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tyrosinase
copper-containing enzyme that catalyzes the hydrolysis of tyrosine

Supplier Sponsors

CAS Number: 9002-10-2
Other(deleted CASRN):126806-17-5
ECHA EC Number:232-653-4
FDA UNII: G2UX40NTG9
MDL:MFCD00082118
Category:cosmetic ingredient for skin conditioning
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
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Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: skin conditioning
 
Suppliers:
Glentham Life Sciences
Tyrosinase, from mushroom
Sigma-Aldrich: Sigma
For experimental / research use only.
Tyrosinase from mushroom lyophilized powder, ≥1000 unit/mg solid
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
cosmetic ingredient for skin conditioning
Recommendation for tyrosinase usage levels up to:
 not for fragrance use.
 
Recommendation for tyrosinase flavor usage levels up to:
 not for flavor use.
 
Safety References:
ClinicalTrials.gov:search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA Substance Registry Services (TSCA):9002-10-2
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
Chemidplus:0009002102
 
References:
Pubchem (sid):135323978
 
Other Information:
HMDB (The Human Metabolome Database):Search
Wikipedia:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 not found in nature
 
Synonyms:
 copper-containing enzyme that catalyzes the hydrolysis of tyrosine
 

Articles:

PubMed:Whitening and anti-wrinkle activities of ferulic acid isolated from Tetragonia tetragonioides in B16F10 melanoma and CCD-986sk fibroblast cells.
PubMed:Inhibition of NAT10 Suppresses Melanogenesis and Melanoma Growth by Attenuating Microphthalmia-Associated Transcription Factor (MITF) Expression.
PubMed:Inhibition of tyrosinase by cherimoya pericarp proanthocyanidins: Structural characterization, inhibitory activity and mechanism.
PubMed:Oil-in-water emulsions stabilized by tyrosinase-crosslinked potato protein.
PubMed:Quercetin as a tyrosinase inhibitor: Inhibitory activity, conformational change and mechanism.
PubMed:Anti-Melanogenic Effects of Flavonoid Glycosides from Limonium tetragonum (Thunb.) Bullock via Inhibition of Tyrosinase and Tyrosinase-Related Proteins.
PubMed:Electrochemical enzyme biosensors based on calcium phosphate materials for tyramine detection in food samples.
PubMed:Protocatechuic Acid from Pear Inhibits Melanogenesis in Melanoma Cells.
PubMed:Purification and Characterization of Latent Polyphenol Oxidase from Apricot (Prunus armeniaca L.).
PubMed:Biological effects and chemical characterization of Iris schachtii Markgr. extracts: A new source of bioactive constituents.
PubMed:Quinoxaline-, dopamine-, and amino acid-derived metabolites from the edible insect Protaetia brevitarsis seulensis.
PubMed:The integrated analysis of RNA-seq and microRNA-seq depicts miRNA-mRNA networks involved in Japanese flounder (Paralichthys olivaceus) albinism.
PubMed:Spectrum Effect Relationship and Component Knock-Out in Angelica Dahurica Radix by High Performance Liquid Chromatography-Q Exactive Hybrid Quadrupole-Orbitrap Mass Spectrometer.
PubMed:Gamma-Irradiated Luteolin Inhibits 3-Isobutyl-1-Methylxanthine-Induced Melanogenesis Through the Regulation of CREB/MITF, PI3K/Akt, and ERK Pathways in B16BL6 Melanoma Cells.
PubMed:Antimelanogenic Effect of Urolithin A and Urolithin B, the Colonic Metabolites of Ellagic Acid, in B16 Melanoma Cells.
PubMed:White grape pomace extracts, obtained by a sequential enzymatic plus ethanol-based extraction, exert antioxidant, anti-tyrosinase and anti-inflammatory activities.
PubMed:An inhibition mechanism of dihydromyricetin on tyrosinase and the joint effects of vitamins B6, D3 or E.
PubMed:Structure of Human Tyrosinase Related Protein 1 Reveals a Binuclear Zinc Active Site Important for Melanogenesis.
PubMed:Kinetics of Tyrosinase Inhibitory Activity Using Vitis vinifera Leaf Extracts.
PubMed:Young leaves of reed (Phragmites communis) suppress melanogenesis and oxidative stress in B16F10 melanoma cells.
PubMed:Chemical composition and biological studies of the essential oil from aerial parts of beta vulgaris subsp. maritima (L.) arcang. growing in Tunisia.
PubMed:Inhibitory effects of Stichopus japonicus extract on melanogenesis of mouse cells via ERK phosphorylation.
PubMed:Inhibitory effect of Gastrodia elata Blume extract on alpha-melanocyte stimulating hormone-induced melanogenesis in murine B16F10 melanoma.
PubMed:Melanin-gamma rays assistants for bismuth oxide nanoparticles synthesis at room temperature for enhancing antimicrobial, and photocatalytic activity.
PubMed:Carvacrol derivatives as mushroom tyrosinase inhibitors; synthesis, kinetics mechanism and molecular docking studies.
PubMed:Novel inhibitors of tyrosinase produced by the 4-substitution of TCT (П).
PubMed:Inhibition on cholinesterase and tyrosinase by alkaloids and phenolics from Aristotelia chilensis leaves.
PubMed:Boosting LPMO-driven lignocellulose degradation by polyphenol oxidase-activated lignin building blocks.
PubMed:Tyrosinase inhibitory mechanism of betulinic acid from Dillenia indica.
PubMed:Mechanistic insights into tyrosinase-mediated crosslinking of soy glycinin derived peptides.
PubMed:Tyrosinase inhibitory activity, molecular docking studies and antioxidant potential of chemotypes of Lippia origanoides (Verbenaceae) essential oils.
PubMed:Effects of matsutake mushroom scent compounds on tyrosinase and murine B16-F10 melanoma cells.
PubMed:Structuring colloidal oat and faba bean protein particles via enzymatic modification.
PubMed:Chemical constituents, radical scavenging activity and enzyme inhibitory capacity of fruits from Cotoneaster pannosus Franch.
PubMed:Inhibition of melanogenesis by jineol from Scolopendra subspinipes mutilans via MAP-Kinase mediated MITF downregulation and the proteasomal degradation of tyrosinase.
PubMed:Combining in vitro, in vivo and in silico approaches to evaluate nutraceutical potentials and chemical fingerprints of Moltkia aurea and Moltkia coerulea.
PubMed:Spectrophotometric Characterization of the Action of Tyrosinase on p-Coumaric and Caffeic Acids: Characteristics of o-Caffeoquinone.
PubMed:Identification of conserved proteins from diverse shell matrix proteome in Crassostrea gigas: characterization of genetic bases regulating shell formation.
PubMed:Antioxidant capacity of phenolic compounds on human cell lines as affected by grape-tyrosinase and Botrytis-laccase oxidation.
PubMed:New caffeic acid derivative from Tithonia diversifolia (Hemsl.) A. Gray butanolic extract and its antioxidant activity.
PubMed:Bioactivities of Achillea phrygia and Bupleurum croceum based on the composition of phenolic compounds: In vitro and in silico approaches.
PubMed:Antioxidant and Anti-tyrosinase Activities of Phenolic Extracts from Rape Bee Pollen and Inhibitory Melanogenesis by cAMP/MITF/TYR Pathway in B16 Mouse Melanoma Cells.
PubMed:Traditionally Used Lathyrus Species: Phytochemical Composition, Antioxidant Activity, Enzyme Inhibitory Properties, Cytotoxic Effects, and in silico Studies of L. czeczottianus and L. nissolia.
PubMed:Screening of Peruvian Medicinal Plants for Tyrosinase Inhibitory Properties: Identification of Tyrosinase Inhibitors in Hypericum laricifolium Juss.
PubMed:Cosmeceutical Effects of Galactomannan Fraction from Arenga pinnata Fruits In vitro.
PubMed:Phenolic profile, antioxidant activity and enzyme inhibitory activities of extracts from aromatic plants used in Mediterranean diet.
PubMed:Allergenicity and Oral Tolerance of Enzymatic Cross-Linked Tropomyosin Evaluated Using Cell and Mouse Models.
PubMed:Shedding light on the biological and chemical fingerprints of three Achillea species (A. biebersteinii, A. millefolium and A. teretifolia).
PubMed:Garcinia subelliptica Merr. (Fukugi): A multipurpose coastal tree with promising medicinal properties.
PubMed:Anti-melasma codrug of retinoic acid assists cutaneous absorption with attenuated skin irritation.
PubMed:Proanthocyanidins purified from fruit pericarp of Clausena lansium (Lour.) Skeels as efficient tyrosinase inhibitors: structure evaluation, inhibitory activity and molecular mechanism.
PubMed:Antimelanogenic, Antioxidant and Antiproliferative Effects of Antrodia camphorata Fruiting Bodies on B16-F0 Melanoma Cells.
PubMed:Peptide Fractions Obtained from Rice By-Products by Means of an Environment-Friendly Process Show In Vitro Health-Related Bioactivities.
PubMed:Chemical composition and some biological activities of the essential oils from basil Ocimum different cultivars.
PubMed:Functional constituents of wild and cultivated Goji (L. barbarum L.) leaves: phytochemical characterization, biological profile, and computational studies.
PubMed:Peroxisome proliferator-activated receptor α (PPARα) contributes to control of melanogenesis in B16 F10 melanoma cells.
PubMed:Investigating the inhibitory activity and mechanism differences between norartocarpetin and luteolin for tyrosinase: A combinatory kinetic study and computational simulation analysis.
PubMed:Alisol B, a triterpene from Alismatis rhizoma (dried rhizome of Alisma orientale), inhibits melanin production in murine B16 melanoma cells.
PubMed:Characterization of glabridin/hydroxypropyl-β-cyclodextrin inclusion complex with robust solubility and enhanced bioactivity.
PubMed:Novel inhibitors of tyrosinase produced by the 4-substitution of TCT.
PubMed:Functional Properties of Novel Epigallocatechin Gallate Glucosides Synthesized by Using Dextransucrase from Leuconostoc mesenteroides B-1299CB4.
PubMed:Mechanism and kinetics of tyrosinase inhibition by glycolic acid: a study using conventional spectroscopy methods and hydrogen/deuterium exchange coupling with mass spectrometry.
PubMed:The inhibition effect of starch nanoparticles on tyrosinase activity and its mechanism.
PubMed:The depigmenting effect of natural resorcinol type polyphenols Kuwanon O and Sanggenon T from the roots of morus australis.
PubMed:Thyroid Hormones Regulate Zebrafish Melanogenesis in a Gender-Specific Manner.
PubMed:Anti-Melanogenic Activities of Heracleum moellendorffii via ERK1/2-Mediated MITF Downregulation.
PubMed:Molecular Cloning and Characteristic Features of a Novel Extracellular Tyrosinase from Aspergillus niger PA2.
PubMed:Chemical exploration of 4-(4-fluorobenzyl)piperidine fragment for the development of new tyrosinase inhibitors.
PubMed:Rice Bran Protein as a Potent Source of Antimelanogenic Peptides with Tyrosinase Inhibitory Activity.
PubMed:Bioactive and functional properties of sour cherry juice (Prunus cerasus).
PubMed:Multicomponent pattern and biological activities of seven Asphodeline taxa: potential sources of natural-functional ingredients for bioactive formulations.
PubMed:Biological evaluation of two Keggin-type polyoxometalates containing glycine as mushroom tyrosinase inhibitors.
PubMed:Tyrosinase inhibitory properties of phenylpropanoid glycosides and flavonoids from Teucrium polium L. var. gnaphalodes.
PubMed:The unravelling of the complex pattern of tyrosinase inhibition.
PubMed:Peroxidase can perform the hydroxylation step in the 'oxidative cascade' during oxidation of tea catechins.
PubMed:Jasmine rice panicle: A safe and efficient natural ingredient for skin aging treatments.
PubMed:Seasonal dynamics of the phytochemical constituents and bioactivities of extracts from Stenoloma chusanum (L.) Ching.
PubMed:Demethyleugenol β-Glucopyranoside Isolated from Agastache rugosa Decreases Melanin Synthesis via Down-regulation of MITF and SOX9.
PubMed:A Novel Heptapeptide with Tyrosinase Inhibitory Activity Identified from a Phage Display Library.
PubMed:Activity changes of antioxidant and detoxifying enzymes in Tenebrio molitor (Coleoptera: Tenebrionidae) larvae infected by the entomopathogenic nematode Heterorhabditis beicherriana (Rhabditida: Heterorhabditidae).
PubMed:Effect of Cd(2+) on tyrosinase: Integration of inhibition kinetics with computational simulation.
PubMed:Extract of Ganoderma formosanum Mycelium as a Highly Potent Tyrosinase Inhibitor.
PubMed:Characterization of a New Flavone and Tyrosinase Inhibition Constituents from the Twigs of Morus alba L.
PubMed:Large-Scale Recombinant Expression and Purification of Human Tyrosinase Suitable for Structural Studies.
PubMed:Effect of inhibition on tyrosinase and melanogenesis of Agastache rugosa Kuntze by lactic acid bacteria fermentation.
PubMed:Real-time monitoring of glucose and phenols intestinal absorption through an integrated Caco-2TC7cells/biosensors telemetric device: Hypoglycemic effect of fruit phytochemicals.
PubMed:Interaction of small molecules with human tyrosinase: A surface plasmon resonance and molecular docking study.
PubMed:Improved antioxidant and anti-tyrosinase activity of polysaccharide from Sargassum fusiforme by degradation.
PubMed:Chemical and biological insights on Cotoneaster integerrimus: A new (-)- epicatechin source for food and medicinal applications.
PubMed:A tandem mass spectrometry method based on selected ions detects low-abundance phenolics in black tea - theatridimensins as products of the oxidative cascade.
PubMed:Biofunctional Activities of Equisetum ramosissimum Extract: Protective Effects against Oxidation, Melanoma, and Melanogenesis.
PubMed:Comparative Depigmentation Effects of Resveratrol and Its Two Methyl Analogues in α-Melanocyte Stimulating Hormone-Triggered B16/F10 Murine Melanoma Cells.
PubMed:Annotation of Different Dehydrocatechin Oligomers by MS/MS and Their Occurrence in Black Tea.
PubMed:Green tea extract as an anti-browning agent for cloudy apple juice.
PubMed:Phenolic compounds and biological effects of edible Rumex scutatus and Pseudosempervivum sempervivum: potential sources of natural agents with health benefits.
PubMed:Antimelanogenesis Activity of Hydrolyzed Ginseng Extract (GINST) via Inhibition of JNK Mitogen-activated Protein Kinase in B16F10 Cells.
PubMed:Non-specific binding sites help to explain mixed inhibition in mushroom tyrosinase activities.
PubMed:Reactions of Flavonoids with o-Quinones Interfere with the Spectrophotometric Assay of Tyrosinase Activity.
PubMed:Effect of Okinawa Propolis on PAK1 Activity, Caenorhabditis elegans Longevity, Melanogenesis, and Growth of Cancer Cells.
PubMed:Response Characteristics of Bisphenols on a Metal-Organic Framework-Based Tyrosinase Nanosensor.
PubMed:Effect of drying on the bioactive compounds, antioxidant, antibacterial and antityrosinase activities of pomegranate peel.
PubMed:Mesoporous carbon-containing voltammetric biosensor for determination of tyramine in food products.
PubMed:Design and synthesis of novel hydroxypyridinone derivatives as potential tyrosinase inhibitors.
PubMed:A naphthoquinone/SAM-mediated biosensor for olive oil polyphenol content.
PubMed:Glutathione as a skin whitening agent: Facts, myths, evidence and controversies.
PubMed:Physiological Activities of Thiacremonone Produced in High Temperature and High Pressure Treated Garlic.
PubMed:Inhibitory Kinetics of Azachalcones and their Oximes on Mushroom Tyrosinase: A Facile Solid-state Synthesis.
PubMed:Emodin isolated from Polygoni Multiflori Ramulus inhibits melanogenesis through the liver X receptor-mediated pathway.
PubMed:Recombinant Tyrosinase from Polyporus arcularius: Overproduction in Escherichia coli, Characterization, and Use in a Study of Aurones as Tyrosinase Effectors.
PubMed:Oligoesculin fraction induces anti-tumor effects and promotes immune responses on B16-F10 mice melanoma.
PubMed:Assessment of the sensitizing capacity and allergenicity of enzymatic cross-linked arginine kinase, the crab allergen.
PubMed:Physiological properties of Scomber japonicus meat hydrolysate prepared by subcritical water hydrolysis.
PubMed:Crystal structure of recombinant tyrosinase-binding protein MtaL at 1.35 Å resolution.
PubMed:Cinnamomum cassia essential oil and its major constituent cinnamaldehyde induced cell cycle arrest and apoptosis in human oral squamous cell carcinoma HSC-3 cells.
PubMed:Biodegradation of phenolic compounds by Basidiomycota and its phenol oxidases: A review.
PubMed:Molecular mechanisms of flavonoids in melanin synthesis and the potential for the prevention and treatment of melanoma.
PubMed:4-Hydroxy cinnamic acid as mushroom preservation: Anti-tyrosinase activity kinetics and application.
PubMed:Effect of the mixtures of squid ink tyrosinase and tannic acid on properties of sardine surimi gel.
PubMed:Dermatologic evaluation of cosmetic formulations containing Chrysanthemum indicum extract.
PubMed:Aspergillus niger PA2: a novel strain for extracellular biotransformation of L-tyrosine into L-DOPA.
PubMed:The albinism of the feral Asinara white donkeys (Equus asinus) is determined by a missense mutation in a highly conserved position of the tyrosinase (TYR) gene deduced protein.
PubMed:Whitening Effect of Watersoluble Royal Jelly from South Korea.
PubMed:One-pot green synthesis of 1,3,5-triarylpentane-1,5-dione and triarylmethane derivatives as a new class of tyrosinase inhibitors.
PubMed:Surface display of glycosylated Tyrosinase related protein-2 (TRP-2) tumour antigen on Lactococcus lactis.
PubMed:Antioxidant, Anti-Tyrosinase and Anti-Inflammatory Activities of Oil Production Residues from Camellia tenuifloria.
PubMed:Melanosis in Penaeus monodon: Involvement of the Laccase-like Activity of Hemocyanin.
PubMed:Anthocyanin contents in the seed coat of black soya bean and their anti-human tyrosinase activity and antioxidative activity.
PubMed:Optimisation and Characterisation of Lipase-Catalysed Synthesis of a Kojic Monooleate Ester in a Solvent-Free System by Response Surface Methodology.
PubMed:Effect-directed analysis of fresh and dried elderberry (Sambucus nigra L.) via hyphenated planar chromatography.
PubMed:Preparation of tyrosinase inhibitors and antibrowning agents using green technology.
PubMed:Inhibitory effects of Na7PMo11CuO40 on mushroom tyrosinase and melanin formation and its antimicrobial activities.
PubMed:N-Nicotinoyl dopamine inhibits skin pigmentation by suppressing of melanosome transfer.
PubMed:Altering the phenolics profile of a green tea leaves extract using exogenous oxidases.
PubMed:Quercetin-3-O-β-d-glucopyranosyl-(1 → 6)-β-d-glucopyranoside suppresses melanin synthesis by augmenting p38 MAPK and CREB signaling pathways and subsequent cAMP down-regulation in murine melanoma cells.
PubMed:Extraction conditions of white rose petals for the inhibition of enzymes related to skin aging.
PubMed:Antimicrobial, antioxidant and anti-tyrosinase properties of extracts of the Mediterranean parasitic plant Cytinus hypocistis.
PubMed:Tyrosinase-based biosensor for determination of bisphenol A in a flow-batch system.
PubMed:In vitro efficacy of Bryophyllum pinnatum leaf extracts as potent therapeutics.
PubMed:Proton pump inhibitors decrease melanogenesis in melanocytes.
PubMed:Influence of Laccase and Tyrosinase on the Antioxidant Capacity of Selected Phenolic Compounds on Human Cell Lines.
PubMed:Identification of tyrosinase specific inhibitors from Xanthium strumarium fruit extract using ultrafiltration-high performance liquid chromatography.
PubMed:Comparative studies on the chemical and enzymatic stability of alpha- and beta-arbutin.
PubMed:Dioscin Derived from Solanum melongena L. "Usukawamarunasu" Attenuates α-MSH-Induced Melanogenesis in B16 Murine Melanoma Cells via Downregulation of Phospho-CREB and MITF.
PubMed:Depigmenting Effect of Winter Medicinal Mushroom Flammulna velutipes (Higher Basidiomycetes) on Melanoma Cells.
PubMed:Seasonal Variations of Metabolome and Tyrosinase Inhibitory Activity of Lespedeza maximowiczii during Growth Periods.
PubMed:Evaluation of the Antioxidant Activities and Tyrosinase Inhibitory Property from Mycelium Culture Extracts.
PubMed:Design, synthesis and biological evaluation of hydroxy substituted amino chalcone compounds for antityrosinase activity in B16 cells.
PubMed:Structure-Activity Relationship Study of Hydroxycoumarins and Mushroom Tyrosinase.
PubMed:Avocado Proanthocyanidins as a Source of Tyrosinase Inhibitors: Structure Characterization, Inhibitory Activity, and Mechanism.
PubMed:Inhibitory effect of brazilein on tyrosinase and melanin synthesis: Kinetics and in silico approach.
PubMed:Functionalities of conjugated compounds of γ-aminobutyric acid with salicylaldehyde or cinnamaldehyde.
PubMed:Inhibitory effect of synthetic aromatic heterocycle thiosemicarbazone derivatives on mushroom tyrosinase: Insights from fluorescence, (1)H NMR titration and molecular docking studies.
PubMed:Cornus officinalis Methanol Extract Upregulates Melanogenesis in Melan-a Cells.
PubMed:Inhibitory effect of apocarotenoids on the activity of tyrosinase: Multi-spectroscopic and docking studies.
PubMed:Evaluation of antioxidant, enzyme inhibition, and cytotoxic activity of three anthraquinones (alizarin, purpurin, and quinizarin).
PubMed:Dietary flavonoid aglycones and their glycosides: Which show better biological significance?
PubMed:Tyrosinase-Catalyzed Hydroxylation of 4-Hexylresorcinol, an Antibrowning and Depigmenting Agent: A Kinetic Study.
PubMed:Two Ganoderma species: profiling of phenolic compounds by HPLC-DAD, antioxidant, antimicrobial and inhibitory activities on key enzymes linked to diabetes mellitus, Alzheimer's disease and skin disorders.
PubMed:Development of tyrosinase biosensor based on quantum dots/chitosan nanocomposite for detection of phenolic compounds.
PubMed:Antioxidant properties of fermented mango leaf extracts.
PubMed:N-Nicotinoyl tyramine, a novel niacinamide derivative, inhibits melanogenesis by suppressing MITF gene expression.
PubMed:Melanogenesis inhibitory activity of Korean Undaria pinnatifida in mouse B16 melanoma cells.
PubMed:Structure-function correlations in tyrosinases.
PubMed:Plant betalains: Chemistry and biochemistry.
PubMed:Discovery of Potent Cysteine-Containing Dipeptide Inhibitors against Tyrosinase: A Comprehensive Investigation of 20 × 20 Dipeptides in Inhibiting Dopachrome Formation.
PubMed:Inhibitory effects of α-Na8SiW11CoO40 on tyrosinase and its application in controlling browning of fresh-cut apples.
PubMed:Sesamol decreases melanin biosynthesis in melanocyte cells and zebrafish: Possible involvement of MITF via the intracellular cAMP and p38/JNK signalling pathways.
PubMed:Phenolic Compounds from the Leaves of Stewartia pseudocamellia Maxim. and their Whitening Activities.
PubMed:Cellular Anti-Melanogenic Effects of a Euryale ferox Seed Extract Ethyl Acetate Fraction via the Lysosomal Degradation Machinery.
PubMed:The pro-enzyme C-terminal processing domain of Pholiota nameko tyrosinase is responsible for folding of the N-terminal catalytic domain.
PubMed:Melanogenesis-inducing effect of cirsimaritin through increases in microphthalmia-associated transcription factor and tyrosinase expression.
PubMed:α-Glucosidase and tyrosinase inhibitory effects of an abietane type diterpenoid taxoquinone from Metasequoia glyptostroboides.
PubMed:Chemical composition and biological activities of essential oil of Beilschmiedia pulverulenta.
PubMed:Betalain induction by l-DOPA application confers photoprotection to saline-exposed leaves of Disphyma australe.
PubMed:Biofunctional properties of enzymatic squid meat hydrolysate.
PubMed:Polyphenoloxidase from Riesling and Dornfelder wine grapes (Vitis vinifera) is a tyrosinase.
PubMed:Effect of Light Wavelengths and Coherence on Growth, Enzymes Activity, and Melanin Accumulation of Liquid-Cultured Inonotus obliquus (Ach.:Pers.) Pilát.
PubMed:Hesperetin induces melanin production in adult human epidermal melanocytes.
PubMed:Cloning and identification of a novel tyrosinase and its overexpression in Streptomyces kathirae SC-1 for enhancing melanin production.
PubMed:Effect of the tyrosinase inhibitor (S)-N-trans-feruloyloctopamine from garlic skin on tyrosinase gene expression and melanine accumulation in melanoma cells.
PubMed:Discrimination between alternative substrates and inhibitors of tyrosinase.
PubMed:Activities of different types of Thai honey on pathogenic bacteria causing skin diseases, tyrosinase enzyme and generating free radicals.
PubMed:Preparation, characterization, and preliminary antibrowning evaluations of norartocarpetin microemulsions.
PubMed:Hair dyes resorcinol and lawsone reduce production of melanin in melanoma cells by tyrosinase activity inhibition and decreasing tyrosinase and microphthalmia-associated transcription factor (MITF) expression.
PubMed:Antioxidant and ACE Inhibitory Activity of Cultivated and Wild Angelica gigas Nakai Extracts Prepared Using Different Extraction Conditions.
PubMed:Functionality study of Na6PMo11FeO40 as a mushroom tyrosinase inhibitor.
PubMed:Preparation of squid skin collagen hydrolysate as an antihyaluronidase, antityrosinase, and antioxidant agent.
PubMed:A simple and sensitive fluorescent sensor for methyl parathion based on L-tyrosine methyl ester functionalized carbon dots.
PubMed:Ultrasonic-assisted enzymatic extraction of silymarin from the Silybum marianum seed shell and evaluation of its antioxidant activity in vitro.
PubMed:Alpha-substituted derivatives of cinnamaldehyde as tyrosinase inhibitors: inhibitory mechanism and molecular analysis.
PubMed:Functional graphene-gold nano-composite fabricated electrochemical biosensor for direct and rapid detection of bisphenol A.
PubMed:3D metal-organic framework as highly efficient biosensing platform for ultrasensitive and rapid detection of bisphenol A.
PubMed:Inhibition effects of benzylideneacetone, benzylacetone, and 4-phenyl-2-butanol on the activity of mushroom tyrosinase.
PubMed:Survey of phytochemical composition and biological effects of three extracts from a wild plant (Cotoneaster nummularia Fisch. et Mey.): a potential source for functional food ingredients and drug formulations.
PubMed:Screening of inhibitors for mushroom tyrosinase using surface plasmon resonance.
PubMed:Differentiation-inducing and anti-proliferative activities of lupeol on canine melanoma cells.
PubMed:New tyrosinase inhibitors from Paecilomyces gunnii.
PubMed:Ginsenoside F1 attenuates hyperpigmentation in B16F10 melanoma cells by inducing dendrite retraction and activating Rho signalling.
PubMed:Whitening Effect of Octaphlorethol A Isolated from Ishige foliacea in an In Vivo Zebrafish Model.
PubMed:A tyrosinase inhibitor from Aspergillus niger.
PubMed:Vitis amurensis Ruprecht root inhibited α-melanocyte stimulating hormone-induced melanogenesis in B16F10 cells.
PubMed:Performance of an active paper based on cinnamon essential oil in mushrooms quality.
PubMed:Microbial ketonization of ginsenosides F1 and C-K by Lactobacillus brevis.
PubMed:Fermented broth in tyrosinase- and melanogenesis inhibition.
PubMed:Anti-tyrosinase, antioxidant, and antibacterial activities of novel 5-hydroxy-4-acetyl-2,3-dihydronaphtho[1,2-b]furans.
PubMed:Technical note: Advantages and limitations of authenticating Palmera goat dairy products by pyrosequencing the melanocortin 1 receptor (MC1R) gene.
PubMed:A potent antibrowning agent from pine needles of Cedrus deodara: 2R,3R-dihydromyricetin.
PubMed:Formulation and characterisation of wheat bran oil-in-water nanoemulsions.
PubMed:Synthesis and biological evaluation of glucosyl curcuminoids.
PubMed:Characterization and storage stability of the extract of Thai mango (Mangifera indica Linn. Cultivar Chok-Anan) seed kernels.
PubMed:Determination of tyrosinase substrate-binding modes reveals mechanistic differences between type-3 copper proteins.
PubMed:Comparison of in vitro and in vivo phototoxicity tests with S-(-)-10,11-dihydroxyfarnesic acid methyl ester produced by Beauveria bassiana KACC46831.
PubMed:Chemical profile and antiacetylcholinesterase, antityrosinase, antioxidant and α-glucosidase inhibitory activity of Cynometra cauliflora L. leaves.
PubMed:S-(-)-10,11-dihydroxyfarnesoic acid methyl ester inhibits melanin synthesis in murine melanocyte cells.
PubMed:Optimization of Phenolics Extracted from Idesia polycarpa Defatted Fruit Residue and Its Antioxidant and Depigmenting Activity In Vitro and In Vivo.
PubMed:Compositional studies and biological activities of some mash bean (Vigna mungo (L.) Hepper) cultivars commonly consumed in Pakistan.
PubMed:Inhibitory effects of ginseng seed on melanin biosynthesis.
PubMed:Bioactive profiles, antioxidant activities, nitrite scavenging capacities and protective effects on H2O2-injured PC12 cells of Glycyrrhiza glabra L. leaf and root extracts.
PubMed:Structure characterization and anti-tyrosinase mechanism of polymeric proanthocyanidins fractionated from kiwifruit pericarp.
PubMed:Inhibitory effect of morin on tyrosinase: insights from spectroscopic and molecular docking studies.
PubMed:High-level production of melanin by a novel isolate of Streptomyces kathirae.
PubMed:Biological activity and molecular docking studies of curcumin-related α,β-unsaturated carbonyl-based synthetic compounds as anticancer agents and mushroom tyrosinase inhibitors.
PubMed:Microbial tyrosinases: promising enzymes for pharmaceutical, food bioprocessing, and environmental industry.
PubMed:Characterization of antiproliferative activity constituents from Artocarpus heterophyllus.
PubMed:A rational workflow for sequential virtual screening of chemical libraries on searching for new tyrosinase inhibitors.
PubMed:Investigation of binding-site homology between mushroom and bacterial tyrosinases by using aurones as effectors.
PubMed:A premature stop codon in the TYRP1 gene is associated with brown coat colour in the European rabbit (Oryctolagus cuniculus).
PubMed:Effect of atmospheric pressure dielectric barrier discharge plasma on the biological activity of naringin.
PubMed:Effect of Vetiveria zizanioides essential oil on melanogenesis in melanoma cells: downregulation of tyrosinase expression and suppression of oxidative stress.
PubMed:The melanogenesis alteration effects of Achillea millefolium L. essential oil and linalyl acetate: involvement of oxidative stress and the JNK and ERK signaling pathways in melanoma cells.
PubMed:In vitro biological evaluation of 100 selected methanol extracts from the traditional medicinal plants of Asia.
PubMed:The crystal structure of a crustacean prophenoloxidase provides a clue to understanding the functionality of the type 3 copper proteins.
PubMed:Evaluation of the antioxidant and melanogenesis inhibitory properties of pracparatum mungo (lu-do huang).
PubMed:An aqueous extract of Limoniastrum guyonianum gall induces anti-tumor effects in melanoma-injected mice via modulation of the immune response.
PubMed:Sensitive bi-enzymatic biosensor based on polyphenoloxidases-gold nanoparticles-chitosan hybrid film-graphene doped carbon paste electrode for carbamates detection.
PubMed:Betulinic acid isolated from Vitis amurensis root inhibits 3-isobutyl-1-methylxanthine induced melanogenesis via the regulation of MEK/ERK and PI3K/Akt pathways in B16F10 cells.
PubMed:Advances in structure-function relationships of tyrosinase from Agaricus bisporus - investigation on heat-induced conformational changes.
PubMed:Hepatoprotective effects and antioxidant, antityrosinase activities of phloretin and phloretin isonicotinyl hydrazone.
PubMed:Inhibitory effect of corn silk on skin pigmentation.
PubMed:Bioelectronic tongue based on lipidic nanostructured layers containing phenol oxidases and lutetium bisphthalocyanine for the analysis of grapes.
PubMed:Structure characterization of proanthocyanidins from Caryota ochlandra Hance and their bioactivities.
PubMed:Physiological effects of formulation containing tannase-converted green tea extract on skin care: physical stability, collagenase, elastase, and tyrosinase activities.
PubMed:Effects of Danshensu and Salvianolic Acid B from Salvia miltiorrhiza Bunge (Lamiaceae) on cell proliferation and collagen and melanin production.
PubMed:Using transcription of six Puccinia triticina races to identify the effective secretome during infection of wheat.
PubMed:Evaluation of crocin and curcumin affinity on mushroom tyrosinase using surface plasmon resonance.
PubMed:pH-induced structural changes of tyrosinase from Agaricus bisporus using fluorescence and in silico methods.
PubMed:Stabilization of food dispersions by enzymes.
PubMed:Hydroalcoholic extract of Rhodiola rosea L. (Crassulaceae) and its hydrolysate inhibit melanogenesis in B16F0 cells by regulating the CREB/MITF/tyrosinase pathway.
PubMed:Isophilippinolide A arrests cell cycle progression and induces apoptosis for anticancer inhibitory agents in human melanoma cells.
PubMed:Mushroom tyrosinase inhibition activity of Aloe vera L. gel from different germplasms.
PubMed:Potato and mushroom polyphenol oxidase activities are differently modulated by natural plant extracts.
PubMed:Antioxidant and tyrosinase inhibitory activities of flavonoids from Trifolium nigrescens Subsp. petrisavi.
PubMed:Antioxidant, antityrosinase, anticholinesterase, and nitric oxide inhibition activities of three malaysian macaranga species.
PubMed:Structural analysis of proanthocyanidins isolated from fruit stone of Chinese hawthorn with potent antityrosinase and antioxidant activity.
PubMed:Tyrosinase inhibitory effect and antioxidative activities of fermented and ethanol extracts of Rhodiola rosea and Lonicera japonica.
PubMed:Chemical composition and tyrosinase inhibitory activity of Cinnamomum cassia essential oil.
PubMed:Purification of a fucoidan from kelp polysaccharide and its inhibitory kinetics for tyrosinase.
PubMed:Applications of Lactobacillus rhamnosus spent culture supernatant in cosmetic antioxidation, whitening and moisture retention applications.
PubMed:Hesperidin Suppresses Melanosome Transport by Blocking the Interaction of Rab27A-Melanophilin.
PubMed:A chiral ligand exchange CE system for monitoring inhibitory effect of kojic acid on tyrosinase.
PubMed:Synthesis, characterization and biological evaluation of paeonol thiosemicarbazone analogues as mushroom tyrosinase inhibitors.
PubMed:Sensitizing potential of enzymatically cross-linked peanut proteins in a mouse model of peanut allergy.
PubMed:The antibrowning agent sulfite inactivates Agaricus bisporus tyrosinase through covalent modification of the copper-B site.
PubMed:Poly-γ-glutamate from Bacillus subtilis inhibits tyrosinase activity and melanogenesis.
PubMed:The mechanism of copper uptake by tyrosinase from Bacillus megaterium.
PubMed:Cinnamomum cassia essential oil inhibits α-MSH-induced melanin production and oxidative stress in murine B16 melanoma cells.
PubMed:Antimelanoma and antityrosinase from Alpinia galangal constituents.
PubMed:Tocotrienols enhance melanosome degradation through endosome docking/fusion proteins in B16F10 melanoma cells.
PubMed:Tyrosinase inhibitory effects and antioxidative activities of saponins from Xanthoceras Sorbifolia nutshell.
PubMed:Inhibitory kinetics of chlorocinnamic acids on mushroom tyrosinase.
PubMed:Inhibitory effects of Cyrtomium fortunei J. Smith root extract on melanogenesis.
PubMed:Antioxidant, antibrowning, and cytoprotective activities of Ligustrum robustum (Rxob.) Blume extract.
PubMed:Physicochemical and biofunctional properties of crab chitosan nanoparticles.
PubMed:Analysis of tyrosinase binders from Glycyrrhiza uralensis root: evaluation and comparison of tyrosinase immobilized magnetic fishing-HPLC and reverse ultrafiltration-HPLC.
PubMed:Octaphlorethol A isolated from Ishige foliacea inhibits α-MSH-stimulated induced melanogenesis via ERK pathway in B16F10 melanoma cells.
PubMed:Immobilized capillary tyrosinase microreactor for inhibitor screening in natural extracts by capillary electrophoresis.
PubMed:Design and synthesis of hydroxypyridinone-L-phenylalanine conjugates as potential tyrosinase inhibitors.
PubMed:Dihydroasparagusic acid: antioxidant and tyrosinase inhibitory activities and improved synthesis.
PubMed:Enzyme inhibitory and antioxidant activities of Viburnum tinus L. relevant to its neuroprotective potential.
PubMed:Hordenine, a single compound produced during barley germination, inhibits melanogenesis in human melanocytes.
PubMed:Phytochemical contents and enzyme inhibitory and antioxidant properties of Anethum graveolens L. (dill) samples cultivated under organic and conventional agricultural conditions.
PubMed:Novel chemical synthesis of ginkgolic acid (13:0) and evaluation of its tyrosinase inhibitory activity.
PubMed:Protective effect of topical application of α-tocopherol and/or N-acetyl cysteine on argemone oil/alkaloid-induced skin tumorigenesis in mice.
PubMed:Bioactive polyphenols from muscadine grape and blackcurrant stably concentrated onto protein-rich matrices for topical applications.
PubMed:Tyrosinase inhibitors from Calceolaria integrifolia s.l.: Calceolaria talcana aerial parts.
PubMed:Inhibitory effects of Korean indigenous plants on tyrosinase and melanogenesis.
PubMed:Inhibitory mechanism of red globe amaranth on tyrosinase.
PubMed:Inhibitory effects of water extract of Flos Inulae on mutation and tyrosinase.
PubMed:Effective inhibition of skin cancer, tyrosinase, and antioxidative properties by astaxanthin and astaxanthin esters from the green alga Haematococcus pluvialis.
PubMed:Agaricus bisporus and related Agaricus species on lignocellulose: production of manganese peroxidase and multicopper oxidases.
PubMed:Total polyphenols and bioactivity of seeds and sprouts in several legumes.
PubMed:Thermal inactivation kinetics of Rabdosia serra (Maxim.) Hara leaf peroxidase and polyphenol oxidase and comparative evaluation of drying methods on leaf phenolic profile and bioactivities.
PubMed:Molecular inhibitory mechanism of tricin on tyrosinase.
PubMed:Inhibitory effects of propyl gallate on tyrosinase and its application in controlling pericarp browning of harvested longan fruits.
PubMed:Decolorization and biodegradation of reactive sulfonated azo dyes by a newly isolated Brevibacterium sp. strain VN-15.
PubMed:Biofunctional constituents from Liriodendron tulipifera with antioxidants and anti-melanogenic properties.
PubMed:Mechanism of silver nanoparticles action on insect pigmentation reveals intervention of copper homeostasis.
PubMed:Influencing the monophenolase/diphenolase activity ratio in tyrosinase.
PubMed:Biofabricated film with enzymatic and redox-capacitor functionalities to harvest and store electrons.
PubMed:Separation of the antioxidant compound quercitrin from Lindera obtusiloba Blume and its antimelanogenic effect on B16F10 melanoma cells.
PubMed:Inhibitory effects of geranic acid derivatives on melanin biosynthesis.
PubMed:Characterization of tyrosinase inhibitors in the twigs of Cudrania tricuspidata and their structure-activity relationship study.
PubMed:Protein cluster formation during enzymatic cross-linking of globular proteins.
PubMed:Influence of ultrasound to the activity of tyrosinase.
PubMed:Effective cooperation of monoclonal antibody and peptide vaccine for the treatment of mouse melanoma.
PubMed:Crude ethanol extracts from grape seeds and peels exhibit anti-tyrosinase activity.
PubMed:Fermenting red ginseng enhances its safety and efficacy as a novel skin care anti-aging ingredient: in vitro and animal study.
PubMed:Identification of a novel phenolic compound in litchi (Litchi chinensis Sonn.) pericarp and bioactivity evaluation.
PubMed:Dioscin: a synergistic tyrosinase inhibitor from the roots of Smilax china.
PubMed:Synthesis and structure-activity relationships and effects of phenylpropanoid amides of octopamine and dopamine on tyrosinase inhibition and antioxidation.
PubMed:Tyrosinase inhibitory effects and antioxidative activities of novel cinnamoyl amides with amino acid ester moiety.
PubMed:Artemisinic acid inhibits melanogenesis through downregulation of C/EBP α-dependent expression of HMG-CoA reductase gene.
PubMed:Kinetic study on the tyrosinase and melanin formation inhibitory activities of carthamus yellow isolated from Carthamus tinctorius L.
PubMed:The evaluation of depigmenting efficacy in the skin for the development of new whitening agents in Korea.
PubMed:Dual inhibition of γ-oryzanol on cellular melanogenesis: inhibition of tyrosinase activity and reduction of melanogenic gene expression by a protein kinase A-dependent mechanism.
PubMed:Synthesis of 4'-thiosemicarbazonegriseofulvin and its effects on the control of enzymatic browning and postharvest disease of fruits.
PubMed:Influence of polysaccharides and storage during processing on the properties of mango seed kernel extract (microencapsulation).
PubMed:Antioxidant and Antityrosinase Activity of Flemingia macrophylla and Glycine tomentella Roots.
PubMed:Biological evaluation of coumarin derivatives as mushroom tyrosinase inhibitors.
PubMed:Tyrosinase inhibitory components of immature calamondin peel.
PubMed:The functional property of egg yolk phosvitin as a melanogenesis inhibitor.
PubMed:Anti-inflammatory activities of an ethanol extract of Ecklonia stolonifera in lipopolysaccharide-stimulated RAW 264.7 murine macrophage cells.
PubMed:Enhancement of the tyrosinase inhibitory activity of Mori Cortex Radicis extract by biotransformation using Leuconostoc paramesenteroides PR.
PubMed:Inhibitory effects of water extract from longan twigs on mutation and nitric oxide production.
PubMed:Inhibition effects of mangosenone F from Garcinia mangostana on melanin formation in B16F10 cells.
PubMed:Tyrosinase inhibition constituents from the roots of Morus australis.
PubMed:Cell-type dependent response of melanoma cells to aloe emodin.
PubMed:Action of tyrosinase on ortho-substituted phenols: possible influence on browning and melanogenesis.
PubMed:Inhibitory effects of naphthols on the activity of mushroom tyrosinase.
PubMed:Changes in tyrosinase specificity by ionic liquids and sodium dodecyl sulfate.
PubMed:Nicotinic acid hydroxamate downregulated the melanin synthesis and tyrosinase activity through activating the MEK/ERK and AKT/GSK3β signaling pathways.
PubMed:NMR, HPLC-ESI-MS, and MALDI-TOF MS analysis of condensed tannins from Delonix regia (Bojer ex Hook.) Raf. and their bioactivities.
PubMed:Inhibition of enzymatic browning of chlorogenic acid by sulfur-containing compounds.
PubMed:Betalain production is possible in anthocyanin-producing plant species given the presence of DOPA-dioxygenase and L-DOPA.
PubMed:Expression of recombinant mature human tyrosinase from Escherichia coli and exhibition of its activity without phosphorylation or glycosylation.
PubMed:An ultrafiltration high-performance liquid chromatography coupled with diode array detector and mass spectrometry approach for screening and characterising tyrosinase inhibitors from mulberry leaves.
PubMed:Methyl cinnamate inhibits adipocyte differentiation via activation of the CaMKK2-AMPK pathway in 3T3-L1 preadipocytes.
PubMed:Bioactive compounds, antioxidant, xanthine oxidase inhibitory, tyrosinase inhibitory and anti-inflammatory activities of selected agro-industrial by-products.
PubMed:Melanogenesis of murine melanoma cells induced by hesperetin, a Citrus hydrolysate-derived flavonoid.
PubMed:Synthesis and antityrosinase mechanism of benzaldehyde thiosemicarbazones: novel tyrosinase inhibitors.
PubMed:New phenolic compounds hydrothermally extracted from the olive oil byproduct alperujo and their antioxidative activities.
PubMed:Momilactione B inhibits protein kinase A signaling and reduces tyrosinase-related proteins 1 and 2 expression in melanocytes.
PubMed:Plant-based Paste Fermented by Lactic Acid Bacteria and Yeast: Functional Analysis and Possibility of Application to Functional Foods.
PubMed:An optical test strip for the detection of benzoic acid in food.
PubMed:Comparative evaluation of rosmarinic acid, methyl rosmarinate and pedalitin isolated from Rabdosia serra (MAXIM.) HARA as inhibitors of tyrosinase and α-glucosidase.
PubMed:Isolation and bioactivities of a non-sericin component from cocoon shell silk sericin of the silkworm Bombyx mori.
PubMed:Enzymatic routes for the production of mono- and di-glucosylated derivatives of hydroxytyrosol.
PubMed:Anti-melanoma, tyrosinase inhibitory and anti-microbial activities of gold nanoparticles synthesized from aqueous leaf extracts of Teraxacum officinale.
PubMed:Solid-phase synthesis of mimosine tetrapeptides and their inhibitory activities on neuraminidase and tyrosinase.
PubMed:Mushroom tyrosinase inhibitors from mung bean (Vigna radiatae L.) extracts.
PubMed:Inhibitory potential of the leaves and berries of Myrtus communis L. (myrtle) against enzymes linked to neurodegenerative diseases and their antioxidant actions.
PubMed:Standardised herbal extract of chlorogenic acid from leaves of Etlingera elatior (Zingiberaceae).
PubMed:Antimelanogenic effect of c-phycocyanin through modulation of tyrosinase expression by upregulation of ERK and downregulation of p38 MAPK signaling pathways.
PubMed:Kojic acid-amino acid amide metal complexes and their melanogenesis inhibitory activities.
PubMed:Inhibitory effect of mulberroside A and its derivatives on melanogenesis induced by ultraviolet B irradiation.
PubMed:Comparative assessment of tea quality by various analytical and sensory methods with emphasis on tea polyphenols.
PubMed:Effects of thymol on mushroom tyrosinase-catalyzed melanin formation.
PubMed:Phenolic tyrosinase inhibitors from the stems of Cudrania cochinchinensis.
PubMed:Antioxidant, anti-inflammatory and anti-browning activities of hot water extracts of oriental herbal teas.
PubMed:Antioxidant and tyrosinase inhibitory constituents from a desugared sugar cane extract, a byproduct of sugar production.
PubMed:Effects of tyrosinase and laccase on oat proteins and quality parameters of gluten-free oat breads.
PubMed:In-vitro neuroprotective properties of the Maydis stigma extracts from four corn varieties.
PubMed:Antioxidant and antimelanogenic behaviors of Paeonia suffruticosa.
PubMed:Rapid screening of enzyme inhibitors using profiling of enzyme-metabolite assay by HPLC (PREMA-HPLC).
PubMed:Crystal structure of Agaricus bisporus mushroom tyrosinase: identity of the tetramer subunits and interaction with tropolone.
PubMed:Synthesis and antityrosinase activities of alkyl 3,4-dihydroxybenzoates.
PubMed:Isolation and tyrosinase inhibitory effects of polyphenols from the leaves of persimmon, Diospyros kaki.
PubMed:Antibrowning and antimicrobial activities of the water-soluble extract from pine needles of Cedrus deodara.
PubMed:Neonicotinoid insecticides: oxidative stress in planta and metallo-oxidase inhibition.
PubMed:Tyrosinase inhibition by water and ethanol extracts of a far eastern sea cucumber, Stichopus japonicus.
PubMed:Tetrahydrofolic Acid is a potent suicide substrate of mushroom tyrosinase.
PubMed:Melanin synthesis inhibitors from Balanophora fungosa.
PubMed:Benzyl benzoates: New phlorizin analogs as mushroom tyrosinase inhibitors.
PubMed:Protein analysis by 31p NMR spectroscopy in ionic liquid: quantitative determination of enzymatically created cross-links.
PubMed:C-terminal processing of tyrosinase is responsible for activation of Pholiota microspora proenzyme.
PubMed:Aggregation and homogenization, surface charge and structural change, and inactivation of mushroom tyrosinase in an aqueous system by subcritical/supercritical carbon dioxide.
PubMed:Interaction of sesamol (3,4-methylenedioxyphenol) with tyrosinase and its effect on melanin synthesis.
PubMed:Antioxidant and antityrosinase activity of mulberry (Morus alba L.) twigs and root bark.
PubMed:Irreversible competitive inhibitory kinetics of cardol triene on mushroom tyrosinase.
PubMed:Effect of protein structural integrity on cross-linking by tyrosinase evidenced by multidimensional heteronuclear magnetic resonance spectroscopy.
PubMed:Inhibition kinetics of chlorobenzaldehyde thiosemicarbazones on mushroom tyrosinase.
PubMed:First structures of an active bacterial tyrosinase reveal copper plasticity.
PubMed:Crystallization and preliminary X-ray crystallographic analysis of a bacterial tyrosinase from Bacillus megaterium.
PubMed:Isolation and identification of radical scavenging and tyrosinase inhibition of polyphenols from Tibouchina semidecandra L.
PubMed:Synthesis and structure-activity relationship study of deoxybenzoins on relaxing effects of porcine coronary artery.
PubMed:Antioxidant and antimelanogenic properties of chestnut flower extract.
PubMed:Enzymatic synthesis and characterization of hydroquinone galactoside using Kluyveromyces lactis lactase.
PubMed:Phenolic Antioxidants from the Leaves of Camellia pachyandra Hu.
PubMed:Anti-inflammatory, antioxidant, anti-tyrosinase and phenolic contents of four Podocarpus species used in traditional medicine in South Africa.
PubMed:Inhibitory effects of hinokitiol on tyrosinase activity and melanin biosynthesis and its antimicrobial activities.
PubMed:Growth-sensitive gold nanoshells precursor nanocomposites for the detection of L-DOPA and tyrosinase activity.
PubMed:Ecklonia cava extracts inhibit lipopolysaccharide induced inflammatory responses in human endothelial cells.
PubMed:Immobilization of tyrosinase in carboxylic and carbonyl group-modified MWNT electrode and its application for sensing phenolics in red wines.
PubMed:Tyrosinase inhibitory constituents from the roots of Morus nigra: a structure-activity relationship study.
PubMed:Inhibitory effect of diphlorethohydroxycarmalol on melanogenesis and its protective effect against UV-B radiation-induced cell damage.
PubMed:Digestibility and allergenicity assessment of enzymatically crosslinked beta-casein.
PubMed:Mushroom tyrosinase in polyelectrolyte multilayers as an optical biosensor for o-diphenols.
PubMed:Nanofibrous membrane based tyrosinase-biosensor for the detection of phenolic compounds.
PubMed:Inhibition of melanogensis by a novel origanoside from Origanum vulgare.
PubMed:Phenolic inhibitors of chemical and enzymatic oxidation in the leaves of Myrica rubra.
PubMed:Acetylcholinesterase, butyrylcholinesterase, and tyrosinase inhibition studies and antioxidant activities of 33 Scutellaria L. taxa from Turkey.
PubMed:Picolyl alkyl amines as novel tyrosinase inhibitors: influence of hydrophobicity and substitution.
PubMed:Isolation, cloning and characterization of a tyrosinase with improved activity in organic solvents from Bacillus megaterium.
PubMed:Protective effects of tea polysaccharides and polyphenols on skin.
PubMed:Optimization of antioxidant activity by response surface methodology in hydrolysates of jellyfish (Rhopilema esculentum) umbrella collagen.
PubMed:Effects of selected organo-sulfur compounds on melanin formation.
PubMed:Chemical components and tyrosinase inhibitors from the twigs of Artocarpus heterophyllus.
PubMed:Phloridzin-induced melanogenesis is mediated by the cAMP signaling pathway.
PubMed:Biosensors for phenolic compounds by immobilization of tyrosinase in photocurable methacrylic-acrylic membranes of varying hydrophilicities.
PubMed:Determination of an antioxidant capacity index by immobilized tyrosinase bioreactor.
PubMed:Characterization of the post-harvest changes in gene transcription in the gill of the Lentinula edodes fruiting body.
PubMed:Antityrosinase and antimicrobial activities of trans-cinnamaldehyde thiosemicarbazone.
PubMed:The tyrosinase-encoding gene of Lentinula edodes, Letyr, is abundantly expressed in the gills of the fruit-body during post-harvest preservation.
PubMed:Inhibitory effect of phlorotannins isolated from Ecklonia cava on mushroom tyrosinase activity and melanin formation in mouse B16F10 melanoma cells.
PubMed:Effect of ionizing radiation on the physiological activities of ethanol extract from hizikia fusiformis cooking drips.
PubMed:Inhibitory effects of methyl trans-cinnamate on mushroom tyrosinase and its antimicrobial activities.
PubMed:Fluorescence detection of tyrosinase activity on dopamine-betaxanthin purified from Portulaca oleracea (common purslane) flowers.
PubMed:Tyrosinase inhibitory polyphenols from roots of Morus lhou.
PubMed:Identification of an Alkylhydroquinone from Rhus succedanea as an Inhibitor of Tyrosinase and Melanogenesis.
PubMed:Phenolic antioxidants from green tea produced from Camellia crassicolumna Var. multiplex.
PubMed:Ecklonia cava ethanolic extracts inhibit lipopolysaccharide-induced cyclooxygenase-2 and inducible nitric oxide synthase expression in BV2 microglia via the MAP kinase and NF-kappaB pathways.
PubMed:Rosmarinic acid, a photo-protective agent against UV and other ionizing radiations.
PubMed:Comparative analysis of quercetin oxidation by electrochemical, enzymatic, autoxidation, and free radical generation techniques: a mechanistic study.
PubMed:A second proPO present in white shrimp Litopenaeus vannamei and expression of the proPOs during a Vibrio alginolyticus injection, molt stage, and oral sodium alginate ingestion.
PubMed:Chitosan-based tyrosinase optical phenol biosensor employing hybrid nafion/sol-gel silicate for MBTH immobilization.
PubMed:Design of a composite amperometric enzyme electrode for the control of the benzoic acid content in food.
PubMed:Effects of Gold Nanoparticles on the Response of Phenol Biosensor Containing Photocurable Membrane with Tyrosinase.
PubMed:A comparison of three amperometric phenoloxidase-Sonogel-Carbon based biosensors for determination of polyphenols in beers.
PubMed:Optimization of tyrosinase inhibition activity of ultrasonic-extracted polysaccharides from longan fruit pericarp.
PubMed:Isolation of tyrosinase inhibitors from Artocarpus heterophyllus and use of its extract as antibrowning agent.
PubMed:Phenolic antioxidants from green tea produced from Camellia taliensis.
PubMed:Antibrowning activity of MRPs in enzyme and fresh-cut apple slice models.
PubMed:Enzyme, protein, carbohydrate, and phenolic contaminants in commercial tyrosinase preparations: potential problems affecting tyrosinase activity and inhibition studies.
PubMed:The anti-melanogenic effect of pycnogenol by its anti-oxidative actions.
PubMed:Molecular and physical characteristics of squid (Todarodes pacificus) skin collagens and biological properties of their enzymatic hydrolysates.
PubMed:Inhibitory effects of cinnamic acid on melanin biosynthesis in skin.
PubMed:PPAR gamma regulates MITF and beta-catenin expression and promotes a differentiated phenotype in mouse melanoma S91.
PubMed:Formation of protein-oligosaccharide conjugates by laccase and tyrosinase.
PubMed:Inhibitory effects of kurarinol, kuraridinol, and trifolirhizin from Sophora flavescens on tyrosinase and melanin synthesis.
PubMed:Identification of geranic acid, a tyrosinase inhibitor in lemongrass (Cymbopogon citratus).
PubMed:A review on spectrophotometric methods for measuring the monophenolase and diphenolase activities of tyrosinase.
PubMed:Immobilised tyrosinase-based biosensor for the detection of tea polyphenols.
PubMed:Dual laccase-tyrosinase based Sonogel-Carbon biosensor for monitoring polyphenols in beers.
PubMed:A thioredoxin of Sinorhizobium meliloti CE52G is required for melanin production and symbiotic nitrogen fixation.
PubMed:Inhibition of the formation of the neurotoxin 5-S-cysteinyl-dopamine by polyphenols.
PubMed:Melanogenesis inhibition by an oolong tea extract in b16 mouse melanoma cells and UV-induced skin pigmentation in brownish guinea pigs.
PubMed:Tissue culture of some lichens and screening of their antioxidant, antityrosinase and antibacterial properties.
PubMed:Naturally occurring tyrosinase inhibitors: mechanism and applications in skin health, cosmetics and agriculture industries.
PubMed:Elucidating the mechanism of laccase and tyrosinase in wheat bread making.
PubMed:Establishment of high-resolution FISH mapping system and its application for molecular cytogenetic characterization of chromosomes in newt, Cynops pyrrhogaster (Urodela, Amphibia).
PubMed:Stereospecificity of mushroom tyrosinase immobilized on a chiral and a nonchiral support.
PubMed:Antioxidant activity, anti-inflammatory activity, and whitening effects of extracts of Elaeagnus multiflora Thunb.
PubMed:Enzymatic determination of BPA by means of tyrosinase immobilized on different carbon carriers.
PubMed:Antioxidant and antimelanogenic activities of polyamine conjugates from corn bran and related hydroxycinnamic acids.
PubMed:Oxyresveratrol as an antibrowning agent for cloudy apple juices and fresh-cut apples.
PubMed:Two potent suicide substrates of mushroom tyrosinase: 7,8,4'-trihydroxyisoflavone and 5,7,8,4'-tetrahydroxyisoflavone.
PubMed:Characterization of the activity of tyrosinase on betanidin.
PubMed:Tyrosinase-aided protein cross-linking: effects on gel formation of chicken breast myofibrils and texture and water-holding of chicken breast meat homogenate gels.
PubMed:Novel peptides with tyrosinase inhibitory activity.
PubMed:Identification and kinetic study of tyrosinase inhibitors found in sake lees.
PubMed:Free radical scavenging, anti-glycation and tyrosinase inhibition properties of a polysaccharide fraction isolated from the rind from Punica granatum.
PubMed:Evaluation of free radical scavenging and antityrosinase activities of standardized longan fruit extract.
PubMed:Synthesis, discovery and mechanism of 2,6-dimethoxy-N-(4-methoxyphenyl)benzamide as potent depigmenting agent in the skin.
PubMed:Biosensor measurements of polar phenolics for the assessment of the bitterness and pungency of virgin olive oil.
PubMed:Tyrosinase inhibitory activity of citrus essential oils.
PubMed:Isolation and Characterization of Strain MMB-1 (CECT 4803), a Novel Melanogenic Marine Bacterium.
PubMed:Hen egg white lysozyme as an inhibitor of mushroom tyrosinase.
PubMed:Inhibitory effects of cis- and trans-isomers of 3,5-dihydroxystilbene on the activity of mushroom tyrosinase.
PubMed:Flavonoids as mushroom tyrosinase inhibitors: a fluorescence quenching study.
PubMed:Fungal tyrosinases: new prospects in molecular characteristics, bioengineering and biotechnological applications.
PubMed:Characterization of the activity of tyrosinase on betaxanthins derived from (R)-amino acids.
PubMed:Remodeling of actin cytoskeleton in lupeol-induced B16 2F2 cell differentiation.
PubMed:Chemometric exploration of an amperometric biosensor array for fast determination of wastewater quality.
PubMed:Physiological activity of irradiated green tea polyphenol on the human skin.
PubMed:Isolation and identification of flavonoids in licorice and a study of their inhibitory effects on tyrosinase.
PubMed:Effects of mushroom tyrosinase on anisaldehyde.
PubMed:Iron and copper metabolism.
PubMed:Inhibition of enzyme activities and the antiwrinkle effect of polyphenol isolated from the persimmon leaf (Diospyros kaki folium) on human skin.
PubMed:Procyanidin trimers to pentamers fractionated from apple inhibit melanogenesis in B16 mouse melanoma cells.
PubMed:Tyrosinase inhibitors from natural and synthetic sources: structure, inhibition mechanism and perspective for the future.
PubMed:DPPH radical-scavenging compounds from dou-chi, a soybean fermented food.
PubMed:Mushroom tyrosinase: catalase activity, inhibition, and suicide inactivation.
PubMed:Characterization of a new tyrosinase from Pycnoporus species with high potential for food technological applications.
PubMed:Tyrosinase inhibitors isolated from the edible brown alga Ecklonia stolonifera.
PubMed:Effect of simultaneous administration of vitamin C, L-cysteine and vitamin E on the melanogenesis.
PubMed:Anticancer therapeutic potential of soy isoflavone, genistein.
PubMed:A sphingolipid and tyrosinase inhibitors from the fruiting body of Phellinus linteus.
PubMed:In vitro antioxidative effects and tyrosinase inhibitory activities of seven hydroxycinnamoyl derivatives in green coffee beans.
PubMed:Chalcones as potent tyrosinase inhibitors: the effect of hydroxyl positions and numbers.
PubMed:Maillard reaction and enzymatic browning affect the allergenicity of Pru av 1, the major allergen from cherry (Prunus avium).
PubMed:Enzymatic grafting of peptides from casein hydrolysate to chitosan. Potential for value-added byproducts from food-processing wastes.
PubMed:Constituents of the leaves of Peucedanum japonicum Thunb. and their biological activity.
PubMed:Inhibitory effect of 4-cyanobenzaldehyde and 4-cyanobenzoic acid on mushroom (Agaricus bisporus) tyrosinase.
PubMed:Biosensors for determination of total and natural antioxidant capacity of red and white wines: comparison with other spectrophotometric and fluorimetric methods.
PubMed:Kinetic study of the oxidation of quercetin by mushroom tyrosinase.
PubMed:Tyrosinase inhibitory activity of cucumber compounds: enzymes responsible for browning in cucumber.
PubMed:Tyrosinase inhibitor from black rice bran.
PubMed:Tyrosinase inhibition kinetics of anisic acid.
PubMed:Toxicity of melanin-free ink of Sepia officinalis to transformed cell lines: identification of the active factor as tyrosinase.
PubMed:Inhibitory effect of red koji extracts on mushroom tyrosinase.
PubMed:Enzyme-catalyzed gel formation of gelatin and chitosan: potential for in situ applications.
PubMed:Mushroom tyrosinase: recent prospects.
PubMed:Inhibition of diphenolase activity of tyrosinase by vitamin b(6) compounds.
PubMed:Inhibitory effects of (S)- and (R)-6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acids on tyrosinase activity.
PubMed:Glabrene and isoliquiritigenin as tyrosinase inhibitors from licorice roots.
PubMed:Tyrosinase inhibition: general and applied aspects.
PubMed:Biosensors designed for environmental and food quality control based on screen-printed graphite electrodes with different configurations.
PubMed:Kinetics of mushroom tyrosinase inhibition by quercetin.
PubMed:Diphenol activation of the monophenolase and diphenolase activities of field bean (Dolichos lablab) polyphenol oxidase.
PubMed:Tyrosinase inhibitors of Pulsatilla cernua root-derived materials.
PubMed:Two OPEEs (organic phase enzyme electrodes) used to check the percentage water content in hydrophobic foods and drugs.
PubMed:Oxidation of polyphenols in phytate-reduced high-tannin cereals: effect on different phenolic groups and on in vitro accessible iron.
PubMed:Mercaptan-capturing properties of mushrooms.
PubMed:Detection of Campylobacter jejuni in poultry samples using an enzyme-linked immunoassay coupled with an enzyme electrode.
PubMed:Competitive inhibition of mushroom tyrosinase by 4-substituted benzaldehydes.
PubMed:Oxidation of bisphenol A and related compounds.
PubMed:An optical biosensor employing tiron-immobilised polypyrrole films for estimating monophenolase activity in apple juice.
PubMed:Effects of wine phenolics and sorghum tannins on tyrosinase activity and growth of melanoma cells.
PubMed:Resveratrol and a novel tyrosinase in Carignan grape juice.
PubMed:Synthesis of the antioxidant hydroxytyrosol using tyrosinase as biocatalyst.
PubMed:Rapid detection of Salmonella typhimurium in chicken carcass wash water using an immunoelectrochemical method.
PubMed:Characterization of tyrosinase- and polyphenol esterase-catalyzed end products using selected phenolic substrates.
PubMed:Molecular design of antibrowning agents.
PubMed:Comparison among differential pulse voltammetry, amperometric biosensor, and HPLC/DAD analysis for polyphenol determination.
PubMed:Enzymatic assay for the determination of olive oil polyphenol content: assay conditions and validation of the method.
PubMed:Activation of a latent mushroom (Agaricus bisporus) tyrosinase isoform by sodium dodecyl sulfate (SDS). Kinetic properties of the SDS-activated isoform.
PubMed:Kinetic study of the activation process of a latent mushroom (Agaricus bisporus) tyrosinase by serine proteases.
PubMed:Kinetics of activation of latent mushroom (Agaricus bisporus) tyrosinase by benzyl alcohol.
PubMed:Kinetic study of the oxidation of gamma-L-glutaminyl-4-hydroxybenzene catalyzed by mushroom (Agaricus bisporus) tyrosinase.
PubMed:Slow-binding inhibition of mushroom (Agaricus bisporus) tyrosinase isoforms by tropolone.
PubMed:Tyrosinase inhibitory activity of the olive oil flavor compounds.
PubMed:Flavonols from saffron flower: tyrosinase inhibitory activity and inhibition mechanism.
PubMed:Characterization of tyrosinase from the cap flesh of portabella mushrooms.
PubMed:Effect of baking and freeze-drying on the direct and indirect mutagenicity of extracts from the edible mushroom Agaricus bisporus.
PubMed:N-acetyl-L-tyrosine (NAT) as a substrate for mushroom tyrosinase.
PubMed:Silk protein, sericin, inhibits lipid peroxidation and tyrosinase activity.
PubMed:Adjuvant therapy of malignant melanoma.
PubMed:Effect of maltol on the oxidation of DL-DOPA, dopamine, N-acetyldopamine (NADA), and norepinephrine by mushroom tyrosinase.
PubMed:Purification and properties of tyrosinase isozymes from the gill of Lentinus edodes fruiting body.
PubMed:Inhibition of polyphenol oxidase by copper-metallothionein from Aspergillus niger.
PubMed:Inhibition of rat, mouse, and human glutathione S-transferase by eugenol and its oxidation products.
PubMed:Effect of kojic acid on the oxidation of DL-DOPA, norepinephrine, and dopamine by mushroom tyrosinase.
PubMed:Contribution of phenolic and quinonoid structures in the mutagenicity of the edible mushroom Agaricus bisporus.
PubMed:Modulation by ascorbic acid of the cutaneous and hepatic biochemical effects induced by topically applied benzanthrone in mice.
PubMed:Liquid chromatographic separation of phenolic drugs using catalytic detection: comparison of an enzyme reactor and enzyme electrode.
PubMed:Effect of different isomers of dihydroxybenzoic acids (DBA) on the rate of DL-dopa oxidation by mushroom tyrosinase.
PubMed:Synergism exerted by 4-methyl catechol, catechol, and their respective quinones on the rate of DL-DOPA oxidation by mushroom tyrosinase.
PubMed:Inactivation of metalloenzymes by food constituents.
PubMed:Inactivation of metalloenzymes by lysinoalanine, phenylethylaminoalanine, alkali-treated food proteins, and sulfur amino acids.
PubMed:Stability of tryptophan during food processing and storage. 1. Comparative losses of tryptophan, lysine and methionine in different model systems.
PubMed:Inactivation of quercetin mutagenicity.
PubMed:Factors which facilitate inactivation of quercetin mutagenicity.
PubMed:Molecular basis of substrate and inhibitory specificity of tyrosinase: phenolic compounds.
PubMed:Functional significance of the crystal cells in the larva of Drosophila melanogaster.
PubMed:Oxidising enzymes: The relationship of oxygenase to tyrosinase.
 
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