EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

(±)-aegeline

Supplier Sponsors

CAS Number: 456-12-2Picture of molecule3D/inchi
Other(deleted CASRN):37791-13-2
FDA UNII: 60T59LN3SG
MDL:MFCD00048045
XlogP3-AA:2.40 (est)
Molecular Weight:297.35403000
Formula:C18 H19 N O3
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:natural substances and extractives
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Soluble in:
 water, 235.3 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
BOC Sciences
For experimental / research use only.
Aegeline > 95%
Odor: characteristic
Use: Aegeline, is a compound that can be extracted from Aegle marmelos leaves, a tree that grows in India. Research has found the essential oil of the tree to be effective against 21 types of bacteria. Aegeline, has also shown to have anti-obesity effects.
TCI AMERICA
For experimental / research use only.
(±)-Aegeline >98.0%(HPLC)(N)
sds
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
natural substances and extractives
Recommendation for (±)-aegeline usage levels up to:
 not for fragrance use.
 
Recommendation for (±)-aegeline flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :15558419
National Institute of Allergy and Infectious Diseases:Data
(E)-N-[2-hydroxy-2-(4-methoxyphenyl)ethyl]-3-phenylprop-2-enamide
Chemidplus:0000456122
 
References:
 (E)-N-[2-hydroxy-2-(4-methoxyphenyl)ethyl]-3-phenylprop-2-enamide
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):15558419
Pubchem (cas):456-12-2
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
HMDB (The Human Metabolome Database):HMDB33435
FooDB:FDB011473
Export Tariff Code:2924.29.7790
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 aegle marmelos leaf
Search Trop Picture
 
Synonyms:
N-(2-hydroxy-2(4-methoxyphenyl)ethyl)-3-phenyl-2-propenamide, (E)-
(E)-N-[2-hydroxy-2-(4-methoxyphenyl)ethyl]-3-phenylprop-2-enamide
2-propenamide, N-(2-hydroxy-2-(4-methoxyphenyl)ethyl)-3-phenyl-, (E)-
 

Articles:

PubMed:Pharmacokinetics and Tissue Distribution of Aegeline after Oral Administration in Mice
PubMed:Overview of regulation of dietary supplements in the USA and issues of adulteration with phenethylamines (PEAs)
PubMed:Aegeline from Aegle marmelos stimulates glucose transport via Akt and Rac1 signaling, and contributes to a cytoskeletal rearrangement through PI3K/Rac1
PubMed:Aegeline, a natural product from the plant Aegle marmelos, mimics the yeast SNARE protein Sec22p in suppressing à-synuclein and Bax toxicity in yeast
PubMed:Aegeline inspired synthesis of novel amino alcohol and thiazolidinedione hybrids with antiadipogenic activity in 3T3-L1 cells
PubMed:Simultaneous Determination of Aegeline and Six Coumarins from Different Parts of the Plant Aegle marmelos Using UHPLC-PDA-MS and Chiral Separation of Aegeline Enantiomers Using HPLC-ToF-MS
PubMed:Aegeline inspired synthesis of novel ?3-AR agonist improves insulin sensitivity in vitro and in vivo models of insulin resistance
PubMed:LOX-1, the Common Therapeutic Target in Hypercholesterolemia: A New Perspective of Antiatherosclerotic Action of Aegeline
PubMed:Corrigendum to "Aegeline, a natural product from the plant Aegle marmelos, mimics the yeast SNARE protein Sec22p in suppressing à-synuclein and Bax toxicity in yeast" [Bioorg. Med. Chem. Lett. 29 (2019) 454-460]
PubMed:Effects of aegeline, a main alkaloid of Aegle Marmelos Correa leaves, on the histamine release from mast cells
PubMed:Inhibition of CYP3A4 and CYP1A2 by Aegle marmelos and its constituents
PubMed:Lipid lowering agents of natural origin: An account of some promising chemotypes
PubMed:Antihyperglycemic and antidyslipidemic agent from Aegle marmelos
PubMed:Interaction of active compounds from Aegle marmelos CORREA with histamine-1 receptor
PubMed:The Role of Adverse Event Reporting in the FDA Response to a Multistate Outbreak of Liver Disease Associated with a Dietary Supplement
PubMed:Two new cytotoxic furoquinoline alkaloids isolated from Aegle marmelos (Linn.) Correa
PubMed:Synthesis of novel N-(2-hydroxy-2-p-tolylethyl)-amide and N-(2-oxo-2-p-tolylethyl)-amide derivatives and their antidyslipidemic and antioxidant activity
PubMed:Synthesis of new N-acryl-1-amino-2-phenylethanol and N-acyl-1-amino-3-aryloxypropanols and evaluation of their antihyperlipidemic, LDL-oxidation and antioxidant activity
PubMed:Anti adipogenic activity of Aegle marmelos Correa
PubMed:Biological Evaluation of Aegle marmelos Fruit Extract and Isolated Aegeline in Alleviating Pain-Depression Dyad: In Silico Analysis of Aegeline on MAO-A and iNOS
PubMed:ACTION OF RANEY NICKEL ON AEGELINE, AEGELONE AND DIHYDROAEGELINE
PubMed:Outbreak of severe hepatitis linked to weight-loss supplement OxyELITE Pro
PubMed:Hydrosoluble formazan XTT: its application to natural products drug discovery for Leishmania
PubMed:Severe Acute Hepatocellular Injury Attributed to OxyELITE Pro: A Case Series
PubMed:Binolam-AlCl: a two-centre catalyst for the synthesis of enantioenriched cyanohydrin O-phosphates
 
Notes:
None found
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