EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes

ginsenoside Rb1
beta-D-glucopyranoside, (3-beta,12-beta)-20-((6-o-beta-d-glucopyranosyl-beta-d-glucopyranosyl)oxy)-12-hydroxydammar-24-en-3-yl 2-o-beta-d-glucopyranosyl-

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CAS Number: 41753-43-9Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:255-532-8
FDA UNII: Search
MDL:MFCD00133367
XlogP3-AA:0.30 (est)
Molecular Weight:1109.30884000
Formula:C54 H92 O23
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:natural substances and extractives
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Boiling Point:1145.90 °C. @ 760.00 mm Hg (est)
Flash Point:1196.00 °F. TCC ( 646.80 °C. ) (est)
logP (o/w): 2.900 (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
Alfa Biotechnology
For experimental / research use only.
Ginsenoside Rb1 98%
BOC Sciences
For experimental / research use only.
Ginsenoside Rb1
ExtraSynthese
For experimental / research use only.
Ginsenoside Rb1 (HPLC) ≥98%
Glentham Life Sciences
Ginsenoside Rb1
Santa Cruz Biotechnology
For experimental / research use only.
Ginsenoside Rb1 ≥98%
Sigma-Aldrich
For experimental / research use only.
Ginsenoside Rb1
primary pharmaceutical reference standard
 
Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intraperitoneal-mouse LD50 1110 mg/kg
Arzneimittel-Forschung. Drug Research. Vol. 25, Pg. 343, 1975.

intravenous-mouse LD50 243 mg/kg
Saengyak Hakhoechi. Journal of the Society of Pharmacognosy. Vol. 10, Pg. 61, 1979.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
natural substances and extractives
Recommendation for ginsenoside Rb1 usage levels up to:
 not for fragrance use.
 
Recommendation for ginsenoside Rb1 flavor usage levels up to:
 not for flavor use.
 
Safety References:
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :73148
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
Chemidplus:0041753439
RTECS:LZ5856000 for cas# 41753-43-9
 
References:
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:41753-43-9
Pubchem (cid):73148
Pubchem (sid):135029701
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
HMDB (The Human Metabolome Database):HMDB35892
FooDB:FDB014677
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 ginseng
Search Trop Picture
 
Synonyms:
 arasaponin E1
pseudoginsenoside D
 ginsenoside RB1
beta-D-glucopyranoside, (3-beta,12-beta)-20-((6-o-beta-d-glucopyranosyl-beta-d-glucopyranosyl)oxy)-12-hydroxydammar-24-en-3-yl 2-o-beta-d-glucopyranosyl-
2-O-beta-glucopyranosyl-(3beta,12beta)-20-((6-o-beta-d-glucopyranosyl-beta-d-glucopyranosyl)oxy)-12-hydroxydammar-24-en-3-yl-beta-d-glucopyranoside
 gynosaponin C
 gypenoside III
 panax saponin E
 sanchinoside E1
 

Articles:

PubMed:Red Ginseng Extract Promotes the Hair Growth in Cultured Human Hair Follicles.
PubMed:Ginsenoside Rb1 Prevents H2O2-Induced HUVEC Senescence by Stimulating Sirtuin-1 Pathway.
PubMed:The ginsenoside 20-O-β-D-glucopyranosyl-20(S)-protopanaxadiol induces autophagy and apoptosis in human melanoma via AMPK/JNK phosphorylation.
PubMed:Ginsenoside Rb1 eliminates HIV-1 (D3)-transduced cytoprotective human macrophages by inhibiting the AKT pathway.
PubMed:A well-refined in vitro model derived from human embryonic stem cell for screening phytochemicals with midbrain dopaminergic differentiation-boosting potential for improving Parkinson's disease.
PubMed:Ginsenoside Rb1 improves energy metabolism in the skeletal muscle of an animal model of postoperative fatigue syndrome.
PubMed:Expression of antiviral cytokines in Crandell-Reese feline kidney cells pretreated with Korean red ginseng extract or ginsenosides.
PubMed:Protective effects of ginsenoside Rb1 on septic rats and its mechanism.
PubMed:[Major hypoglycemic ingredients of panax notoginseng saponins for treating diabetes].
PubMed:Subacute oral toxicity study of korean red ginseng extract in sprague-dawley rats.
PubMed:Evaluation of glucosidases of Aspergillus niger strain comparing with other glucosidases in transformation of ginsenoside Rb1 to ginsenosides Rg3.
PubMed:Characterization of a ginsenoside-transforming β-glucosidase from Paenibacillus mucilaginosus and its application for enhanced production of minor ginsenoside F₂.
PubMed:Efficacy comparison of Korean ginseng and American ginseng on body temperature and metabolic parameters.
PubMed:Ginsenoside rb1 modulates level of monoamine neurotransmitters in mice frontal cortex and cerebellum in response to immobilization stress.
PubMed:Red ginseng protects against gentamicin-induced balance dysfunction and hearing loss in rats through antiapoptotic functions of ginsenoside Rb1.
PubMed:Reduction of hepatitis A virus on FRhK-4 cells treated with Korean red ginseng extract and ginsenosides.
PubMed:Ginseng panaxoside Rb1 reduces body weight in diet-induced obese mice.
PubMed:Microbial transformation of ginsenoside Rb1 to compound K by Lactobacillus paralimentarius.
PubMed:Lactobacillus ginsenosidimutans sp. nov., isolated from kimchi with the ability to transform ginsenosides.
PubMed:Ginsenosides Rb₁ and Rd regulate proliferation of mature keratinocytes through induction of p63 expression in hair follicles.
PubMed:Ginsenoside Re ameliorates inflammation by inhibiting the binding of lipopolysaccharide to TLR4 on macrophages.
PubMed:Highly selective microbial transformation of major ginsenoside Rb1 to gypenoside LXXV by Esteya vermicola CNU120806.
PubMed:Enzymatic biotransformation of ginsenoside Rb1 to compound K by recombinant β-glucosidase from Microbacterium esteraromaticum.
PubMed:Ginsenoside Rb1 inhibits osteoclastogenesis by modulating NF-κB and MAPKs pathways.
PubMed:Ginsenoside Rb1 inhibits cell activation and liver fibrosis in rat hepatic stellate cells.
PubMed:Porosity changes and retention of ginsenosides in North American ginseng root using different dehydration processes.
PubMed:Ginsenoside Rb1 inhibits proliferation and inflammatory responses in rat aortic smooth muscle cells.
PubMed:Ginsenoside Rb1 improves spatial learning and memory by regulation of cell genesis in the hippocampal subregions of rats.
PubMed:Antiobesity and antihyperglycemic effects of ginsenoside Rb1 in rats.
PubMed:Application of gamma irradiation in ginseng for both photodegradation of pesticide pentachloronitrobenzene and microbial decontamination.
PubMed:Effects of red ginseng extract on UVB irradiation-induced skin aging in hairless mice.
PubMed:Effects of extrusion process variables on extractable ginsenosides in wheat-ginseng extrudates.
PubMed:Ginsenosides Rb1 and Rg1 suppress triglyceride accumulation in 3T3-L1 adipocytes and enhance beta-cell insulin secretion and viability in Min6 cells via PKA-dependent pathways.
PubMed:Optimization of lipase-catalyzed synthesis of ginsenoside Rb1 esters using response surface methodology.
PubMed:Optimization of ginsenosides hydrolyzing beta-glucosidase production from Aspergillus niger using response surface methodology.
PubMed:Biotransformation of ginsenoside Rb1, crocin, amygdalin, geniposide, puerarin, ginsenoside Re, hesperidin, poncirin, glycyrrhizin, and baicalin by human fecal microflora and its relation to cytotoxicity against tumor cells.
PubMed:Eastern blotting and immunoaffinity concentration using monoclonal antibody for ginseng saponins in the field of traditional chinese medicines.
PubMed:Effects of population, age, and cultivation methods on ginsenoside content of wild American ginseng (Panax quinquefolium).
PubMed:Transformation of ginsenosides Rb1 and Re from Panax ginseng by food microorganisms.
PubMed:Determination of ginsenosides Rb1, Rc, and Re in different dosage forms of ginseng by negative ion electrospray liquid chromatography-mass spectrometry.
PubMed:Isolation of dammarane saponins from Panax notoginseng by high-speed counter-current chromatography.
PubMed:Modulation of lipopolysaccharide-induced proinflammatory cytokine production in vitro and in vivo by the herbal constituents apigenin (chamomile), ginsenoside Rb(1) (ginseng) and parthenolide (feverfew).
PubMed:[Study on the nootropic mechanism of ginsenoside Rb1 and Rg1--influence on mouse brain development].
PubMed:[Ginsenoside-Rb1 as a suppressor in central modulation of feeding in the rat].
 
Notes:
Constit. of Panax ginseng (ginseng)
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