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propagermanium
3,3'-(1,3-dioxo-1,3-digermoxanediyl)dipropionic acid; 3,3'-(dioxodigermoxanylene) dipropanoic acid; germanate(2-), bis(2-carboxylatoethyl)trioxodi-, dihydrogen

Supplier Sponsors

Name:3-[[2-carboxyethyl(oxo)germyl]oxy-oxogermyl]propanoic acid
CAS Number: 12758-40-6Picture of molecule3D/inchi
Other(deleted CASRN):122402-75-9
ECHA EINECS - REACH Pre-Reg:235-800-0
FDA UNII: 1Q2P9TO9Q7
Nikkaji Web:J92.671J
Beilstein Number:4141883
MDL:MFCD00049319
Molecular Weight:339.40010000
Formula:C6 H10 Ge2 O7
NMR Predictor:Predict (works with chrome, Edge or firefox)
CAS Number: 126595-07-1Picture of molecule3D/inchi
FDA UNII: Search
Category:cosmetic ingredient for skin conditioning
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Soluble in:
 water, 1.09E+04 mg/L @ 20 °C (exp)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: skin conditioning
 
Suppliers:
BOC Sciences
For experimental / research use only.
Propagermanium 98%
Odor: characteristic
Use: Propagermanium is an organometallic compound of germanium that is sold as an alternative medicine for the treatment of Hepatitis B under the development of Astellas Pharma and Sanwa Kagaku Kenkyusho. Hepatitis B
Glentham Life Sciences
Bis(2-carboxyethylgermanium(IV) sesquioxide)
Sigma-Aldrich: Aldrich
For experimental / research use only.
Bis(2-carboxyethylgermanium(IV) sesquioxide) 99%
sds
TCI AMERICA
For experimental / research use only.
Bis[2-carboxyethylgermanium(IV)] Sesquioxide >98.0%(T)
sds
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-dog LD > 4000 mg/kg
GASTROINTESTINAL: NAUSEA OR VOMITING GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
Kiso to Rinsho. Clinical Report. Vol. 24, Pg. 19, 1990.

intraperitoneal-mouse LD50 1250 mg/kg
SKIN AND APPENDAGES (SKIN): HAIR: OTHER BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Kiso to Rinsho. Clinical Report. Vol. 24, Pg. 5, 1990.

intravenous-mouse LD50 > 200 mg/kg
Drugs in Japan Vol. -, Pg. 1195, 1995.

oral-mouse LD50 5600 mg/kg
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
Kiso to Rinsho. Clinical Report. Vol. 24, Pg. 5, 1990.

intraperitoneal-rat LD50 1670 mg/kg
GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE
Kiso to Rinsho. Clinical Report. Vol. 24, Pg. 5, 1990.

intravenous-rat LD50 > 200 mg/kg
Drugs in Japan Vol. -, Pg. 1195, 1995.

oral-rat LD50 7050 mg/kg
GASTROINTESTINAL: OTHER CHANGES GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Kiso to Rinsho. Clinical Report. Vol. 24, Pg. 5, 1990.

Dermal Toxicity:
subcutaneous-mouse LD50 > 4000 mg/kg
Drugs in Japan Vol. -, Pg. 1195, 1995.

subcutaneous-rat LD50 > 4000 mg/kg
SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"
Kiso to Rinsho. Clinical Report. Vol. 24, Pg. 5, 1990.

Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
cosmetic ingredient for skin conditioning
Recommendation for propagermanium usage levels up to:
 not for fragrance use.
 
Recommendation for propagermanium flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
Chemical Carcinogenesis Research Information System:Search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA Substance Registry Services (TSCA):12758-40-6
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :83030
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:2
3-[[2-carboxyethyl(oxo)germyl]oxy-oxogermyl]propanoic acid
Chemidplus:0012758406
RTECS:UA2459750 for cas# 12758-40-6
 
References:
 3-[[2-carboxyethyl(oxo)germyl]oxy-oxogermyl]propanoic acid
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):83030
Pubchem (sid):135041190
Pubchem (cas):126595-07-1
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEBI:View
KEGG (GenomeNet):C13086
HMDB (The Human Metabolome Database):Search
Export Tariff Code:2931.90.9050
ChemSpider:View
Wikipedia:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 not found in nature
 
Synonyms:
3-[[2-carboxyethyl(oxo)germyl]oxy-oxogermyl]propanoic acid
3,3'-(1,3-dioxo-1,3-digermoxanediyl)dipropionic acid; 3,3'-(dioxodigermoxanylene) dipropanoic acid; germanate(2-), bis(2-carboxylatoethyl)trioxodi-, dihydrogen
 propanoic acid, 3,3'-(1,3-dioxo-1,3-digermoxanediyl)bis-
 
 
Notes:
None found
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