cucurbitacin C, 5988-76-1

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CODE184529 CODE184529
Product(s):
5988-76-1 Cucurbitacin C

CAS Number:	5988-76-1	3D/inchi
Other(deleted CASRN):	20137-42-2
FDA UNII:	938A8MM70H
Nikkaji Web:	J8.327E
XlogP3-AA:	2.80 (est)
Molecular Weight:	560.72816000
Formula:	C32 H48 O8
NMR Predictor:	Predict (works with chrome, Edge or firefox)

Category:natural substances and extractives

US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:

Google Scholar:	Search
Google Books:	Search
Google Scholar: with word "volatile"	Search
Google Scholar: with word "flavor"	Search
Google Scholar: with word "odor"	Search
Google Patents:	Search
US Patents:	Search
EU Patents:	Search
Pubchem Patents:	Search
PubMed:	Search
NCBI:	Search

Physical Properties:

Assay:	95.00 to 100.00
Food Chemicals Codex Listed:	No
Soluble in:
	water, 0.7021 mg/L @ 25 °C (est)

Organoleptic Properties:

Odor and/or flavor descriptions from others (if found).

Cosmetic Information:

None found

Suppliers:

BOC Sciences

For experimental / research use only.

Cucurbitacin C

Safety Information:


Hazards identification

Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements

Pictogram

Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined

Safety in Use Information:

Category:
natural substances and extractives
Recommendation for cucurbitacin C usage levels up to:
	not for fragrance use.

Recommendation for cucurbitacin C flavor usage levels up to:
	not for flavor use.

Safety References:

EPI System: View

AIDS Citations:Search

Cancer Citations:Search

Toxicology Citations:Search

EPA ACToR:Toxicology Data

EPA Substance Registry Services (SRS):Registry

Laboratory Chemical Safety Summary :5281317

National Institute of Allergy and Infectious Diseases:Data

[(E,6R)-6-[(3S,8S,9R,10R,13R,14S,16R,17R)-3,16-dihydroxy-9-(hydroxymethyl)-4,4,13,14-tetramethyl-11-oxo-1,2,3,7,8,10,12,15,16,17-decahydrocyclopenta[a]phenanthren-17-yl]-6-hydroxy-2-methyl-5-oxohept-3-en-2-yl] acetate

Chemidplus:0005988761

References:

	[(E,6R)-6-[(3S,8S,9R,10R,13R,14S,16R,17R)-3,16-dihydroxy-9-(hydroxymethyl)-4,4,13,14-tetramethyl-11-oxo-1,2,3,7,8,10,12,15,16,17-decahydrocyclopenta[a]phenanthren-17-yl]-6-hydroxy-2-methyl-5-oxohept-3-en-2-yl] acetate
NIST Chemistry WebBook:	Search Inchi
Pubchem (cid):	5281317
Pubchem (cas):	5988-76-1

Other Information:

(IUPAC):	Atomic Weights of the Elements 2011 (pdf)
Videos:	The Periodic Table of Videos
tgsc:	Atomic Weights use for this web site
(IUPAC):	Periodic Table of the Elements
CHEBI:	View
KEGG (GenomeNet):	C08795
HMDB (The Human Metabolome Database):	HMDB34706
FooDB:	FDB013239
VCF-Online:	VCF Volatile Compounds in Food
ChemSpider:	View

Potential Blenders and core components note

None Found

Potential Uses:

None Found

Occurrence (nature, food, other):note

cucumis sativus
Search Trop Picture

Synonyms:

[(E,6R)-6-[(3S,8S,9R,10R,13R,14S,16R,17R)-3,16-	dihydroxy-9-(hydroxymethyl)-4,4,13,14-tetramethyl-11-oxo-1,2,3,7,8,10,12,15,16,17-decahydrocyclopenta[a]phenanthren-17-yl]-6-hydroxy-2-methyl-5-oxohept-3-en-2-yl] acetate
19-	norlanosta-5,23-diene-11,22-dione, 25-(acetyloxy)-3,16,20-trihydroxy-9-(hydroxymethyl)-, (3beta,9beta,10alpha,16alpha,23E)- (9CI)

Articles:

PubMed:Conspecific and Heterospecific Aboveground Herbivory Both Reduce Preference by a Belowground Herbivore.

PubMed:Plant science. Biosynthesis, regulation, and domestication of bitterness in cucumber.

PubMed:23,24-Dihydrocucurbitacin C: a new compound regarded as the next metabolite of cucurbitacin C.

PubMed:Linking agricultural practices, mycorrhizal fungi, and traits mediating plant-insect interactions.

PubMed:Cucurbitacin D induces fetal hemoglobin synthesis in K562 cells and human hematopoietic progenitors through activation of p38 pathway and stabilization of the γ-globin mRNA.

PubMed:Cucurbitacin B induces apoptosis and S phase cell cycle arrest in BEL-7402 human hepatocellular carcinoma cells and is effective via oral administration.

PubMed:New cucurbitane-type triterpenoids from Bryonia aspera.

PubMed:Studies on the cytotoxicity of cucurbitacins isolated from Cayaponia racemosa (Cucurbitaceae).

PubMed:Role of cucurbitacin C in resistance to spider mite (Tetranychus urticae) in cucumber (Cucumis sativus L.).

Notes:

None found