5,7,4'-trimethyl apigenin, 5631-70-9

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CODE170173 CODE170173
Product(s):
5631-70-9 4',5,7-Trimethoxyflavone 98%
4',5,7-Trimethoxyflavone is a flavonoid showing anti-inflammatory activity.

Name:	5,7-dimethoxy-2-(4-methoxyphenyl)chromen-4-one
CAS Number:	5631-70-9	3D/inchi
FDA UNII:	F50JU8E74U
Nikkaji Web:	J145.241J
XlogP3:	2.20 (est)
Molecular Weight:	312.32152000
Formula:	C18 H16 O5
BioActivity Summary:	listing
NMR Predictor:	Predict (works with chrome, Edge or firefox)

Category:natural substances and extractives

US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:

Google Scholar:	Search
Google Books:	Search
Google Scholar: with word "volatile"	Search
Google Scholar: with word "flavor"	Search
Google Scholar: with word "odor"	Search
Google Patents:	Search
US Patents:	Search
EU Patents:	Search
Pubchem Patents:	Search
PubMed:	Search
NCBI:	Search

Physical Properties:

Assay:	95.00 to 100.00
Food Chemicals Codex Listed:	No
Boiling Point:	506.50 °C. @ 760.00 mm Hg (est)
Flash Point:	438.00 °F. TCC ( 225.50 °C. ) (est)
logP (o/w):	3.530 (est)
Soluble in:
	water, 6.512 mg/L @ 25 °C (est)

Organoleptic Properties:

Odor and/or flavor descriptions from others (if found).

Cosmetic Information:

None found

Suppliers:

BOC Sciences

For experimental / research use only.

4',5,7-Trimethoxyflavone 98%

Odor: characteristic

Use: 4',5,7-Trimethoxyflavone is a flavonoid showing anti-inflammatory activity.

ExtraSynthese

For experimental / research use only.

Apigenin-4',5,7-trimethylether (HPLC) ≥95%

Safety Information:


Hazards identification

Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements

Pictogram

Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined

Safety in Use Information:

Category:
natural substances and extractives
Recommendation for 5,7,4'-trimethyl apigenin usage levels up to:
	not for fragrance use.

Recommendation for 5,7,4'-trimethyl apigenin flavor usage levels up to:
	not for flavor use.

Safety References:

EPI System: View

AIDS Citations:Search

Cancer Citations:Search

Toxicology Citations:Search

EPA ACToR:Toxicology Data

EPA Substance Registry Services (SRS):Registry

Laboratory Chemical Safety Summary :79730

National Institute of Allergy and Infectious Diseases:Data

5,7-dimethoxy-2-(4-methoxyphenyl)chromen-4-one

Chemidplus:0005631709

References:

	5,7-dimethoxy-2-(4-methoxyphenyl)chromen-4-one
NIST Chemistry WebBook:	Search Inchi
Pubchem (cid):	79730
Pubchem (sid):	135037229

Other Information:

(IUPAC):	Atomic Weights of the Elements 2011 (pdf)
Videos:	The Periodic Table of Videos
tgsc:	Atomic Weights use for this web site
(IUPAC):	Periodic Table of the Elements
CHEMBL:	View
KEGG (GenomeNet):	C14985
HMDB (The Human Metabolome Database):	HMDB30842
FooDB:	FDB002800
VCF-Online:	VCF Volatile Compounds in Food
ChemSpider:	View

Potential Blenders and core components note

None Found

Potential Uses:

None Found

Occurrence (nature, food, other):note

	mandarin peel Search Trop Picture
	orange pericarp Search Trop Picture
	orthosiphon spicatus Search Trop Picture

Synonyms:

	apigenin trimethyl ether
	apigenin-4',5,7-trimethyl ether
	apigenin-4',5,7-trimethylether
4H-1-	benzenopyran-4-one, 5,7-dimethoxy-2-(4-methoxyphenyl)-
5,7-	dimethoxy-2-(4-methoxyphenyl)-4H-1-benzenopyran-4-one
5,7-	dimethoxy-2-(4-methoxyphenyl)chromen-4-one
4',5,7-	trimethoxyflavone
4',5,7-	trimethyl-apigenin
5,7,4'-	trimethylapigenin

Articles:

PubMed:Effects of the natural flavone trimethylapigenin on cardiac potassium currents.

PubMed:Anticholinesterase activity of 7-methoxyflavones isolated from Kaempferia parviflora.

PubMed:Activation of the CFTR Cl- channel by trimethoxyflavone in vitro and in vivo.

PubMed:Bioactive compounds from Lippia javanica and Hoslundia opposita.

PubMed:Lipophilic flavonoids from Orthosiphon spicatus prevent oxidative inactivation of 15-lipoxygenase.

Notes:

a flavonoid from the east asian medicinal plant orthosiphon spicatus; prevents oxidative inactivation of 15-lipoxygenase. Occurs in the peel of Citrus reticulata (mandarin)

5,7,4'-trimethyl apigenin 4H-1-benzenopyran-4-one, 5,7-dimethoxy-2-(4-methoxyphenyl)-

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Articles:

5,7,4'-trimethyl apigenin
4H-1-benzenopyran-4-one, 5,7-dimethoxy-2-(4-methoxyphenyl)-