Category:natural substances and extractives
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
Assay: | 95.00 to 100.00
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Food Chemicals Codex Listed: | No |
Soluble in: |
| water, 177.8 mg/L @ 25 °C (est) |
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found). |
Cosmetic Information:
Suppliers:
Safety Information:
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Hazards identification |
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Classification of the substance or mixture |
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
None found. |
GHS Label elements, including precautionary statements |
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Pictogram | |
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Hazard statement(s) |
None found. |
Precautionary statement(s) |
None found. |
Oral/Parenteral Toxicity: |
Not determined
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Dermal Toxicity: |
Not determined
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Inhalation Toxicity: |
Not determined
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Safety in Use Information:
Category: | natural substances and extractives |
Recommendation for harmalol usage levels up to: | | not for fragrance use.
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Recommendation for harmalol flavor usage levels up to: |
| not for flavor use.
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Safety References:
References:
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
4,9- | dihydro-1-methyl-3H-pyrido(3,4-b)indol-7-ol | 1- | methyl-2,3,4,9-tetrahydropyrido[3,4-b]indol-7-one | 3H- | pyrido(3,4-b)indol-7-ol, 4,9-dihydro-1-methyl- (8CI)(9CI) |
Articles:
PubMed:Therapeutic role of harmalol targeting nucleic acids: Biophysical perspective and in vitro cytotoxicity. |
PubMed:Indole Alkaloids from Plants as Potential Leads for Antidepressant Drugs: A Mini Review. |
PubMed:Determination of Tryptamines and β-Carbolines in Ayahuasca Beverage Consumed During Brazilian Religious Ceremonies. |
PubMed:Parts-per-trillion detection of harmala alkaloids in Undaria pinnatifida algae by on-line solid phase extraction capillary electrophoresis mass spectrometry. |
PubMed:Antifungal activity of β-carbolines on Penicillium digitatum and Botrytis cinerea. |
PubMed:DNA binding and apoptotic induction ability of harmalol in HepG2: Biophysical and biochemical approaches. |
PubMed:Quality criterion to optimize separations in capillary electrophoresis: Application to the analysis of harmala alkaloids. |
PubMed:A rapid and simple method for the determination of psychoactive alkaloids by CE-UV: application to Peganum Harmala seed infusions. |
PubMed:The Potential of β Carbolin Alkaloids to Hinder Growth and Reverse Chloroquine Resistance in Plasmodium falciparum. |
PubMed:Targeting different RNA motifs by beta carboline alkaloid, harmalol: a comparative photophysical, calorimetric, and molecular docking approach. |
PubMed:Corrigendum to "Binding of alkaloid harmalol to DNA: Photophysical and calorimetric approach" [J. Photochem. Photobiol. B: Biol. 130 (2014) 272-280]. |
PubMed:Fast determination of harmala alkaloids in edible algae by capillary electrophoresis mass spectrometry. |
PubMed:Sequence specific binding of beta carboline alkaloid harmalol with deoxyribonucleotides: binding heterogeneity, conformational, thermodynamic and cytotoxic aspects. |
PubMed:Comment on "Binding of alkaloid harmalol to DNA: photophysical and calorimetric approach". |
PubMed:Inhibition of myeloperoxidase activity by the alkaloids of Peganum harmala L. (Zygophyllaceae). |
PubMed:Inhibition of monoamine oxidase (MAO) by β-carbolines and their interactions in live neuronal (PC12) and liver (HuH-7 and MH1C1) cells. |
PubMed:Binding of alkaloid harmalol to DNA: photophysical and calorimetric approach. |
PubMed:Pharmacological and therapeutic effects of Peganum harmala and its main alkaloids. |
PubMed:Simultaneous determination of harmine, harmaline and their metabolites harmol and harmalol in beagle dog plasma by UPLC-ESI-MS/MS and its application to a pharmacokinetic study. |
PubMed:Recent pharmacological developments in β-carboline alkaloid "harmaline". |
PubMed:Simultaneous determination of alkaloids and flavonoids from aerial parts of Passiflora species and dietary supplements using UPLC-UV-MS and HPTLC. |
PubMed:Harmine is a potent antimalarial targeting Hsp90 and synergizes with chloroquine and artemisinin. |
PubMed:Combined fluorescence spectroscopy and molecular modeling studies on the interaction between harmalol and human serum albumin. |
PubMed:Metabolism and disposition of N,N-dimethyltryptamine and harmala alkaloids after oral administration of ayahuasca. |
PubMed:Harmaline and harmalol inhibit the carcinogen-activating enzyme CYP1A1 via transcriptional and posttranslational mechanisms. |
PubMed:The inhibition activity of selected beta-carboline alkaloids on enzymes of acetylcholinesterase and butyrylcholinesterase. |
PubMed:Inhibition of human cytochrome P450 enzymes 3A4 and 2D6 by β-carboline alkaloids, harmine derivatives. |
PubMed:Beta-carboline alkaloids harmaline and harmalol induce melanogenesis through p38 mitogen-activated protein kinase in B16F10 mouse melanoma cells. |
PubMed:Interaction of β-carboline alkaloids with RNA. |
PubMed:Beta-carboline alkaloids bind DNA. |
PubMed:Inhibitory effect of hydroxyindoles and their analogues on human melanoma tyrosinase. |
PubMed:beta-Carboline alkaloids in Peganum harmala and inhibition of human monoamine oxidase (MAO). |
PubMed:Harmol induces apoptosis by caspase-8 activation independently of Fas/Fas ligand interaction in human lung carcinoma H596 cells. |
PubMed:Floral nectar composition of Peganum harmala L. |
PubMed:Antiplatelet activity of beta-carboline alkaloids from Perganum harmala: a possible mechanism through inhibiting PLCgamma2 phosphorylation. |
PubMed:Effect of Peganum harmala or its beta-carboline alkaloids on certain antibiotic resistant strains of bacteria and protozoa from poultry. |
PubMed:Partial least squares-based multivariate spectral calibration method for simultaneous determination of beta-carboline derivatives in Peganum harmala seed extracts. |
PubMed:Antioxidant properties of beta-carboline alkaloids are related to their antimutagenic and antigenotoxic activities. |
PubMed:Determination of beta-carboline alkaloids in foods and beverages by high-performance liquid chromatography with electrochemical detection at a glassy carbon electrode modified with carbon nanotubes. |
PubMed:Preparation, structure and spasmolytic activities of some derivatives of harmine series of alkaloids. |
PubMed:High-affinity binding of beta-carbolines to imidazoline I2B receptors and MAO-A in rat tissues: norharman blocks the effect of morphine withdrawal on DOPA/noradrenaline synthesis in the brain. |
PubMed:Comparison of the Protective Effect of Indole beta-carbolines and R-(-)-deprenyl Against Nitrogen Species-Induced Cell Death in Experimental Culture Model of Parkinson's Disease. |
PubMed:Protective effect of 1-methylated beta-carbolines against 3-morpholinosydnonimine-induced mitochondrial damage and cell viability loss in PC12 cells. |
PubMed:Microbial metabolites of harman alkaloids. |
PubMed:N-methylated beta-carbolines protect PC12 cells from cytotoxic effect of MPP+ by attenuation of mitochondrial membrane permeability change. |
PubMed:HPLC method for the analysis of harmol, harmalol, harmine and harmaline in the seeds of Peganum harmala L. |
PubMed:Determination of N,N-dimethyltryptamine and beta-carboline alkaloids in human plasma following oral administration of Ayahuasca. |
PubMed:Protective effect of harmaline and harmalol against dopamine- and 6-hydroxydopamine-induced oxidative damage of brain mitochondria and synaptosomes, and viability loss of PC12 cells. |
PubMed:Comparative study on the vasorelaxant effects of three harmala alkaloids in vitro. |
PubMed:Protective effect of harmalol and harmaline on MPTP neurotoxicity in the mouse and dopamine-induced damage of brain mitochondria and PC12 cells. |
PubMed:Effects of some beta-carboline alkaloids on intact Trypanosoma cruzi epimastigotes. |
PubMed:The effects of beta-carbolines in rats trained with ibogaine as a discriminative stimulus. |
PubMed:beta-Carboline alkaloids as matrices for UV-matrix-assisted laser desorption/ionization time-of-flight mass spectrometry in positive and negative ion modes. Analysis of proteins of high molecular mass, and of cyclic and acyclic oligosaccharides. |
PubMed:Genotoxic effects of structurally related beta-carboline alkaloids. |
PubMed:Behavioural effects of Passiflora incarnata L. and its indole alkaloid and flavonoid derivatives and maltol in the mouse. |
PubMed:Simple beta-carboline alkaloids as nucleic acids fluorochromes. |
PubMed:[Radioprotective effect of gamma-harmine and its carboline analogues]. |
PubMed:Inhibition of platelet aggregation and arachidonic acid metabolism by B-carboline alkaloids. |
PubMed:The cation receptor subsite of the choline transporter in preimplantation mouse conceptuses resembles a cation receptor subsite of several amino acid transporters. |
PubMed:Effect of harmalol on blood pressure in anaesthetized rats. |
PubMed:Antioxidative properties of harmane and beta-carboline alkaloids. |
PubMed:Fluorescence of harmol, harmalol and 2-hydroxycarbazole in concentrated hydroxide solutions. |
PubMed:Synthesis and characterization of novel biologically active platinum(II) and palladium(II) complexes of some beta-carboline alkaloids. |
PubMed:Inhibition of calcium channels by harmaline and other harmala alkaloids in vascular and intestinal smooth muscles. |
PubMed:Mutagenicities of nitrosated carboline derivatives. |
PubMed:Interaction of carbolines and some GABA receptor ligands with the GABA and the benzodiazepine receptors. |
PubMed:Food-borne amines and amides as potential precursors of endogenous carcinogens. |
PubMed:Effects of betacarbolines on the automaticity of the guinea pig sinus node. |
PubMed:Ionization processes of some harmala alkaloids. |
PubMed:Rat brain aryl acylamidase: further characterization of multiple forms. |
PubMed:Competitive inhibition of sodium-dependent high affinity choline uptake by harmala alkaloids. |
PubMed:The effect of harmaline and related harmala alkaloids on ouabain-stimulated contractions of the guinea-pig ileum. |
PubMed:The effect of harmaline and related beta-carbolines on the acetylcholine-stimulated contractions of guinea-pig ileum. |
PubMed:Affinity of beta-carbolines on rat brain benzodiazepine and opiate binding sites. |
PubMed:Cardiovascular actions of three harmala alkaloids: harmine, harmaline, and harmalol. |
PubMed:The inhibitory effect of reserpine on the active sodium transport across the frog bladder. |
PubMed:UDP glucuronyltransferase and phenolsulfotransferase in vivo and in vitro. Conjugation of harmol and harmalol. |
PubMed:Glucuronidation of 3-O-methylnoradrenaline, harmalol and some related compounds. |
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