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pomolic acid

Supplier Sponsors

CAS Number: 13849-91-7Picture of molecule3D/inchi
FDA UNII: 60HAB1ZK1T
Nikkaji Web:J14.871G
XlogP3-AA:5.90 (est)
Molecular Weight:472.70936000
Formula:C30 H48 O4
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:natural substances and extractives
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
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Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Soluble in:
 water, 0.00396 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
BOC Sciences
For experimental / research use only.
Pomolic acid
 
Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
natural substances and extractives
Recommendation for pomolic acid usage levels up to:
 not for fragrance use.
 
Recommendation for pomolic acid flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :382831
National Institute of Allergy and Infectious Diseases:Data
(1R,2R,4aS,6aR,6aS,6bR,8aR,10S,12aR,14bS)-1,10-dihydroxy-1,2,6a,6b,9,9,12a-heptamethyl-2,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicene-4a-carboxylic acid
Chemidplus:0013849917
 
References:
 (1R,2R,4aS,6aR,6aS,6bR,8aR,10S,12aR,14bS)-1,10-dihydroxy-1,2,6a,6b,9,9,12a-heptamethyl-2,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicene-4a-carboxylic acid
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):382831
Pubchem (cas):13849-91-7
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEBI:View
CHEMBL:View
HMDB (The Human Metabolome Database):HMDB35106
FooDB:FDB013736
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 hyptis capitata
Search Trop Picture
 rosa woodsii
Search Trop Picture
 
Synonyms:
(1R,2R,4aS,6aR,6aS,6bR,8aR,10S,12aR,14bS)-1,10-dihydroxy-1,2,6a,6b,9,9,12a-heptamethyl-2,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicene-4a-carboxylic acid
 

Articles:

PubMed:[Apoptosis as the basic mechanism of cytotoxic action of ursolic and pomolic acids in glioma cells].
PubMed:Antitumor‑ and apoptosis‑inducing effects of pomolic acid against SK‑MEL‑2 human malignant melanoma cells are mediated via inhibition of cell migration and sub‑G1 cell cycle arrest.
PubMed:Pomolic acid induces apoptosis and inhibits multidrug resistance protein MRP1 and migration in glioblastoma cells.
PubMed:Anti-hepatitis, antioxidant activities and bioactive compounds of Dracocephalum heterophyllum extracts.
PubMed:The Potential of Triterpenoids from Loquat Leaves (Eriobotrya japonica) for Prevention and Treatment of Skin Disorder.
PubMed:Pomolic acid suppresses HIF1α/VEGF-mediated angiogenesis by targeting p38-MAPK and mTOR signaling cascades.
PubMed:Pomolic Acid Inhibits Invasion of Breast Cancer Cells Through the Suppression of CXC Chemokine Receptor Type 4 Expression. Buyun Kim, Ji-Hun Kim, Byoungduck Park.
PubMed:Suppression of MMP-9 and FAK expression by pomolic acid via blocking of NF-κB/ERK/mTOR signaling pathways in growth factor-stimulated human breast cancer cells.
PubMed:Pomolic acid inhibits metastasis of HER2 overexpressing breast cancer cells through inactivation of the ERK pathway.
PubMed:Chemical characterization of the main bioactive constituents from fruits of Ziziphus jujuba.
PubMed:Secondary Metabolites from Leaves of Manilkara subsericea (Mart.) Dubard.
PubMed:[Chemical constituents from medical and edible plants of Rosa roxburghii].
PubMed:Pomolic Acid Inhibits Invasion of Breast Cancer Cells Through the Suppression of CXC Chemokine Receptor Type 4 Expression.
PubMed:Isolation, characterization, and anthelminthic activities of a novel dichapetalin and other constituents of Dichapetalum filicaule.
PubMed:[Triterpene constituents from Rosa cymosa Tratt].
PubMed:[Determination of five triterpenic acids from Salvia chinensis of different parts by RP-HPLC-PDA].
PubMed:Catunarosides I-L, four new triterpenoid saponins from the stem bark of Catunaregam spinosa.
PubMed:Pharmacogenomic Characterization of Cytotoxic Compounds from Salvia officinalis in Cancer Cells.
PubMed:Cytotoxic compounds from the fruits of Uapaca togoensis towards multifactorial drug-resistant cancer cells.
PubMed:[Chemical constituents from roots of Rubus parvifolius].
PubMed:Antiulcer activity of the ethanolic extract and ethyl acetate fraction of the leaves of Markhamia tomentosa in rats.
PubMed:Triterpenoids from the fruits and leaves of the blackberry (Rubus allegheniensis) and their inhibitory activities on foam cell formation in human monocyte-derived macrophage.
PubMed:Triterpene saponins from the roots of Ilex asprella.
PubMed:Hepatoprotective triterpenes from traditional Tibetan medicine Potentilla anserina.
PubMed:[Isolation of pomolic acid from Chamaenerion angustifolium and evaluation of its genotoxicity by microbiological tests].
PubMed:Plant extracts inhibit ADP-induced platelet activation in humans: their potential therapeutic role as ADP antagonists.
PubMed:Protein tyrosine phosphatase 1B inhibitory activities of ursane- and lupane-type triterpenes from Sorbus pohuashanensis.
PubMed:[Chemical constituents from the root of Ilex cornuta].
PubMed:Triterpenoids from Fragaria ananassa calyx and their inhibitory effects on melanogenesis in B16-F10 mouse melanoma cells.
PubMed:Sibiricasaponins A-E, five new triterpenoid saponins from the aerial parts of Polygala sibirica L.
PubMed:Pomolic acid induces apoptosis in SK-OV-3 human ovarian adenocarcinoma cells through the mitochondrial-mediated intrinsic and death receptor-induced extrinsic pathways.
PubMed:Simultaneous determination of seven major triterpenoids in Pyrola decorata H. Andres by LC-MS method.
PubMed:[Non-anthraquinones constituents from the roots of Knoxia valerianoides].
PubMed:New flavane gallates isolated from the leaves of Plicosepalus curviflorus and their hypoglycemic activity.
PubMed:(24S)-ergostane-3β,5α,6β-triol from Hedyotis chrysotricha with inhibitory activity on migration of SK-HEP-1 human hepatocarcinoma cells.
PubMed:Analgesic and anti-inflammatory activities of the methanol extract of Elaeagnus oldhamii Maxim. in mice.
PubMed:Triterpenes from Callicarpa integerrima Champ.
PubMed:Pomolic acid, triterpenoid isolated from Licania pittieri, as competitive antagonist of ADP-induced aggregation of human platelets.
PubMed:Anticancer properties of pomolic acid-induced AMP-activated protein kinase activation in MCF7 human breast cancer cells.
PubMed:LC-UV assay method and UPLC/Q-TOF-MS characterisation of saponins from Ilex paraguariensis A. St. Hil. (mate) unripe fruits.
PubMed:[Anti-bacteria activity of Puraboeo rutescens and Lysionotus pauciflorus].
PubMed:[Studies on the chemical constituents from the leave of Paulownia tomentosa].
PubMed:Triterpenoids isolated from Zizyphus jujuba inhibit foam cell formation in macrophages.
PubMed:Lignans and other constituents from the roots of the Vietnamese medicinal plant Pseuderanthemum palatiferum.
PubMed:Pomolic acid of Licania pittieri elicits endothelium-dependent relaxation in rat aortic rings.
PubMed:[Studies on the chemical constituents of Callicarpa kochiana].
PubMed:Antiprotozoal activities of some constituents of Markhamia tomentosa (Bignoniaceae).
PubMed:A new natural azulene-type pigment from Oreocnide frutescens.
PubMed:Antifibrotic activity of triterpenoids from the aerial parts of Euscaphis japonica on hepatic stellate cells.
PubMed:Study on determination of pentacyclic triterpenoids in Chaenomeles by HPLC-ELSD.
PubMed:Scuteflorins A and B, dihydropyranocoumarins from Scutellaria lateriflora.
PubMed:Stimulation of glucose uptake by triterpenoids from Weigela subsessilis.
PubMed:Pentacyclic triterpenoids from the aerial parts of Lantana camara and their nematicidal activity.
PubMed:Spathoside, a cerebroside and other antibacterial constituents of the stem bark of Spathodea campanulata.
PubMed:Aldose-reductase- and protein-glycation-inhibitory principles from the whole plant of Duchesnea chrysantha.
PubMed:Anti-inflammatory and apoptotic activities of pomolic acid isolated from Cecropia pachystachya.
PubMed:New pomolic acid triterpene glycosides from Zygophyllum eichwaldii.
PubMed:[Studies on triterpenoid constituents in leaf of Ilex pernyi].
PubMed:1H and 13C NMR spectral data of new saponins from Cordia piauhiensis.
PubMed:Pomolic acid-induced apoptosis in cells from patients with chronic myeloid leukemia exhibiting different drug resistance profile.
PubMed:Production of triterpene acids by cell suspension cultures of Olea europaea.
PubMed:[Triterpenes from herb of Potentilla chinesis].
PubMed:[Studies on triterpenoids from Potentilla chinensis].
PubMed:Trypanocidal activity of triterpenes from Arrabidaea triplinervia and derivatives.
PubMed:Triterpenes from natural and transformed roots of Plocama pendula.
PubMed:Potential cancer chemopreventive agents from Arbutus unedo.
PubMed:Anti-complementary activity of ursane-type triterpenoids from Weigela subsessilis.
PubMed:Pomolic acid may overcome multidrug resistance mediated by overexpression of anti-apoptotic Bcl-2 proteins.
PubMed:[Triterpenes from root of Rhaponticum uniflorum].
PubMed:Two new triterpenoid saponins from Sarcandra glabra.
PubMed:Inhibitory effect on TNF-alpha-induced IL-8 production in the HT29 cell of constituents from the leaf and stem of Weigela subsessilis.
PubMed:Characterization of two minor saponins from Cordia piauhiensis by 1H and 13C NMR spectroscopy.
PubMed:Pomolic acid triggers mitochondria-dependent apoptotic cell death in leukemia cell line.
PubMed:Antiproliferative constituents from Umbelliferae plants VII. Active triterpenes and rosmarinic acid from Centella asiatica.
PubMed:Triterpenoids from Brazilian Ilex species and their in vitro antitrypanosomal activity.
PubMed:Phenolic compounds obtained from stems of Couepia ulei with the potential to induce quinone reductase.
PubMed:Triterpene acids from the leaves of Perilla frutescens and their anti-inflammatory and antitumor-promoting effects.
PubMed:New anthracene derivatives from Coussarea macrophylla.
PubMed:[Chemical constituents from the fruit of Rosa bella Rehd. et Wils].
PubMed:Glycosides from the leaves of Ilex hylonoma.
PubMed:Antimicrobial triterpenes from Debregeasia salicifolia.
PubMed:Proposed active constituents of Dipladenia martiana.
PubMed:[Isolation and identification of Triterpenoid compounds in the fruits of Chaenomeles lagenaria (Loisel.) Koidz].
PubMed:[Chemical constituents of the stem and root of Syzygium buxifolium Hook. Et Arn].
PubMed:Cytotoxic triterpene acids from the Peruvian medicinal plant Polylepis racemosa.
PubMed:Triterpene saponins from Randia formosa.
PubMed:Triterpenoid saponins from Ilex latifolia.
PubMed:Anti-AIDS agents. 30. Anti-HIV activity of oleanolic acid, pomolic acid, and structurally related triterpenoids.
PubMed:Triterpene saponins from Scabiosa rotata.
PubMed:Triterpenoids from Acaena pinnatifida R. et P.
PubMed:Mazusaponins I-IV, triterpene saponins from Mazus miquelii.
PubMed:[Studies on the constituents of Leucoseptrum stellipillum].
PubMed:Cytotoxic triterpenes from a Chinese medicine, Goreishi.
 
Notes:
None found
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