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Category:natural substances and extractives
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00
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| Food Chemicals Codex Listed: | No |
| Boiling Point: | 819.90 °C. @ 760.00 mm Hg (est)
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| Flash Point: | 533.00 °F. TCC ( 278.10 °C. ) (est)
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| logP (o/w): | 1.640 (est) |
| Soluble in: |
| | water, 1329 mg/L @ 25 °C (est) |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). |
Cosmetic Information:
Suppliers:
Safety Information:
| Preferred SDS: View |
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
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Not determined
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | | natural substances and extractives |
| Recommendation for cynarine usage levels up to: | | | not for fragrance use.
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| Recommendation for cynarine flavor usage levels up to: |
| | not for flavor use.
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Safety References:
References:
| | (1R,3R,4S,5R)-1,3-bis[[(E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]oxy]-4,5-dihydroxycyclohexane-1-carboxylic acid |
| NIST Chemistry WebBook: | Search Inchi |
| Canada Domestic Sub. List: | 30964-13-7 |
| Pubchem (cid): | 5281769 |
| Pubchem (sid): | 135079016 |
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| | caffeic acid 1-carboxy-4,5-dihydroxy-1,3-cyclohexylene ester | | | cinarin | | | cinarine | | | cyclohexanecarboxylic acid, 1,3-bis((3-(3,4-dihydroxyphenyl)-1-oxo-2-propenyl)oxy)-4,5-dihydroxy- | | | cynarin | | 1,5- | dicaffeoyl qunic acid | | 1,5- | dicaffeoylqunic acid | | (1R,3R,4S,5R)-1,3-bis[[(E)-3-(3,4- | dihydroxyphenyl)prop-2-enoyl]oxy]-4,5-dihydroxycyclohexane-1-carboxylic acid | | | listrocol | | | nivellipid | | | phemocil | | | plemocil | | | quinic acid 1,5-dicaffeic ester |
Articles:
| PubMed:[Regulation of syringin, chlorogenic acid and 1,5-dicaffeoylquinic acid biosynthesis in cell suspension cultures of Saussurea involucrata]. |
| PubMed:[A method based on endogenous fluorescence determination for screening NAMPT inhibitors]. |
| PubMed:Q&A: The nutrient hunter. |
| PubMed:Artichoke, cynarin and cyanidin downregulate the expression of inducible nitric oxide synthase in human coronary smooth muscle cells. |
| PubMed:[Development and validation of method for the determination of cynarin, luteolin in plasma]. |
| PubMed:Development of an automated method for Folin-Ciocalteu total phenolic assay in artichoke extracts. |
| PubMed:Inhibition of P-glycoprotein-mediated transport by S-adenosylmethionine and cynarin in multidrug-resistant human uterine sarcoma MES-SA/Dx5 cells. |
| PubMed:A new validated HPTLC method for quantitative determination of 1, 5-dicaffeoylquinic acid in Inula crithmoides roots. |
| PubMed:Effects of saline stress on mineral composition, phenolic acids and flavonoids in leaves of artichoke and cardoon genotypes grown in floating system. |
| PubMed:[Simultaneous determination of 6 active components in Chrysanthemum morifolium by HPLC]. |
| PubMed:Chip-based protein-protein interaction studied by atomic force microscopy. |
| PubMed:Cynarin-rich sunflower (Helianthus annuus) sprouts possess both antiglycative and antioxidant activities. |
| PubMed:Polyphenol compounds in artichoke plant tissues and varieties. |
| PubMed:Determination of major phenolic compounds in Echinacea spp. raw materials and finished products by high-performance liquid chromatography with ultraviolet detection: single-laboratory validation matrix extension. |
| PubMed:1,5-dicaffeoylquinic acid protects primary neurons from amyloid β 1-42-induced apoptosis via PI3K/Akt signaling pathway. |
| PubMed:Caffeoylquinic acid derived free radicals identified during antioxidant reactions of bitter tea (Ilex latifolia and Ilex kudincha). |
| PubMed:[Phytotherapy with a mixture of dry extracts with hepato-protective effects containing artichoke leaves in the management of functional dyspepsia symptoms]. |
| PubMed:An improved LC-MS/MS method for simultaneous determination of 1,5-dicaffeoylquinic acid and its active metabolites in human plasma and its application to a pharmacokinetic study in patients. |
| PubMed:Metabolic profile of the bioactive compounds of burdock (Arctium lappa) seeds, roots and leaves. |
| PubMed:Phytocontact dermatitis caused by artichoke: an exceptionally rare case. |
| PubMed:Blocking effect of an immuno-suppressive agent, cynarin, on CD28 of T-cell receptor. |
| PubMed:Effect of two artichoke extracts (36_U and 36_EB) on rat ileum (with respect to bowel syndrome) and the peristaltic threshold. |
| PubMed:Simultaneous determination of 1,5-dicaffeoylquinic acid and its active metabolites in human plasma by liquid chromatography-tandem mass spectrometry for pharmacokinetic studies. |
| PubMed:Proliferative activity of Echinacea angustifolia root extracts on cancer cells: Interference with doxorubicin cytotoxicity. |
| PubMed:Determination of phenolic compounds in fennel by HPLC and HPLC-MS using a monolithic reversed-phase column. |
| PubMed:Immuno-suppressive effect of blocking the CD28 signaling pathway in T-cells by an active component of Echinacea found by a novel pharmaceutical screening method. |
| PubMed:Genetic diversity in seed populations of Echinacea purpurea controls the capacity for regeneration, route of morphogenesis and phytochemical composition. |
| PubMed:Choleretic effects of yarrow (Achillea millefolium s.l.) in the isolated perfused rat liver. |
| PubMed:Pharmacokinetics and metabolism of 1,5-dicaffeoylquinic acid in rats following a single intravenous administration. |
| PubMed:Metabolic profile of 1,5-dicaffeoylquinic acid in rats, an in vivo and in vitro study. |
| PubMed:Mass spectrometry of 1,3- and 1,5-dicaffeoylquinic acids. |
| PubMed:Efficacy of different Cynara scolymus preparations on liver complaints. |
| PubMed:A new dilignan from Cynara cardunculus. |
| PubMed:Identification of isomeric dicaffeoylquinic acids from Eleutherococcus senticosus using HPLC-ESI/TOF/MS and 1H-NMR methods. |
| PubMed:Evaluation of antioxidant activity of some natural polyphenolic compounds using the Briggs-Rauscher reaction method. |
| PubMed:Simultaneous analysis of alkamides and caffeic acid derivatives for the identification of Echinacea purpurea, Echinacea angustifolia, Echinacea pallida and Parthenium integrifolium roots. |
| PubMed:Phytochemical variation in echinacea from roots and flowerheads of wild and cultivated populations. |
| PubMed:Major dicaffeoylquinic acids from Artemisia vulgaris. |
| PubMed:Comparison of chemical components and antioxidants capacity of different Echinacea species. |
| PubMed:Activity of artichoke leaf extract on reactive oxygen species in human leukocytes. |
| PubMed:Dicaffeoylquinic and dicaffeoyltartaric acids are selective inhibitors of human immunodeficiency virus type 1 integrase. |
| PubMed:Echinacoside and caffeoyl conjugates protect collagen from free radical-induced degradation: a potential use of Echinacea extracts in the prevention of skin photodamage. |
| PubMed:Radical scavenger activity of different 3',4'-dihydroxyflavonols and 1,5-dicaffeoylquinic acid studied by inhibition of chemiluminescence. |
| PubMed:Direct characterization of caffeoyl esters with antihyaluronidase activity in crude extracts from Echinacea angustifolia roots by fast atom bombardment tandem mass spectrometry. |
| PubMed:TLC and HPLC analysis of Echinacea pallida and E. angustifolia roots. |
| PubMed:Hepatoprotective activity of polyphenolic compounds from Cynara scolymus against CCl4 toxicity in isolated rat hepatocytes. |
| PubMed:[Phospholipid fractions and free fatty acids in the serum of patients with hypertriglyceridemia treated with 1,5-dicaffeequinine acid]. |
| PubMed:[Blood coagulation and fibrinolysis systems in patients with hypertriglyceridemia treated with 1,5-dicoffeechinic acid]. |
| PubMed:[1,5-dicoffeechinic acid in the treatment of hypertriglyceridemia]. |
| PubMed:[Electroretinographic investigations in subjects in chronic exposure to carbon disulphide: III. Cynarex effect on ERG related to blood lipid pattern (author's transl)]. |
| PubMed:[Platelet aggregation in workers chronically exposed to carbon disulfide and subjected to prophylactic treatment with Cynarex]. |
| PubMed:[Determination of cynarin by HPLC in pharmaceutical dosage forms]. |
| PubMed:[Cynarix. Therapeutic experiences with Cynarix in disorders of fat metabolism in general practice]. |
| PubMed:[Electroretinographic investigations in subjects with chronic exposure to carbon disulphide: II. Effect of cynarex administration of ERG curves (author's transl)]. |
| PubMed:Frequently used lipid-lowering drugs having no guaranteed effect. |
| PubMed:Effect of 1,5-dicaffeylquinic acid (cynarine) on cholesterol levels in serum and liver of acute ethanol-treated rats. |
| PubMed:Effect of 1,5-dicaffeoylquinic acid on ethanol-induced hypertriglyceridemia. Short communication. |
| PubMed:[Effect of 1,5-dicafleylquinic acid (cynarine) on hypertriglyceridemia in aged patients]. |
| PubMed:[Treatment of nephrotic syndromes with cynarine]. |
| PubMed:[Treatment of nephrotic syndromes with cynarine]. |
| PubMed:[Isolation and determination of cynarine, chlorogenic acid and caffeic acid with thin-layer chromatography]. |
| PubMed:[ON POLYPHENOL COMPOUNDS OF THE ARTICHOKE (SYNARA SCOLYMUS L.). II. EXTRACTION OF CYNARINE SALTS]. |
| PubMed:Therapeutic effects of 1-4-dicaffeil quinic acid (cynarine) administered by oral, rectal, intravenous and intraduodenal way. |
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3D/inchi