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norathyriol

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CAS Number: 3542-72-1Picture of molecule3D/inchi
FDA UNII: Search
Nikkaji Web:J13.004D
XlogP3-AA:2.10 (est)
Molecular Weight:260.20196000
Formula:C13 H8 O6
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:information only not used for fragrances or flavors
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
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PubMed:Search
NCBI:Search
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Soluble in:
 water, 30.33 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
BOC Sciences
For experimental / research use only.
Norathyriol 98.5%
Odor: characteristic
Use: Norathyriol isolated from the herbs of Mangifera indica L. It is a potent PTP1B inhibitor with good cell permeability and oral availability. anti-inflammatory;
 
Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
information only not used for fragrances or flavors
Recommendation for norathyriol usage levels up to:
 not for fragrance use.
 
Recommendation for norathyriol flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :5281656
National Institute of Allergy and Infectious Diseases:Data
1,3,6,7-tetrahydroxyxanthen-9-one
Chemidplus:0003542721
 
References:
 1,3,6,7-tetrahydroxyxanthen-9-one
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):5281656
Pubchem (cas):3542-72-1
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEBI:View
CHEMBL:View
KEGG (GenomeNet):C10086
HMDB (The Human Metabolome Database):Search
FooDB:FDB030004
ChemSpider:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 not found in nature
 
Synonyms:
1,3,6,7-tetrahydroxyxanthen-9-one
1,3,6,7-tetrahydroxyxantone
9H-xanthen-9-one, 1,3,6,7-tetrahydroxy-
 

Articles:

PubMed:In Vitro Comparative Study of the Inhibitory Effects of Mangiferin and Its Aglycone Norathyriol towards UDP-Glucuronosyl Transferase (UGT) Isoforms.
PubMed:Naturally occurring xanthone and benzophenone derivatives exert significant anti-proliferative and proapoptotic effects in vitro on synovial fibroblasts and macrophages from rheumatoid arthritis patients.
PubMed:In Vitro and In Vivo Effects of Norathyriol and Mangiferin onα-Glucosidase.
PubMed:Pharmacokinetics of mangiferin and its metabolite-norathyriol, Part 2: Influence of UGT, CYP450, P-gp, and enterobacteria and the potential interaction in Rhizoma Anemarrhenae decoction with timosaponin B2 as the major contributor.
PubMed:Pharmacokinetics of mangiferin and its metabolite-Norathyriol, Part 1: Systemic evaluation of hepatic first-pass effect in vitro and in vivo.
PubMed:Hypouricaemic action of mangiferin results from metabolite norathyriol via inhibiting xanthine oxidase activity.
PubMed:Estrogen modulation properties of mangiferin and quercetin and the mangiferin metabolite norathyriol.
PubMed:Norathyriol reverses obesity- and high-fat-diet-induced insulin resistance in mice through inhibition of PTP1B.
PubMed:Host-guest inclusion system of norathyriol with β-cyclodextrin and its derivatives: preparation, characterization, and anticancer activity.
PubMed:Biflavonoids, main constituents from Garcinia bakeriana leaves.
PubMed:Mangiferin and its aglycone, norathyriol, improve glucose metabolism by activation of AMP-activated protein kinase.
PubMed:Norathyriol suppresses transformation in JB6 P+ cells by the inhibition of Akt.
PubMed:Yeast-mediated xanthone synthesis through oxidative intramolecular cyclization.
PubMed:Mangiferin aglycone attenuates radiation-induced damage on human intestinal epithelial cells.
PubMed:Norathyriol suppresses skin cancers induced by solar ultraviolet radiation by targeting ERK kinases.
PubMed:Structure elucidation of in vivo and in vitro metabolites of mangiferin.
PubMed:Deglycosylation of puerarin and other aromatic C-glucosides by a newly isolated human intestinal bacterium.
PubMed:The phenolic acids from bacterial degradation of the mangiferin aglycone are quantified in the feces of pigs after oral ingestion of an extract of Cyclopia genistoides (honeybush tea).
PubMed:In vitro modulation of ABCB1/P-glycoprotein expression by polyphenols from Mangifera indica.
PubMed:Benzophenone O-glycosides from Hypericum elegans.
PubMed:In vitro effects of Mangifera indica and polyphenols derived on ABCB1/P-glycoprotein activity.
PubMed:Mangiferin and hesperidin metabolites are absorbed from the gastrointestinal tract of pigs after oral ingestion of a Cyclopia genistoides (honeybush tea) extract.
PubMed:Effects of the mango components mangiferin and quercetin and the putative mangiferin metabolite norathyriol on the transactivation of peroxisome proliferator-activated receptor isoforms.
PubMed:Two proteins, Mn2+, and low molecular cofactor are required for C-glucosyl-cleavage of mangiferin.
PubMed:Xanthone derivatives: new insights in biological activities.
PubMed:Isolation of a human intestinal bacterium that transforms mangiferin to norathyriol and inducibility of the enzyme that cleaves a C-glucosyl bond.
PubMed:Inhibition of the arachidonic acid cascade by norathyriol via blockade of cyclooxygenase and lipoxygenase activity in neutrophils.
PubMed:Decreased protein kinase C activation mediates inhibitory effect of norathyriol on serotonin-mediated endothelial permeability.
PubMed:Evidence for the involvement of protein kinase C inhibition by norathyriol in the reduction of phorbol ester-induced neutrophil superoxide anion generation and aggregation.
PubMed:Examination of the inhibitory effect of norathyriol in formylmethionyl-leucyl-phenylalanine-induced respiratory burst in rat neutrophils.
PubMed:Induction of calcium release from sarcoplasmic reticulum of skeletal muscle by xanthone and norathyriol.
PubMed:Synthesis and antiplatelet effects of omega-aminoalkoxylxanthones.
PubMed:Effect of norathyriol, isolated from Tripterospermum lanceolatum, on A23187-induced pleurisy and analgesia in mice.
PubMed:gamma-Pyrone compounds. 5. Synthesis and antiplatelet effects of xanthonoxypropanolamines and related compounds.
PubMed:Inhibitory effect of norathyriol, a xanthone from Tripterospermum lanceolatum, on cutaneous plasma extravasation.
PubMed:Gamma-pyrone compounds. II: Synthesis and antiplatelet effects of tetraoxygenated xanthones.
PubMed:Antihaemostatic and antithrombotic effect of some antiplatelet agents isolated from Chinese herbs.
PubMed:Vasorelaxation of rat thoracic aorta caused by norathyriol isolated from Gentianaceae.
PubMed:Novel inhibitory actions on platelet thromboxane and inositolphosphate formation by xanthones and their glycosides.
 
Notes:
None found
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