor growth and cachexia in walker 256 tumor-bearing rats.
PubMed:Walker-256 tumor growth is inhibited by the independent or associative chronic ingestion of shark liver and fish oil: a response linked by the increment of peritoneal macrophages nitrite production in Wistar rats.
PubMed:An update on the therapeutic role of alkylglycerols.
PubMed:Squalene as novel food factor.
PubMed:Multiple beneficial health effects of natural alkylglycerols from shark liver oil.
PubMed:Vaccination, squalene and anti-squalene antibodies: facts or fiction?
PubMed:Which alkylglycerols from shark liver oil have anti-tumour activities?
PubMed:Effect of chronic supplementation with shark liver oil on immune responses of exercise-trained rats.
PubMed:Acute and repeated dose (28 days) oral safety studies of an alkoxyglycerol extract from shark liver oil in rats.
PubMed:The effect of shark liver oil on the tumor infiltrating lymphocytes and cytokine pattern in mice.
PubMed:Biological and pharmacological activities of squalene and related compounds: potential uses in cosmetic dermatology.
PubMed:[The clinical and experimental research of metabolic effects of shark liver oil].
PubMed:Supercritical carbon dioxide fractionation of nonesterified alkoxyglycerols obtained from shark liver oil.
PubMed:[Shark liver oil as a supporting therapy in atopic dermatitis].
PubMed:The influence of shark liver oils on normal and transformed mammalian cells in culture.
PubMed:Occurrence of polybrominated diphenyl ethers and polychlorinated biphenyls in shark liver oil supplements.
PubMed:[Health properties of shark oil].
PubMed:1 -O-alkyl-2-(omega-oxo)acyl-sn-glycerols from shark oil and human milk fat are potential precursors of PAF mimics and GHB.
PubMed:[Biological action and clinical application of shark liver oil].
PubMed:A study on fatty acid composition of fish oil from two marine fish, Eusphyra blochii and Carcharhinus bleekeri.
PubMed:Tetra- and tribromophenoxyanisoles in marine samples from Oceania.
PubMed:Humoral defence improvement and haematopoiesis stimulation in sows and offspring by oral supply of shark-liver oil to mothers during gestation and lactation.
PubMed:[Effect of high doses of shark liver oil supplementation on T cell polarization and peripheral blood polymorphonuclear cell function].
PubMed:Oral intake of shark liver oil modifies lipid composition and improves motility and velocity of boar sperm.
PubMed:Natural alkylglycerols restrain growth and metastasis of grafted tumors in mice.
PubMed:Natural 1-O-alkylglycerols reduce platelet-activating factor-induced release of [3H]-serotonin in rabbit platelets.
PubMed:Cytostatic and cytotoxic effects of alkylglycerols (Ecomer).
PubMed:Inhibitory effect of Greenland shark liver oil combined with squalen and arctic birch ashes on angiogenesis and L-1 sarcoma growth in Balb/c mice.
PubMed:[Modification of innate immunity in humans by active components of shark liver oil].
PubMed:Effect of squalene and shark liver oil on serum cholesterol level in hamsters.
PubMed:The antipromoting effect of alkyloglycerols from shark liver oil.
PubMed:[The assessment of the effectiveness of the shark liver oil in recurrent aphthous stomatitis treatment: clinical and immunological studies].
PubMed:The synergistic effect of lactic acid bacteria and alkylglycerols on humoral immunity in mice.
PubMed:[Studies on the genotoxic effects of crude liver oils from 3 species of Mediterranean sharks by means of in vitro micronucleus test using human lymphocytes].
PubMed:Inhibitory effect of shark liver oil on cutaneous angiogenesis induced in Balb/c mice by syngeneic sarcoma L-1, human urinary bladder and human kidney tumour cells.
PubMed:Shark liver oil-induced lipoid pneumonia in pigs: correlation of thin-section CT and histopathologic findings.
PubMed:Exogenous lipoid pneumonia: high-resolution CT findings.
PubMed:Some biological actions of alkylglycerols from shark liver oil.
PubMed:Diets enriched in menhaden fish oil, seal oil, or shark liver oil have distinct effects on the lipid and fatty-acid composition of guinea pig heart.
PubMed:Modulation of platelet-activating-factor production by incorporation of naturally occurring 1-O-alkylglycerols in phospholipids of human leukemic monocyte-like THP-1 cells.
PubMed:Shark oil pneumonia. An overlooked entity.
PubMed:[Shark liver oil (alkoxyglycerol) and cancer treatment].
PubMed:[The National Board of Health and Welfare prohibits Ecomer. Shark liver oil is suspected of adverse effects].
PubMed:Carcinogenicity of diethylnitrosamine in vitamin-A-deficient mice.
PubMed:Stimulation of immune reactivity by methoxy-substituted glycerol ethers incorporated into the feed.
PubMed:1-O-(2-hydroxyalkyl)glycerols isolated from Greenland shark liver oil.
PubMed:Fortification of shark liver oil with iron.
PubMed:Separation of neutral lipids of shark liver by "dry-column" chromatography.
PubMed:Basking shark liver oil sterols and glyceryl ethers. UCLA-12-686.
PubMed:Gas chromatographic-mass spectrometric analysis of isoprenoid hydrocarbons and fatty acids in shark liver oil products.
PubMed:Effect of shark liver oil on plasma cholesterol and lipoprotein pattern in man.
PubMed:Biological and chemical estimation of vitamin D in shark-liver oil.
PubMed:[Shark liver oil; medicoindustrial importance].
PubMed:Deodorization of shark liver oil.
PubMed:Note on a color reaction for shark-liver oil.
PubMed:The spectrophotometric examination of shark liver oils and products derived from them.
PubMed:Effect of storage and acidity on the protection of vitamin A in shark liver oil by antioxidants.
PubMed:Local therapy of shark-liver oil in nyctalopia.
PubMed:Australian shark liver oil.
PubMed:Chemical composition of shark liver oil.
PubMed:The utilisation of by-products of the shark liver oil industry.
PubMed:Studies on the destruction of vitamin A in shark-liver oil; some factors affecting the stability.
PubMed:Studies on the destruction of vitamin A in shark-liver oil; effect of some anti-oxidants on the stabilisation of vitamin A.
PubMed:Studies on the destruction of vitamin A in shark-liver oil; catalytic activity of metals.
PubMed:Studies on the destruction of vitamin A in shark-liver oil; relation between vitamin A destruction and peroxide number.
 
Notes:
tsca definition 2008: extractives and their physically modified derivatives. it consists primarily of the glycerides of c14-c18 and c16-c22 unsatd. fatty acids. (squaliformes).
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