equol
(S)-3,4-dihydro-3-(4-hydroxyphenyl)-2H-1-benzopyran-7-ol

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  CODE173247 CODE173247
  Product(s):
  531-95-3 Equol >98%
  Equol ,a metabolite of soybeans, is an important isoflavone in humans specifically binds to 5a-DHT, has a modest affinity for recombinant estrogen receptor ERb. Phase 2.

Name: (3S)-3-(4-hydroxyphenyl)-3,4-dihydro-2H-chromen-7-ol CAS Number: 531-95-3 3D/inchi ECHA EINECS - REACH Pre-Reg: 208-522-2 FDA UNII: 2T6D2HPX7Q Nikkaji Web: J14.375H MDL: MFCD00200962 XlogP3-AA: 3.00 (est) Molecular Weight: 242.27418000 Formula: C15 H14 O3 NMR Predictor: Predict (works with chrome, Edge or firefox) Category:antioxidants, hair conditioning, skin conditioning   US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information: Google Scholar: Search Google Books: Search Google Scholar: with word "volatile" Search Google Scholar: with word "flavor" Search Google Scholar: with word "odor" Search Google Patents: Search US Patents: Search EU Patents: Search Pubchem Patents: Search PubMed: Search NCBI: Search   Physical Properties: Assay: 95.00 to 100.00 Food Chemicals Codex Listed: No Soluble in:   water, 72.3 mg/L @ 25 °C (est)   Organoleptic Properties: Odor and/or flavor descriptions from others (if found).   Cosmetic Information: CosIng: cosmetic data Cosmetic Uses: antioxidants hair conditioning skin conditioning   Suppliers: Alfa Biotechnology For experimental / research use only. Equol 98% BOC Sciences For experimental / research use only. Equol >98% Odor: characteristic Use: Equol ,a metabolite of soybeans, is an important isoflavone in humans specifically binds to 5a-DHT, has a modest affinity for recombinant estrogen receptor ERb. Phase 2. Indis NV For experimental / research use only. Equol Santa Cruz Biotechnology For experimental / research use only. (S)-Equol ≥98%   Safety Information:   Hazards identification   Classification of the substance or mixture GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) None found. GHS Label elements, including precautionary statements   Pictogram   Hazard statement(s) None found. Precautionary statement(s) None found. Oral/Parenteral Toxicity: Not determined Dermal Toxicity: Not determined Inhalation Toxicity: Not determined   Safety in Use Information: Category: antioxidants, hair conditioning, skin conditioning Recommendation for equol usage levels up to:   not for fragrance use.   Recommendation for equol flavor usage levels up to:   not for flavor use.   Safety References: EPI System: View ClinicalTrials.gov:search Chemical Carcinogenesis Research Information System:Search AIDS Citations:Search Cancer Citations:Search Toxicology Citations:Search EPA ACToR:Toxicology Data EPA Substance Registry Services (SRS):Registry Laboratory Chemical Safety Summary :91469 National Institute of Allergy and Infectious Diseases:Data (3S)-3-(4-hydroxyphenyl)-3,4-dihydro-2H-chromen-7-ol Chemidplus:0000531953   References:   (3S)-3-(4-hydroxyphenyl)-3,4-dihydro-2H-chromen-7-ol NIST Chemistry WebBook: Search Inchi Pubchem (cid): 91469 Pubchem (sid): 135048637   Other Information: (IUPAC): Atomic Weights of the Elements 2011 (pdf) Videos: The Periodic Table of Videos tgsc: Atomic Weights use for this web site (IUPAC): Periodic Table of the Elements CHEBI: View CHEMBL: View KEGG (GenomeNet): C14131 HMDB (The Human Metabolome Database): HMDB02209 FooDB: FDB021824 VCF-Online: VCF Volatile Compounds in Food ChemSpider: View Wikipedia: View   Potential Blenders and core components note None Found   Potential Uses: None Found   Occurrence (nature, food, other):note   found in nature   Synonyms: 2H-1- benzopyran-7-ol, 3,4-dihydro-3-(4-hydroxyphenyl)-, (3S)- 3,4- dihydro-3-(4-hydroxyphenyl)-(S)-2H-1-benzopyran-7-ol (S)-3,4- dihydro-3-(4-hydroxyphenyl)-2H-1-benzopyran-7-ol S- equol (3S)-3-(4- hydroxyphenyl)-3,4-dihydro-2H-chromen-7-ol   Articles:   None found yet. Try the PubMed Search.

Notes: Equol is a metabolite of daidzein, a phytoestrogen common in the human diet and abundant in soy. Intestinal bacteria in humans can reduce daidzein to equol, and can be found in normal human urine. The clinical effectiveness of soy isoflavones may be a function of the ability to biotransform soy isoflavones to the more potent estrogenic metabolite, equol, which may enhance the actions of soy isoflavones, owing to its greater affinity for estrogen receptors, unique antiandrogenic properties, and superior antioxidant activity. However, not all individuals consuming daidzein produce equol. Only approximately one-third to one-half of the population is able to metabolize daidzein to equol. This high variability in equol production is presumably attributable to interindividual differences in the composition of the intestinal microflora, which may play an important role in the mechanisms of action of isoflavones. (PMID: 17579895, 17579894) [HMDB]