phytosphingosine
1,3,4-octadecanetriol, 2-amino-, (2S,3S,4R)-

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  CODE177050 CODE177050
  Product(s):
  554-62-1 Phytosphingosine >95%

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  P1765 Phytosphingosine >98.0%(T)
  SDS

Name: (2S,3S,4R)-2-aminooctadecane-1,3,4-triol CAS Number: 554-62-1 3D/inchi FDA UNII: GIN46U9Q2Q Nikkaji Web: J13.584D XlogP3-AA: 4.60 (est) Molecular Weight: 317.51343000 Formula: C18 H39 N O3 NMR Predictor: Predict (works with chrome, Edge or firefox) Category:cosmetic ingredient for skin and hair conditioning   US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information: Google Scholar: Search Google Books: Search Google Scholar: with word "volatile" Search Google Scholar: with word "flavor" Search Google Scholar: with word "odor" Search Google Patents: Search US Patents: Search EU Patents: Search Pubchem Patents: Search PubMed: Search NCBI: Search   Physical Properties: Assay: 95.00 to 100.00 Food Chemicals Codex Listed: No Soluble in:   water, 25.28 mg/L @ 25 °C (est)   Organoleptic Properties: Odor and/or flavor descriptions from others (if found).   Cosmetic Information: CosIng: cosmetic data Cosmetic Uses: hair conditioning skin conditioning   Suppliers: BOC Sciences For experimental / research use only. Phytosphingosine >95% Santa Cruz Biotechnology For experimental / research use only. Phytosphingosine 98% TCI AMERICA For experimental / research use only. Phytosphingosine >98.0%(T) sds   Safety Information: Preferred SDS: View   Hazards identification   Classification of the substance or mixture GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) None found. GHS Label elements, including precautionary statements   Pictogram   Hazard statement(s) None found. Precautionary statement(s) None found. Oral/Parenteral Toxicity: Not determined Dermal Toxicity: Not determined Inhalation Toxicity: Not determined   Safety in Use Information: Category: cosmetic ingredient for skin and hair conditioning Recommendation for phytosphingosine usage levels up to:   not for fragrance use.   Recommendation for phytosphingosine flavor usage levels up to:   not for flavor use.   Safety References: EPI System: View AIDS Citations:Search Cancer Citations:Search Toxicology Citations:Search EPA ACToR:Toxicology Data EPA Substance Registry Services (SRS):Registry Laboratory Chemical Safety Summary :122121 National Institute of Allergy and Infectious Diseases:Data (2S,3S,4R)-2-aminooctadecane-1,3,4-triol Chemidplus:0000554621   References:   (2S,3S,4R)-2-aminooctadecane-1,3,4-triol NIST Chemistry WebBook: Search Inchi Pubchem (cid): 122121 Pubchem (sid): 135257073   Other Information: (IUPAC): Atomic Weights of the Elements 2011 (pdf) Videos: The Periodic Table of Videos tgsc: Atomic Weights use for this web site (IUPAC): Periodic Table of the Elements CHEBI: View CHEMBL: View KEGG (GenomeNet): C12144 HMDB (The Human Metabolome Database): HMDB04610 FooDB: FDB023381 Export Tariff Code: 2922.19.9590 ChemSpider: View   Potential Blenders and core components note None Found   Potential Uses: None Found   Occurrence (nature, food, other):note   not found in nature   Synonyms: (2S,3S,4R)-2- aminooctadecane-1,3,4-triol 1,3,4- octadecanetriol, 2-amino-, (2S,3S,4R)-   Articles:   None found yet. Try the PubMed Search.

Notes: Phytosphingosine is a phospholipid. Phospholipids are a class of lipids and a major component of all biological membranes; sphingolipid metabolites, such as sphingosine and ceramide, are highly bioactive compounds and are involved in diverse cell processes, including cell-cell interaction, cell proliferation, differentiation, and apoptosis. Phytosphingosine is also one of the most widely distributed natural sphingoid bases, which is abundant in fungi and plants, and also found in animals including humans. Phytosphingosine is structurally similar to sphingosine; phytosphingosine possesses a hydroxyl group at C-4 of the sphingoid long-chain base. The physiological roles of phytosphingosine are largely unknown. Phytosphingosine induces apoptosis in human T-cell lymphoma and non-small cell lung cancer cells, and induces caspase-independent cytochrome c release from mitochondria. In the presence of caspase inhibitors, phytosphingosine-induced apoptosis is almost completely suppressed, suggesting that phytosphingosine-induced apoptosis is largely dependent on caspase activities. (PMID: 12576463, 12531554, 8046331, 8048941,8706124) [HMDB]