|
Category: cosmetic and fragrance agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Appearance: | yellowish to dark amber liquid (est) |
| Food Chemicals Codex Listed: | No |
Organoleptic Properties:
| Odor Strength:low |
| Odor Description:at 100.00 %. bland |
| Odor and/or flavor descriptions from others (if found). |
Cosmetic Information:
Suppliers:
Safety Information:
| |
| Hazards identification |
| |
| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
| |
| Pictogram | |
| |
| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
|
Not determined
|
| Dermal Toxicity: |
|
Not determined
|
| Inhalation Toxicity: |
|
Not determined
|
Safety in Use Information:
| Category: | | cosmetic and fragrance agents |
| RIFM Fragrance Material Safety Assessment: Search |
| IFRA Code of Practice Notification of the 49th Amendment to the IFRA Code of Practice |
| contains the following IFRA (Annex) restricted components: (non-analysis max. level reference only) |
| carvone | Max. Found: 8.00 % and Reason: Sensitization |
| longifolene | Max. Found: 1.8 % and Reason: Sensitization |
| Recommendation for nigella sativa seed oil usage levels up to: | | | 2.0000 % in the fragrance concentrate.
|
| |
| Recommendation for nigella sativa seed oil flavor usage levels up to: |
| | not for flavor use.
|
Safety References:
References:
| | nigella sativa l. seed oil |
| Pubchem (sid): | 135353902 |
Other Information:
| Export Tariff Code: | 3301.29.6000 |
| FDA Listing of Food Additive Status: | View |
| Wikipedia: | View |
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| | black seed oil cold pressed | | | black seed oil steam distilled | | black | caraway seed oil | | roman | coriander oil | | black | cumin / nigella sativa oil | | | cumin black oil | | black | cumin oil | | black | cumin oil organic | | black | cumin seed oil organic | | | fennel flower oil | | | fixed oil expressed from the seeds of black caraway, nigella sativa l., ranunculaceae |
Articles:
| PubMed:Scolicidal effects of black cumin seed (Nigella sativa) essential oil on hydatid cysts. |
| PubMed:Enhanced cytotoxicity and apoptosis by thymoquinone in combination with zoledronic acid in hormone- and drug-resistant prostate cancer cell lines. |
| PubMed:The thymoquinone-induced production of reactive oxygen species promotes dedifferentiation through the ERK pathway and inflammation through the p38 and PI3K pathways in rabbit articular chondrocytes. |
| PubMed:Apoptotic activities of thymoquinone, an active ingredient of black seed (Nigella sativa), in cervical cancer cell lines. |
| PubMed:Thymoquinone inhibits proliferation and invasion of human nonsmall-cell lung cancer cells via ERK pathway. |
| PubMed:Mitigating role of thymoquinone rich fractions from Nigella sativa oil and its constituents, thymoquinone and limonene on lipidemic-oxidative injury in rats. |
| PubMed:Dietary supplementation of chloroquine with nigella sativa seed and oil extracts in the treatment of malaria induced in mice with plasmodium berghei. |
| PubMed:Thymoquinone induces apoptosis in human colon cancer HCT116 cells through inactivation of STAT3 by blocking JAK2- and Src‑mediated phosphorylation of EGF receptor tyrosine kinase. |
| PubMed:Stable isotope dilution gas chromatography-mass spectrometry for quantification of thymoquinone in black cumin seed oil. |
| PubMed:Effects of Nigella sativa L. seed oil on abnormal semen quality in infertile men: a randomized, double-blind, placebo-controlled clinical trial. |
| PubMed:Natural products as topoisomerase II poisons: effects of thymoquinone on DNA cleavage mediated by human topoisomerase IIα. |
| PubMed:Increased 5-HT Levels Following Repeated Administration of Nigella sativa L. (Black Seed) Oil Produce Antidepressant Effects in Rats. |
| PubMed:Cytotoxicity of Nigella sativa seed oil and extract against human lung cancer cell line. |
| PubMed:Topical Nigella Sativa for nasal symptoms in elderly. |
| PubMed:Authentication of Nigella sativa seed oil in binary and ternary mixtures with corn oil and soybean oil using FTIR spectroscopy coupled with partial least square. |
| PubMed:Thymoquinone causes multiple effects, including cell death, on dividing plant cells. |
| PubMed:The effect of thymoquinone, an active component of Nigella sativa, on isoproterenol induced myocardial injury. |
| PubMed:Molecular targeting of Akt by thymoquinone promotes G(1) arrest through translation inhibition of cyclin D1 and induces apoptosis in breast cancer cells. |
| PubMed:Thymoquinone inhibits autophagy and induces cathepsin-mediated, caspase-independent cell death in glioblastoma cells. |
| PubMed:Thymoquinone: fifty years of success in the battle against cancer models. |
| PubMed:The clinical outcome of adjuvant therapy with black seed oil on intractable paediatric seizures: a pilot study. |
| PubMed:Evaluation of topical black seed oil in the treatment of allergic rhinitis. |
| PubMed:Thymoquinone-loaded nanostructured lipid carriers: preparation, gastroprotection, in vitro toxicity, and pharmacokinetic properties after extravascular administration. |
| PubMed:Thymoquinone-induced reactive oxygen species causes apoptosis of chondrocytes via PI3K/Akt and p38kinase pathway. |
| PubMed:Elucidation of mechanisms of actions of thymoquinone-enriched methanolic and volatile oil extracts from Nigella sativa against cardiovascular risk parameters in experimental hyperlipidemia. |
| PubMed:Thymoquinone attenuates tumor growth in ApcMin mice by interference with Wnt-signaling. |
| PubMed:Effects of selected bioactive natural products on the vascular endothelium. |
| PubMed:Hepatoprotective and immunological functions of Nigella sativa seed oil against hypervitaminosis A in adult male rats. |
| PubMed:Effects of black seed oil on resolution of hepato-renal toxicity induced bybromobenzene in rats. |
| PubMed:Thymoquinone protects cultured rat primary neurons against amyloid β-induced neurotoxicity. |
| PubMed:Blood pressure lowering effect of Nigella sativa L. seed oil in healthy volunteers: a randomized, double-blind, placebo-controlled clinical trial. |
| PubMed:Hormetic/cytotoxic effects of Nigella sativa seed alcoholic and aqueous extracts on MCF-7 breast cancer cells alone or in combination with doxorubicin. |
| PubMed:NADPH quinone oxidoreductase 1 mediates breast cancer cell resistance to thymoquinone-induced apoptosis. |
| PubMed:Distribution of primary and specialized metabolites in Nigella sativa seeds, a spice with vast traditional and historical uses. |
| PubMed:Cadmium-induced hepatotoxicity and its abrogation by thymoquinone. |
| PubMed:Thymoquinone prevents and ameliorates dextran sulfate sodium-induced colitis in mice. |
| PubMed:Stabilization of emulsion and butter like products containing essential fatty acids using kalonji seeds extract and curcuminoids. |
| PubMed:Anticancer activity of Nigella sativa (black seed) - a review. |
| PubMed:Upregulation of chemoprotective enzymes and glutathione by Nigella sativa (black seed) and thymoquinone in CCl4-intoxicated rats. |
| PubMed:Protective effect of Nigella sativa oil against tramadol-induced tolerance and dependence in mice: role of nitric oxide and oxidative stress. |
| PubMed:Lindane-induced biochemical perturbations in rat serum and attenuation by omega-3 and Nigella sativa seed oil. |
| PubMed:Antiatherogenic Potential of Nigella sativa Seeds and Oil in Diet-Induced Hypercholesterolemia in Rabbits. |
| PubMed:Oleic and linoleic acids are active principles in Nigella sativa and stabilize an E(2)P conformation of the Na,K-ATPase. Fatty acids differentially regulate cardiac glycoside interaction with the pump. |
| PubMed:Investigation of lipids profiles of Nigella, lupin and artichoke seed oils to be used as healthy oils. |
| PubMed:Validated high-performance thin-layer chromatographic method for the quantification of thymoquinone in Nigella Sativa extracts and formulations. |
| PubMed:Chemical composition of Nigella sativa L. seed extracts obtained by supercritical carbon dioxide. |
| PubMed:Thymoquinone supplementation attenuates cyclophosphamide-induced cardiotoxicity in rats. |
| PubMed:Review on molecular and therapeutic potential of thymoquinone in cancer. |
| PubMed:Protective effects of black cumin (Nigella sativa) oil on TNBS-induced experimental colitis in rats. |
| PubMed:Studies on molecular mechanisms of growth inhibitory effects of thymoquinone against prostate cancer cells: role of reactive oxygen species. |
| PubMed:Structure-activity studies on therapeutic potential of Thymoquinone analogs in pancreatic cancer. |
| PubMed:Protective effects of Nigella sativa oil and thymoquinone against toxicity induced by the anticancer drug cyclophosphamide. |
| PubMed:Thymoquinone from nutraceutical black cumin oil activates Neu4 sialidase in live macrophage, dendritic, and normal and type I sialidosis human fibroblast cells via GPCR Galphai proteins and matrix metalloproteinase-9. |
| PubMed:Radioprotective effects of black seed (Nigella sativa) oil against hemopoietic damage and immunosuppression in gamma-irradiated rats. |
| PubMed:Terpene conjugates of the Nigella sativa seed-oil constituent thymoquinone with enhanced efficacy in cancer cells. |
| PubMed:Thymoquinone-induced relaxation of isolated rat pulmonary artery. |
| PubMed:Antimicrobial effect of garlic (Allium sativum). |
| PubMed:Multiple molecular targets underlie the antidiabetic effect of Nigella sativa seed extract in skeletal muscle, adipocyte and liver cells. |
| PubMed:Anti-inflammatory effects of the Nigella sativa seed extract, thymoquinone, in pancreatic cancer cells. |
| PubMed:Gastroprotective effect of an aqueous suspension of black cumin Nigella sativa on necrotizing agents-induced gastric injury in experimental animals. |
| PubMed:Ancient nigella seeds from Boyali Höyük in north-central Turkey. |
| PubMed:Effects of Nigella sativa seed extract on ameliorating lung tissue damage in rats after experimental pulmonary aspirations. |
| PubMed:Oral and intraperitoneal LD50 of thymoquinone, an active principle of Nigella sativa, in mice and rats. |
| PubMed:Therapeutic effects of Nigella sativa on chronic HAART-induced hyperinsulinemia in rats. |
| PubMed:Amelioration of chronic relapsing experimental autoimmune encephalomyelitis (cr-eae) using thymoquinone - biomed 2009. |
| PubMed:Comparison of chemical composition and antibacterial activity of Nigella sativa seed essential oils obtained by different extraction methods. |
| PubMed:HIV-1 protease inhibitor induced oxidative stress suppresses glucose stimulated insulin release: protection with thymoquinone. |
| PubMed:From here to eternity - the secret of Pharaohs: Therapeutic potential of black cumin seeds and beyond. |
| PubMed:Potentiation of Valproate-induced Anticonvulsant Response by Nigella sativa Seed Constituents: The Role of GABA Receptors. |
| PubMed:Anti-tumor properties of blackseed (Nigella sativa L.) extracts. |
| PubMed:An investigation of the analgesic and anti-inflammatory effects of Nigella sativa seed polyphenols. |
| PubMed:Immunomodulatory and therapeutic properties of the Nigella sativa L. seed. |
| PubMed:Nigella sativa (black seed) oil does not affect the T-helper 1 and T-helper 2 type cytokine production from splenic mononuclear cells in allergen sensitized mice. |
| PubMed:Determination of isopropylmethylphenols in black seed oil by differential pulse voltammetry. |
| PubMed:Thymoquinone extracted from black seed triggers apoptotic cell death in human colorectal cancer cells via a p53-dependent mechanism. |
| PubMed:Black cumin seed essential oil, as a potent analgesic and antiinflammatory drug. |
| PubMed:Thymoquinone and Nigella sativa oil protection against methionine-induced hyperhomocysteinemia in rats. |
| PubMed:Effect of Nigella sativa (black seed) on subjective feeling in patients with allergic diseases. |
| PubMed:Radical scavenging activity of black cumin (Nigella sativa L.), coriander (Coriandrum sativum L.), and niger (Guizotia abyssinica Cass.) crude seed oils and oil fractions. |
| PubMed:A simple differential pulse polarographic method for the determination of thymoquinone in black seed oil. |
| PubMed:Thymoquinone-induced relaxation of guinea-pig isolated trachea. |
| PubMed:Pharmacological and toxicological properties of Nigella sativa. |
| PubMed:Characterization of phospholipid composition of black cumin (Nigella sativa L.) seed oil. |
| PubMed:Cytogenetic studies on Nigella sativa seeds extract and thymoquinone on mouse cells infected with schistosomiasis using karyotyping. |
| PubMed:Effects of Nigella sativa fixed oil on blood homeostasis in rat. |
| PubMed:Inhibitory effects of thymoquinone against 20-methylcholanthrene-induced fibrosarcoma tumorigenesis. |
| PubMed:Protective effect of black seed oil from Nigella sativa against murine cytomegalovirus infection. |
| PubMed:High performance liquid chromatographic analysis of the pharmacologically active quinones and related compounds in the oil of the black seed (Nigella sativa L.). |
| PubMed:Inhibition of benzo(a)pyrene-induced forestomach carcinogenesis in mice by thymoquinone. |
| PubMed:The in vitro anti-tumor activity of some crude and purified components of blackseed, Nigella sativa L. |
| PubMed:The cardiovascular actions of the volatile oil of the black seed (Nigella sativa) in rats: elucidation of the mechanism of action. |
| PubMed:The respiratory effects of the volatile oil of the black seed (Nigella sativa) in guinea-pigs: elucidation of the mechanism(s) of action. |
| PubMed:Sterols in the seed oil of Nigella sativa. |
|
Known in Europe as Black Caraway or Black Cumin is a small plant, originating in the Middle East like so many other spice plants, culinary herbs, etc. Nigella Sativa is cultivated in France and Germany and it is found abundantly growing wild in Egypt, Asiatic Turkey and the Balkan States.
Inhibition of beta lactamases with extracts of nigella sativa l.
a plant genus of the family ranunculaceae that contains alpha-hederin, a triterpene saponin in the seeds, and is the source of black seed oil.
|
