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mangostin
9H-xanthen-9-one, 1,3,6-trihydroxy-7-methoxy-2,8-bis(3-methyl-2-butenyl)

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Name:1,3,6-trihydroxy-7-methoxy-2,8-bis(3-methylbut-2-enyl)xanthen-9-one
CAS Number: 6147-11-1Picture of molecule3D/inchi
FDA UNII: U6RIV93RU1
Nikkaji Web:J8.348H
MDL:MFCD00135200
XlogP3-AA:6.30 (est)
Molecular Weight:410.46642000
Formula:C24 H26 O6
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:cosmetic ingredient for skin conditioning
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
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PubMed:Search
NCBI:Search
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Soluble in:
 water, 0.0002026 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: skin conditioning
 
Suppliers:
Alfa Biotechnology
For experimental / research use only.
Alpha-Mangostin 98%
BOC Sciences
For experimental / research use only.
a-Mangostin >98%
Odor: characteristic
Use: It was isolated from Garcinia mangostana Linn (Guttiferae). It is an anti-inflammatory agent.
Glentham Life Sciences
alpha-Mangostin
Santa Cruz Biotechnology
For experimental / research use only.
Mangostin
Shaanxi Y-Herb Biotechnology
Natural Xanthones 10%-90% Anti Aging Peel Powder Alpha Mangostin Mangosteen Extract
Sigma-Aldrich: Sigma
For experimental / research use only.
a-Mangostin ≥98% (HPLC)
TCI AMERICA
For experimental / research use only.
a-Mangostin >97.0%(HPLC)
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
cosmetic ingredient for skin conditioning
Recommendation for mangostin usage levels up to:
 not for fragrance use.
 
Recommendation for mangostin flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :5281650
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:1
1,3,6-trihydroxy-7-methoxy-2,8-bis(3-methylbut-2-enyl)xanthen-9-one
Chemidplus:0006147111
RTECS:ZD6122420 for cas# 6147-11-1
 
References:
 1,3,6-trihydroxy-7-methoxy-2,8-bis(3-methylbut-2-enyl)xanthen-9-one
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):5281650
Pubchem (sid):135023262
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEBI:View
CHEMBL:View
KEGG (GenomeNet):C10080
HMDB (The Human Metabolome Database):HMDB35796
FooDB:FDB014546
Export Tariff Code:2932.99.7000
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
Wikipedia:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 mangosteen purple mangosteen fruit
Search Trop Picture
 
Synonyms:
alpha-mangostin
1,3,6-trihydroxy-7-methoxy-2,8-bis(3-methylbut-2-enyl)xanthen-9-one
9H-xanthen-9-one, 1,3,6-trihydroxy-7-methoxy-2,8-bis(3-methyl-2-butenyl)
 

Articles:

PubMed:Bioactivity-Guided Identification of Botanical Inhibitors of Ketohexokinase.
PubMed:Protective effect of α-mangostin against iodixanol-induced apoptotic damage in LLC-PK1 cells.
PubMed:Xanthones Isolated from the Pericarp of Mangosteen Inhibit Neurotransmitter Receptors Expressed in Xenopus Oocytes.
PubMed:Effects of Long-Term Alpha-mangostin Supplementation on Hyperglycemia and Insulin Resistance in Type 2 Diabetic Rats Induced by High Fat Diet and Low Dose Streptozotocin.
PubMed:In vitro assays in natural products research - a matter of concentration and relevance to in vivo administration using resveratrol, α-mangostin/γ-mangostin and xanthohumol as examples.
PubMed:Hypoglycaemic activity of ethanolic extract of Garcinia mangostana Linn. in normoglycaemic and streptozotocin-induced diabetic rats.
PubMed:In vivo antibacterial activity of Garcinia mangostana pericarp extract against methicillin-resistant Staphylococcus aureus in a mouse superficial skin infection model.
PubMed:Inhibition of Cell Proliferation in an NRAS Mutant Melanoma Cell Line by Combining Sorafenib and α-Mangostin.
PubMed:Acute Garcinia mangostana (mangosteen) supplementation does not alleviate physical fatigue during exercise: a randomized, double-blind, placebo-controlled, crossover trial.
PubMed:α-Mangostin, a Natural Agent, Enhances the Response of NRAS Mutant Melanoma to Retinoic Acid.
PubMed:DNA Protection against Oxidative Damage Using the Hydroalcoholic Extract of Garcinia mangostana and Alpha-Mangostin.
PubMed:Delivery of tanshinone IIA and α-mangostin from gold/PEI/cyclodextrin nanoparticle platform designed for prostate cancer chemotherapy.
PubMed:Synthesis and in vitro evaluation of the anticancer potential of new aminoalkanol derivatives of xanthone.
PubMed:Natural Xanthones from Garcinia mangostana with Multifunctional Activities for the Therapy of Alzheimer's Disease.
PubMed:α-Mangostin Inhibits α-Synuclein-Induced Microglial Neuroinflammation and Neurotoxicity.
PubMed:Antitumor and apoptosis-inducing effects of α-mangostin extracted from the pericarp of the mangosteen fruit (Garcinia mangostana L.)in YD-15 tongue mucoepidermoid carcinoma cells.
PubMed:A Novel Biological Role of α-Mangostin in Modulating Inflammatory Response through the Activation of SIRT-1 Signaling Pathway.
PubMed:Antiproliferative and apoptosis induction of α-mangostin in T47D breast cancer cells.
PubMed:Protective effect of alpha-mangostin against oxidative stress induced-retinal cell death.
PubMed:Nanoformulated alpha-mangostin ameliorates Alzheimer's disease neuropathology by elevating LDLR expression and accelerating amyloid-beta clearance.
PubMed:Evidence of the gastroprotective and anti- Helicobacter pylori activities of β-mangostin isolated from Cratoxylum arborescens (vahl) blume.
PubMed:β-Hydroxyacyl-acyl Carrier Protein Dehydratase (FabZ) from Francisella tularensis and Yersinia pestis: Structure Determination, Enzymatic Characterization, and Cross-Inhibition Studies.
PubMed:Investigation of Therapeutic Effects of α-Mangostin on Thioacetamide-Induced Cirrhosis in Rats.
PubMed:Alpha-Mangostin Partially Preserves Expression of Ammonia-Metabolizing Enzymes in Thioacetamide-Induced Fibrotic and Cirrhotic Rats.
PubMed:Screening of mammalian DNA polymerase and topoisomerase inhibitors from Garcinia mangostana L. and analysis of human cancer cell proliferation and apoptosis.
PubMed:Nordihydroguaiaretic acid (NDGA) and α-mangostin inhibit the growth of Mycobacterium tuberculosis by inducing autophagy.
PubMed:Co-solvation effect on the binding mode of the α-mangostin/β-cyclodextrin inclusion complex.
PubMed:Transferrin-modified liposome promotes α-mangostin to penetrate the blood-brain barrier.
PubMed:Depositing α-mangostin nanoparticles to sebaceous gland area for acne treatment.
PubMed:Anti-biofilm activity of α-mangostin isolated from Garcinia mangostana L.
PubMed:Discovery of α-mangostin as a novel competitive inhibitor against mutant isocitrate dehydrogenase-1.
PubMed:Synthesis of α - mangostin-D-glucoside in supercritical carbon dioxide media.
PubMed:α-Mangostin Regulates Hepatic Steatosis and Obesity through SirT1-AMPK and PPARγ Pathways in High-Fat Diet-Induced Obese Mice.
PubMed:Neuroprotective Effects of Alpha-Mangostin on MPP(+)-Induced Apoptotic Cell Death in Neuroblastoma SH-SY5Y Cells.
PubMed:α- and γ-mangostin cause shape changes, inhibit aggregation and induce cytolysis of rat platelets.
PubMed:Molecular Cloning and Characterization of a Xanthone Prenyltransferase from Hypericum calycinum Cell Cultures.
PubMed:Discovery of γ-Mangostin as an Amyloidogenesis Inhibitor.
PubMed:Understanding of tolerance in TRAIL-induced apoptosis and cancelation of its machinery by α-mangostin, a xanthone derivative.
PubMed:In vitro and in vivo characterization of the anticancer activity of Thai stingless bee (Tetragonula laeviceps) cerumen.
PubMed:Daily consumption of a mangosteen-based drink improves in vivo antioxidant and anti-inflammatory biomarkers in healthy adults: a randomized, double-blind, placebo-controlled clinical trial.
PubMed:Identification of hepatoprotective xanthones from the pericarps of Garcinia mangostana, guided with tert-butyl hydroperoxide induced oxidative injury in HL-7702 cells.
PubMed:Dose-Independent ADME Properties and Tentative Identification of Metabolites of α-Mangostin from Garcinia mangostana in Mice by Automated Microsampling and UPLC-MS/MS Methods.
PubMed:Involvement of NF-ΚB and HSP70 signaling pathways in the apoptosis of MDA-MB-231 cells induced by a prenylated xanthone compound, α-mangostin, from Cratoxylum arborescens [Corrigendum].
PubMed:Antibacterial Compounds from Propolis of Tetragonula laeviceps and Tetrigona melanoleuca (Hymenoptera: Apidae) from Thailand.
PubMed:A Method of Effectively Improved α-Mangostin Bioavailability.
PubMed:A review of the efficacy of dietary polyphenols in experimental models of inflammatory bowel diseases.
PubMed:Alpha-mangostin attenuation of hyperglycemia-induced ocular hypoperfusion and blood retinal barrier leakage in the early stage of type 2 diabetes rats.
PubMed:In vivo Antimalarial Activity of α-Mangostin and the New Xanthone δ-Mangostin.
PubMed:Trichostemonoate, a new anticancer tirucallane from the stem bark of Walsura trichostemon.
PubMed:α-Mangostin Improves Glucose Uptake and Inhibits Adipocytes Differentiation in 3T3-L1 Cells via PPARγ, GLUT4, and Leptin Expressions.
PubMed:Cytotoxic effect and mechanism inducing cell death of α-mangostin liposomes in various human carcinoma and normal cells.
PubMed:Fabrication and In Vitro/In Vivo Performance of Mucoadhesive Electrospun Nanofiber Mats Containing α-Mangostin.
PubMed:Functional beverage of Garcinia mangostana (mangosteen) enhances plasma antioxidant capacity in healthy adults.
PubMed:The inhibitory activity of aldose reductase in vitro by constituents of Garcinia mangostana Linn.
PubMed:Isoprenylated xanthone and benzophenone constituents of the pericarp of Garcinia planchonii.
PubMed:Intestinal microbial dysbiosis and colonic epithelial cell hyperproliferation by dietary α-mangostin is independent of mouse strain.
PubMed:Synthesis and membrane-protective activity of novel derivatives of α-mangostin at the C-4 position.
PubMed:Inhibitory Effect of Alpha-Mangostin on Adhesion of Candida albicans to Denture Acrylic.
PubMed:Xanthones from mangosteen (Garcinia mangostana): multi-targeting pharmacological properties.
PubMed:Molecular screening of insecticides with sigma glutathione S-transferases (GST) in cotton aphid Aphis gossypii using docking.
PubMed:Mechanisms of α-mangostin-induced antinociception in a rodent model.
PubMed:Chemistry of α-mangostin. Studies on the semisynthesis of minor xanthones from Garcinia mangostana.
PubMed:Involvement of NF-κB and HSP70 signaling pathways in the apoptosis of MDA-MB-231 cells induced by a prenylated xanthone compound, α-mangostin, from Cratoxylum arborescens.
PubMed:The Antibacterial Effects of Apacaries Gel on Streptococcus mutans: An in vitro Study.
PubMed:α-Mangostin disrupts the development of Streptococcus mutans biofilms and facilitates its mechanical removal.
PubMed:α-Mangostin from Cratoxylum arborescens demonstrates apoptogenesis in MCF-7 with regulation of NF-κB and Hsp70 protein modulation in vitro, and tumor reduction in vivo.
PubMed:Antibacterial activity of Garcinia mangostana extracts on oral pathogens.
PubMed:Inhibition of CHOP accentuates the apoptotic effect of α-mangostin from the mangosteen fruit (Garcinia mangostana) in 22Rv1 prostate cancer cells.
PubMed:Prenylated xanthones from mangosteen as promising cholinesterase inhibitors and their molecular docking studies.
PubMed:Mangostanaxanthones I and II, new xanthones from the pericarp of Garcinia mangostana.
PubMed:Antibacterial tetraoxygenated xanthones from the immature fruits of Garcinia cowa.
PubMed:Metabolite footprinting of Plasmodium falciparum following exposure to Garcinia mangostana Linn. crude extract.
PubMed:Alpha-mangostin promotes myoblast differentiation by modulating the gene-expression profile in C2C12 cells.
PubMed:Efficient enzymatic systems for synthesis of novel α-mangostin glycosides exhibiting antibacterial activity against Gram-positive bacteria.
PubMed:Inhibition of cell proliferation, migration and invasion of B16-F10 melanoma cells by α-mangostin.
PubMed:α-Mangostin suppresses human gastric adenocarcinoma cells in vitro via blockade of Stat3 signaling pathway.
PubMed:In vitro antiplasmodial activity of benzophenones and xanthones from edible fruits of Garcinia species.
PubMed:Downregulation of tumor necrosis factor and other proinflammatory biomarkers by polyphenols.
PubMed:A new coumarin from Calophyllum hosei.
PubMed:Alpha-mangostin inhibits intracellular fatty acid synthase and induces apoptosis in breast cancer cells.
PubMed:Alpha-mangostin suppresses IL-6 and IL-8 expression in P. gingivalis LPS-stimulated human gingival fibroblasts.
PubMed:α-Mangostin suppresses the viability and epithelial-mesenchymal transition of pancreatic cancer cells by downregulating the PI3K/Akt pathway.
PubMed:Characteristics and anticancer properties of bacterial cellulose films containing ethanolic extract of mangosteen peel.
PubMed:Pharmacokinetic characterization of mangosteen (Garcinia mangostana) fruit extract standardized to α-mangostin in C57BL/6 mice.
PubMed:Anti-angiogenic actions of the mangosteen polyphenolic xanthone derivative α-mangostin.
PubMed:Synthesis of xanthone derivatives based on α-mangostin and their biological evaluation for anti-cancer agents.
PubMed:A new furanoxanthone from Garcinia mangostana.
PubMed:Dietary α-mangostin, a xanthone from mangosteen fruit, exacerbates experimental colitis and promotes dysbiosis in mice.
PubMed:Comparison of the biological activity of two different isolates from mangosteen.
PubMed:β Mangostin suppress LPS-induced inflammatory response in RAW 264.7 macrophages in vitro and carrageenan-induced peritonitis in vivo.
PubMed:The in vitro antimalarial interaction of 9-hydroxycalabaxanthone and α-mangostin with mefloquine/artesunate.
PubMed:Quantitative analysis of α-mangostin in hydrophilic ointment using near-infrared spectroscopy.
PubMed:α-Mangostin inhibits hypoxia-driven ROS-induced PSC activation and pancreatic cancer cell invasion.
PubMed:Cytotoxic prenylated xanthones from the pericarps of Garcinia mangostana.
PubMed:α-Mangostin-induced apoptosis is mediated by estrogen receptor α in human breast cancer cells.
PubMed:Absorption, tissue distribution, tissue metabolism and safety of α-mangostin in mangosteen extract using mouse models.
PubMed:Rapid identification of cholinesterase inhibitors from the seedcases of mangosteen using an enzyme affinity assay.
PubMed:High-throughput, high-content screening for novel pigmentation regulators using a keratinocyte/melanocyte co-culture system.
PubMed:Physicochemical properties and anti-Propionibacterium acnes activity of film-forming solutions containing alpha-mangostin-rich extract.
PubMed:γ-Mangostin from Garcinia mangostana pericarps as a dual agonist that activates Both PPARα and PPARδ.
PubMed:α-Mangostin: a dietary antioxidant derived from the pericarp of Garcinia mangostana L. inhibits pancreatic tumor growth in xenograft mouse model.
PubMed:Immunomodulatory activities of alpha-mangostin on peripheral blood mononuclear cells.
PubMed:Altered mRNA expression related to the apoptotic effect of three xanthones on human melanoma SK-MEL-28 cell line.
PubMed:A concise and efficient total synthesis of α-mangostin and β-mangostin from Garcinia mangostana.
PubMed:Suppressive effect of mangosteen rind extract on the spontaneous development of atopic dermatitis in NC/Tnd mice.
PubMed:Phytochemical, antimicrobial and antiprotozoal evaluation of Garcinia mangostana pericarp and α-mangostin, its major xanthone derivative.
PubMed:Anti-cancer effects of naturally occurring compounds through modulation of signal transduction and miRNA expression in human colon cancer cells.
PubMed:Antitumour and free radical scavenging effects of γ-mangostin isolated from Garcinia mangostana pericarps against hepatocellular carcinoma cell.
PubMed:α-Mangostin induces mitochondrial dependent apoptosis in human hepatoma SK-Hep-1 cells through inhibition of p38 MAPK pathway.
PubMed:Antidiabetic effect of α-mangostin and its protective role in sexual dysfunction of streptozotocin induced diabetic male rats.
PubMed:Antileptospiral activity of xanthones from Garcinia mangostana and synergy of gamma-mangostin with penicillin G.
PubMed:α-Mangostin suppresses lipopolysaccharide-induced invasion by inhibiting matrix metalloproteinase-2/9 and increasing E-cadherin expression through extracellular signal-regulated kinase signaling in pancreatic cancer cells.
PubMed:α-mangostin: one of the best dietary supplements.
PubMed:Inhibitory effects of α-mangostin on mammalian DNA polymerase, topoisomerase, and human cancer cell proliferation.
PubMed:Polyphenols from the mangosteen (Garcinia mangostana) fruit for breast and prostate cancer.
PubMed:Inhibition of autophagy augments the anticancer activity of α-mangostin in chronic myeloid leukemia cells.
PubMed:Combating Helicobacter pylori infections with mucoadhesive nanoparticles loaded with Garcinia mangostana extract.
PubMed:The effect of gartanin, a naturally occurring xanthone in mangosteen juice, on the mTOR pathway, autophagy, apoptosis, and the growth of human urinary bladder cancer cell lines.
PubMed:Electrospun chitosan-based nanofiber mats loaded with Garcinia mangostana extracts.
PubMed:A study on dispersion and characterisation of α-mangostin loaded pH sensitive microgel systems.
PubMed:Pharmacokinetic properties of pure xanthones in comparison to a mangosteen fruit extract in rats.
PubMed:Distribution of major xanthones in the pericarp, aril, and yellow gum of mangosteen (Garcinia mangostana linn.) fruit and their contribution to antioxidative activity.
PubMed:α -Mangostin from Cratoxylum arborescens (Vahl) Blume Demonstrates Anti-Ulcerogenic Property: A Mechanistic Study.
PubMed:Microencapsulation of alpha-mangostin into PLGA microspheres and optimization using response surface methodology intended for pulmonary delivery.
PubMed:α-Mangostin: anti-inflammatory activity and metabolism by human cells.
PubMed:Α-mangostin and gambogic acid as potential inhibitors of the p53-MDM2 interaction revealed by a yeast approach.
PubMed:Protective effect of alpha-mangostin against type-I collagen formation in thioacetamide-induced cirrhotic rat.
PubMed:Mechanisms of vasorelaxation to gamma-mangostin in the rat aorta.
PubMed:Design and synthesis of amphiphilic xanthone-based, membrane-targeting antimicrobials with improved membrane selectivity.
PubMed:α-Mangostin Reduced ER Stress-mediated Tumor Growth through Autophagy Activation.
PubMed:Cytotoxicity and structure-activity relationships of xanthone derivatives from Mesua beccariana, Mesua ferrea and Mesua congestiflora towards nine human cancer cell lines.
PubMed:Virtual screening of Indonesian herbal database as HIV-1 reverse transcriptase inhibitor.
PubMed:Anti-tumorigenicity of dietary α-mangostin in an HT-29 colon cell xenograft model and the tissue distribution of xanthones and their phase II metabolites.
PubMed:[Optimize technique of extracting alpha-mangostin from pericarp of Garcinia mangostana by supersonic wave using central composite design-response surface methodology].
PubMed:Alpha-mangostin induces changes in glutathione levels associated with glutathione peroxidase activity in rat brain synaptosomes.
PubMed:A miniaturized flow-through cell to evaluate skin permeation of endoxifen.
PubMed:Potent activity against multidrug-resistant Mycobacterium tuberculosis of α-mangostin analogs.
PubMed:Single dose oral pharmacokinetic profile of α-mangostin in mice.
PubMed:Benzophenone and xanthone derivatives from the inflorescences of Garcinia cowa.
PubMed:Inhibition of human aldose reductase-like protein (AKR1B10) by α- and γ-mangostins, major components of pericarps of mangosteen.
PubMed:New "hyphenated" CPC-HPLC-DAD-MS strategy for simultaneous isolation, analysis and identification of phytochemicals: application to xanthones from Garcinia mangostana.
PubMed:Significant anti-invasive activities of α-mangostin from the mangosteen pericarp on two human skin cancer cell lines.
PubMed:Rapid bactericidal action of alpha-mangostin against MRSA as an outcome of membrane targeting.
PubMed:Mangosteen xanthones mitigate ovalbumin-induced airway inflammation in a mouse model of asthma.
PubMed:Application of NIR spectroscopy for the quality control of mangosteen pericarp powder: quantitative analysis of alpha-mangostin in mangosteen pericarp powder and capsule.
PubMed:Effects of alpha-mangostin on the expression of anti-inflammatory genes in U937 cells.
PubMed:Alpha-mangostin suppresses MMP-2 and MMP-9 expression in head and neck squamous carcinoma cells.
PubMed:In vitro and in vivo anti-colon cancer effects of Garcinia mangostana xanthones extract.
PubMed:Inflammation-related disorders in the tryptophan catabolite pathway in depression and somatization.
PubMed:Investigation of biological activities of dichloromethane and ethyl acetate fractions of Platonia insignis Mart. seed.
PubMed:Synthesis, SAR and biological evaluation of natural and non-natural hydroxylated and prenylated xanthones as antitumor agents.
PubMed:Neuroprotective effect of α-mangostin and curcumin against iodoacetate-induced cell death.
PubMed:Oxidative stress contributes to outcome severity in a Drosophila melanogaster model of classic galactosemia.
PubMed:Gamma-mangostin, a micronutrient of mangosteen fruit, induces apoptosis in human colon cancer cells.
PubMed:In vivo toxicity and antitumor activity of mangosteen extract.
PubMed:Alterations in cell cycle and induction of apoptotic cell death in breast cancer cells treated with α-mangostin extracted from mangosteen pericarp.
PubMed:Antibacterial activity of xanthones from Garcinia mangostana (L.) and their structure-activity relationship studies.
PubMed:α-Mangostin induces apoptosis and suppresses differentiation of 3T3-L1 cells via inhibiting fatty acid synthase.
PubMed:alpha-Mangostin enhances betulinic acid cytotoxicity and inhibits cisplatin cytotoxicity on HCT 116 colorectal carcinoma cells.
PubMed:Xanthones in mangosteen juice are absorbed and partially conjugated by healthy adults.
PubMed:Anti-angiogenic effect of α-mangostin.
PubMed:Antiproliferative effect of α-mangostin on canine osteosarcoma cells.
PubMed:Anthelminthic properties of mangostin and mangostin diacetate.
PubMed:Apoptosis, antimicrobial and antioxidant activities of phytochemicals from Garcinia malaccensis Hk.f.
PubMed:α-Mangostin, a xanthone from mangosteen fruit, promotes cell cycle arrest in prostate cancer and decreases xenograft tumor growth.
PubMed:Solid dispersions of α-mangostin improve its aqueous solubility through self-assembly of nanomicelles.
PubMed:Α-mangostin, a polyphenolic xanthone derivative from mangosteen, attenuates β-amyloid oligomers-induced neurotoxicity by inhibiting amyloid aggregation.
PubMed:Protective effect of α-mangostin on cardiac reperfusion damage by attenuation of oxidative stress.
PubMed:Antifibrotic constituents from Garcinia mangostana.
PubMed:Free radical scavenger properties of α-mangostin: thermodynamics and kinetics of HAT and RAF mechanisms.
PubMed:Combined microwave-assisted extraction and high-speed counter-current chromatography for separation and purification of xanthones from Garcinia mangostana.
PubMed:[Study on ultraviolet-screening effect of extracts from mangosteen (Garcinia mangostana Linn.) pericarp].
PubMed:A search for mosquito larvicidal compounds by blocking the sterol carrying protein, AeSCP-2, through computational screening and docking strategies.
PubMed:Cytotoxic effect of xanthones from pericarp of the tropical fruit mangosteen (Garcinia mangostana Linn.) on human melanoma cells.
PubMed:α-Mangostin extracted from the pericarp of the mangosteen (Garcinia mangostana Linn) reduces tumor growth and lymph node metastasis in an immunocompetent xenograft model of metastatic mammary cancer carrying a p53 mutation.
PubMed:Effects of α-mangostin on apoptosis induction of human colon cancer.
PubMed:α-Mangostin induces apoptosis in human chondrosarcoma cells through downregulation of ERK/JNK and Akt signaling pathway.
PubMed:γ-Mangostin increases serotonin 2A/2C, muscarinic, histamine and bradykinin receptor mRNA expression.
PubMed:Cytotoxic and NF-κB inhibitory constituents of the stems of Cratoxylum cochinchinense and their semisynthetic analogues.
PubMed:Microbial metabolism of α-mangostin isolated from Garcinia mangostana L.
PubMed:Antimicrobial actions of α-mangostin against oral streptococci.
PubMed:α-Mangostin, a dietary xanthone, induces autophagic cell death by activating the AMP-activated protein kinase pathway in glioblastoma cells.
PubMed:Pharmacokinetics of α-mangostin in rats after intravenous and oral application.
PubMed:Apoptotic effects of γ-mangostin from the fruit hull of Garcinia mangostana on human malignant glioma cells.
PubMed:Apoptotic effect of alpha-mangostin on head and neck squamous carcinoma cells.
PubMed:A new prenylated xanthone from Garcinia xipshuanbannaensis Y.H. Li.
PubMed:Antiplasmodial constituents from the fruit pericarp of Pentadesma butyracea.
PubMed:Xanthones, biflavanones and triterpenes from Pentadesma grandifolia (Clusiaceae): structural determination and bioactivity.
PubMed:Alpha-mangostin suppresses phorbol 12-myristate 13-acetate-induced MMP-2/MMP-9 expressions via alphavbeta3 integrin/FAK/ERK and NF-kappaB signaling pathway in human lung adenocarcinoma A549 cells.
PubMed:Free radical scavenging and anti-acne activities of mangosteen fruit rind extracts prepared by different extraction methods.
PubMed:Antioxidant, free radical-scavenging activity and cytotoxicity of different solvent extracts and their phenolic constituents from the fruit hull of mangosteen (Garcinia mangostana).
PubMed:The alpha-mangostin prevention on cisplatin-induced apoptotic death in LLC-PK1 cells is associated to an inhibition of ROS production and p53 induction.
PubMed:Anti-acne-inducing bacterial activity of mangosteen fruit rind extracts.
PubMed:alpha-Mangostin, a novel dietary xanthone, suppresses TPA-mediated MMP-2 and MMP-9 expressions through the ERK signaling pathway in MCF-7 human breast adenocarcinoma cells.
PubMed:The biological activity of alpha-mangostin, a larvicidal botanic mosquito sterol carrier protein-2 inhibitor.
PubMed:Preparative separation of major xanthones from mangosteen pericarp using high-performance centrifugal partition chromatography.
PubMed:Xanthones from mangosteen inhibit inflammation in human macrophages and in human adipocytes exposed to macrophage-conditioned media.
PubMed:New medicinal properties of mangostins: analgesic activity and pharmacological characterization of active ingredients from the fruit hull of Garcinia mangostana L.
PubMed:1,3,6-Trihy-droxy-7-meth-oxy-2,8-bis-(3-methyl-but-2-en-yl)-9H-xanthen-9-one.
PubMed:Antioxidant activity of mangostin in cell-free system and its effect on K562 leukemia cell line in photodynamic therapy.
PubMed:Effects of alpha-mangostin on mitochondrial energetic metabolism.
PubMed:Renoprotection by alpha-Mangostin is related to the attenuation in renal oxidative/nitrosative stress induced by cisplatin nephrotoxicity.
PubMed:Cytotoxic xanthone constituents of the stem bark of Garcinia mangostana (mangosteen).
PubMed:Bioavailability and antioxidant effects of a xanthone-rich Mangosteen (Garcinia mangostana) product in humans.
PubMed:Mitigation of mitochondrial dysfunction and regulation of eNOS expression during experimental myocardial necrosis by alpha-mangostin, a xanthonic derivative from Garcinia mangostana.
PubMed:Antifungal activity of alpha-mangostin against Candida albicans.
PubMed:Cytotoxic geranylated xanthones and O-alkylated derivatives of alpha-mangostin.
PubMed:Panaxanthone isolated from pericarp of Garcinia mangostana L. suppresses tumor growth and metastasis of a mouse model of mammary cancer.
PubMed:In vitro inhibition of multiple cytochrome P450 isoforms by xanthone derivatives from mangosteen extract.
PubMed:Comparison of bioactive compounds content, free radical scavenging and anti-acne inducing bacteria activities of extracts from the mangosteen fruit rind at two stages of maturity.
PubMed:Bioaccessibility, biotransformation, and transport of alpha-mangostin from Garcinia mangostana (Mangosteen) using simulated digestion and Caco-2 human intestinal cells.
PubMed:Xanthones from mangosteen prevent lipopolysaccharide-mediated inflammation and insulin resistance in primary cultures of human adipocytes.
PubMed:Anti-cancer effects of xanthones from pericarps of mangosteen.
PubMed:Validation of LC for the determination of alpha-mangostin in mangosteen peel extract: a tool for quality assessment of Garcinia mangostana L.
PubMed:The natural xanthone alpha-mangostin reduces oxidative damage in rat brain tissue.
PubMed:Alpha-mangostin suppresses PC-3 human prostate carcinoma cell metastasis by inhibiting matrix metalloproteinase-2/9 and urokinase-plasminogen expression through the JNK signaling pathway.
PubMed:Anti-oxidative and anti-inflammatory activities of some isolated constituents from the stem bark of Allanblackia monticola Staner L.C (Guttiferae).
PubMed:ROS scavenging capacity and neuroprotective effect of alpha-mangostin against 3-nitropropionic acid in cerebellar granule neurons.
PubMed:Effects of compounds from Garcinia mangostana on inflammatory mediators in RAW264.7 macrophage cells.
PubMed:Xanthones from the seeds of Allanblackia monticola and their apoptotic and antiproliferative activities.
PubMed:Antibacterial activity of Thai medicinal plants against methicillin-resistant Staphylococcus aureus.
PubMed:Thin-layer chromatography-densitometric analysis of alpha-mangostin content in Garcinia mangostana fruit rind extracts.
PubMed:Apoptotic effects on B-cell chronic lymphocytic leukemia (B-CLL) cells of heterocyclic compounds isolated from Guttiferaes.
PubMed:Xanthones from the botanical dietary supplement mangosteen (Garcinia mangostana) with aromatase inhibitory activity.
PubMed:Cytotoxicity of prenylated xanthones and other constituents from the wood of Garcinia merguensis.
PubMed:Garcinia mangostana: a source of potential anti-cancer lead compounds against CEM-SS cell line.
PubMed:Ameliorative prospective of alpha-mangostin, a xanthone derivative from Garcinia mangostana against beta-adrenergic cathecolamine-induced myocardial toxicity and anomalous cardiac TNF-alpha and COX-2 expressions in rats.
PubMed:Effects of alpha-mangostin from mangosteen pericarp extract and imidacloprid on Nilaparvata lugens (Stal.) and non-target organisms: toxicity and detoxification mechanism.
PubMed:Inhibitory effect of xanthones isolated from the pericarp of Garcinia mangostana L. on rat basophilic leukemia RBL-2H3 cell degranulation.
PubMed:Anti-inflammatory activity of mangostins from Garcinia mangostana.
PubMed:Cardioprotective effect of alpha-mangostin, a xanthone derivative from mangosteen on tissue defense system against isoproterenol-induced myocardial infarction in rats.
PubMed:Xanthones with quinone reductase-inducing activity from the fruits of Garcinia mangostana (Mangosteen).
PubMed:Discovery of platelet-type 12-human lipoxygenase selective inhibitors by high-throughput screening of structurally diverse libraries.
PubMed:Oligomeric proanthocyanidins from mangosteen pericarps.
PubMed:HPLC analysis of selected xanthones in mangosteen fruit.
PubMed:Characterized mechanism of alpha-mangostin-induced cell death: caspase-independent apoptosis with release of endonuclease-G from mitochondria and increased miR-143 expression in human colorectal cancer DLD-1 cells.
PubMed:Antioxidant xanthones from Cratoxylum cochinchinense.
PubMed:The novel botanical insecticide for the control brown planthopper (Nilaparvata lugens Stal.).
PubMed:Antimalarial and vasorelaxant constituents of the leaves of Allanblackia monticola (Guttiferae).
PubMed:Quantitative and qualitative determination of six xanthones in Garcinia mangostana L. by LC-PDA and LC-ESI-MS.
PubMed:Xanthones from Garcinia mangostana (Guttiferae).
PubMed:Natural products that reduce rotavirus infectivity identified by a cell-based moderate-throughput screening assay.
PubMed:Prenylated xanthones as potential antiplasmodial substances.
PubMed:Cytotoxic and antimalarial prenylated xanthones from Cratoxylum cochinchinense.
PubMed:Antioxidant xanthones from the pericarp of Garcinia mangostana (Mangosteen).
PubMed:Cytotoxic prenylated xanthones from the young fruit of Garcinia mangostana.
PubMed:Prenylated xanthone derivatives with antiplasmodial activity from Allanblackia monticola STANER L.C.
PubMed:Garcinone B reduces prostaglandin E2 release and NF-kappaB-mediated transcription in C6 rat glioma cells.
PubMed:Xanthones induce cell-cycle arrest and apoptosis in human colon cancer DLD-1 cells.
PubMed:Antimicrobial effects of Thai medicinal plants against acne-inducing bacteria.
PubMed:Antibacterial activity of alpha-mangostin against vancomycin resistant Enterococci (VRE) and synergism with antibiotics.
PubMed:A geranylated biphenyl derivative from Garcinia malvgostana.
PubMed:Inhibitory effects of crude alpha-mangostin, a xanthone derivative, on two different categories of colon preneoplastic lesions induced by 1, 2-dimethylhydrazine in the rat.
PubMed:Preferential target is mitochondria in alpha-mangostin-induced apoptosis in human leukemia HL60 cells.
PubMed:Antimalarial xanthones from Calophyllum caledonicum and Garcinia vieillardii.
PubMed:gamma-Mangostin inhibits inhibitor-kappaB kinase activity and decreases lipopolysaccharide-induced cyclooxygenase-2 gene expression in C6 rat glioma cells.
PubMed:Alpha-mangostin induces Ca2+-ATPase-dependent apoptosis via mitochondrial pathway in PC12 cells.
PubMed:Biological activities of alpha-mangostin derivatives against acidic sphingomyelinase.
PubMed:Induction of apoptosis by xanthones from mangosteen in human leukemia cell lines.
PubMed:Inhibition of cyclooxygenase and prostaglandin E2 synthesis by gamma-mangostin, a xanthone derivative in mangosteen, in C6 rat glioma cells.
PubMed:Inhibition of lipoprotein oxidation by prenylated xanthones derived from mangostin.
PubMed:Inhibition of acidic sphingomyelinase by xanthone compounds isolated from Garcinia speciosa.
PubMed:Inhibition of eukaryote protein kinases and of a cyclic nucleotide-binding phosphatase by prenylated xanthones.
PubMed:Characterization of estrogenicity of phytoestrogens in an endometrial-derived experimental model.
PubMed:Effect of gamma-mangostin through the inhibition of 5-hydroxy-tryptamine2A receptors in 5-fluoro-alpha-methyltryptamine-induced head-twitch responses of mice.
PubMed:Plant-derived leading compounds for chemotherapy of human immunodeficiency virus (HIV) infection.
PubMed:[Novel types of receptor antagonists from the medicinal plant Garcinia mangostana].
PubMed:Antimalarial xanthones from Garcinia cowa.
PubMed:Gamma-mangostin, a novel type of 5-hydroxytryptamine 2A receptor antagonist.
PubMed:Evaluation of the antifungal activity of natural xanthones from Garcinia mangostana and their synthetic derivatives.
PubMed:Pharmacological properties of alpha-mangostin, a novel histamine H1 receptor antagonist.
PubMed:Histaminergic and serotonergic receptor blocking substances from the medicinal plant Garcinia mangostana.
PubMed:Antibacterial activity of xanthones from guttiferaeous plants against methicillin-resistant Staphylococcus aureus.
PubMed:The mode of inhibitory action of alpha-mangostin, a novel inhibitor, on the sarcoplasmic reticulum Ca(2+)-pumping ATPase from rabbit skeletal muscle.
PubMed:Active constituents against HIV-1 protease from Garcinia mangostana.
PubMed:Mangostin inhibits the oxidative modification of human low density lipoprotein.
PubMed:Inhibition of wheat embryo calcium-dependent protein kinase and other kinases by mangostin and gamma-mangostin.
PubMed:Antimicrobial activities of Garcinia mangostana.
PubMed:Effect of mangostin, a xanthone from Garcinia mangostana Linn. in immunopathological & inflammatory reactions.
PubMed:Pharmacological profile of mangostin and its derivatives.
 
Notes:
Pigment from Garcinia mangostana (mangosteen)
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