EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

sphinganine
1,3-octadecanediol, 2-amino-, [R-(R*,S*)]-

Supplier Sponsors

CAS Number: 764-22-7Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:212-116-0
FDA UNII: YT0ZSD64HM
Nikkaji Web:J14.383I
MDL:MFCD07371371
XlogP3-AA:5.80 (est)
Molecular Weight:301.51423000
Formula:C18 H39 N O2
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:cosmetic ingredient for skin and hair conditioning
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
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Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Soluble in:
 water, 1.525 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: hair conditioning
skin conditioning
 
Suppliers:
BOC Sciences
For experimental / research use only.
D-erythro-Dihydrosphingosine 95%
Carbosynth
For experimental / research use only.
Sphinganine
Sigma-Aldrich: Sigma
For experimental / research use only.
D-erythro-Dihydrosphingosine ≥98%
sds
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
cosmetic ingredient for skin and hair conditioning
Recommendation for sphinganine usage levels up to:
 not for fragrance use.
 
Recommendation for sphinganine flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
ClinicalTrials.gov:search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :91486
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
(2S,3R)-2-aminooctadecane-1,3-diol
Chemidplus:0000764227
 
References:
 (2S,3R)-2-aminooctadecane-1,3-diol
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):91486
Pubchem (sid):135048893
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEBI:View
CHEMBL:View
Golm Metabolome Database:Search
KEGG (GenomeNet):C00836
HMDB (The Human Metabolome Database):HMDB00269
FooDB:FDB021924
ChemSpider:View
Wikipedia:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 not found in nature
 
Synonyms:
(2S,3R)-2-aminooctadecane-1,3-diol
 dihydro-C18-sphingosine
D-erythro-2-amino-1,3-octadecanediol
1,3-octadecanediol, 2-amino-, [R-(R*,S*)]-
 

Articles:

PubMed:Identification of Signaling Pathways Targeted by the Food Contaminant FB1: Transcriptome and Kinome Analysis of Samples from Pig Liver and Intestine.
PubMed:Role of mycotoxins in the pathobiology of autism: A first evidence.
PubMed:Evaluation of Efficacy and Toxicity of Exfoliated Silicate Nanoclays as a Feed Additive for Fumonisin Detoxification.
PubMed:Oral administration of fumonisin B1 and T-2 individually and in combination affects hepatic total and mitochondrial membrane lipid profile of rabbits.
PubMed:An LC/MS/MS method for the simultaneous determination of individual sphingolipid species in B cells.
PubMed:Gastrointestinal Degradation of Fumonisin B₁ by Carboxylesterase FumD Prevents Fumonisin Induced Alteration of Sphingolipid Metabolism in Turkey and Swine.
PubMed:Elevated nuclear sphingoid base-1-phosphates and decreased histone deacetylase activity after fumonisin B1 treatment in mouse embryonic fibroblasts.
PubMed:Fumonisins affect the intestinal microbial homeostasis in broiler chickens, predisposing to necrotic enteritis.
PubMed:Evidence for fumonisin inhibition of ceramide synthase in humans consuming maize-based foods and living in high exposure communities in Guatemala.
PubMed:Dose-dependent effects on sphingoid bases and cytokines in chickens fed diets prepared with fusarium verticillioides culture material containing fumonisins.
PubMed:A blood spot method for detecting fumonisin-induced changes in putative sphingolipid biomarkers in LM/Bc mice and humans.
PubMed:Efficacy of AdiDetox™ in reducing the toxicity of fumonisin B1 in rats.
PubMed:Effects of orally administered fumonisin B₁ (FB₁), partially hydrolysed FB₁, hydrolysed FB₁ and N-(1-deoxy-D-fructos-1-yl) FB₁ on the sphingolipid metabolism in rats.
PubMed:A metabonomic analysis of the effect of quercetin on toxicity induced by chronic exposure to low-level dichlorvos in rat plasma.
PubMed:Metabonomic analysis of the joint toxic action of long-term low-level exposure to a mixture of four organophosphate pesticides in rat plasma.
PubMed:Toxic c17-sphinganine analogue mycotoxin, contaminating tunisian mussels, causes flaccid paralysis in rodents.
PubMed:Mycotoxins: occurrence, toxicology, and exposure assessment.
PubMed:Characterization of the yeast actin patch protein App1p phosphatidate phosphatase.
PubMed:Study of the chemical reduction of the fumonisins toxicity using allyl, benzyl and phenyl isothiocyanate in model solution and in food products.
PubMed:Determination of sphingoid bases from hydrolyzed glucosylceramide in rice and wheat by online post-column high-performance liquid chromatography with O-phthalaldehyde derivatization.
PubMed:Metabolomic analysis of rat plasma following chronic low-dose exposure to dichlorvos.
PubMed:Increased sphingoid base-1-phosphates and failure of neural tube closure after exposure to fumonisin or FTY720.
PubMed:Alkaline cooking (nixtamalisation) and the reduction in the in vivo toxicity of fumonisin-contaminated corn in a rat feeding bioassay.
PubMed:Royal jelly increases collagen production in rat skin after ovariectomy.
PubMed:Evaluation of pathological effects in broilers during fumonisins and clays exposure.
PubMed:Efficacy of a mycotoxin binder against dietary fumonisin, deoxynivalenol, and zearalenone in rats.
PubMed:Sphinganine and sphingosine levels and ratio in urine and blood samples from a Catalonian population, Spain.
PubMed:Induction of apoptosis by sphingosine, sphinganine, and C(2)-ceramide in human colon cancer cells, but not by C(2)-dihydroceramide.
PubMed:Evaluation of fumonisin biomarkers in a cross-sectional study with two high-risk populations in China.
PubMed:Individual fumonisin exposure and sphingoid base levels in rural populations consuming maize in South Africa.
PubMed:Characterization of the human LPIN1-encoded phosphatidate phosphatase isoforms.
PubMed:Sphingoid base levels in humans consuming fumonisin-contaminated maize in rural areas of the former Transkei, South Africa: a cross-sectional study.
PubMed:Maternal fumonisin exposure as a risk factor for neural tube defects.
PubMed:High-throughput analysis of sphingosine 1-phosphate, sphinganine 1-phosphate, and lysophosphatidic acid in plasma samples by liquid chromatography-tandem mass spectrometry.
PubMed:Genomic analysis of Fusarium verticillioides.
PubMed:Fumonisin concentrations and in vivo toxicity of nixtamalized Fusarium verticillioides culture material: evidence for fumonisin-matrix interactions.
PubMed:Subchronic mycotoxicoses in rats. Histopathological changes and modulation of the sphinganine to sphingosine (Sa/So) ratio imbalance induced by Fusarium verticillioides culture material, due to the coexistence of aflatoxin B1 in the diet.
PubMed:Validation of fumonisin biomarkers in F344 rats.
PubMed:Biomarkers of exposure to fumonisin mycotoxins: a review.
PubMed:Fumonisin concentration and ceramide synthase inhibitory activity of corn, masa, and tortilla chips.
PubMed:Sphinganine causes early activation of JNK and p38 MAPK and inhibition of AKT activation in HT-29 human colon cancer cells.
PubMed:Exposure to fumonisins and the occurrence of neural tube defects along the Texas-Mexico border.
PubMed:Mechanism of action of sphingolipids and their metabolites in the toxicity of fumonisin B1.
PubMed:Activated carbon does not prevent the toxicity of culture material containing fumonisin B1 when fed to weanling piglets.
PubMed:Recent advances on the use of adsorbent materials for detoxification of Fusarium mycotoxins.
PubMed:Development of a liquid chromatography/tandem mass spectrometry method for the quantification of fumonisin B1, B2 and B3 in cornflakes.
PubMed:Endotoxin exposure alters brain and liver effects of fumonisin B1 in BALB/c mice: implication of blood brain barrier.
PubMed:Fumonisin B-glucose reaction products are less toxic when fed to swine.
PubMed:Myriocin prevents fumonisin B1-induced sphingoid base accumulation in mice liver without ameliorating hepatotoxicity.
PubMed:Comparison of urinary sphingolipids in human populations with high and low maize consumption as a possible biomarker of fumonisin dietary exposure.
PubMed:Glucose reaction with fumonisin B1 partially reduces its toxicity in swine.
PubMed:Efflux of sphingoid bases by P-glycoprotein in human intestinal Caco-2 cells.
PubMed:Inhibition of sphingolipid biosynthesis decreases phosphorylated ERK2 in LLC-PK1 cells.
PubMed:Prevention of fumonisin-induced maternal and developmental toxicity in rats by certain plant extracts.
PubMed:Toxicity of maize containing known levels of fumonisin B1 during force-feeding of ducks.
PubMed:Efficacy of a commercial mycotoxin binder in alleviating effects of ochratoxin A, fumonisin B1, moniliformin and zearalenone in adult mink.
PubMed:Fumonisins disrupt sphingolipid metabolism, folate transport, and neural tube development in embryo culture and in vivo: a potential risk factor for human neural tube defects among populations consuming fumonisin-contaminated maize.
PubMed:Total fumonisins are reduced in tortillas using the traditional nixtamalization method of mayan communities.
PubMed:[Survey on the fumonisins intake and the urinary Sa/So ratio of people suffered from a high incidence of esophageal cancer].
PubMed:Comparison of the toxicity of several fumonisin derivatives in a 28-day feeding study with female B6C3F(1) mice.
PubMed:Host resistance to Trypanosoma cruzi infection is enhanced in mice fed Fusarium verticillioides (=F. moniliforme) culture material containing fumonisins.
PubMed:Sphingoid bases and ceramide induce apoptosis in HT-29 and HCT-116 human colon cancer cells.
PubMed:Toxicology and carcinogenesis studies of fumonisin B1 (cas no. 116355-83-0) in F344/N rats and B6C3F1 mice (feed studies).
PubMed:DNA damage in human fibroblasts exposed to fumonisin B(1).
PubMed:Sphingolipids as biomarkers of fumonisin exposure and risk of esophageal squamous cell carcinoma in china.
PubMed:Fumonisin B(1) induces apoptosis in LLC-PK(1) renal epithelial cells via a sphinganine- and calmodulin-dependent pathway.
PubMed:A cross-sectional study of human serum sphingolipids, diet and physiologic parameters.
PubMed:The induction and persistence of altered sphingolipid biosynthesis in rats treated with fumonisin B1.
PubMed:Instability of N-acetylated fumonisin B1 (FA1) and the impact on inhibition of ceramide synthase in rat liver slices.
PubMed:Reaction of fumonisin with glucose prevents promotion of hepatocarcinogenesis in female F344/N rats while maintaining normal hepatic sphinganine/sphingosine ratios.
PubMed:Toxicity of culture material of Fusarium verticillioides strain MRC 826 to nonhuman primates.
PubMed:Ineffectiveness of activated carbon in reducing the alteration of sphingolipid metabolism in rats exposed to fumonisin-contaminated diets.
PubMed:The effect of a single gavage dose of fumonisin B(2) on the sphinganine and sphingosine concentrations in vervet monkeys.
PubMed:Determination of sphinganine, sphingosine and Sa/So ratio in urine of humans exposed to dietary fumonisin B1.
PubMed:Tissue sphinganine as a biomarker of fumonisin-induced apoptosis.
PubMed:A mechanistic approach to modelling the risk of liver tumours in mice exposed to fumonisin B1 in the diet.
PubMed:Molecular dynamics simulations on the mycotoxin fumonisin B1.
PubMed:Disruption of sphingolipid metabolism in small intestines, liver and kidney of mice dosed subcutaneously with fumonisin B(1).
PubMed:Sequence of cardiovascular changes leading to pulmonary edema in swine fed culture material containing fumonisin.
PubMed:Epigenetic properties of fumonisin B(1): cell cycle arrest and DNA base modification in C6 glioma cells.
PubMed:Modulation of programmed cell death by medicinal plants.
PubMed:Sphinganine/sphingosine ratio in plasma and urine as a possible biomarker for fumonisin exposure in humans in rural areas of Africa.
PubMed:Fumonisin contamination of food: progress in development of biomarkers to better assess human health risks.
PubMed:Fumonisin B1 induces apoptosis in cultured human keratinocytes through sphinganine accumulation and ceramide depletion.
PubMed:Effects of fumonisin B1-contaminated feeds on weanling angora goats.
PubMed:Characterization of cell-cycle arrest by fumonisin B1 in CV-1 cells.
PubMed:Effects of fumonisin B1 in pregnant rats. Part 2.
PubMed:Extraction, quantification, and biological availability of fumonisin B1 incorporated into the Oregon test diet and fed to rainbow trout.
PubMed:Inhibition of sphingolipid biosynthesis in rat primary hepatocyte cultures by fumonisin B1 and other structurally related compounds.
PubMed:Effects of fumonisin B1 in pregnant rats.
PubMed:Induction of apoptosis by fumonisin B1 in HT29 cells is mediated by the accumulation of endogenous free sphingoid bases.
PubMed:Lack of embryotoxicity of fumonisin B1 in New Zealand white rabbits.
PubMed:Effect of fumonisin B1 on the levels and fatty acid composition of selected lipids in rat liver in vivo.
PubMed:Fumonisins - Importance and occurence of a new group of mycotoxins.
PubMed:Disruption of sphingolipid metabolism in non-human primates consuming diets of fumonisin-containing Fusarium moniliforme culture material.
PubMed:Fumonisins and Alternaria alternata lycopersici toxins: sphinganine analog mycotoxins induce apoptosis in monkey kidney cells.
PubMed:Effect of fumonisin B1 on protein and lipid synthesis in primary rat hepatocytes.
PubMed:Regulation of phosphatidate phosphatase activity from the yeast Saccharomyces cerevisiae by phospholipids.
PubMed:Development of a new method for the analysis of sphinganine and sphingosine in urine and tissues.
PubMed:Response of growing swine to dietary exposure to pure fumonisin B1 during an eight-week period: growth and clinical parameters.
PubMed:Studies on the reproductive effects of Fusarium moniliforme culture material in rats and the biodistribution of [14C] fumonisin B1 in pregnant rats.
PubMed:Subchronic toxic effects of Fusarium moniliforme and fumonisin B1 in rats and mice.
PubMed:Determination of hydrolysed fumonisin B1 (HFB1) in corn by competitive direct enzyme-linked immunosorbent assay.
PubMed:Chronic toxicity of fumonisins from Fusarium moniliforme culture material (M-1325) to mink.
PubMed:Fumonisin B1 alters sphingolipid metabolism and disrupts the barrier function of endothelial cells in culture.
PubMed:Regulation of lipid biosynthesis in Saccharomyces cerevisiae by fumonisin B1.
PubMed:Subchronic toxicity of fumonisin B1 to male and female rats.
PubMed:Pilot study on the plasma pharmacokinetics of fumonisin B1 in cows following a single dose by oral gavage or intravenous administration.
PubMed:Individual and combined effects of feeding Fusarium moniliforme culture material, containing known levels of fumonisin B1, and aflatoxin B1 in the young turkey poult.
PubMed:Regulation of phosphatidate phosphatase activity from the yeast Saccharomyces cerevisiae by sphingoid bases.
PubMed:Fumonisins--mycotoxins produced by Fusarium moniliforme.
PubMed:Increases in serum sphingosine and sphinganine and decreases in complex sphingolipids in ponies given feed containing fumonisins, mycotoxins produced by Fusarium moniliforme.
PubMed:Phytosphingosine is a characteristic component of the glycolipids in the vertebrate intestine.
 
Notes:
Sphinganine is a blocker postlysosomal cholesterol transport by inhibition of low-density lipoprotein-induced esterification of cholesterol and cause unesterified cholesterol to accumulate in perinuclear vesicles. It has been suggested the possibility that endogenous sphinganine may inhibit cholesterol transport in Niemann-Pick Type C (NPC) disease. (PMID 1817037) [HMDB]
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