EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

sialyllactose
N-acetylneuraminoyllactose

Supplier Sponsors

CAS Number: 35890-38-1Picture of molecule3D/inchi
Other(deleted CASRN):10012-84-7
FDA UNII: 3J7TAL60G3
Nikkaji Web:J603.805K
Beilstein Number:0075357
MDL:MFCD00166999
XlogP3-AA:-7.50 (est)
Molecular Weight:633.55563000
Formula:C23 H39 N O19
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:cosmetic ingredient for skin conditioning
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
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Google Scholar: with word "odor"Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Soluble in:
 water, 1e+006 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: skin conditioning
 
Suppliers:
BOC Sciences
For experimental / research use only.
3'-SIALYLLACTOSE
Sigma-Aldrich: Sigma
For experimental / research use only.
3'-Sialyllactose from bovine milk or colostrum, ≥97% (HPLC)
sds
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
cosmetic ingredient for skin conditioning
Recommendation for sialyllactose usage levels up to:
 not for fragrance use.
 
Recommendation for sialyllactose flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA Substance Registry Services (TSCA):35890-38-1
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :123914
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
Chemidplus:0035890381
 
References:
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):123914
Pubchem (sid):135078951
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
HMDB (The Human Metabolome Database):HMDB00825
FooDB:FDB021795
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
Wikipedia:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 found in nature
 
Synonyms:
N-acetylneuraminoyllactose
D-glucose, O-(N-acetyl-alpha-neuraminosyl)-(2-3)-O-beta-D-galactopyranosyl-(1-4)-
3-sialyllactose
 

Articles:

PubMed:3'-Sialyllactose protects against osteoarthritic development by facilitating cartilage homeostasis.
PubMed:Human milk oligosaccharide consumption by probiotic and human-associated bifidobacteria and lactobacilli.
PubMed:Production of human milk oligosaccharides by enzymatic and whole-cell microbial biotransformations.
PubMed:Dietary Human Milk Oligosaccharides but Not Prebiotic Oligosaccharides Increase Circulating Natural Killer Cell and Mesenteric Lymph Node Memory T Cell Populations in Noninfected and Rotavirus-Infected Neonatal Piglets.
PubMed:Growth and Morbidity of Gambian Infants are Influenced by Maternal Milk Oligosaccharides and Infant Gut Microbiota.
PubMed:Fucosyllactose and L-fucose utilization of infant Bifidobacterium longum and Bifidobacterium kashiwanohense.
PubMed:Cell-Free Spent Media Obtained from Bifidobacterium bifidum and Bifidobacterium crudilactis Grown in Media Supplemented with 3'-Sialyllactose Modulate Virulence Gene Expression in Escherichia coli O157:H7 and Salmonella Typhimurium.
PubMed:Structures of the Streptococcus sanguinis SrpA Binding Region with Human Sialoglycans Suggest Features of the Physiological Ligand.
PubMed:Porcine Milk Oligosaccharides and Sialic Acid Concentrations Vary Throughout Lactation.
PubMed:Characterization of porcine milk oligosaccharides during early lactation and their relation to the fecal microbiome.
PubMed:It All Starts with a Sandwich: Identification of Sialidases with Trans-Glycosylation Activity.
PubMed:Temporal Change of the Content of 10 Oligosaccharides in the Milk of Chinese Urban Mothers.
PubMed:NMR analysis on the sialic acid-binding mechanism of an R-type lectin mutant by natural evolution-mimicry.
PubMed:Galactooligosaccharide and Sialyllactose Content in Commercial Lactose Powders from Goat and Cow Milk.
PubMed:Gut microbiota analysis reveals a marked shift to bifidobacteria by a starter infant formula containing a synbiotic of bovine milk-derived oligosaccharides and Bifidobacterium animalis subsp. lactis CNCM I-3446.
PubMed:Oligosaccharides in Urine, Blood, and Feces of Piglets Fed Milk Replacer Containing Galacto-oligosaccharides.
PubMed:Short communication: Quantification of carbohydrates in whey permeate products using high-performance anion-exchange chromatography with pulsed amperometric detection.
PubMed:Comparative transcriptomics reveals key differences in the response to milk oligosaccharides of infant gut-associated bifidobacteria.
PubMed:Chemical characterization of milk oligosaccharides of the eastern quoll (Dasyurus viverrinus).
PubMed:Attenuation of food allergy symptoms following treatment with human milk oligosaccharides in a mouse model.
PubMed:Comparison of milk oligosaccharides pattern in colostrum of different horse breeds.
PubMed:In vitro impact of human milk oligosaccharides on Enterobacteriaceae growth.
PubMed:4-O-Acetyl-sialic acid (Neu4,5Ac2) in acidic milk oligosaccharides of the platypus (Ornithorhynchus anatinus) and its evolutionary significance.
PubMed:Growth and safety evaluation of infant formulae containing oligosaccharides derived from bovine milk: a randomized, double-blind, noninferiority trial.
PubMed:Functional role and mechanisms of sialyllactose and other sialylated milk oligosaccharides.
PubMed:Can an ancestral condition for milk oligosaccharides be determined? Evidence from the Tasmanian echidna (Tachyglossus aculeatus setosus).
PubMed:Select human milk oligosaccharides directly modulate peripheral blood mononuclear cells isolated from 10-d-old pigs.
PubMed:Exposure of Bifidobacterium longum subsp. infantis to Milk Oligosaccharides Increases Adhesion to Epithelial Cells and Induces a Substantial Transcriptional Response.
PubMed:Neutral and acidic milk oligosaccharides of the striped skunk (Mephitidae: Mephitis mephitis).
PubMed:In vitro fermentation characteristics of select nondigestible oligosaccharides by infant fecal inocula.
PubMed:Methodologies for screening of bacteria-carbohydrate interactions: anti-adhesive milk oligosaccharides as a case study.
PubMed:Biotechnological production of human milk oligosaccharides.
PubMed:Quantification of bovine milk oligosaccharides using liquid chromatography-selected reaction monitoring-mass spectrometry.
PubMed:Chemical characterization of the oligosaccharides in Bactrian camel (Camelus bactrianus) milk and colostrum.
PubMed:Neutral and acidic oligosaccharides in Holstein-Friesian colostrum during the first 3 days of lactation measured by high performance liquid chromatography on a microfluidic chip and time-of-flight mass spectrometry.
PubMed:Permeate from cheese whey ultrafiltration is a source of milk oligosaccharides.
PubMed:Determination of sialyl and neutral oligosaccharide levels in transition and mature milks of Samoan women, using anthranilic derivatization followed by reverse phase high performance liquid chromatography.
PubMed:Genetic engineering of Escherichia coli for the economical production of sialylated oligosaccharides.
PubMed:Sialyl oligosaccharides of human colostrum: changes in concentration during the first three days of lactation.
PubMed:Sialyloligosaccharides in human and bovine milk and in infant formulas: variations with the progression of lactation.
PubMed:Inhibition of Helicobacter pylori adhesion to human gastric mucus by a high-molecular-weight constituent of cranberry juice.
 
Notes:
Sialyllactose is an oligossaccharide found in both human breast milk and cow's milk. It is the predominant sialylated component in milk. Sialyllactose has recently been shown to inhibit the infection of HIV-1 virus. Sialyllactose is also responsible for the inhibitory activity of milk on cholera toxin. [HMDB]
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